List of works by Tanja D de Gruijl

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A CD34(+) human cell line model of myeloid dendritic cell differentiation: evidence for a CD14(+)CD11b(+) Langerhans cell precursor

scientific article published on 7 September 2006

A Human Cell Line Model for Interferon-α Driven Dendritic Cell Differentiation

scientific article published on 7 August 2015

A Phase I Open-Label Clinical Trial Evaluating the Therapeutic Vaccine hVEGF26-104/RFASE in Patients with Advanced Solid Malignancies

scientific article published on 26 October 2020

A Reconstructed Human Melanoma-in-Skin Model to Study Immune Modulatory and Angiogenic Mechanisms Facilitating Initial Melanoma Growth and Invasion

scientific article published in 2023

A bispecific antibody antagonizes pro-survival CD40 signaling and promotes Vγ9Vδ2 T cell-mediated antitumor responses in human B-cell malignancies

scientific article published on 11 November 2020

A bispecific nanobody approach to leverage the potent and widely applicable tumor cytolytic capacity of Vγ9Vδ2-T cells.

scientific article published on 20 October 2017

A functional bioassay to determine the activity of anti-VEGF antibody therapy in blood of patients with cancer.

scientific article published on 30 August 2016

A genetically engineered adenovirus vector targeted to CD40 mediates transduction of canine dendritic cells and promotes antigen-specific immune responses in vivo

scientific article

A novel allogeneic off-the-shelf dendritic cell vaccine for post-remission treatment of elderly patients with acute myeloid leukemia

scientific article published on 23 July 2018

A postmigrational switch among skin-derived dendritic cells to a macrophage-like phenotype is predetermined by the intracutaneous cytokine balance.

scientific article

A role for multidrug resistance protein 4 (MRP4; ABCC4) in human dendritic cell migration

scientific article published on 14 July 2008

A safety and immunogenicity study of immunization with hVEGF26-104/RFASE in cynomolgus monkeys

scientific article published on 05 March 2018

A single-component CD40-targeted adenovirus vector displays highly efficient transduction and activation of dendritic cells in a human skin substrate system

scientific article published on 01 May 2005

ABC drug transporters and immunity: novel therapeutic targets in autoimmunity and cancer

scientific article published on 10 September 2009

Activated iNKT cells promote Vγ9Vδ2-T cell anti-tumor effector functions through the production of TNF-α.

scientific article published on 4 November 2011

Adenocarcinoma of the uterine cervix shows impaired recruitment of cDC1 and CD8+ T cells and elevated β-Catenin activation compared to squamous cell carcinoma

scientific article published on 27 March 2020

Adjuvant treatment of early-stage melanoma by local i.d. administration of low-dose CpG-B and GM-CSF increases recurrence-free survival: long-term follow-up of three randomized clinical trials.

scientific article published on 4 November 2015

Allogeneic dendritic cell (DC) vaccination as an “off the shelf” treatment to prevent or delay relapse in elderly acute myeloid leukemia patients: results of Phase I/IIa safety and feasibility study.

scientific article published on 7 November 2013

Aminobisphosphonates inhibit dendritic cell-mediated antigen-specific activation of CD1d-restricted iNKT cells.

scientific article

An α-galactosylceramide nose job shapes up iNKT cells

scientific article published on 01 January 2012

Apoptotic blebs from leukemic cells as a preferred source of tumor-associated antigen for dendritic cell-based vaccines

scientific article published on 03 January 2014

Apoptotic vesicles as tumor vaccine.

scientific article published on 7 December 2015

Arming oncolytic viruses to leverage antitumor immunity

scientific article published on 10 May 2015

Arming the Melanoma Sentinel Lymph Node through Local Administration of CpG-B and GM-CSF: Recruitment and Activation of BDCA3/CD141(+) Dendritic Cells and Enhanced Cross-Presentation

scientific article published on 29 January 2015

Attenuation of invariant natural killer T-cell anergy induction through intradermal delivery of alpha-galactosylceramide

scientific article published on 08 June 2010

Autologous tumor cell vaccination combined with systemic CpG-B and IFN-α promotes immune activation and induces clinical responses in patients with metastatic renal cell carcinoma: a phase II trial.

scientific article

Bispecific antibody platforms for cancer immunotherapy

scientific article published on 20 August 2014

Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression

scientific article published on 4 January 2017

Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway

scientific article published on 01 October 2020

Bulldozing β-linked glycolipids for recognition by invariant NKT cells

scientific article published on 01 January 2012

CD14(+) macrophage-like cells as the linchpin of cervical cancer perpetrated immune suppression and early metastatic spread: A new therapeutic lead?

