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List of works by David P. Lane

'Mind the gap'

scientific article published on 01 December 2002

A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 16 March 2018

A Novel Unstructured Scaffold Based on 4EBP1 Enables the Functional Display of a Wide Range of Bioactive Peptides ⬇️

scientific article published on October 7, 2010

A comparison and optimization of methods and factors affecting the transformation of Escherichia coli.

scientific article

A comparison of immunohistochemical markers of cell proliferation with experimentally determined growth fraction.

scientific article published on October 1991

A death in the life of p53

scientific article published in Nature

A general approach to protein folding using thermostable exoshells

scientific article published in 2021

A generic scaffold for conversion of peptide ligands into homogenous biosensors.

scientific article published on 29 March 2013

A novel CDK inhibitor, CYC202 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival.

scientific article published on 3 February 2005

A quantitative study of the in vitro binding of the C-terminal domain of p21 to PCNA: affinity, stoichiometry, and thermodynamics

scientific article published on 01 June 2000

A role for the human single-stranded DNA binding protein HSSB/RPA in an early stage of nucleotide excision repair

scientific article

A search for synergy in the binding kinetics of Trastuzumab and Pertuzumab whole and F(ab) to Her2.

scientific article

A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen

scientific article

A spatiotemporal characterization of the effect of p53 phosphorylation on its interaction with MDM2.

scientific article

A study of cell proliferation in formalin-fixed, wax-embedded bone marrow trephine biopsies using the monoclonal antibody PC10, reactive with proliferating cell nuclear antigen (PCNA)

scientific article published on 01 January 1992

A unique role for p53 in the regulation of M2 macrophage polarization

scientific article

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein-protein interactions identifies a novel putative Mdm2-binding site in p53.

scientific article published on 9 November 2017

Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form ⬇️

scientific article published on May 1, 1990

Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level

scientific article published on October 2004

Activation of p53 in cervical carcinoma cells by small molecules.

scientific article published in July 2000

Activation of the cryptic DNA binding function of mutant forms of p53.

scientific article published on July 1993

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

scientific article (publication date: 4 May 2000)

An immune complex assay for SV40 T antigen ⬇️

scientific article published on January 10, 1977

An immunoaffinity purification procedure for SV40 large T antigen

scientific article published on 01 July 1985

An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53

scientific article published on 01 July 1992

An immunochemical investigation of SV40 T-antigens. 2. Quantitation of antigens and antibody activities

scientific article published on 01 January 1980

An immunocytochemical study of p53 and bcl-2 protein expression in Hodgkin's disease

scientific article published on 01 June 1993

Anatomy of Mdm2 and Mdm4 in evolution.

scientific article published on 10 January 2017

Anthony Dipple Carcinogenesis Award. p53 from pathway to therapy.

scientific article published in July 2004

Anti-c-Met antibodies recognising a temperature sensitive epitope, inhibit cell growth

scientific article published on July 2013

Antibody Addition and Detection for Staining Caenorhabditis elegans

scientific article published on 01 September 2006

Antibody addition to Drosophila specimens and detection using enzyme-linked reagents

scientific article published on 01 September 2006

Antibody addition to Drosophila specimens and detection using fluorochrome-linked reagents

scientific article published on 01 September 2006

Antibody purification on protein a or protein g columns

scientific article published on 01 June 2006

Archival analysis of p53 genetic and protein alterations in Chinese esophageal cancer.

scientific article published on October 1991

Assessing the Efficacy of Mdm2/Mdm4-Inhibiting Stapled Peptides Using Cellular Thermal Shift Assays.

scientific article published on 10 July 2015

Assessment of p53 protein expression in normal, benign, and malignant oral mucosa

scientific article published on 01 April 1992

Assessment of proliferating cell nuclear antigen expression in precursor stages of gastric carcinoma using the PC10 antibody to PCNA.

scientific article published on April 1993

Asymmetric PCR-based strategy for genetic analysis of the p53 tumor suppressor gene in cell lines and tumor tissues

scientific article published on 01 January 1991

Attaching suspension cells to slides using a cytocentrifuge

scientific article published on 01 August 2006

Attaching suspension cells to slides using chemical linkers

scientific article published on 01 August 2006

Author Correction: The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding

scientific article published on 18 July 2018

Autophagic degradation of the inhibitory p53 isoform Δ133p53α as a regulatory mechanism for p53-mediated senescence.

scientific article published on 21 August 2014

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.

scientific article published on 23 April 2018

Awakening angels ⬇️

scientific article published on August 13, 1998

Benzene Probes in Molecular Dynamics Simulations Reveal Novel Binding Sites for Ligand Design.

scientific article

Binding antibodies to tissue sections

scientific article published on 01 June 2006

Binding of Translationally Controlled Tumour Protein to the N-terminal domain of HDM2 is inhibited by nutlin-3.

