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List of works by Mohamed Trebak

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction

scientific article published on 29 April 2019

A new selective pharmacological enhancer of the Orai1 Ca2+ channel reveals roles for Orai1 in smooth and skeletal muscle functions

scientific article published on 13 January 2020

A novel native store-operated calcium channel encoded by Orai3: selective requirement of Orai3 versus Orai1 in estrogen receptor-positive versus estrogen receptor-negative breast cancer cells

scientific article

A novel role for epidermal growth factor receptor tyrosine kinase and its downstream endoplasmic reticulum stress in cardiac damage and microvascular dysfunction in type 1 diabetes mellitus

scientific article published on 04 June 2012

Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration

scientific article

Augmented EGF receptor tyrosine kinase activity impairs vascular function by NADPH oxidase-dependent mechanism in type 2 diabetic mouse

scientific article published on 31 May 2015

CD4+CD25+Foxp3 regulatory T cells and vascular dysfunction in hypertension

scientific article published on October 2013

Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function

scientific article published on 13 September 2016

Calcium signalling in T cells

scientific article published on 01 March 2019

Calcium/Calmodulin-dependent protein kinase II delta 6 (CaMKIIdelta6) and RhoA involvement in thrombin-induced endothelial barrier dysfunction

scientific article

Chronic inhibition of endoplasmic reticulum stress and inflammation prevents ischaemia-induced vascular pathology in type II diabetic mice.

scientific article published on 17 February 2012

Chronic inhibition of epidermal growth factor receptor tyrosine kinase and extracellular signal-regulated kinases 1 and 2 (ERK1/2) augments vascular response to limb ischemia in type 2 diabetic mice.

scientific article published on 7 November 2011

Complex functions of phosphatidylinositol 4,5-bisphosphate in regulation of TRPC5 cation channels

scientific article

Complex regulation of the TRPC3, 6 and 7 channel subfamily by diacylglycerol and phosphatidylinositol-4,5-bisphosphate

scientific article published on 17 October 2007

Complex role of STIM1 in the activation of store-independent Orai1/3 channels.

scientific article published on March 2014

Cross-talk between N-terminal and C-terminal domains in stromal interaction molecule 2 (STIM2) determines enhanced STIM2 sensitivity

scientific article published on 01 March 2019

Dichotomous role of the human mitochondrial Na+/Ca2+/Li+ exchanger NCLX in colorectal cancer growth and metastasis

scientific article published on 11 September 2020

Differential role for stromal interacting molecule 1 in the regulation of vascular function

scientific article published on 27 June 2014

Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels

scientific article published on 29 August 2020

Emerging perspectives in store-operated Ca2+ entry: roles of Orai, Stim and TRP.

scientific article published on 5 September 2006

Emerging roles of Orai3 in pathophysiology

scientific article published on 21 May 2013

Endoplasmic reticulum stress is involved in cardiac damage and vascular endothelial dysfunction in hypertensive mice.

scientific article published on 26 April 2012

Enhanced Ca2+ entry due to Orai1 plasma membrane insertion increases IL-8 secretion by cystic fibrosis airways

scientific article published on 26 August 2011

Enhanced NF-κB activity impairs vascular function through PARP-1-, SP-1-, and COX-2-dependent mechanisms in type 2 diabetes.

scientific article

Enhanced p22phox expression impairs vascular function through p38 and ERK1/2 MAP kinase-dependent mechanisms in type 2 diabetic mice.

scientific article published on 31 January 2014

Essential Role of Smooth Muscle STIM1 in Hypertension and Cardiovascular Dysfunction.

scientific article published on 28 July 2016

Essential role for STIM1/Orai1-mediated calcium influx in PDGF-induced smooth muscle migration

scientific article

Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration

scientific article published on 13 April 2009

Francisella tularensis Catalase Restricts Immune Function by Impairing TRPM2 Channel Activity.

scientific article published on 17 December 2015

Golgi-Associated Protein Kinase C-ε Is Delivered to Phagocytic Cups: Role of Phosphatidylinositol 4-Phosphate

scientific article published on 24 May 2017

Impedance analysis of GPCR-mediated changes in endothelial barrier function: overview and fundamental considerations for stable and reproducible measurements

scientific article

Induction of store-operated calcium entry (SOCE) suppresses glioblastoma growth by inhibiting the Hippo pathway transcriptional coactivators YAP/TAZ

scientific article published on 06 August 2018

Interleukin-10 Released by CD4 + CD25 + Natural Regulatory T Cells Improves Microvascular Endothelial Function Through Inhibition of NADPH Oxidase Activity in Hypertensive Mice ⬇️

scientific article published on November 1, 2011

L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins

scientific article published on 08 July 2020

Leaky Ryanodine receptors increases Amyloid-beta load and induces memory impairments in Tg2576 mouse model of Alzheimer disease