scientific article published on 7 May 2015

CD1d-Invariant Natural Killer T Cell-Based Cancer Immunotherapy: α-Galactosylceramide and Beyond

scientific article published on 02 July 2018

CD1d-restricted antigen presentation by Vγ9Vδ2-T cells requires trogocytosis

scientific article

CD4(+)CD25hi regulatory T-cell frequency correlates with persistence of human papillomavirus type 16 and T helper cell responses in patients with cervical intraepithelial neoplasia

scientific article

CD40-targeted adenoviral cancer vaccines: the long and winding road to the clinic

scientific article published on June 2012

CD40-targeted adenoviral gene transfer to dendritic cells through the use of a novel bispecific single-chain Fv antibody enhances cytotoxic T cell activation

article

CD40-targeted dendritic cell delivery of PLGA-nanoparticle vaccines induce potent anti-tumor responses

scientific article published on 26 November 2014

CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy

scholarly article by Sadia Zafar et al published 2018 in OncoImmunology

CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis

scientific article

Chapter six--Adenovirus-based immunotherapy of cancer: promises to keep

scientific article published on January 2012

Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation

scientific article published on 12 July 2011

Chemically engineered glycan-modified cancer vaccines to mobilize skin dendritic cells

scientific article published on 31 October 2019

Circulating Valpha24+Vbeta11+ NKT cell numbers and dendritic cell CD1d expression in hepatitis C virus infected patients.

scientific article published on February 2005

Circulating invariant natural killer T-cell numbers predict outcome in head and neck squamous cell carcinoma: updated analysis with 10-year follow-up

scientific article published on 17 January 2012

Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases

scientific article

Clinical experience with α-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B/C infection.

scientific article published on 18 December 2010

Combination of NK Cells and Cetuximab to Enhance Anti-Tumor Responses in RAS Mutant Metastatic Colorectal Cancer

scientific article

Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial

scientific article published on 10 February 2012

Comparative phenotypic and functional analysis of migratory dendritic cell subsets from human oral mucosa and skin

scientific article published on 13 July 2017

Comparison of a novel CXCL12/CCL5 dependent migration assay with CXCL8 secretion and CD86 expression for distinguishing sensitizers from non-sensitizers using MUTZ-3 Langerhans cells

scientific article published on 28 October 2009

Constitutively active GSK3β as a means to bolster dendritic cell functionality in the face of tumour-mediated immune suppression

scientific article published on 19 July 2019

Constitutively active STAT5b induces cytokine-independent growth of the acute myeloid leukemia-derived MUTZ-3 cell line and accelerates its differentiation into mature dendritic cells.

scientific article published on March 2006

Correction to: Autologous tumor cell vaccination combined with systemic CpG-B and IFN-α promotes immune activation and induces clinical responses in patients with metastatic renal cell carcinoma: a phase II trial

scientific article published on 01 June 2019

Correction: Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody

scientific article published in May 2017

Corrigendum: CD1d-Invariant Natural Killer T Cell-Based Cancer Immunotherapy: α-Galactosylceramide and Beyond

scholarly article published in Frontiers in Immunology

Cross-talk between tumor and myeloid cells: how to tip the balance in favor of antitumor immunity

scientific article published on January 2011

Defining the critical hurdles in cancer immunotherapy

scientific article published on 14 December 2011

Delivery route, MyD88 signaling and cross-priming events determine the anti-tumor efficacy of an adenovirus based melanoma vaccine

scientific article

Dendritic Cell Plasticity in Tumor-Conditioned Skin: CD14(+) Cells at the Cross-Roads of Immune Activation and Suppression

scientific article

Dendritic cells require multidrug resistance protein 1 (ABCC1) transporter activity for differentiation

scientific article published on 01 May 2006

Development of thyroglobulin antibodies after GVAX immunotherapy is associated with prolonged survival

scientific article

Differential capacity of human interleukin-4 and interferon-α monocyte-derived dendritic cells for cross-presentation of free versus cell-associated antigen

scientific article published on 28 July 2015

Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells.

scientific article published on 14 May 2016

Effects of antigen-expressing immunostimulatory liposomes on chemotaxis and maturation of dendritic cells in vitro and in human skin explants.

