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List of works by Jon C. Mirsalis

(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium.

scientific article

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

scientific article

A protocol and guide for the in vitro rat hepatocyte DNA-repair assay

scientific article published on 01 October 1987

A protocol and guide for the in vivo rat hepatocyte DNA-repair assay

scientific article published on 01 October 1987

A strategy for the application of transgenic rodent mutagenesis assays

scientific article

Analysis of the mutagenic potential of ENU and MMS in germ cells of male C57BL/6 lacI transgenic mice

scientific article published on 01 February 1997

Biodistribution, Toxicology, and Radiation Dosimetry of 5-HT1A-Receptor Agonist Positron Emission Tomography Ligand [11C]CUMI-101 ⬇️

scientific article published on October 12, 2011

Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[18F]-ADAM in rats and monkeys

scientific article published on 10 October 2009

Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays.

scientific article published in January 1996

Comparative mutagenicity testing of a drug candidate, U-48753E: mechanism of induction of gene mutations in mammalian cells and quantitation of potential hazard

scientific article published in June 1989

Comparative studies on the genotoxic activity of mainstream smoke condensate from cigarettes which burn or only heat tobacco

scientific article published on January 1990

Detection of DNA damage in primary cultures of rat hepatocytes following in vivo and in vitro exposure to genotoxic agents

scientific article published on 01 January 1982

Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay

scientific article published in January 1982

Detection of unscheduled DNA synthesis in hepatocytes isolated from rats treated with genotoxic agents: an in vivo- in vitro assay for potential carcinogens and mutagens

scientific article published on 01 July 1980

Development of a new generation of 4-aminoquinoline antimalarial compounds using predictive pharmacokinetic and toxicology models.

scientific article

Dosing regimens for transgenic animal mutagenesis assays

scientific article published on 01 January 1993

Effects of soya bean flakes and liquorice root extract on enzyme induction and toxicity in B6C3F1 mice

scientific article published on 01 May 1993

Efficacy of Tilorone Dihydrochloride against Ebola Virus Infection

scientific article published on 13 November 2017

Evaluation of Antitrypanosomal Dihydroquinolines for Hepatotoxicity, Mutagenicity, and Methemoglobin Formation In Vitro

scientific article

Evaluation of Cardiac Toxicity Biomarkers in Rats from Different Laboratories

scientific article

Evaluation of arylimidamides DB1955 and DB1960 as candidates against visceral leishmaniasis and Chagas' disease: in vivo efficacy, acute toxicity, pharmacokinetics, and toxicology studies

scientific article

Evaluation of chemopreventive agents for genotoxic activity

scientific article published on 25 February 2007

Evaluation of mutant frequencies of chemically induced tumors and normal tissues in lambda/cII transgenic mice.

scientific article published in January 2005

Evaluation of positive controls for the in vitro unscheduled DNA synthesis assay using hepatocytes from induced (Aroclor 1254) and uninduced male cynomolgus monkey.

scientific article published in January 1997

Evaluation of the Activity of Lamivudine and Zidovudine against Ebola Virus

scientific article published on 30 November 2016

Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses

scientific article

Evaluation of unscheduled DNA synthesis (UDS) and replicative DNA synthesis (RDS) following treatment of rats and mice with p-dichlorobenzene

scientific article published in January 1998

Examination of genotoxicity, toxicity and morphologic alterations in hepatocytes following in vivo or in vitro exposure to methapyrilene ⬇️

scientific article published on June 1, 1988

Factors that affect the sensitivity of the in vivo-in vitro hepatocyte DNA repair assay in the male rat

scientific article published on 01 November 1987

Gene expression analysis reveals new possible mechanisms of vancomycin-induced nephrotoxicity and identifies gene markers candidates

scientific article published on 16 October 2008

Gene expression profiling of mouse host response to Listeria monocytogenes infection

scientific article published on 15 August 2005

Genetic toxicology studies comparing the activity of sidestream smoke from cigarettes which burn or only heat tobacco

scientific article published in February 1990

Genetic toxicology testing of the antimalarial drugs chloroquine and a new analog, AQ-13.

scientific article published on January 2001

Genotoxicity and carcinogenicity studies of soy isoflavones

scientific article published in July 2002

Genotoxicity and toxicity of the potential cancer-preventive agent polyphenon E.

scientific article

Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene

scientific article

In Vitro and In Vivo Activity of Amiodarone Against Ebola Virus

scientific article published on 22 November 2018

In Vivo Activity of Amodiaquine against Ebola Virus Infection

scientific article published on 27 December 2019

In vivo measurement of unscheduled DNA synthesis and S-phase synthesis as an indicator of hepatocarcinogenesis in rodents

scientific article

In vivo transgenic mutation assays

scientific article published in October 2003

In vivo transgenic mutation assays

scientific article published on 01 January 2000

Increased CCL2 expression and macrophage/monocyte migration during microbicide-induced vaginal irritation

scientific article

Increased stress associated with head-out plethysmography testing can exacerbate respiratory effects and lead to mortality in rats

scientific article published on 11 May 2019

Induction of hepatic cell proliferation and unscheduled DNA synthesis in mouse hepatocytes following in vivo treatment.