scientific article

Biological significance of a small highly conserved region in the N terminus of the p53 tumour suppressor protein.

scientific article

Bradford assay

scientific article published on 01 November 2006

C-terminal phosphorylation of Hsp70 and Hsp90 regulates alternate binding to co-chaperones CHIP and HOP to determine cellular protein folding/degradation balances

scientific article

Cell-cycle arrest and inhibition of Cdk4 activity by small peptides based on the carboxy-terminal domain of p21WAF1

scientific article published on 01 January 1997

Cellular delivery of impermeable effector molecules in the form of conjugates with peptides capable of mediating membrane translocation.

scientific article

Cellular proteins reactive with monoclonal antibodies directed against simian virus 40 T-antigen ⬇️

scientific article published on May 1, 1982

Cellular targets for SV40 large T-antigen.

scientific article

Characterisation of epitopes on human p53 using phage-displayed peptide libraries: insights into antibody-peptide interactions.

scientific article published on April 1995

Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell.

scientific article

Characterization of a new intrabody directed against the N-terminal region of human p53.

scientific article

Characterization of human p53 antigens employing primate specific monoclonal antibodies ⬇️

scientific article published on December 1, 1983

Characterization of the complex between SV40 large T antigen and the 53K host protein in transformed mouse cells.

scientific article published in January 1980

Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

scientific article

Characterization, chemical optimization and anti-tumour activity of a tubulin poison identified by a p53-based phenotypic screen

scientific article

Characterizing the conformational landscape of MDM2-binding p53 peptides using Molecular Dynamics simulations

scientific article published on 15 November 2017

Clinical utility of the immunocytochemical detection of p53 protein in cytological specimens

scientific article published on 01 June 1994

Coming to terms with death: apoptosis in cancer and immune development

scientific article published on 01 April 1994

Comparative analysis of p53 protein immunoreactivity in prostatic, lung and breast carcinomas.

scientific article published in January 1992

Comparative study of the p53-mdm2 and p53-MDMX interfaces

scientific article published on 01 January 1999

Comparison between p53 staining in tissue sections and p53 proteins levels measured by an ELISA technique

scientific article

Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

scientific article published on 15 December 2011

Constitutional mutation in exon 8 of the p53 gene in a patient with multiple primary tumours: molecular and immunohistochemical findings

article

Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin-SV40 T antigen genes

scientific article published on September 1987

Counterstains

scientific article published on 01 June 2006

Coupling between gamma irradiation, p53 induction and the apoptotic response depends upon cell type in vivo

scientific article published on 01 May 1995

Crystallization of eIF4E complexed with eIF4GI peptide and glycerol reveals distinct structural differences around the cap-binding site

scientific article

Curing cancer with p53.

scientific article

Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis: a potent drug combination.

scientific article published on November 2007

Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation

scientific article

Defective nuclear localization of p53 protein in a Chinese hamster cell line is associated with the formation of stable cytoplasmic protein multimers in cells with gene amplification.

scientific article published on September 2000

Design of a novel MDM2 binding peptide based on the p53 family

scientific article published on 14 September 2009

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

scientific article

Detecting and quantifying p53 isoforms at mRNA level in cell lines and tissues.

scientific article

Detecting p53 Isoforms at Protein Level ⬇️

scientific article published on January 1, 2013

Detection of alkaline phosphatase-labeled reagents

scientific article published on 01 June 2006

Detection of gold-labeled reagents

scientific article published on 01 June 2006

Detection of horseradish peroxidase-labeled reagents with aminoethylcarbazole

scientific article published on 01 June 2006

Detection of horseradish peroxidase-labeled reagents with chloronaphthol

scientific article published on 01 June 2006

Detection of horseradish peroxidase-labeled reagents with diaminobenzidine/metal

scientific article published on 01 June 2006

Detection of the 113p53 protein isoform: a p53-induced protein that feeds back on the p53 pathway to modulate the p53 response in zebrafish.

scientific article

Detection of β-Galactosidase-Labeled Reagents

scientific article published on 01 June 2006

Development of CDK inhibitors as cancer therapeutics.

scientific article published on 17 June 2005

Development of a novel multiplex in vitro binding assay to profile p53-DNA interactions

scientific article published in August 2010

Differences in the transactivation domains of p53 family members: a computational study

scientific article

Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

scientific article

Differential expression of p53, p21waf1/cip1 and hdm2 dependent on DNA damage in Bloom's syndrome fibroblasts

scientific article published on 01 December 1998

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

scientific article published on November 1993

Differential scanning fluorimetry as secondary screening platform for small molecule inhibitors of Bcl-XL.

scientific article

Dimerization of the core domain of the p53 family: a computational study

scientific article published on 01 January 2009

Directed evolution of p53 variants with altered DNA-binding specificities by in vitro compartmentalization.