scientific article published on 26 September 2013

Epidermis-to-dermis migration of immature Langerhans cells upon topical irritant exposure is dependent on CCL2 and CCL5.

scientific article published in July 2010

Epstein-Barr virus-encoded BARF1 protein is a decoy receptor for macrophage colony stimulating factor and interferes with macrophage differentiation and activation

scientific article

Evaluation of Explant Responses to STING Ligands: Personalized Immunosurgical Therapy for Head and Neck Squamous Cell Carcinoma

article

Evidence for a coordinate role of CD14+ antigen-presenting cells and regulatory T cells in conditioning the microenvironment of metastatic lymph nodes from patients with cervical cancer

Expansion of dendritic cell precursors from human CD34(+) progenitor cells isolated from healthy donor blood; growth factor combination determines proliferation rate and functional outcome.

scientific article published in August 2002

Exploiting the CD1d-iNKT cell axis for potentiation of DC-based cancer vaccines

scientific article published on 01 January 2014

Exploring dendritic cell based vaccines targeting survivin for the treatment of head and neck cancer patients.

scientific article published on 20 June 2013

Exposure of CD34+ precursors to cytostatic anthraquinone-derivatives induces rapid dendritic cell differentiation: implications for cancer immunotherapy.

scientific article

Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format

scientific article published on 27 October 2020

Favorable outcome in clinically stage II melanoma patients is associated with the presence of activated tumor infiltrating T-lymphocytes and preserved MHC class I antigen expression

scientific article published in August 2008

Feasibility of flowcytometric quantitation of immune effector cell subsets in the sentinel lymph node of the breast after cryopreservation

scientific article published on 26 October 2011

Functional characterization of a STAT3-dependent dendritic cell-derived CD14(+) cell population arising upon IL-10-driven maturation.

scientific article

Functional delivery of viral miRNAs via exosomes

scientific article (publication date: 6 April 2010)

Generation and characterization of CD1d-specific single-domain antibodies with distinct functional features

scientific article

Glycan-Modified Apoptotic Melanoma-Derived Extracellular Vesicles as Antigen Source for Anti-Tumor Vaccination

scientific article published on 28 August 2019

Glycan-modified liposomes boost CD4+ and CD8+ T-cell responses by targeting DC-SIGN on dendritic cells

scientific article published on 15 February 2012

Glyco-Dendrimers as Intradermal Anti-Tumor Vaccine Targeting Multiple Skin DC Subsets

scientific article published on 12 August 2019

Gram-positive bacteria: a major microbial ‘turn-on’ for invariant NKT cells

scientific article published on 01 January 2012

High PD-1 expression on regulatory and effector T-cells in lung cancer draining lymph nodes

scientific article

High and interrelated rates of PD-L1+CD14+ antigen-presenting cells and regulatory T cells mark the microenvironment of metastatic lymph nodes from patients with cervical cancer

scientific article published on 31 October 2014

High efficiency transduction of dendritic cells by adenoviral vectors targeted to DC-SIGN.

scientific article published on 20 March 2005

High myeloid-derived suppressor cell frequencies in the duodenum are associated with enteropathy associated T-cell lymphoma and its precursor lesions

scientific article published on 24 June 2016

High susceptibility of c-KIT+CD34+ precursors to prolonged doxorubicin exposure interferes with Langerhans cell differentiation in a human cell line model.

scientific article published on 24 March 2011

High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status

scientific article published on 25 October 2016

Highly specific and potently activating Vγ9Vδ2-T cell specific nanobodies for diagnostic and therapeutic applications.

scientific article published on 30 June 2016

Human dendritic cell line models for DC differentiation and clinical DC vaccination studies

scientific article published on 29 July 2008

IL-10 conditioning of human skin affects the distribution of migratory dendritic cell subsets and functional T cell differentiation.

scientific article

IL-21 in cancer immunotherapy: At the right place at the right time.

scientific article published on 16 April 2013

IL-21 promotes the expansion of CD27+ CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells.

