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List of works by John P. Lydon

A Gata2-Dependent Transcription Network Regulates Uterine Progesterone Responsiveness and Endometrial Function.

scientific article

A Novel Effect of β-Adrenergic Receptor on Mammary Branching Morphogenesis and its Possible Implications in Breast Cancer.

scientific article published on 11 January 2017

A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse.

scientific article published on 24 October 2017

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland

scientific article published on 19 February 2015

A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland.

scientific article published on 10 March 2015

A bioluminescence reporter mouse that monitors expression of constitutively active β-catenin

scientific article

A distal super enhancer mediates estrogen-dependent mouse uterine–specific gene transcription of Insulin-like growth factor 1 (Igf1)

article

A mouse model engineered to conditionally express the progesterone receptor-B isoform

scientific article published on 10 August 2018

A mouse model for endometrioid ovarian cancer arising from the distal oviduct.

scientific article

A mouse model to dissect progesterone signaling in the female reproductive tract and mammary gland

scientific article

A mouse transgenic approach to induce β-catenin signaling in a temporally controlled manner.

scientific article published on 2 December 2010

A murine uterine transcriptome, responsive to steroid receptor coactivator-2, reveals transcription factor 23 as essential for decidualization of human endometrial stromal cells

scientific article

A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis

scientific article published on July 2012

A novel LacZ reporter mouse reveals complex regulation of the progesterone receptor promoter during mammary gland development.

scientific article published in November 2002

A repressive role for prohibitin in estrogen signaling.

scientific article

A role for site-specific phosphorylation of mouse progesterone receptor at serine 191 in vivo

scientific article

ARID1A Is Essential for Endometrial Function during Early Pregnancy

scientific article

Aberrant Activation of the RANK Signaling Receptor Induces Murine Salivary Gland Tumors

scientific article published on 10 June 2015

Ablation of Indian hedgehog in the murine uterus results in decreased cell cycle progression, aberrant epidermal growth factor signaling, and increased estrogen signaling

scientific article

Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization.

scientific article

Activated AKT pathway promotes establishment of endometriosis

scientific article published on 26 February 2014

Activin-like kinase 2 functions in peri-implantation uterine signaling in mice and humans

scientific article

Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression

scientific article published on 14 March 2013

Application of (13) C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation

scientific article published on 01 October 2015

Application of 13C isotope labeling using liquid chromatography mass spectrometry (LC-MS) to determining phosphate-containing metabolic incorporation

scientific article published on December 2013

BMPR2 is required for postimplantation uterine function and pregnancy maintenance

scientific article

Bmp2 is critical for the murine uterine decidual response

scientific article

Bone growth and turnover in progesterone receptor knockout mice

scientific article published on 14 February 2008

C/EBPbeta (CCAAT/enhancer binding protein) controls cell fate determination during mammary gland development

scientific journal article

CDH1 is essential for endometrial differentiation, gland development, and adult function in the mouse uterus

scientific journal article

COUP-TFII mediates progesterone regulation of uterine implantation by controlling ER activity

scientific article

CUZD1 is a critical mediator of the JAK/STAT5 signaling pathway that controls mammary gland development during pregnancy

scientific article

Cell type-specific targeted mutations of Kras and Pten document proliferation arrest in granulosa cells versus oncogenic insult to ovarian surface epithelial cells

scientific article

Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts

scientific article published on 16 June 2016

Conditional Ablation of Progesterone Receptor Membrane Component 2 Causes Female Premature Reproductive Senescence

scientific article published on 22 December 2016

Conditional abrogation of transforming growth factor-β receptor 1 in PTEN-inactivated endometrium promotes endometrial cancer progression in mice.

scientific article

Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity.

scientific article published on 17 November 2011

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice

scientific article

Connective tissue growth factor is required for normal follicle development and ovulation

scientific article

Constitutive activation of smoothened leads to female infertility and altered uterine differentiation in the mouse.