scientific article

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents ⬇️

scientific article published on October 29, 2010

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

scientific article published on May 2008

Discriminating functional and non-functional p53 in human tumours by p53 and MDM2 immunohistochemistry

scientific article published on 01 November 2005

Diversity of human p53 mutants revealed by complex formation to SV40 T antigen

scientific article published on January 1, 1992

Dominant nonresponsiveness in the induction of autoimmunity to liver-specific F antigen ⬇️

scientific article published on December 1, 1975

Double-edged swords as cancer therapeutics: simultaneously targeting p53 and NF-kappaB pathways.

scientific article published on December 2008

Drug discovery in the p53 pathway.

scientific article published on 12 March 2000

Drugging the p53 pathway: understanding the route to clinical efficacy

scientific article published on March 2014

Effect of VH-VL Families in Pertuzumab and Trastuzumab Recombinant Production, Her2 and FcγIIA Binding.

scientific article

Enhanced antigen detection in immunohistochemical staining using a 'digitized' chimeric antibody.

scientific article

Enhancing Specific Disruption of Intracellular Protein Complexes by Hydrocarbon Stapled Peptides Using Lipid Based Delivery ⬇️

scientific article

Enlarged family of putative helicases

scientific article published in Nature

Enzyme-linked immunosorbent assay for p53 in gastrointestinal malignancy: comparison with immunohistochemistry

scientific article published on 01 November 1993

Epithelial proliferation in Barrett's esophagus by proliferating cell nuclear antigen immunolocalization

scientific article published on 01 December 1992

Epitope mapping by competition assay

scientific article published on 01 July 2006

Epitope mapping of antibodies recognising the N-terminal domain of simian virus large tumour antigen.

scientific article published in January 1998

Epitope mapping using bacteriophage peptide libraries.

scientific article published on April 1993

Epitope mapping using synthetic biotin-labeled peptides

scientific article published on 01 July 2006

Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy.

scientific article published on November 2010

Evidence for allosteric effects on p53 oligomerization induced by phosphorylation.

scientific article published on 10 November 2017

Exploiting the p53 Pathway for Therapy.

scientific article published on 13 February 2017

Exploiting the p53 pathway for cancer diagnosis and therapy

scientific article published on 01 January 2003

Exploiting the p53 pathway for the diagnosis and therapy of human cancer.

scientific article published on January 2005

Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines.

scientific article published on January 1991

Expression of mutant p53 in melanoma

scientific article published on 01 November 1991

Expression of p53 in premalignant and malignant squamous epithelium.

scientific article published on October 1991

Expression of p53 in reactive mesothelium

scientific article published on 01 January 1993

Expression of p53 protein in infiltrating and in-situ breast carcinomas

scientific article published on 01 November 1991

Expression of the p53 protein in a spectrum of astrocytic tumours

scientific article published on December 1, 1992

Expression of the p53 tumour suppressor gene product is a determinant of chemosensitivity.

scientific article published on February 1994

Fixing Caenorhabditis elegans in Bouin's fixative

scientific article published on 01 September 2006

Fixing Caenorhabditis elegans in Paraformaldehyde

scientific article published on 01 September 2006

Fixing attached cells in organic solvents

scientific article published on 01 August 2006

Fixing attached cells in paraformaldehyde

scientific article published on 01 August 2006

Fixing suspension cells with paraformaldehyde

scientific article published on 01 August 2006

Flow cytometric characterisation of proliferating cell nuclear antigen using the monoclonal antibody PC10

scientific article published on January 1, 1992

Functional characterization of p53 pathway components in the ancient metazoan Trichoplax adhaerens

scientific article published on 28 September 2016

Gating by tryptophan 73 exposes a cryptic pocket at the protein-binding interface of the oncogenic eIF4E protein.

scientific article

Genetic and immunochemical analysis of mutant p53 in human breast cancer cell lines

scientific article published on June 1, 1990

Growing adherent cells directly on tissue dishes

scientific article published on 01 August 2006

Growing adherent cells on coverslips or multiwell slides

scientific article published on 01 August 2006

Growth factor stimulation of proliferating cell nuclear antigen (PCNA) in human breast epithelium in organ culture ⬇️

scientific article published on July 1, 1991

HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy.

scientific article published on 6 June 2007

HPV-16 E7 or adenovirus E1A can overcome the growth arrest of cells immortalized with a temperature-sensitive p53.

scientific article

HSP70 Binding Sites in the Tumor Suppressor Protein p53 ⬇️

scientific article published on August 1, 1997

Haemangiopericytomas: the prognostic value of immunohistochemical staining with a monoclonal antibody to proliferating cell nuclear antigen (PCNA)

scientific article published on 01 July 1991

Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.

