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Authors whose works are in public domain in at least one jurisdiction

List of works by Irmgard Merfort

A 1,5-cis-guaianolide glucoside from flowers of Arnica mollis

A new assay format for NF-kappaB based on a DNA triple helix and a fluorescence resonance energy transfer

scientific article

A taraxasterol derivative and phenolic compounds from Hieracium gymnocephalum

scientific article published on 26 July 2002

Abietane diterpenes induce cytotoxic effects in human pancreatic cancer cell line MIA PaCa-2 through different modes of action ⬇️

scientific article published on March 19, 2012

Acetylated and other flavonoid glycosides from Arnica chamissonis

scientific article published on 25 July 2002

Allergenic potential of Arnica-containing formulations in Arnica-allergic patients

scientific article published on 01 November 2009

Altitudinal variation of secondary metabolite profiles in flowering heads of Arnica montana cv. ARBO.

scientific article published on 6 January 2006

Analysis of the nitric oxide-cyclic guanosine monophosphate pathway in experimental liver cirrhosis suggests phosphodiesterase-5 as potential target to treat portal hypertension

article published in 2018

Anti-carcinogenic effects of the flavonoid luteolin.

scientific article published on 22 October 2008

Anti-inflammatory activities of hypocretenolides from Leontodon hispidus

scientific article

Anti-inflammatory activity of hispidol A 25-methyl ether, a triterpenoid isolated from Ponciri Immaturus Fructus

scientific article published on 24 October 2009

Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae)

scientific article published on 01 July 2002

Anti-inflammatory and immune-regulatory mechanisms prevent contact hypersensitivity to Arnica montana L.

scientific article

Anti-inflammatory effects of glycyrol isolated from Glycyrrhiza uralensis in LPS-stimulated RAW264.7 macrophages

scientific article

Anti-oxidant, anti-inflammatory and anti-allergic activities of luteolin

scientific article

Antitumoral and antiangiogenic efficacy of bisphosphonates in vitro and in a murine RENCA model

scientific article

Backbone flexibility controls the activity and specificity of a protein-protein interface – specificity in snake venom metalloproteases (SVMPs).

scientific article published on 19 April 2011

Backbone flexibility controls the activity and specificity of a protein-protein interface: specificity in snake venom metalloproteases

scientific article

Bifunctional Duocarmycin Analogues as Inhibitors of Protein Tyrosine Kinases

scientific article published on 08 January 2019

Biological Evaluation and Structural Determinants of p38α Mitogen‐Activated‐Protein Kinase and c‐Jun‐N‐Terminal Kinase 3 Inhibition by Flavonoids ⬇️

scientific article published on December 10, 2010

Biological studies on Brazilian plants used in wound healing.

scientific article

Bornyl (3,4,5-trihydroxy)-cinnamate--an optimized human neutrophil elastase inhibitor designed by free energy calculations

scientific article published on 29 November 2007

Botanicals in dermatology: an evidence-based review

scientific article

Caffeoylquinic acids from flowers of Arnica montana and Arnica chamissonis

scientific article published on 25 July 2002

Catechin derivatives from Parapiptadenia rigida with in vitro wound-healing properties.

scientific article

Cell-cycle changes and oxidative stress response to magnetite in A549 human lung cells.

scientific article

Cellular uptake and toxic effects of fine and ultrafine metal-sulfate particles in human A549 lung epithelial cells

scientific article

Ceramide-1-phosphate inhibits cigarette smoke-induced airway inflammation.

scientific article published on 22 January 2015

Chromenes from Arnica lessingii and A. amplexicaulis

scientific article published in 2003

Comparison of In-Vitro and Ex-Vivo Wound Healing Assays for the Investigation of Diabetic Wound Healing and Demonstration of a Beneficial Effect of a Triterpene Extract

scientific article

Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones

scientific article

Cytotoxic clerodane diterpenes from Zuelania guidonia

scientific article published on 31 January 2014

Cytotoxicity and genotoxicity of size-fractionated iron oxide (magnetite) in A549 human lung epithelial cells: role of ROS, JNK, and NF-κB.