scientific article

Constitutive activation of transforming growth factor Beta receptor 1 in the mouse uterus impairs uterine morphology and function

scientific article

Constitutive expression of progesterone receptor isoforms promotes the development of hormone-dependent ovarian neoplasms

scientific article published on 06 October 2020

Correction: Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization.

scientific article published on 29 September 2015

Correction: COUP-TFII Mediates Progesterone Regulation of Uterine Implantation by Controlling ER Activity

Correction: Perturbing the Cellular Levels of Steroid Receptor Coactivator-2 Impairs Murine Endometrial Function.

scientific article published on 18 November 2015

Cre-mediated recombination in cell lineages that express the progesterone receptor

scientific article published on February 2005

Critical tumor suppressor function mediated by epithelial Mig-6 in endometrial cancer

scientific article published on 27 June 2013

Decreased epithelial progesterone receptor A at the window of receptivity is required for preparation of the endometrium for embryo attachment.

scientific article published in February 2017

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

scientific journal article

Deficiency in DGCR8-dependent canonical microRNAs causes infertility due to multiple abnormalities during uterine development in mice.

scientific article published on 2 February 2016

Deletion of RhoA in progesterone receptor expressing cells leads to luteal insufficiency and infertility in female mice.

scientific article published on 11 May 2017

Differential mouse-strain specific expression of Junctional Adhesion Molecule (JAM)-B in placental structures

scientific article published on 25 February 2016

Disruption of steroid and prolactin receptor patterning in the mammary gland correlates with a block in lobuloalveolar development

scientific article published in December 2002

Distinct functions and regulation of epithelial progesterone receptor in the mouse cervix, vagina, and uterus

scientific article published on 17 March 2016

Dysregulation of Uterine Signaling Pathways in Progesterone Receptor-Cre Knockout of Dicer ⬇️

scientific article published on July 13, 2012

ERBB receptor feedback inhibitor 1 regulation of estrogen receptor activity is critical for uterine implantation in mice

scientific article

Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization

scientific article published on 31 January 2019

Endogenous YAP1 Activation Drives Immediate Onset of Cervical Carcinoma In Situ in Mice

scientific article published on 27 July 2020

Endometrial Expression of Steroidogenic Factor 1 Promotes Cystic Glandular Morphogenesis.

scientific article

Enhanced sexual behaviors and androgen receptor immunoreactivity in the male progesterone receptor knockout mouse

scientific article published on 7 July 2005

Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit Is Required for Uterine Epithelial Integrity

scientific article published on 05 April 2019

Epithelial progesterone receptor exhibits pleiotropic roles in uterine development and function ⬇️

scientific article published on December 12, 2011

Epithelial-stromal interaction and progesterone receptors in the mouse uterus

scientific article published on 26 January 2010

Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis

scientific article

Estrogen-regulated prohibitin is required for mouse uterine development and adult function.

scientific article

FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation

scientific article published on 19 November 2018

Fibroblast growth factor receptor two (FGFR2) regulates uterine epithelial integrity and fertility in mice.

scientific article published on 16 January 2014

Finally! A model for progesterone receptor action in normal human breast

scientific article published on July 2009

Foxa2 is essential for mouse endometrial gland development and fertility.

scientific article

From the ranks of mammary progesterone mediators, RANKL takes the spotlight ⬇️

scientific article published on September 22, 2011

Functional role of progestin and the progesterone receptor in the suppression of spermatogenesis in rodents ⬇️

scientific article published on 01 March 2013

GATA2 is expressed at critical times in the mouse uterus during pregnancy.

scientific article

GATA4 and GATA6 Knockdown During Luteinization Inhibits Progesterone Production and Gonadotropin Responsiveness in the Corpus Luteum of Female Mice

scientific article

Gap junction communication between uterine stromal cells plays a critical role in pregnancy-associated neovascularization and embryo survival.