scientific article published on 12 February 2013

Identification and characterization of ErbB-3-binding protein-1 as a target for immunotherapy

scientific article

Immunologic and biologic properties of the primary tumor during prolonged neoadjuvant chemoimmunotherapy

scientific article

Immunological effects of everolimus in patients with metastatic renal cell cancer

scientific article published in October 2017

Immunomodulation of the melanoma sentinel lymph node: a novel adjuvant therapeutic option

scientific article published on 28 July 2006

Improved Induction of Anti-Melanoma T Cells by Adenovirus-5/3 Fiber Modification to Target Human DCs

scientific article published on 18 July 2018

Improved efficacy of mitoxantrone in patients with castration-resistant prostate cancer after vaccination with GM-CSF-transduced allogeneic prostate cancer cells

scientific article

Improving CLL Vγ9Vδ2-T-cell fitness for cellular therapy by ex vivo activation and ibrutinib

scientific article published on 13 September 2018

In Vivo Efficacy of Umbilical Cord Blood Stem Cell-Derived NK Cells in the Treatment of Metastatic Colorectal Cancer

scientific article published on 06 February 2017

In situ Delivery of Antigen to DC-SIGN(+)CD14(+) Dermal Dendritic Cells Results in Enhanced CD8(+) T-Cell Responses

scientific article

In situ Delivery of Tumor Antigen- and Adjuvant-Loaded Liposomes Boosts Antigen-Specific T-Cell Responses by Human Dermal Dendritic Cells

scientific article published on 17 June 2015

In situ loading of skin dendritic cells with apoptotic bleb-derived antigens for the induction of tumor-directed immunity.

scientific article published on 3 July 2014

In the mix: the potential benefits of adding GM-CSF to CpG-B in the local treatment of patients with early-stage melanoma

scientific article published on 26 December 2019

In vitro priming of tumor-specific cytotoxic T lymphocytes using allogeneic dendritic cells derived from the human MUTZ-3 cell line.

scientific article published on 9 February 2006

Inactivating PSMB5 mutations and P-glycoprotein (multidrug resistance-associated protein/ATP-binding cassette B1) mediate resistance to proteasome inhibitors: ex vivo efficacy of (immuno)proteasome inhibitors in mononuclear blood cells from patients

scientific article published on 10 January 2012

Indoleamine 2,3-Dioxygenase Expression Pattern in the Tumor Microenvironment Predicts Clinical Outcome in Early Stage Cervical Cancer.

scientific article published on 11 July 2018

Inducing antitumor T cell immunity: comparative functional analysis of interstitial versus Langerhans dendritic cells in a human cell line model.

scientific article

Induction of dendritic cell maturation in the skin microenvironment by soluble factors derived from colon carcinoma

scientific article published on 14 April 2014

Insights from immuno-oncology: the Society for Immunotherapy of Cancer Statement on access to IL-6-targeting therapies for COVID-19

scientific article published on 01 April 2020

Intradermal CpG-B activates both plasmacytoid and myeloid dendritic cells in the sentinel lymph node of melanoma patients

article

Intradermal delivery of TLR agonists in a human explant skin model: preferential activation of migratory dendritic cells by polyribosinic-polyribocytidylic acid and peptidoglycans.

scientific article published on 6 March 2013

Intradermal delivery of adenoviral type-35 vectors leads to high efficiency transduction of mature, CD8+ T cell-stimulating skin-emigrated dendritic cells

scientific article published in August 2006

Intravenously usable fully serotype 3 oncolytic adenovirus coding for CD40L as an enabler of dendritic cell therapy

scientific article published on 7 December 2016

Irreversible electroporation of locally advanced pancreatic cancer transiently alleviates immune suppression and creates a window for antitumor T cell activation

scientific article published on 28 August 2019

Irritant-Induced Migration of Langerhans Cells Coincides with an IL-10-Dependent Switch to a Macrophage-Like Phenotype ⬇️

scientific article published on November 11, 2010

Langerin is a natural barrier to HIV-1 transmission by Langerhans cells

scientific article

Langerin-mediated internalization of a modified peptide routes antigens to early endosomes and enhances cross-presentation by human Langerhans cells

scientific article

Leukemia-specific T-cell reactivity induced by leukemic dendritic cells is augmented by 4-1BB targeting

scientific article published on 14 December 2006

Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses

scientific article published on 27 May 2020

Local Adjuvant Treatment with Low-Dose CpG-B Offers Durable Protection against Disease Recurrence in Clinical Stage I-II Melanoma: Data from Two Randomized Phase II Trials

scientific article published in October 2017

Local administration of PF-3512676 CpG-B instigates tumor-specific CD8+ T-cell reactivity in melanoma patients

scientific article published on 01 July 2008

Local administration of granulocyte/macrophage colony-stimulating factor increases the number and activation state of dendritic cells in the sentinel lymph node of early-stage melanoma

scientific article published on 01 November 2004

Local delivery of CpG-B and GM-CSF induces concerted activation of effector and regulatory T cells in the human melanoma sentinel lymph node

scientific article published on 2 March 2016

MUTZ-3, a human cell line model for the cytokine-induced differentiation of dendritic cells from CD34+ precursors.