scientific article

High Mdm4 levels suppress p53 activity and enhance its half-life in acute myeloid leukaemia

scientific article

High efficiency gene transfer into mammalian cells

scientific article published on 01 December 1984

High levels of p53 protein in UV-irradiated normal human skin

scientific article published on 01 January 1993

Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A

scientific article published on 01 November 2002

Host proteins that bind to or mimic SV40 large T antigen: using antibodies to look at protein interactions and their significance.

scientific article

How cells choose to die ⬇️

scientific article published on November 1, 2001

Human and plant proliferating-cell nuclear antigen have a highly conserved binding site for the p53-inducible gene product p21WAF1

scientific article published on 01 May 1996

Hypophosphorylation of Mdm2 augments p53 stability

scientific article

Identification of novel mdm2 binding peptides by phage display.

scientific article published on November 1996

Identification of the RNA2 protein of Saccharomyces cerevisiae

scientific article published on 01 March 1986

If you wanna be loved

scientific article published on 01 December 1999

Immunoaffinity purification: binding of antigen to antibody-bead matrix in a column

scientific article published on 01 June 2006

Immunoaffinity purification: binding of antigen to antibody-bead matrix in a suspension

scientific article published on 01 June 2006

Immunoaffinity purification: coupling antibodies to activated beads

scientific article published on 01 June 2006

Immunoaffinity purification: coupling antibodies to protein a or g bead columns

scientific article published on 01 June 2006

Immunoaffinity purification: eluting antigens from immunoaffinity columns

scientific article published on 01 June 2006

Immunoblotting: antigen detection using chemiluminescence

scientific article published on 01 June 2006

Immunoblotting: antigen detection using chromogenic methods

scientific article published on 01 June 2006

Immunoblotting: preparing cell lysates

scientific article published on 01 August 2006

Immunoblotting: preparing immunoprecipitated proteins

scientific article published on 01 August 2006

Immunoblotting: preparing protein solutions

scientific article published on 01 August 2006

Immunoblotting: semi-dry electrophoretic transfer of proteins from gels to membranes

scientific article published on 01 June 2006

Immunoblotting: submerged electrophoretic transfer of proteins from gels to membranes

scientific article published on 01 June 2006

Immunochemical analysis of the interaction of p53 with MDM2;--fine mapping of the MDM2 binding site on p53 using synthetic peptides.

scientific article published on September 1994

Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumours.

scientific article published on January 1993

Immunohistochemical detection of p53 and bcl-2 proteins in non-Hodgkin's lymphoma

scientific article published on 01 January 1993

Immunoprecipitation: denaturing lysis

scientific article published on 01 September 2006

Immunoprecipitation: lysing bacteria by sonication

scientific article published on 01 September 2006

Immunoprecipitation: lysing yeast cells using glass beads

scientific article published on 01 September 2006

Immunoprecipitation: preclearing the lysate

scientific article published on 01 September 2006

Immunoprecipitation: purifying the immune complexes

scientific article published on 01 September 2006

Improved eIF4E Binding Peptides by Phage Display Guided Design: Plasticity of Interacting Surfaces Yield Collective Effects ⬇️

scientific article published on October 19, 2012

Improving cancer therapy by non-genotoxic activation of p53.

scientific article

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine)

scientific article published on 01 December 2002

In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202.

scientific article published on July 2005

In vitro selection of mutant HDM2 resistant to Nutlin inhibition

scientific article

Increased expression of mutant forms of p53 oncogene in primary lung cancer

scientific article published in The Lancet

Indirect detection using fluorochrome-labeled reagents

scientific article published on 01 August 2006

Indirect detection using horseradish peroxidase-labeled reagents

scientific article published on 01 August 2006

Induction of endogenous beta-galactosidase by ionizing radiation complicates the analysis of p53-LacZ transgenic mice

scientific article published on 01 October 2001

Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity.

scientific article published on 27 June 2017

Inhibition of NLRP3 inflammasome activation by cell-permeable stapled peptides

scientific article published on 20 March 2019

Inhibition of cell proliferation by the PCNA-binding region of p21 expressed as a GFP miniprotein

scientific article published on 01 May 2001

Inhibition of nutlin-resistant HDM2 mutants by stapled peptides

scientific article

Inhibitors of cyclin-dependent kinases as anti-cancer therapeutics

scientific article published on 01 December 2000

Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange

scientific article

International network of cancer genome projects

scientific article

Investigating peptide sequence variations for 'double-click' stapled p53 peptides

scientific article

Isg15 controls p53 stability and functions.

scientific article published on 20 May 2014

Isolation and analysis of the fission yeast gene encoding polymerase delta accessory protein PCNA.

