List of works - Lutgarde Serneels

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

scientific article

Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein

scientific article

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

scientific journal article

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

scientific article

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

scientific article

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells

scientific journal article

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

scientific journal article

Molecular Analysis of the Human and Mouse α2M Family ⬇️

scientific article published on September 10, 1994

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

scientific journal article

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

scientific journal article

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

scientific article

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

scientific article published on 01 May 2019

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

scientific article published on 28 October 2019

Structure and Targeting in ES Cells of the Gene Coding for Mouse α2‐Macroglobulin ⬇️

scientific article published on September 10, 1994

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

scientific article

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

scientific article

β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment ⬇️

scientific article published on August 20, 2012

List of works by Lutgarde Serneels

Cell autonomous regulation of hippocampal circuitry via Aph1b-γ-secretase/neuregulin 1 signalling

Cloning, characterization, and chromosomal localization to 4p16 of the human gene (LRPAP1) coding for the alpha 2-macroglobulin receptor-associated protein and structural comparison with the murine gene coding for the 44-kDa heparin-binding protein

Coordinated and widespread expression of gamma-secretase in vivo: evidence for size and molecular heterogeneity

Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo

Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone

Mice lacking Dfna5 show a diverging number of cochlear fourth row outer hair cells

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

Molecular Analysis of the Human and Mouse α2M Family ⬇️

Presenilin 1 mediates the turnover of telencephalin in hippocampal neurons via an autophagic degradative pathway

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition

Stem-cell-derived human microglia transplanted in mouse brain to study human disease

Structure and Targeting in ES Cells of the Gene Coding for Mouse α2‐Macroglobulin ⬇️

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts

The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex

β‐Secretase (BACE1) inhibition causes retinal pathology by vascular dysregulation and accumulation of age pigment ⬇️