scientific article published on July 2002

Matched skin and sentinel lymph node samples of melanoma patients reveal exclusive migration of mature dendritic cells

scientific article

Mechanisms of intimate and long-distance cross-talk between glioma and myeloid cells: how to break a vicious cycle.

scientific article

Melanoma Sequentially Suppresses Different DC Subsets in the Sentinel Lymph Node, Affecting Disease Spread and Recurrence

scientific article published on 21 September 2017

Metronomic cyclophosphamide attenuates mTOR-mediated expansion of regulatory T cells, but does not impact clinical outcome in patients with metastatic renal cell cancer treated with everolimus

scientific article published on 11 February 2019

Micro-environmental cross-talk in an organotypic human melanoma-in-skin model directs M2-like monocyte differentiation via IL-10

scientific article published on 07 June 2020

Monitoring regulatory T cells in clinical samples: consensus on an essential marker set and gating strategy for regulatory T cell analysis by flow cytometry

scientific article published on 28 June 2015

Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.

scientific article published on 19 October 2015

Mutz-3-derived Langerhans cells are a model to study HIV-1 transmission and potential inhibitors

scientific article

Myeloid derived suppressor and dendritic cell subsets are related to clinical outcome in prostate cancer patients treated with prostate GVAX and ipilimumab

scientific article published on 16 September 2014

Nodal metastasis in cervical cancer occurs in clearly delineated fields of immune suppression in the pelvic lymph catchment area

scientific article published on 28 September 2015

Notch controls generation and function of human effector CD8+ T cells

scientific article published on 04 February 2013

Oncolytic adenovirus ORCA-010 increases the type-1 T cell stimulatory capacity of melanoma-conditioned dendritic cells

scientific article published on 17 April 2020

Oncolytic adenovirus shapes the ovarian tumor microenvironment for potent tumor-infiltrating lymphocyte tumor reactivity

scientific article published on 01 January 2020

Overcoming bortezomib resistance in human B cells by anti-CD20/rituximab-mediated complement-dependent cytotoxicity and epoxyketone-based irreversible proteasome inhibitors

scientific article published on 10 January 2013

PD-L1 and PD-L2 Expression in Cervical Cancer: Regulation and Biomarker Potential

scientific article published in 2020

Phase 1 study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell carcinoma

scientific article published on 09 November 2018

Phase I-II study of everolimus and low-dose oral cyclophosphamide in patients with metastatic renal cell cancer

scientific article published on 30 November 2011

Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells

scientific article published on 25 November 2015

Positive & Negative Roles of Innate Effector Cells in Controlling Cancer Progression

Potent antitumor immunity generated by a CD40-targeted adenoviral vaccine

scientific article published on 11 July 2011

Pre-operative intradermal administration of CpG-B ± GM-CSF in stage I-III melanoma patients arms the sentinel lymph node: evidence for reduced tumor spread.

scientific article published on 7 November 2013

Preferential Langerhans cell differentiation from CD34(+) precursors upon introduction of ABCG2 (BCRP).

scientific article published on 29 March 2011

Prevention of Vγ9Vδ2 T Cell Activation by a Vγ9Vδ2 TCR Nanobody.

scientific article published on 28 November 2016

Priming of PRAME- and WT1-specific CD8(+) T cells in healthy donors but not in AML patients in complete remission: Implications for immunotherapy

scientific article published in April 2013

Procedures for the expansion of CD14(+) precursors from acute myeloid leukemic cells to facilitate dendritic cell-based immunotherapy

scientific article published on November 2013

Prognostic effect of different PD-L1 expression patterns in squamous cell carcinoma and adenocarcinoma of the cervix

scientific article published on 08 April 2016

Prolonged maturation and enhanced transduction of dendritic cells migrated from human skin explants after in situ delivery of CD40-targeted adenoviral vectors

scientific article published on 01 November 2002

Prostanoids play a major role in the primary tumor-induced inhibition of dendritic cell differentiation

scientific article

Proteasome inhibitors as experimental therapeutics of autoimmune diseases

scientific article published on 28 January 2015

Recent advances in antigen-loaded dendritic cell-based strategies for treatment of minimal residual disease in acute myeloid leukemia

scientific article published on January 2010

Recent developments and future challenges in immune checkpoint inhibitory cancer treatment.