scientific article

Killing tumor cells with viruses—a question of specificity ⬇️

scientific article published on 01 September 1998

Labeling antibodies with biotin

scientific article published on 01 July 2006

Labeling antibodies with fluorochromes

scientific article published on 01 July 2006

Labeling antibodies with iodine

scientific article published on 01 July 2006

Labeling monoclonal antibodies by biosynthesis

scientific article published on 01 July 2006

Lipids Shape the Electron Acceptor-Binding Site of the Peripheral Membrane Protein Dihydroorotate Dehydrogenase.

scientific article published on 17 January 2018

Localization of p53, retinoblastoma and host replication proteins at sites of viral replication in herpes-infected cells

scientific article published in Nature

Loss of chromosome 17p13 sequences and mutation of p53 in human breast carcinomas

scientific article published on 01 March 1991

Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

scientific article

Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice

scientific article published on December 1, 1991

Low p53 protein expression in salivary gland tumours compared with lung carcinomas

scientific article published on 01 January 1992

Lysing tissue-culture cells for immunoprecipitation

scientific article published on 01 September 2006

MDM2 SNP309 is associated with high grade node positive breast tumours and is in linkage disequilibrium with a novel MDM2 intron 1 polymorphism.

scientific article

MDM2-arbiter of p53's destruction ⬇️

scientific article published on October 1, 1997

MDM4 downregulates p53 transcriptional activity and response to stress during differentiation.

scientific article published in April 2011

Macrocyclic α helical peptide therapeutic modality: A perspective of learnings and challenges.

scientific article published on 16 March 2018

Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics

scientific article

Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone

scientific article published on 09 July 2018

Mdm2 and p53 are highly conserved from placozoans to man.

scientific article

Mdm2 binding to a conformationally sensitive domain on p53 can be modulated by RNA

scientific article published on 01 April 2000

Mdm2 in evolution

scientific article

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

scientific article

Mechanism of Stapled Peptide Binding to MDM2: Possible Consequences for Peptide Design

scientific article published on 01 April 2014

Modification of two distinct COOH-terminal domains is required for murine p53 activation by bacterial Hsp70

scientific article

Modulation of p53 binding to MDM2: computational studies reveal important roles of Tyr100

scientific article

Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response

scientific article

Modulation of the p53-MDM2 interaction by phosphorylation of Thr18: a computational study.

scientific article published on 20 August 2007

Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.

scientific article published on November 1993

Molecular evolution of the thermosensitive PAb1620 epitope of human p53 by DNA shuffling

scientific article published on 01 September 1999

Molecular recognition and the future of monoclonal antibodies

scientific article published in Nature

Monoclonal antibodies to a proenkephalin A fusion peptide synthesized in Escherichia coli recognize novel proenkephalin A precursor forms

scientific article published in December 1988

Monoclonal antibodies to leucine enkephalin

scientific article published on 01 June 1983

Monoclonal antibody analysis of the proliferating cell nuclear antigen (PCNA). Structural conservation and the detection of a nucleolar form ⬇️

scientific article published on May 1, 1990

Monoclonal antibody to simian virus 40 small t ⬇️

scientific article published on September 1, 1984

Mounting Samples in DPX

scientific article published on 01 June 2006

Multiple peptide conformations give rise to similar binding affinities: molecular simulations of p53-MDM2

scientific article published on 19 September 2008

Mutant conformation of p53. Precise epitope mapping using a filamentous phage epitope library

scientific article published on June 5, 1992

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.

scientific article published in July 2015

Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion

scientific article

Mutant p53 uses p63 as a molecular chaperone to alter gene expression and induce a pro-invasive secretome

scientific article

Mutant p53, EGF receptor and c-erbB-2 expression in human breast cancer

scientific article published on 01 December 1991

Mutational spectra and immunohistochemical analyses of p53 in human cancers

scientific article published on 01 March 1992

Mutations in p53 are frequent in the preneoplastic stage of mouse mammary tumor development.

scientific article

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners.

scientific article

NPMc(+) AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anticancer compounds.

scientific article published on 15 June 2011

Negative regulation of viral enhancers in undifferentiated embryonic stem cells

scientific article published on 01 September 1985

Nuclear export inhibitor leptomycin B induces the appearance of novel forms of human Mdm2 protein.

scientific article published on February 2003

Nutlin-3 inhibits the NFkappaB pathway in a p53-dependent manner: implications in lung cancer therapy.

scientific article published on 27 June 2007

Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

scientific article published on 5 August 2015

O6-methylguanine in the SV40 origin of replication inhibits binding but increases unwinding by viral large T antigen.

scientific article

On the expression of the p53 protein in human cancer.

scientific article published on January 1994

On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: a Brownian dynamics study.

scientific article published on 16 January 2013

On the origin of the stereoselective affinity of Nutlin-3 geometrical isomers for the MDM2 protein

scientific article

Oncogenic intelligence: Cell immortalization and transformation by the p53 gene ⬇️

scientific article published on December 13, 1984

Over-expression of p53 nuclear oncoprotein in colorectal adenomas

scientific article published on 01 March 1992

Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma ⬇️

scientific article published on January 1, 1992

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2.