scientific article

Generation of a mouse for conditional excision of progesterone receptor

scientific article published in August 2006

Genotype differences in behavior and tyrosine hydroxylase expression between wild-type and progesterone receptor knockout mice

scientific article published on February 2006

Glandular defects in the mouse uterus with sustained activation of TGF-beta signaling is associated with altered differentiation of endometrial stromal cells and formation of stromal compartment

scientific article published in PLoS ONE

Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.

scientific article published on 17 February 2016

Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.

scientific article published in September 2017

Histopathologic and transcriptomic phenotypes of a conditional RANKL transgenic mouse thymus

scientific article published in 2022

Hormonal defect in maspin heterozygous mice reveals a role of progesterone in pubertal ductal development

scientific article

Hormone dependence in premalignant mammary progression.

scientific article

Human Endometrial Stromal Cell Decidualization Requires Transcriptional Reprogramming by PLZF.

scientific article

Hyaluronan in cervical epithelia protects against infection-mediated preterm birth

scientific article

Identification of murine uterine genes regulated in a ligand-dependent manner by the progesterone receptor.

scientific article published on 21 April 2005

Impaired LH surge amplitude in gonadotrope-specific progesterone receptor knockout mice

scientific article published on 01 January 2020

Impaired Progesterone-Responsiveness of CD11c Dendritic Cells Affects the Generation of CD4 Regulatory T Cells and Is Associated With Intrauterine Growth Restriction in Mice

scientific article published on 25 February 2019

In vivo analysis of progesterone receptor action in the uterus during embryo implantation

scientific article published on 06 January 2008

Increased FOXL2 expression alters uterine structures and functions†

scientific article published on 25 August 2020

Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus

scientific article published on 03 September 2006

Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis

scientific article published in September 2004

Integrated chromatin immunoprecipitation sequencing and microarray analysis identifies FOXA2 target genes in the glands of the mouse uterus

scientific article published on 11 September 2013

Liver receptor homolog-1 is essential for pregnancy

scientific article published on 30 June 2013

Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice.

scientific article

Loss of CDH1 and Pten accelerates cellular invasiveness and angiogenesis in the mouse uterus.

scientific article

Loss of Fertility in the Absence of Progesterone Receptor Expression in Kisspeptin Neurons of Female Mice

scientific article

Maternal heparin-binding-EGF deficiency limits pregnancy success in mice.

scientific article

Maximal Dexamethasone Inhibition of Luminal Epithelial Proliferation Involves Progesterone Receptor (PR)- and Non-PR-Mediated Mechanisms in Neonatal Mouse Uterus

scientific article published on 16 April 2015

Mig-6 modulates uterine steroid hormone responsiveness and exhibits altered expression in endometrial disease

scholarly article

Mig-6 suppresses endometrial cancer associated with Pten deficiency and ERK activation

scientific article

Minireview: Steroid Receptor Coactivator-3: A Multifarious Coregulator in Mammary Gland Metastasis ⬇️

scientific article published on November 3, 2010

Mouse models of implantation.

scientific article published on 27 June 2007

NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy

scientific journal article

Negative elongation factor is essential for endometrial function

scientific article published on 17 October 2018

New insights into progesterone receptor signaling in the endometrium required for embryo implantation

scientific article published on 01 December 2019

Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse.

scientific article published on 11 October 2011

Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.

scientific article published on 19 April 2017

Nuclear receptor coactivator-6 attenuates uterine estrogen sensitivity to permit embryo implantation.

scientific article

Oviductal Retention of Embryos in Female Mice Lacking Estrogen Receptor α in the Isthmus and the Uterus

scientific article published on 01 February 2020

PR-Set7 deficiency limits uterine epithelial population growth hampering postnatal gland formation in mice

scientific article published on 21 July 2017

Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells

scientific journal article

Pathway-centric integrative analysis identifies RRM2 as a prognostic marker in breast cancer associated with poor survival and tamoxifen resistance

scientific article

Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice.