scientific article published on 18 July 2011

Decreased helenalin-induced cytotoxicity by flavonoids from Arnica as studied in a human lung carcinoma cell line ⬇️

scientific article published on October 1, 1995

Determination of the wound healing effect of Calendula extracts using the scratch assay with 3T3 fibroblasts.

scientific article published on 23 September 2009

Development of a structural model for NF-kappaB inhibition of sesquiterpene lactones using self-organizing neural networks

scientific article published on April 2006

Dimethylfumarate inhibits NF-{kappa}B function at multiple levels to limit airway smooth muscle cell cytokine secretion.

scientific article published on 22 May 2009

Discovery of Tricyclic Clerodane Diterpenes as Sarco/Endoplasmic Reticulum Ca2+-ATPase Inhibitors and Structure–Activity Relationships

Disease relevant modifications of the methylome and transcriptome by particulate matter (PM2.5) from biomass combustion

scientific article published on 25 July 2017

Effect of sesquiterpene lactones on the expression of the activation marker CD69 and of IL-2 in T-lymphocytes in whole blood ⬇️

scientific article published on May 1, 2003

Endophytic Streptomyces in the traditional medicinal plant Arnica montana L.: secondary metabolites and biological activity

scientific article published on 04 June 2015

Ent-kaurane glycosides and sesquiterpene lactones of the hirsutinolide type from Vernonia triflosculosa

scientific article

Evaluating ancient Egyptian prescriptions today: Anti-inflammatory activity of Ziziphus spina-christi.

scientific article published on 02 February 2016

Evaluation of Tanacetum larvatum for an anti-inflammatory activity and for the protection against indomethacin-induced ulcerogenesis in rats

scientific article

Fermentation Enhances the Biological Activity of Allium cepa Bulb Extracts ⬇️

scientific article published on February 22, 2012

Flavonoid Glucuronides from the Flowers of Arnica montana1

scientific article published on 01 June 1988

Flavonoid Glycosides and Other Hydrophilic Compounds from Flowers of Heterotheca inuloides

scientific article published on 01 August 1990

Flavonoid Glycosides from Arnica montana and Arnica chamissonis

scientific article published on 01 October 1987

Flavonoid and phenolic acid patterns in seven Hieracium species

scientific article published on 25 July 2002

Flavonoid distribution in Arnica subgenus chamissonis

scientific article published on 25 July 2002

Flavonoid distribution in arnica subgenera Montana and Austromontana

scientific article published on 25 July 2002

Flavonoid glucosides and dicaffeoylquinic acids from flowerheads of Buphthalmum salicifolium1Dedicated to Professor Dr. G. Willuhn, Institute of Pharmaceutical Biology, Heinrich-Heine-Universität on the occasion of his 65th birthday.1

scientific article published on 25 July 2002

Flavonoid glycosides from Arnica amplexicaulis and Arnica mollis

scientific article published on 12 May 2003

Flavonoid glycosides in flowers of Arnica acaulis, subgenus Montana

scientific article published on 10 February 2003

Flavonoide ausArnica montanaundArnica chamissonis1

scientific article published on 6 March 2007

Flavonoids of Arnica sachalinensis, subgenus Andropurpurea

article published in 2003

Flavonol quantification and stability of phenolics in fermented extracts from fresh Betula pendula leaves

scientific article published on 7 February 2010

Four new flavonol glycosides from the leaves of Brugmansia suaveolens

scientific article published on 22 May 2014

Free Energy Calculations on Snake Venom Metalloproteinase BaP1 ⬇️

scientific article published on April 17, 2012

From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

scientific article (publication date: 2014)

Further sesquiterpene lactones from Viguiera robusta and the potential anti-inflammatory activity of a heliangolide: inhibition of human neutrophil elastase release.

scientific article published in July 2008

Gene expression profiling of human bronchial epithelial cells exposed to fine particulate matter (PM2.5) from biomass combustion

scientific article published on 26 March 2018

Genome-wide comparison between IL-17 and combined TNF-alpha/IL-17 induced genes in primary murine hepatocytes

scientific article

Glycyrol induces apoptosis in human Jurkat T cell lymphocytes via the Fas-FasL/caspase-8 pathway

scientific article published on 17 August 2010

Guaianolides from Viguiera gardneri inhibit the transcription factor NF-kappaB.