scientific article published on September 2002

P53 abnormalities and outcomes in colorectal cancer: a systematic review.

scientific article

PCNA binding proteins in Drosophila melanogaster : the analysis of a conserved PCNA binding domain ⬇️

scientific article published on September 1, 1998

Phage Peptide Libraries

scientific article published on June 1996

Pilot screening programme for small molecule activators of p53.

scientific article

Polygenic control of the immune response to F antigen

scientific article published on 01 January 1981

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

scientific article

Preparing acetone powders

scientific article published on 01 June 2006

Preparing cell smears from tissue samples for immunostaining

scientific article published on 01 June 2006

Preparing early whole-mount Drosophila embryos for immunostaining

scientific article published on 01 September 2006

Preparing frozen tissue sections for immunostaining

scientific article published on 01 June 2006

Preparing late whole-mount Drosophila embryos for immunostaining

scientific article published on 01 September 2006

Preparing paraffin tissue sections for immunostaining

scientific article published on 01 June 2006

Prognostic value of proliferating cell nuclear antigen in gastric carcinoma ⬇️

scientific article published on August 1, 1991

Proliferating cell nuclear antigen and S phase fraction in endometrial stromal sarcoma ⬇️

scientific article published on August 1, 1992

Proliferating cell nuclear antigen immunolocalization in gastro-intestinal epithelia

scientific article published on 01 January 1991

Protein Quantitation: UV Detection

scientific article published on 01 June 2006

Protein interactions at the carboxyl terminus of p53 result in the induction of its in vitro transactivation potential ⬇️

scientific article published on July 10, 1997

Protein quantitation: bradford spot test

scientific article published on 01 June 2006

Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage.

scientific article published on 22 May 2018

Purification of antibodies on an antigen column

scientific article published on 01 June 2006

R-Roscovitine simultaneously targets both the p53 and NF-kappaB pathways and causes potentiation of apoptosis: implications in cancer therapy.

scientific article published on 2 November 2007

R248Q mutation--Beyond p53-DNA binding.

scientific article published on 7 October 2015

Rapid colorimetric detection of p53 protein function using DNA-gold nanoconjugates with applications for drug discovery and cancer diagnostics

scientific article published on 05 May 2018

Rapid induction of apoptosis mediated by peptides that bind initiation factor eIF4E.

scientific article published on June 2000

Ras-induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

scientific article published on 01 July 1992

Rational design and biophysical characterization of thioredoxin-based aptamers: insights into peptide grafting.

scientific article published on 3 November 2009

Reactivation of mutant p53: Constraints on mechanism highlighted by principal component analysis of the DNA binding domain

scientific article published on 18 June 2016

Reactivation of p53: from peptides to small molecules.

scientific article published on 08 December 2010

Recognition Dynamics of p53 and MDM2: Implications for Peptide Design.

scientific article published on 24 December 2015

Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

scientific article

Regulation of p53 protein expression in human breast cancer cell lines

scientific article published on 01 July 1993

Regulation of the Cryptic Sequence-specific DNA-binding Function of p53 by Protein Kinases ⬇️

scientific article published on January 1, 1994

Regulation of the specific DNA binding function of p53

scientific article published on November 27, 1992

Requirement for the replication protein SSB in human DNA excision repair

scientific article published in Nature

Role of the N-terminal lid in regulating the interaction of phosphorylated MDMX with p53.

scientific article published in December 2017

SNPing Away at Cancer

scientific article published on 01 September 2010

SUMO-1 modification activates the transcriptional response of p53

scientific article

SV40 large T shares an antigenic determinant with a cellular protein of molecular weight 68,000.

scientific article

Seeking synergy in p53 transcriptional activation for cancer therapy

scientific article published on October 1, 2012

Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1

scientific article

Seliciclib (CYC202, R-roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model.

scientific article

Simian virus 40 large T-antigen-dependent DNA replication is activated by protein phosphatase 2A in vitro.

scientific article

Small molecular weight variants of p53 are expressed in human melanoma cells and are induced by the DNA-damaging agent cisplatin.

scientific article

Small peptides activate the latent sequence-specific DNA binding function of p53.

scientific article

Small-molecule inhibitors of the p53 suppressor HDM2: have protein-protein interactions come of age as drug targets?

scientific article published in July 2004

Specific activation of the p53 pathway by low dose actinomycin D: a new route to p53 based cyclotherapy.

scientific article

Stabilizing the eIF4G1 α-helix increases its binding affinity with eIF4E: implications for peptidomimetic design strategies.