Leukotriene-C4 synthase, a critical enzyme in the activation of store-independent Orai1/Orai3 channels, is required for neointimal hyperplasia

scientific article

Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity

scientific article published on 09 November 2019

Low-Voltage-Activated CaV3.1 Calcium Channels Shape T Helper Cell Cytokine Profiles.

scientific article published on 28 March 2016

Mechanism of endoplasmic reticulum stress-induced vascular endothelial dysfunction

scientific article

Mechanisms of STIM1 activation of store-independent leukotriene C4-regulated Ca2+ channels

scientific article

Mechanisms of phospholipase C-regulated calcium entry

scientific article published on May 2004

Mitochondria control store-operated Ca2+ entry through Na+ and redox signals

scientific article

Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer

scientific article published in 2022

Multiple types of calcium channels arising from alternative translation initiation of the Orai1 message

scientific article

New developments in the signaling mechanisms of the store-operated calcium entry pathway

scientific article published on 07 June 2008

Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma

scientific article published on 8 June 2015

Nuclear factor kappa B inhibition improves conductance artery function in type 2 diabetic mice

scientific article published on January 2015

Oncogenic KRAS suppresses store-operated Ca 2+ entry and I CRAC through ERK pathway-dependent remodelling of STIM expression in colorectal cancer cell lines

scientific article published on 14 March 2018

Orai channel-mediated Ca2+ signals in vascular and airway smooth muscle

scientific article published on 30 December 2015

Orai1-mediated I (CRAC) is essential for neointima formation after vascular injury.

scientific article

Orai3 is an estrogen receptor α-regulated Ca²⁺ channel that promotes tumorigenesis

scientific article

PKC-ε pseudosubstrate and catalytic activity are necessary for membrane delivery during IgG-mediated phagocytosis.

scientific article

Poly(ADP-ribose) polymerase 1 inhibition improves coronary arteriole function in type 2 diabetes mellitus.

scientific article published on 26 March 2012

Redox control of the senescence regulator interleukin-1α and the secretory phenotype

scientific article published on 23 September 2013

Redox-control of the alarmin, Interleukin-1α

scientific article published on 17 April 2013

Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease ⬇️

scientific article published on August 22, 2012

STIM and Orai proteins as novel targets for cancer therapy. A Review in the Theme: Cell and Molecular Processes in Cancer Metastasis

scientific article

STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion

scientific article published on 21 March 2013

STIM1 and Orai1: novel targets for vascular diseases? ⬇️

scientific article published on July 24, 2011

STIM1 controls endothelial barrier function independently of Orai1 and Ca2+ entry

scientific article

Signalling mechanisms for TRPC3 channels.

scientific article published on January 2004

Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension.

scientific article

Stim1 and Orai1 mediate CRAC currents and store-operated calcium entry important for endothelial cell proliferation

scientific article published on 09 October 2008

Store-Independent Orai Channels Regulated by STIM

scientific article published on 10 October 2018

Store-independent Orai1/3 channels activated by intracrine leukotriene C4: role in neointimal hyperplasia

scientific article

Study of the Endogenous CRAC Channel Using shRNA-Mediated Gene Silencing.

scientific article published in January 2018

TRPC channels in smooth muscle cells

scientific article

The Induction of Yes-Associated Protein Expression After Arterial Injury Is Crucial for Smooth Muscle Phenotypic Modulation and Neointima Formation ⬇️

scientific article published on August 23, 2012

The TRPC3/6/7 subfamily of cation channels

scientific article

The mammalian TRPC cation channels

scientific article published in December 2004

The native ORAI channel trio underlies the diversity of Ca2+ signaling events

scientific article published on 15 May 2020

The non-excitable smooth muscle: calcium signaling and phenotypic switching during vascular disease

scientific article published on 26 March 2008

The remote allosteric control of Orai channel gating

scientific article published on 30 August 2019

Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca(2+)) Permeable Non-selective Cation Channel

scientific article published on January 2016

Transient receptor potential canonical 7: a diacylglycerol-activated non-selective cation channel

scientific article published on January 2014

Urotensin-II promotes vascular smooth muscle cell proliferation through store-operated calcium entry and EGFR transactivation

scientific article published on 9 August 2013

Vascular balloon injury and intraluminal administration in rat carotid artery

scientific article

What role for store-operated Ca²⁺ entry in muscle?

scientific article published on May 2013

miR-424/322 regulates vascular smooth muscle cell phenotype and neointimal formation in the rat.

scientific article published on 26 February 2013

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