scientific article

Induction of hepatic mutations in lacI transgenic mice

scientific article published in May 1993

Induction of unscheduled DNA synthesis in primary cultures of rat pancreatic cells following in vivo and in vitro treatment with genotoxic agents

scientific article published on 01 January 1984

Induction of unscheduled DNA synthesis in primary cultures of rat, mouse, hamster, monkey, and human hepatocytes

scientific article published on September 1988

Induction of unscheduled DNA synthesis in rat hepatocytes following in vivo treatment with dinitrotoluene

scientific article published on 01 January 1982

Lead optimization of 3-carboxyl-4(1H)-quinolones to deliver orally bioavailable antimalarials

scientific article

Lead optimization of antimalarial propafenone analogues.

scientific article published on 29 June 2012

Measurement of unscheduled DNA synthesis and S-phase synthesis in rodent hepatocytes following in vivo treatment: testing of 24 compounds.

scientific article published in January 1989

Measurement of unscheduled DNA synthesis in rat kidney cells following in vivo treatment with genotoxic agents

scientific article published in January 1985

Metabolism, Pharmacokinetics, Tissue Distribution, and Stability Studies of the Prodrug Analog of an Anti-Hepatitis B Virus Dinucleoside Phosphorothioate ⬇️

scientific article published on February 10, 2012

Microarray evaluation of the Listeria monocytogenes infection and amoxicillin treatment in mice

scientific article published in May 2008

Micronucleated erythrocyte frequency in peripheral blood of B6C3F(1) mice from short-term, prechronic, and chronic studies of the NTP carcinogenesis bioassay program.

scientific article published in January 2000

Mutagenic response to benzene and tris(2,3-dibromopropyl)-phosphate in the lambda lacI transgenic mouse mutation assay: a standardized approach to in vivo mutation analysis

scientific article published in January 1996

Mutagenicity databases

scientific article published on 01 January 1993

Mutational spectrum of dimethylnitrosamine in the liver of 3- and 6-week-old lacI transgenic mice

scientific article published in January 1999

Neurological assessments after treatment with the antimalarial β-arteether in neonatal and adult rats

scientific article published on 6 April 2011

New candidate biomarkers in the female genital tract to evaluate microbicide toxicity

scientific article (publication date: 2014)

Nonprofit organizations and pharmaceutical research and development

article

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs

scientific article

Pharmacokinetics and dose-range finding toxicity of a novel anti-HIV active integrase inhibitor

scientific article

Pharmacokinetics of the antimalarial drug, AQ-13, in rats and cynomolgus macaques

scientific article published on May 2004

Preclinical Evaluations To Identify Optimal Linezolid Regimens for Tuberculosis Therapy

scientific article

Preclinical acute toxicity studies and dosimetry estimates of the novel sigma-1 receptor radiotracer, [18F]SFE.

scientific article published in September 2006

Preclinical pharmacokinetic, toxicological and biomarker evaluation of SR16157, a novel dual-acting steroid sulfatase inhibitor and selective estrogen receptor modulator ⬇️

scientific article published on August 25, 2010

Preclinical studies on the pharmacokinetics, safety, and toxicology of oxfendazole: toward first in human studies

scientific article published on 20 February 2015

Professional toxicology societies: web based resources

scientific article published on January 2001

Pyridine does not induce unscheduled DNA synthesis (UDS) in hepatocytes of male B6C3F1 mice treated in vivo

scientific article published on 01 September 2000

Quantitative proteomics for cardiac biomarker discovery using isoproterenol-treated nonhuman primates

scientific article

Radiation-induced point mutations, deletions and micronuclei in lacI transgenic mice

scientific article published in June 1994

Role of gut flora in the genotoxicity of dinitrotoluene

scientific article published in Nature

Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component

scientific article

Serum Biomarkers Reveal Long-term Cardiac Injury in Isoproterenol-treated African Green Monkeys ⬇️

scientific article published on March 28, 2013

Skin irritation, basal epithelial cell proliferation, and carcinogenicity evaluations of a representative specialty acrylate and methacrylate

scientific article published on February 2003

Spectrum of mutations in kidney, stomach, and liver from lacI transgenic mice recovered after treatment with tris(2,3-dibromopropyl)phosphate

scientific article published on January 1996

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120

article

Tenofovir disoproxil fumarate: toxicity, toxicokinetics, and toxicogenomics analysis after 13 weeks of oral administration in mice

scientific article

The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: evaluation of 24 drug candidates

scientific article published on 01 June 1989

The role of cell proliferation in chemical carcinogenesis.

scientific article published on January 1990

The role of hyperplasia in liver carcinogenesis

scientific article published on January 1990

Toxicity of a quinocarmycin analog, DX-52-1, in rats and dogs in relation to clinical outcome

scientific article published on 18 January 2003

Toxicity of dolastatin 10 in mice, rats and dogs and its clinical relevance

scientific article published on 01 January 1999

Transgenic Animal Models for Detection of In Vivo Mutations ⬇️

scientific article published on January 1, 1995

Transgenic animal models for measuring mutations in vivo

scientific article

Transgenic animals in toxicology.

scientific article published in January 1994

Transgenic models for detection of mutations in tumors and normal tissues of rodents

scientific article published on December 1995

Transgenic mouse mutation assay systems can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens

scientific article

Vaccination with a recombinant vaccinia vaccine containing the B7-1 co-stimulatory molecule causes no significant toxicity and enhances T cell-mediated cytotoxicity

scientific article published on 01 February 2000

WITHDRAWN: Neurological assessments after treatment with the antimalarial β-arteether in neonatal and adult rats ⬇️

scientific article published on March 2, 2011

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