scientific article published on 19 November 2010

Staining immunoblots for total protein using India ink

scientific article published on 01 June 2006

Staining immunoblots for total protein using ponceau s

scientific article published on 01 June 2006

Staining yeast

scientific article published on 01 September 2006

Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations

scientific article

Stapled Peptides with Improved Potency and Specificity That Activate p53 ⬇️

scientific article published on December 18, 2012

Stapled peptide design: principles and roles of computation

scientific article published on 17 June 2016

Stapled peptides in the p53 pathway: computer simulations reveal novel interactions of the staples with the target protein.

scientific article published on 15 November 2010

Stereoisomerism of stapled peptide inhibitors of the p53-Mdm2 interaction: an assessment of synthetic strategies and activity profiles

scientific article published on 30 May 2019

Storage of ascitic fluid

scientific article published on 01 July 2006

Storage of purified antibodies

scientific article published on 01 June 2006

Storage of sera

scientific article published on 01 July 2006

Storage of tissue culture supernatants

scientific article published on 01 July 2006

Strategies for manipulating the p53 pathway in the treatment of human cancer.

scientific article

Stress, specificity and the NEDD8 proteome ⬇️

scientific article published on April 15, 2012

Stripping immunoblots for reprobing or storage

scientific article published on 01 June 2006

Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design

scientific article

Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.

scientific article

Structure and function of SV40 large-T antigen.

scientific article

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

scientific article

Structure-activity relationship of truncated and substituted analogues of the intracellular delivery vector Penetratin

scientific article published on 01 February 2000

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids

scientific article published on 11 December 2017

Substrate specificity of cyclins determined by electrostatics

scientific article published on 06 July 2007

Such an obsession.

scientific article published on 5 January 2006

Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

scientific article

Surfing the p53 network

scientific article (publication date: 16 November 2000)

T antigen is bound to a host protein in SY40-transformed cells ⬇️

scientific article (publication date: 15 March 1979)

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

scientific article published on 29 April 2020

The MDM2/MDMX-p53 Antagonist PM2 Radiosensitizes Wild-Type p53 Tumors

scientific article published on 19 July 2018

The N terminus of the murine p53 tumour suppressor is an independent regulatory domain affecting activation and thermostability

scientific article published on 01 January 1998

The RNA helicase p68 (DDX5) is selectively required for the induction of p53-dependent p21 expression and cell-cycle arrest after DNA damage.

scientific article published on 17 September 2012

The adenovirus Ela gene induces differentiation of F9 teratocarcinoma cells.

scientific article published on May 1987

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis

scientific article published on 01 July 1991

The assessment of proliferating cell nuclear antigen (PCNA)immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S + G2 + M phase fraction (flow cytometric analysis) and prognosis

scientific article published on 01 September 2002

The complex between simian virus 40 T antigen and a specific host protein.

scientific article published in November 1980

The conformational change of a murine temperature-sensitive p53 protein is independent of a change in phosphorylation status

scientific article published on August 1, 1992

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

scientific article

The dominating effect of mutant p53

scientific article published on 01 March 1995

The effects of Antibody Engineering CH and CL in Trastuzumab and Pertuzumab recombinant models: Impact on antibody production and antigen-binding

scientific article published on 15 January 2018

The electrostatic surface of MDM2 modulates the specificity of its interaction with phosphorylated and unphosphorylated p53 peptides.

scientific article published on 26 December 2007

The expression of p53 tumor-suppressor protein during progression of gastric and colorectal carcinomas.

scientific article

The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4.

scientific article

The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage.

scientific article published on 21 November 2016

The immune response to p53 in breast cancer patients is directed against immunodominant epitopes unrelated to the mutational hot spot ⬇️

scientific article published on November 15, 1992

The immunocytochemical detection of p53 protein in cytological specimens: technical considerations.

scientific article published on April 1994

The p53 inducing drug dosage may determine quiescence or senescence ⬇️

scientific article published on November 1, 2010

The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression.

scientific article

The p53 isoforms are differentially modified by Mdm2.

scientific article

The p53-Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

scientific article

The p53-Mdm2 pathway: targets for the development of new anticancer therapeutics.

scientific article

The promise of molecular oncology ⬇️

scientific article published on May 1, 1998

The regulation of p53 function: Steiner Award Lecture.

scientific article published on June 1994

The relationship of p53 immunostaining to survival in carcinoma of the lung ⬇️

scientific article published on October 1, 1992

The role of TP53 in breast cancer development.

scientific article published on January 1993

The role of the p53 protein in the apoptotic response.

scientific article published on August 1994

Therapeutic anti-cancer activity of antibodies targeting sulfhydryl bond constrained epitopes on unglycosylated RON receptor tyrosine kinase

scientific article published on 15 August 2019

Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others

scientific article

Thermodynamic stability of wild-type and mutant p53 core domain

scientific article published in December 1997

Transcription - guarding the genome by sensing DNA damage

scientific article published on 01 September 2004

Translating p53 into the clinic.