scientific article

Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB

scientific article published on 01 September 1997

Helenanolide type sesquiterpene lactones. Part 5: the role of glutathione addition under physiological conditions

scientific article published on 01 December 1999

High-performance thin layer chromatography for quality control of multicomponent herbal drugs: example of cangzhu xianglian san

scientific article published on September 1, 2010

High-resolution crystal structure of the snake venom metalloproteinase BaP1 complexed with a peptidomimetic: insight into inhibitor binding

scientific article

Hopane-type saponins from the seeds of Glinus lotoides

scientific article published in March 2005

Hyaluronidase decreases neutrophils infiltration to the inflammatory site

scientific article

Hyaluronidase modulates inflammatory response and accelerates the cutaneous wound healing

scientific article

IL-1β and TNFα Differentially Influence NF-κB Activity and FasL-Induced Apoptosis in Primary Murine Hepatocytes During LPS-Induced Inflammation

scholarly article by Julia Rex et al published 2019 in Frontiers in Physiology

Identification of rosmarinic acid as the major active constituent in Cordia americana

scientific article published on 10 February 2010

In vitro and in vivo analysis of pro- and anti-inflammatory effects of weak and strong contact allergens

scientific article published on November 2010

In vitro behaviour of sesquiterpene lactones and sesquiterpene lactone-containing plant preparations in human blood, plasma and human serum albumin solutions

scientific article published in March 2004

In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica.

scientific article

In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts

scientific article published on 09 December 2016

Influence of Birch Bark Triterpenes on Keratinocytes and Fibroblasts from Diabetic and Nondiabetic Donors

scientific article

Inhibition of GSK3 differentially modulates NF-kappaB, CREB, AP-1 and beta-catenin signaling in hepatocytes, but fails to promote TNF-alpha-induced apoptosis

scientific article published on 31 December 2007

Inhibition of NF-κB and AP-1 by dimethylfumarate correlates with down-regulated IL-6 secretion and proliferation in human lung fibroblasts

scientific article published on 7 December 2010

Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus

scientific article published on 21 October 2009

Inhibition of inflammatory cytokine production and lymphocyte proliferation by structurally different sesquiterpene lactones correlates with their effect on activation of NF-kappaB

scientific article published on 01 September 2001

Inhibition of the transcription factor NF-kappa B by sesquiterpene lactones from Podachaenium eminens

scientific article published on 01 October 2000

Inhibition of transcription factor NF-kappaB by sesquiterpene lactones: a proposed molecular mechanism of action

scientific article published on 01 November 1999

Inhibitory effects of Piper umbellatum and Piper peltatum extracts towards myotoxic phospholipases A2 from Bothrops snake venoms: isolation of 4-nerolidylcatechol as active principle

scientific article published in May 2005

Interactions of chemicals and metal ions with proteins and role for immune responses

scientific article

Interleukin-1β enhances FasL-induced caspase-3/-7 activity without increasing apoptosis in primary mouse hepatocytes

scientific article published on 31 December 2014

Isolation of Flavonoids from Deguelia duckeana and Their Effect on Cellular Viability, AMPK, eEF2, eIF2 and eIF4E.

scientific article published on 6 February 2016

IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES.

scientific article published on 30 June 2011

Leaf phenolics of Punica granatum

Lipid Atlas of Keratinocytes and Betulin Effects on its Lipidome Profiled by Comprehensive UHPLC-MS/MS with Data Independent Acquisition Using Targeted Data Processing

scientific article published on 06 September 2019

Lipoprotein turnover and possible remnant accumulation in preeclampsia: insights from the Freiburg Preeclampsia H.E.L.P.-apheresis study.

scientific article published on 14 March 2018

Mastering analytical challenges for the characterization of pentacyclic triterpene mono- and diesters of Calendula officinalis flowers by non-aqueous C30 HPLC and hyphenation with APCI-QTOF-MS.