scientific article

Perturbing the cellular levels of steroid receptor coactivator-2 impairs murine endometrial function

scientific article

Postnatal deletion of Wnt7a inhibits uterine gland morphogenesis and compromises adult fertility in mice

scientific article

Progesterone Receptor Serves the Ovary as a Trigger of Ovulation and a Terminator of Inflammation

scientific article published on 01 April 2020

Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation

scientific article

Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.

scientific article published on 5 March 2013

Progesterone involvement in breast development and tumorigenesis--as revealed by progesterone receptor "knockout" and "knockin" mouse models

scientific article published on November 2003

Progesterone modulates the T-cell response via glucocorticoid receptor-dependent pathways

scientific article published on 28 January 2019

Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells

scientific article published on 06 September 2013

Progesterone receptor knockout mice have an improved glucose homeostasis secondary to beta -cell proliferation

scientific article

Progesterone receptors in mammary gland development and tumorigenesis

scientific article published on April 2003

Progesterone receptors mediate male aggression toward infants

scientific article

Progesterone receptors: a key for neuroprotection in experimental stroke.

scientific article published on 25 May 2012

Progesterone signaling inhibits cervical carcinogenesis in mice

scientific article published on 05 September 2013

Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability

scientific article published on 6 August 2012

Progesterone's role in mammary gland development and tumorigenesis as disclosed by experimental mouse genetics

scientific article

Progesterone-action in the murine uterus and mammary gland requires steroid receptor coactivator 2: relevance to the human.

scientific article published on May 2007

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms.

scientific article

Pten and Dicer1 loss in the mouse uterus causes poorly differentiated endometrial adenocarcinoma

scientific article published on 25 August 2020

Repressor of estrogen receptor activity (REA) is essential for mammary gland morphogenesis and functional activities: studies in conditional knockout mice

scientific article

Reprint of "Steroid receptor coactivators as therapeutic targets in the female reproductive system".

scientific article

Reproductive functions of progesterone receptors.

scientific article

Research resource: Genome-wide profiling of progesterone receptor binding in the mouse uterus.

scientific article

Retinoid signaling controlled by SRC-2 in decidualization revealed by transcriptomics

article

Revealing progesterone's role in uterine and mammary gland biology: insights from the mouse.

scientific article

Role of the progesterone receptor (PR) in susceptibility of mouse mammary gland to 7,12-dimethylbenz[a]anthracene-induced hormone-independent preneoplastic lesions in vitro

scientific article published in December 2002

SOX17 regulates uterine epithelial-stromal cross-talk acting via a distal enhancer upstream of Ihh

scientific article published in Nature Communications

Short-term RANKL exposure initiates a neoplastic transcriptional program in the basal epithelium of the murine salivary gland

scientific article published on 18 June 2019

Signal transducer and activator of transcription‐3 (Stat3) plays a critical role in implantationviaprogesterone receptor in uterus ⬇️

scientific article published on March 26, 2013

Stem cells: Cues from steroid hormones

scientific article published in June 2010

Steroid Receptor Coactivator-2 Controls the Pentose Phosphate Pathway through RPIA in Human Endometrial Cancer Cells

scientific article published in Scientific Reports

Steroid receptor coactivator 2 is critical for progesterone-dependent uterine function and mammary morphogenesis in the mouse

scientific article

Steroid receptor coactivator 2 is essential for progesterone-dependent uterine function and mammary morphogenesis: insights from the mouse--implications for the human.

scientific article published on 12 October 2006

Steroid receptor coactivator 2 is required for female fertility and mammary morphogenesis: insights from the mouse, relevance to the human

scientific article

Steroid receptor coactivators as therapeutic targets in the female reproductive system

scientific article published on 04 July 2015

Stromal progesterone receptors mediate induction of Indian Hedgehog (IHH) in uterine epithelium and its downstream targets in uterine stroma.

scientific article published on 16 April 2009

Suppression of ERalpha activity by COUP-TFII is essential for successful implantation and decidualization

scientific article

Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression.