scientific article published on 26 October 2010

Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

scientific article published on 9 March 2015

Tumour diagnosis

scientific article published in Nature

Tumour suppressor genes and molecular chaperones.

scientific article published in March 1993

Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage.

scientific article

Tumour-specific therapeutic adenovirus vectors: repression of transgene expression in healthy cells by endogenous p53.

scientific article published in February 2001

Turning the key on p53.

scientific article published in February 2004

Two Pathways for Base Excision Repair in Mammalian Cells

scientific article published in Journal of Biological Chemistry

Two different viral transforming proteins bind the same host tumour antigen

scientific article published in Nature

Two distinct signaling pathways activate the latent DNA binding function of p53 in a casein kinase II-independent manner.

scientific article published on July 1995

Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6.

scientific article published on 15 January 2007

Ubiquitination of HEXIM1 by HDM2.

scientific article

Unmasking hidden epitopes using the microwave oven

scientific article published on 01 September 2006

Unmasking hidden epitopes using the pressure cooker

scientific article published on 01 September 2006

Unmasking hidden epitopes with proteases

scientific article published on 01 September 2006

Updates on p53: modulation of p53 degradation as a therapeutic approach

scientific article published on 08 January 2008

Use of monoclonal antibodies as probes of simian virus 40 T antigen ATPase activity.

scientific article published in November 1981

Use of simian virus 40 large T-beta-galactosidase fusion proteins in an immunochemical analysis of simian virus 40 large T antigen.

scientific article published on June 1985

Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity.

scientific article published on 17 January 2012

Using the polymerase chain reaction to modify expression plasmids for epitope mapping.

scientific article published on April 1989

Wetting of nonconserved residue-backbones: A feature indicative of aggregation associated regions of proteins.

scientific article

When monoclonal antibodies are not monospecific: Hybridomas frequently express additional functional variable regions

scientific article published on 27 February 2018

Why is F19Ap53 unable to bind MDM2? Simulations suggest crack propagation modulates binding.

scientific article published on 15 June 2012

Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9

scientific article published on 15 January 2012

Worrying about p53

scientific article published on 01 November 1992

mAb806 binding to epidermal growth factor receptor: a computational study

scientific article published on 18 November 2014

p14 Arf promotes small ubiquitin-like modifier conjugation of Werners helicase

scientific journal article

p53 Research: the past thirty years and the next thirty years.

scientific article

p53 and human cancers.

scientific article published on July 1994

p53 directly transactivates Δ133p53α, regulating cell fate outcome in response to DNA damage

scientific article

p53 expression and prognosis in gastric carcinoma

scientific article published on 01 April 1992

p53 expression in colorectal adenomas ⬇️

scientific article published on January 1, 1993

p53 expression is common in malignant mesothelioma

scientific article published on October 1, 1992

p53 immunohistochemistry in malignant fibrous histiocytomas and other mesenchymal tumours

scientific article published on 01 September 1992

p53 immunostaining as a marker for oral cancer in diagnostic cytopathology--preliminary report

scientific article published on 01 February 1994

p53 immunostaining as a marker of malignant disease in diagnostic cytopathology

scientific article published on 01 August 1991

p53 in health and disease

scientific article (publication date: April 2007)

p53 in tumour pathology: can we trust immunohistochemistry?--Revisited!

scientific article published on 01 January 1994

p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish.

scientific article published on February 2009

p53 isoform Δ113p53/Δ133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage

scientific article

p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence

scientific article

p53 isoforms can regulate p53 transcriptional activity.

scientific article

p53 isoforms regulate aging- and tumor-associated replicative senescence in T lymphocytes

scientific article

p53 isoforms regulate astrocyte-mediated neuroprotection and neurodegeneration.

scientific article published on 22 April 2016

p53 isoforms regulate premature aging in human cells.

scientific article published on 12 February 2018

p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients.

scientific article

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis

scientific article published on 01 November 1992

p53 mutations in colorectal cancer ⬇️

scientific article published on October 1, 1990

p53 protein accumulates frequently in early bronchial neoplasia.

scientific article published in October 1993

p53 protein in odontogenic cysts: increased expression in some odontogenic keratocysts ⬇️

scientific article published on November 1, 1992

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

scientific article

p53 transcriptional pathways in breast cancer: the good, the bad and the complex

scientific article published on 01 March 2010

p53, c-erbB-2 and the epidermal growth factor receptor in the benign and malignant prostate

scientific article published on February 1, 1992

p53--integrating the complexity

scientific article published on 01 September 1996

p53-dependent growth arrest following calcium phosphate-mediated transfection of murine fibroblasts.

scientific article published on May 1995

p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.

scientific article

p53: 25 years of research and more questions to answer.

scientific article

p53: oncogene or anti-oncogene?

scientific article

p53: out of Africa.

scientific article published on April 2016

p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts

scientific article

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