scientific article published on 21 October 2015

Methylated Flavonoids from Arnica montana and Arnica chamissonis

scientific article published on 01 February 1984

Mining and evaluation of molecular relationships in literature

scientific article published on 13 January 2012

Modeling the TNFα-Induced Apoptosis Pathway in Hepatocytes ⬇️

scientific article published on April 20, 2011

NF-κB DNA binding activity of sesquiterpene lactones from Anthemis arvensis and Anthemis cotula

scientific article published on 05 July 2010

NMR spectral analysis of polyphenols from Punica granatum

article by Mahmoud A.M. Nawwar et al published 25 July 2002 in Phytochemistry

Natural compounds as inhibitors of human neutrophil elastase

scientific article published on 20 April 2007

Neural networks as valuable tools to differentiate between sesquiterpene lactones' inhibitory activity on serotonin release and on NF-kappaB.

scientific article

New sesquiterpene lactones from Arnica tincture prepared from fresh flowerheads of Arnica montana

scientific article published in November 2005

Noxa/Mcl-1 balance influences the effect of the proteasome inhibitor MG-132 in combination with anticancer agents in pancreatic cancer cell lines

scientific article published on July 2012

ON/OFF and beyond--a boolean model of apoptosis

scientific article

Optimisation of a human neutrophil elastase assay and investigation of the effect of sesquiterpene lactones

scientific article published on September 2005

Oxidative stress and inflammatory response to printer toner particles in human epithelial A549 lung cells

scientific article published on 29 November 2012

Particulate Matter (PM2.5) from Biomass Combustion Induces an Anti-Oxidative Response and Cancer Drug Resistance in Human Bronchial Epithelial BEAS-2B Cells

scientific article published on 06 November 2020

Patented inhibitors (2002 - 2005) of the transcription factor NF-kappaB.

scientific article published in June 2006

Perspectives on Sesquiterpene Lactones in Inflammation and Cancer ⬇️

scientific article published on October 1, 2011

Phase-contrast MR flow imaging: A tool to determine hepatic hemodynamics in rats with a healthy, fibrotic, or cirrhotic liver

scientific article

Phosphodiesterases in the Liver as Potential Therapeutic Targets of Cirrhotic Portal Hypertension

scientific article published on 28 August 2020

Phytomedicines prepared from Arnica flowers inhibit the transcription factors AP-1 and NF-kappaB and modulate the activity of MMP1 and MMP13 in human and bovine chondrocytes.

scientific article published on 8 May 2009

Plant phenolics inhibit neutrophil elastase

scientific article published on 01 October 2006

Polyphenolic metabolites of Epilobium hirsutum

Polyphenolic metabolites of Rhamnus disperma

PyWATER: a PyMOL plug-in to find conserved water molecules in proteins by clustering.

scientific article

Quantitative structure-activity relationship of sesquiterpene lactones as inhibitors of the transcription factor NF-kappaB

scientific article published on 01 November 2004

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

scientific article published on 23 August 2013

Reseda luteola L. extract displays antiproliferative and pro-apoptotic activities that are related to its major flavonoids

scientific article published in July 2010

Review of the analytical techniques for sesquiterpenes and sesquiterpene lactones

scientific article

Revised editorial guidelines for manuscripts on the pharmacology of plant extracts

scientific article published on 06 June 2017

Role of cysteine residues of p65/NF-kappaB on the inhibition by the sesquiterpene lactone parthenolide and N-ethyl maleimide, and on its transactivating potential

scientific article

Screening for anti-inflammatory activity of 12 Arnica (Asteraceae) species assessed by inhibition of NF-kappaB and release of human neutrophil elastase

scientific article published on 30 October 2008

Sesquiterpene lactones as inhibitors of IL-8 expression in HeLa cells.

scientific article

Sesquiterpene lactones from Dimerostemma species (Asteraceae) and in vitro potential anti-inflammatory activities.

scientific article published on September 2006

Sesquiterpene lactones from Montanoa hibiscifolia that inhibit the transcription factor NF-kappa B.

