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List of works by Trever G Bivona

A Case of Metastatic Atypical Neuroendocrine Tumor with ALK Translocation and Diffuse Brain Metastases

scientific article published on 15 May 2017

A framework for understanding and targeting residual disease in oncogene-driven solid cancers

scientific article published on May 2016

AUY922 effectively overcomes MET- and AXL-mediated resistance to EGFR-TKI in lung cancer cells

scientific article

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells

scientific article published on 01 February 2020

AXL mediates resistance to PI3Kα inhibition by activating the EGFR/PKC/mTOR axis in head and neck and esophageal squamous cell carcinomas

scientific article

AXL receptor tyrosine kinase as a therapeutic target in NSCLC.

scientific article published on 30 April 2015

Abstract 265: Cotargeting EGFR, STAT3 and Src-Notch pathways: a promising approach to improve the efficacy of EGFR-TKIs in the treatment of NSCLC patients

Activating Mutations Cluster in the “Molecular Brake” Regions of Protein Kinases and Do Not Associate with Conserved or Catalytic Residues

article

Activation of signal transducer and activator of transcription 3 (STAT3) signaling in EGFR mutant non-small-cell lung cancer (NSCLC)

scientific article published on 4 May 2017

Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer ⬇️

scientific article published on July 1, 2012

Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment

scientific article published on 05 January 2021

An improved CTC isolation scheme for pairing with downstream genomics: Demonstrating clinical utility in metastatic prostate, lung and pancreatic cancer

scientific article published on 22 June 2016

Analysis of K-Ras phosphorylation, translocation, and induction of apoptosis

scientific article published in January 2008

Analysis of Ras activation in living cells with GFP-RBD.

scientific article published in January 2006

Analysis of Ras and Rap activation in living cells using fluorescent Ras binding domains

article

Aurora kinase A drives the evolution of resistance to third-generation EGFR inhibitors in lung cancer

scientific article published on 26 November 2018

BRAF Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale

scientific article published on 17 September 2019

BRAF in Lung Cancers: Analysis of Patient Cases Reveals Recurrent BRAF Mutations, Fusions, Kinase Duplications, and Concurrent Alterations

scientific article published on 19 April 2018

Betacellulin drives therapy resistance in glioblastoma

scientific article published on 03 November 2019

CD74-ROS1 Fusion in NSCLC Detected by Hybrid Capture-Based Tissue Genomic Profiling and ctDNA Assays

scientific article published in February 2017

CIC-DUX4 oncoprotein drives sarcoma metastasis and tumorigenesis via distinct regulatory programs

scientific article published on 22 July 2019

Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII.

scientific article

Cell-Free DNA Next-Generation Sequencing in Pancreatobiliary Carcinomas.

scientific article published on 24 June 2015

Circulating tumor DNA analysis in patients with EGFR mutant lung cancer.

scientific article published in November 2018

Co-activation of STAT3 and YES-Associated Protein 1 (YAP1) Pathway in EGFR-Mutant NSCLC.

scientific article

Co-occurring Alterations in the RAS-MAPK Pathway Limit Response to MET Inhibitor Treatment in MET Exon 14 Skipping Mutation-Positive Lung Cancer

scientific article published on 23 September 2019

Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma

scientific article

Common Co-activation of AXL and CDCP1 in EGFR-mutation-positive Non-smallcell Lung Cancer Associated With Poor Prognosis

scientific article published on 5 February 2018

Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells

scientific article published on 05 September 2018

Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer

scientific article published on 4 September 2017

Current Landscape of Targeted Therapy in Lung Cancer.

scientific article published on 8 August 2017

Dampening oncogenic RAS signaling

scientific article published on 01 March 2019

Differential Subcellular Localization Regulates Oncogenic Signaling by ROS1 Kinase Fusion Proteins

scientific article published on 11 December 2018

Dividing and conquering the variation among variants in EML4-ALK lung cancer

scientific article published on 01 March 2017

EGFR targeted therapy resistance: current status, challenges, and future outlook

scientific article published on 01 May 2020

Emerging Targeted Therapies for the Treatment of Non-small Cell Lung Cancer

scientific article published on 26 February 2019

Emerging application of genomics-guided therapeutics in personalized lung cancer treatment.

scientific article

Engineering Multidimensional Evolutionary Forces to Combat Cancer

scientific article published on 16 April 2019

Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers.

scientific article published on 6 November 2017

FAS and NF-κB signalling modulate dependence of lung cancers on mutant EGFR.

scientific article published on March 2011

FGFR fusions in the driver's seat

scientific article published on June 2013

Functional screening identifies aryl hydrocarbon receptor as suppressor of lung cancer metastasis

scientific article published on 19 November 2020

Genetics and biomarkers in personalisation of lung cancer treatment ⬇️

scientific article published on August 24, 2013

Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers

scientific article published on 7 November 2011

HSP70 dependence in rhabdomyosarcoma: Seed or soil?

scientific article published on 29 September 2016

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

scientific article

Imaging PD-L1 Expression with ImmunoPET.

scientific article published on 10 November 2017

Immunohistochemistry to Study YAP in Human Tissue Samples

scientific article published on 01 January 2019

Inactivation of Capicua drives cancer metastasis

scientific article

Intersectin activates Ras but stimulates transcription through an independent pathway involving JNK.

scientific article published on 11 September 2003

Liquid Biopsy for Advanced Non-Small Cell Lung Cancer (NSCLC): A Statement Paper from the IASLC

article

Long non-coding RNA ESCCAL-1 promotes esophageal squamous cell carcinoma by down regulating the negative regulator of APOBEC3G

scientific article published on 06 September 2020

Mapping the molecular determinants of BRAF oncogene dependence in human lung cancer.