scientific article

Targeting iCre expression to murine progesterone receptor cell-lineages using bacterial artificial chromosome transgenesis

scientific article published on December 2006

Targeting reverse tetracycline-dependent transactivator to murine mammary epithelial cells that express the progesterone receptor

scientific article published in October 2007

The Antiproliferative Action of Progesterone in Uterine Epithelium Is Mediated by Hand2 ⬇️

scientific article published on February 18, 2011

The Autophagy Gene Atg16L1 is Necessary for Endometrial Decidualization

scientific article published on 01 January 2020

The Germ Cell Gene TDRD1 as an ERG Target Gene and a Novel Prostate Cancer Biomarker

scientific article published on 8 June 2016

The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization.

scientific article

The RANKL signaling axis is sufficient to elicit ductal side-branching and alveologenesis in the mammary gland of the virgin mouse

scientific journal article

The Synergistic Effect of Conditional Pten Loss and Oncogenic K-ras Mutation on Endometrial Cancer Development Occurs via Decreased Progesterone Receptor Action

scientific article published on 27 October 2009

The autophagy protein, FIP200 (RB1CC1) mediates progesterone responses governing uterine receptivity and decidualization†

scientific article published on 01 April 2020

The differences in neuroprotective efficacy of progesterone and medroxyprogesterone acetate correlate with their effects on brain-derived neurotrophic factor expression

scientific article published on 26 March 2009

The epidermal growth factor receptor critically regulates endometrial function during early pregnancy

scientific article

The essential role of GATA transcription factors in adult murine prostate

scientific article published on 25 June 2016

The histone methyltransferase EZH2 is required for normal uterine development and function in mice†

scientific article published on 01 August 2019

The p160 steroid receptor coactivator 2, SRC-2, regulates murine endometrial function and regulates progesterone-independent and -dependent gene expression

scientific article published on 07 June 2007

The p160/steroid receptor coactivator family: potent arbiters of uterine physiology and dysfunction

scientific article published on 8 October 2014

The pattern of beta-catenin responsiveness within the mammary gland is regulated by progesterone receptor

scientific article published on 19 September 2007

The transcriptional repressor Blimp1/PRDM1 regulates the maternal decidual response in mice

scientific article published on 03 June 2020

Three-Dimensional High-Frequency Ultrasonography for Early Detection and Characterization of Embryo Implantation Site Development in the Mouse

scientific article

Transcriptional response of the murine mammary gland to acute progesterone exposure

scientific article published on 07 August 2008

Transforming growth factor beta signaling and decidual integrity in mice†

scientific article published on 09 September 2020

Using CRISPR/Cas9 engineering to generate a mouse with a conditional knockout allele for the promyelocytic leukemia zinc finger transcription factor

scientific article published on 23 January 2019

Uterine ALK3 is essential during the window of implantation

scientific article

Uterine Development and Fertility Are Dependent on Gene Dosage of the Nuclear Receptor Coregulator REA ⬇️

scientific article published on May 14, 2012

Uterine Gαq/11 signaling, in a progesterone-dependent manner, critically regulates the acquisition of uterine receptivity in the female mouse

scientific article published on 15 May 2019

Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms

scientific article

Uterine function in the mouse requires speckle-type poz protein.

scientific article published on 13 March 2018

Uterine glucocorticoid receptors are critical for fertility in mice through control of embryo implantation and decidualization.

scientific article

Uterine-Specific Loss of Tsc2 Leads to Myometrial Tumors in Both the Uterus and Lungs ⬇️

scientific article published on July 2, 2013

VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.

scientific article published on 02 August 2013

WNK1 regulates uterine homeostasis and its ability to support pregnancy

scientific article published on 13 October 2020

WNT4 is a key regulator of normal postnatal uterine development and progesterone signaling during embryo implantation and decidualization in the mouse.

scientific article

WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development

scientific article

β-Catenin activation contributes to the pathogenesis of adenomyosis through epithelial-mesenchymal transition.

scientific article

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