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List of works by Maria João Bonifácio

A single- and multiple-dose study to investigate the pharmacokinetics and pharmacodynamics of opicapone, a novel COMT inhibitor, in rat.

scientific article published on 19 July 2017

Blood pressure-decreasing effect of etamicastat alone and in combination with antihypertensive drugs in the spontaneously hypertensive rat

scientific article published on 09 October 2014

Carbamazepine aggravates absence seizures in two dedicated mouse models

scientific article published on 23 March 2015

Catechol-O-methyltransferase and its inhibitors in Parkinson's disease

scientific article

Characterization of the interaction of the novel antihypertensive etamicastat with human dopamine-β-hydroxylase: comparison with nepicastat.

scientific article

Cloning and gene silencing of LAT2, the L-3,4-dihydroxyphenylalanine (L-DOPA) transporter, in pig renal LLC-PK1 epithelial cells.

scientific article published in October 2004

Computation of the binding affinities of catechol-O-methyltransferase inhibitors: multisubstate relative free energy calculations.

scientific article published on 25 January 2012

Discovery of a Potent, Long-Acting, and CNS-Active Inhibitor (BIA 10-2474) of Fatty Acid Amide Hydrolase

scientific article published on 11 September 2018

Discovery of a long-acting, peripherally selective inhibitor of catechol-O-methyltransferase.

scientific article published in April 2010

Effect of opicapone multiple-dose regimens on levodopa pharmacokinetics.

scientific article

Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action

scientific article published on 30 March 2015

Eslicarbazepine and the enhancement of slow inactivation of voltage-gated sodium channels: a comparison with carbamazepine, oxcarbazepine and lacosamide.

scientific article published on 19 September 2014

Etamicastat, a new dopamine-ß-hydroxylase inhibitor, pharmacodynamics and metabolism in rat.

scientific article

Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation

scientific article

In-vivo evaluation of prolonged release bilayer tablets of anti-Parkinson drugs in Göttingen minipigs

scientific article published on 28 April 2011

Inhibition of catechol-O-methyltransferase in the cynomolgus monkey by opicapone after acute and repeated administration

scientific article published on 02 October 2018

Kinetic inhibitory profile of BIA 3-202, a novel fast tight-binding, reversible and competitive catechol-O-methyltransferase inhibitor.

scientific article

Kinetics and crystal structure of catechol-o-methyltransferase complex with co-substrate and a novel inhibitor with potential therapeutic application

scientific article

N-acetylation of etamicastat, a reversible dopamine-β-hydroxylase inhibitor

scientific article published on 6 September 2013

Opicapone enhances the reversal of MPTP-induced Parkinson-like syndrome by levodopa in cynomolgus monkeys

scientific article published on 18 November 2020

Opicapone: a short lived and very long acting novel catechol-O-methyltransferase inhibitor following multiple dose administration in healthy subjects

scientific article (publication date: 21 October 2013)

Organ-specific overexpression of renal LAT2 and enhanced tubular L-DOPA uptake precede the onset of hypertension

scientific article published on 15 September 2003

Pharmacokinetics, pharmacodynamics and tolerability of opicapone, a novel catechol-O-methyltransferase inhibitor, in healthy subjects: prediction of slow enzyme-inhibitor complex dissociation of a short-living and very long-acting inhibitor.

scientific article published in February 2013

Preclinical pharmacological evaluation of the fatty acid amide hydrolase inhibitor BIA 10-2474

scientific article published on 12 February 2020

Role of P-glycoprotein and permeability upon the brain distribution and pharmacodynamics of etamicastat: a comparison with nepicastat.

scientific article published on 27 April 2015

Single-Dose Tolerability, Pharmacokinetics, and Pharmacodynamics of Etamicastat (BIA 5-453), a New Dopamine β-Hydroxylase Inhibitor, in Healthy Subjects

scientific article published on 01 February 2012

Species differences in pharmacokinetic and pharmacodynamic properties of nebicapone.

scientific article

Synthesis and biological evaluation of a novel series of "ortho-nitrated" inhibitors of catechol-O-methyltransferase

scientific article published on December 2005

Targeting pharmacoresistant epilepsy and epileptogenesis with a dual-purpose antiepileptic drug

scientific article published on 2 December 2014