scientific article published on 08 September 2015

Response to Comment on "mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells".

scientific article

Sampling tumor-draining lymph nodes for phenotypic and functional analysis of dendritic cells and T cells

scientific article published on July 2002

Selective transduction of dendritic cells in human lymph nodes and superior induction of high-avidity melanoma-reactive cytotoxic T cells by a CD40-targeted adenovirus

scientific article published on 01 September 2010

Selective transduction of mature DC in human skin and lymph nodes by CD80/CD86-targeted fiber-modified adenovirus-5/3.

scientific article published in November 2009

Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes

scientific article published on 16 October 2020

Selectively hampered activation of lymph node-resident dendritic cells precedes profound T cell suppression and metastatic spread in the breast cancer sentinel lymph node

scientific article published on 22 May 2019

Sensing of latent EBV infection through exosomal transfer of 5'pppRNA

scientific article published on 14 January 2016

Serum-free generation of antigen presenting cells from acute myeloid leukaemic blasts for active specific immunisation ⬇️

scientific article published on April 11, 2003

Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy

scientific article published on 01 January 2021

Standardized and flexible eight colour flow cytometry panels harmonized between different laboratories to study human NK cell phenotype and function.

scientific article

Sunitinib pretreatment improves tumor-infiltrating lymphocyte expansion by reduction in intratumoral content of myeloid-derived suppressor cells in human renal cell carcinoma

scientific article

T cell profiling reveals high CD4+CTLA-4 + T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment

scientific article

TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients

scientific article

Targeting C-type lectin receptors: a high-carbohydrate diet for dendritic cells to improve cancer vaccines

scientific article

Targeting Toll-like receptor 7/8 enhances uptake of apoptotic leukemic cells by monocyte-derived dendritic cells but interferes with subsequent cytokine-induced maturation ⬇️

scientific article published on September 22, 2010

Targeting the acute myeloid leukemic stem cell compartment by enhancing tumor cell-based vaccines

scientific article published on August 2013

The ABC of dendritic cell development and function

scientific article published on 21 August 2009

The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments.

scientific article published on 31 May 2017

The effect of everolimus and low-dose cyclophosphamide on immune cell subsets in patients with metastatic renal cell carcinoma: results from a phase I clinical trial

scientific article published on 17 January 2019

The effects of systemic treatment with aminobisphosphonates and statins on circulating Vγ9Vδ2-T cells in patients with advanced cancer

scientific article published on 16 October 2017

The novel bispecific diabody alphaCD40/alphaCD28 strengthens leukaemic dendritic cell-induced T-cell reactivity

scientific article published on 19 May 2008

Topical rather than intradermal application of the TLR7 ligand imiquimod leads to human dermal dendritic cell maturation and CD8+ T-cell cross-priming

scientific article published on 24 June 2014

Transcriptional profiling of human skin-resident Langerhans cells and CD1a+ dermal dendritic cells: differential activation states suggest distinct functions

scientific article published on 24 April 2008

Tumor-mediated inhibition of human dendritic cell differentiation and function is consistently counteracted by combined p38 MAPK and STAT3 inhibition

scientific article published on August 2012

Tumor-specific CD8+ T cell reactivity in the sentinel lymph node of GM-CSF-treated stage I melanoma patients is associated with high myeloid dendritic cell content

scientific article published on 01 May 2006

Unimpaired immune functions in the absence of Mrp4 (Abcc4).

scientific article published on 3 May 2009

Unlocking the therapeutic potential of primary tumor-draining lymph nodes ⬇️

scientific article published on 03 April 2019

Up-regulation of drug resistance-related vaults during dendritic cell development

scientific article published on 01 February 2002

Vaccination approach to anti-angiogenic treatment of cancer

scientific article

Vγ9Vδ2-T cells as antigen presenting cells for iNKT cell based cancer immunotherapy.

scientific article

Whole body PD-1 and PD-L1 positron emission tomography in patients with non-small-cell lung cancer

scientific article published in Nature Communications

Whole-cell cancer vaccination: from autologous to allogeneic tumor- and dendritic cell-based vaccines

scientific article published on 04 June 2008

mTOR Inhibition Per Se Induces Nuclear Localization of FOXP3 and Conversion of Invariant NKT (iNKT) Cells into Immunosuppressive Regulatory iNKT Cells

scientific article published on 3 August 2015

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