scientific article published in April 2004

Sesquiterpene lactones induce distinct forms of cell death that modulate human monocyte-derived macrophage responses

scientific article published on January 2007

Sesquiterpene lactones inhibit Yersinia invasin protein-induced IL-8 and MCP-1 production in epithelial cells

scientific article published on 13 September 2005

Sesquiterpene lactones inhibit luciferase but not beta-galactosidase activity in vitro and ex vivo

scientific article

Sesquiterpene lactones of Arnica cordifolia, subgenus Austromontana

article published in 2002

Skin penetration behaviour of sesquiterpene lactones from different Arnica preparations using a validated GC-MSD method

scientific article published on 23 August 2006

Skin penetration studies of Arnica preparations and of their sesquiterpene lactones

scientific article published in October 2004

Steroids with anti-inflammatory activity from Vernonia nigritiana Oliv. & Hiern

scientific article published on 24 September 2013

Stress fibers, autophagy and necrosis by persistent exposure to PM2.5 from biomass combustion

scientific article published on 3 July 2017

Structural and conformational analysis of proanthocyanidins from Parapiptadenia rigida and their wound-healing properties

scientific article published on 10 May 2011

Structure and cytotoxicity of arnamial and related fungal sesquiterpene aryl esters.

scientific article

Studies of ent-kaurane diterpenes from Oyedaea verbesinoides for their inhibitory activity on vascular smooth muscle contraction

scientific article published in June 2003

Studies on the anti-inflammatory activity of phytopharmaceuticals prepared from Arnica flowers

scientific article

Study of sesquiterpene lactones from Milleria quinqueflora on their anti-inflammatory activity using the transcription factor NF-kappa B as molecular target

scientific article

Study of three sesquiterpene lactones from Tithonia diversifolia on their anti-inflammatory activity using the transcription factor NF-kappa B and enzymes of the arachidonic acid pathway as targets

scientific article published on 01 October 1998

Surface plasmon resonance analysis of nuclear factor-kappaB protein interactions with the sesquiterpene lactone helenalin.

scientific article published on 20 February 2010

Switch from type II to I Fas/CD95 death signaling on in vitro culturing of primary hepatocytes

scientific article

TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation

scientific article published on 05 September 2018

Tannins from the leaves of Punica granatum

scientific article published on 4 March 2003

Target Fishing by Cross-Docking to Explain Polypharmacological Effects

The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65

scientific article

The clerodane diterpene casearin J induces apoptosis of T-ALL cells through SERCA inhibition, oxidative stress, and interference with Notch1 signaling

scientific article published on 28 January 2016

The effect of sesquiterpene lactones on the release of human neutrophil elastase

scientific article published in March 2003

The occurrence of lanosterol and 24-methylenelanost-8-en-3β-ol in leaves of symphoricarpus albus

scientific article published on 25 July 2002

The sesquiterpene lactone polymatin B from Smallanthus sonchifolius induces different cell death mechanisms in three cancer cell lines

scientific article

Thirty-seven flavonoids from flowers ofArnica longifolia

scientific article published on 25 July 2002

Topical application of solubilized Reseda luteola extract reduces ultraviolet B-induced inflammation in vivo.

scientific article published on 17 July 2009

Tormentil for active ulcerative colitis: an open-label, dose-escalating study

scientific article

Traditionally used Veronica officinalis inhibits proinflammatory mediators via the NF-κB signalling pathway in a human lung cell line

scientific article

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

scientific article published on 26 October 2010

Tumor necrosis factor α sensitizes primary murine hepatocytes to Fas/CD95-induced apoptosis in a Bim- and Bid-dependent manner ⬇️

scientific article published on September 24, 2010

Unusual phenolic glycosides from Cotoneaster orbicularis

scientific article published on 01 March 2000

Validated HPTLC methods for the determination of salicin in Salix sp. and of harpagoside in Harpagophytum [corrected] procumbens

scientific article published on 7 July 2008

Validation of a GC-FID method for rapid quantification of nicotine in fermented extracts prepared from Nicotiana tabacum fresh leaves and studies of nicotine metabolites

scientific article

Wide Distribution of Foxicin Biosynthetic Gene Clusters in Streptomyces Strains - An Unusual Secondary Metabolite with Various Properties ⬇️

scientific article published on 21 February 2017

[Arnica: new insights on the molecular mode of action of a traditional medicinal plant]

scientific article published on 01 April 2003

[Current information on the metabolism of flavonoids. I. Absorption and metabolism of flavonols]

scientific article published on 01 March 1998

[Current understanding of the metabolism of flavonoids. II. Adsorption and metabolism of flavones, flavonones, flavanes, proanthocyanidens and isoflavonoids]

scientific article published on 01 July 1998

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