scientific article published on 03 February 2014

Mechanisms of Resistance to Epidermal Growth Factor Receptor Inhibitors and Novel Therapeutic Strategies to Overcome Resistance in NSCLC Patients

scientific article published on 29 August 2012

Mechanisms of resistance to EGFR targeted therapies ⬇️

scientific article published on January 28, 2013

Membranes as messengers in T cell adhesion signaling

scientific article published on April 2004

Metastasis: From head to tail

scientific article published on 5 January 2017

Molecular landscape of BRAF-mutant NSCLC reveals an association between clonality and driver mutations and identifies targetable non-V600 driver mutations

scientific article published on 12 June 2020

Multi-faceted epigenetic dysregulation of gene expression promotes esophageal squamous cell carcinoma

scientific article published on 22 July 2020

NF-κB-activating complex engaged in response to EGFR oncogene inhibition drives tumor cell survival and residual disease in lung cancer

scientific article

Neoadjuvant Oncogene-Targeted Therapy in Early Stage Non-Small-Cell Lung Cancer as a Strategy to Improve Clinical Outcome and Identify Early Mechanisms of Resistance

scientific article published on 8 June 2016

Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer

scientific article published on 30 November 2017

Novel computational method for predicting polytherapy switching strategies to overcome tumor heterogeneity and evolution.

scientific article published on 13 March 2017

Oncogenic Signaling Pathways in The Cancer Genome Atlas

scientific article published in April 2018

Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy

scientific article published on 01 December 2019

PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis.

scientific article published on February 2006

Pathologic Complete Response to Neoadjuvant Crizotinib in a Lung Adenocarcinoma Patient With a MET Exon 14 Skipping Mutation

scientific article published on 20 November 2018

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

scientific article

Plasma mRNA expression levels of BRCA1 and TS as potential predictive biomarkers for chemotherapy in gastric cancer

scientific article

Polytherapy and Targeted Cancer Drug Resistance

scientific article published on 26 February 2019

Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer

scientific article

Pretreatment EGFR T790M Mutation and BRCA1 mRNA Expression in Erlotinib-Treated Advanced Non–Small-Cell Lung Cancer Patients with EGFR Mutations ⬇️

scientific article published on January 13, 2011

Principles of Resistance to Targeted Cancer Therapy: Lessons from Basic and Translational Cancer Biology

scientific article published on 24 January 2019

RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers

scientific article published on 13 August 2018

RAS signaling in ALK fusion lung cancer

scientific article published on 22 February 2016

RAS-MAPK dependence underlies a rational polytherapy strategy in EML4-ALK-positive lung cancer.

scientific article published on 24 August 2015

RAS-MAPK in ALK targeted therapy resistance

scientific article published on December 2015

RAS-MAPK signaling influences the efficacy of ALK-targeting agents in lung cancer

scientific article published on 29 October 2015

Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion.

scientific article

Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

scientific article published on April 2004

Ras pathway signaling on endomembranes

scientific article

Ras signalling on the endoplasmic reticulum and the Golgi

scientific article published on May 2002

Recent advances in personalized lung cancer medicine

scientific article

Resiliency of Lung Cancers to EGFR Inhibitor Treatment Unveiled, Offering Opportunities to Divide and Conquer EGFR Inhibitor Resistance ⬇️

scientific article published on October 1, 2012

Resistance is futile: overcoming resistance to targeted therapies in lung adenocarcinoma

scientific article

Secrets of Drug Resistance in NSCLC Exposed by New Molecular Definition of EMT ⬇️

scientific article published on November 21, 2012

Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment

scientific article published on February 2004

Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer

scientific article published on 10 October 2017

Superior Efficacy and Selectivity of Novel Small-Molecule Kinase Inhibitors of T790M-Mutant EGFR in Preclinical Models of Lung Cancer

scientific article published on 12 January 2017

Synthetic Essentiality of Metabolic Regulator PDHK1 in PTEN-Deficient Cells and Cancers

scientific article published on 01 August 2019

TNF-driven adaptive response mediates resistance to EGFR inhibition in lung cancer

scientific article published on 3 April 2018

Targeting Oncogenic BRAF: Past, Present, and Future

scientific article published on 16 August 2019

The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies

scientific article published on 09 February 2015

The Hippo effector YAP regulates the response of cancer cells to MAPK pathway inhibitors

scientific article published on 27 April 2015

The evolving understanding of immunoediting and the clinical impact of immune escape.

scientific article

The impact of EGFR T790M mutations and BIM mRNA expression on outcome in patients with EGFR-mutant NSCLC treated with erlotinib or chemotherapy in the randomized phase III EURTAC trial

scientific article published on 3 February 2014

Therapy-Induced Evolution of Human Lung Cancer Revealed by Single-Cell RNA Sequencing

scientific article published on 07 August 2020

Tracking Down Response and Resistance to TRK Inhibitors

scientific article published in January 2016

Transcriptomic-metabolomic reprogramming in EGFR-mutant NSCLC early adaptive drug escape linking TGFβ2-bioenergetics-mitochondrial priming

scientific article published on 11 November 2016

Understanding and targeting resistance mechanisms in NSCLC.

scientific article published in October 2017

Use of nonsteroidal anti-inflammatory drugs predicts improved patient survival for PIK3CA-altered head and neck cancer

scientific article published on 25 January 2019

YAP in MAPK pathway targeted therapy resistance

scientific article

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