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List of works by Shigehisa Kitano

A novel method for evaluating antibody-dependent cell-mediated cytotoxicity by flowcytometry using cryopreserved human peripheral blood mononuclear cells

scientific article published on 27 January 2016

A phase 1 study of niraparib in Japanese patients with advanced solid tumors ⬇️

scholarly article

Abstract 2813: Clinical impact of immune microenvironment according to intratumoral locations of esophageal squamous cell carcinoma

scholarly article

Abstract LB-019: Anti-CD4 monoclonal antibody immunotherapy exerts an antitumor effect by replacing the T cell receptor repertoire in patients with gastrointestinal cancer

scholarly article

Anti-PD-1 antibody and anti-PD-Li antibody -from basic and clinic-

scientific article published on 01 February 2017

Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432

scientific article published on 15 September 2009

Approach to the Adult Acute Lymphoblastic Leukemia Patient

scientific article published on 06 August 2019

Association of CD204+ macrophages with poor outcomes of malignant lymphomas not in remission treated by allogeneic HCT

scientific article published on 08 October 2019

Association of antithyroglobulin antibodies with the development of thyroid dysfunction induced by nivolumab

article

Biomarkers for Immune Checkpoint Inhibitors in Melanoma

article published in 2018

CD20+ tumor-infiltrating immune cells and CD204+ M2 macrophages are associated with prognosis in thymic carcinoma

scientific article published on 11 April 2020

CD4+ T-cell Immunity in the Peripheral Blood Correlates with Response to Anti-PD-1 Therapy

scientific article published on 23 December 2019

Chimeric Antigen Receptor T-Cells for the Treatment of B-Cell Acute Lymphoblastic Leukemia.

scientific article published on 19 February 2018

Clinical Development of Immune Checkpoint Inhibitors

scientific article

Combination Therapy of Immune Checkpoint Inhibitors

scientific article published in September 2017

Comparison of tumor-infiltrating lymphocytes between primary and metastatic tumors in breast cancer patients

scientific article published on 11 October 2016

Complete Pathological Response to Neoadjuvant Pembrolizumab in a Patient With Chemoresistant Upper Urinary Tract Urothelial Carcinoma: A Case Report

scientific article published on 24 September 2020

Comprehensive immunohistochemical analysis of tumor microenvironment immune status in esophageal squamous cell carcinoma

scientific article published on 15 June 2016

Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomes

scientific article

Correlation between the expression of folate receptor alpha (FRα) and clinicopathological features in patients with lung adenocarcinoma

scientific article published on 11 May 2020

DNA mismatch repair deficiency in surgically resected lung adenocarcinoma: Microsatellite instability analysis using the Promega panel

scientific article

Deletion of chromosome arm 15q in a case of minimally differentiated hypoplastic AML-M0

scientific article published on 01 July 2008

Determination of cellularly processed HLA-A2402-restricted novel CTL epitopes derived from two cancer germ line genes, MAGE-A4 and SAGE

scientific article

Development of immune checkpoint inhibitor in colorectal cancer

scientific article published on 01 November 2016

Development of immune checkpoint inhibitors

scientific article published in January 2017

Diagnostic significance of intratumoral CD8+ tumor-infiltrating lymphocytes in medullary carcinoma

scientific article published on 6 November 2017

Discovery of a Good Responder Subtype of Esophageal Squamous Cell Carcinoma with Cytotoxic T-Lymphocyte Signatures Activated by Chemoradiotherapy

scientific article published in December 2015

Do all patients in the phase I oncology trials need to be hospitalized? Domestic but outstanding issues for globalization of drug development in Japan

scientific article

Donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene: detailed immunological function following add-back after haplo-identical transplantation

scientific article

Dose exploration results from Phase 1 study of cemiplimab, a human monoclonal programmed death (PD)-1 antibody, in Japanese patients with advanced malignancies

scientific article published on 04 November 2020

Elevated fibrin-related markers in patients with malignant diseases suspected of having thrombotic disorders

scientific article published on 31 July 2009

Enhancement of antitumor effect by peptide vaccine therapy in combination with anti-CD4 antibody: Study in a murine model

scientific article published on 19 February 2016

Enhancement of tumor-reactive cytotoxic CD4+ T cell responses after ipilimumab treatment in four advanced melanoma patients

scientific article published on October 2013

Erratum to: Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation

scientific article

Feasibility study of nivolumab as neoadjuvant chemotherapy for locally esophageal carcinoma: FRONTiER (JCOG1804E)

scientific article published on 12 May 2020

First-in-human phase 1 study of IT1208, a defucosylated humanized anti-CD4 depleting antibody, in patients with advanced solid tumors

scientific article published on 24 July 2019

First-in-human phase I study of E7090, a novel selective fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors

scientific article published on 01 February 2020

Generation of peptide-specific CD8+ T cells by phytohemagglutinin-stimulated antigen-mRNA-transduced CD4+ T cells.

scientific article published on 19 June 2006

Granzyme B is a novel interleukin-18 converting enzyme.

scientific article published on 17 June 2010

HER2-specific T-cell immune responses in patients vaccinated with truncated HER2 protein complexed with nanogels of cholesteryl pullulan

scientific article published on 01 December 2006

High Absolute Monocyte Count Predicts Poor Clinical Outcome in Patients with Castration-Resistant Prostate Cancer Treated with Docetaxel Chemotherapy

scientific article published on 30 June 2016

Histological Characteristics of Lung Adenocarcinoma with Uncommon Actionable Alterations: Special Emphasis on MET exon 14 Skipping Alterations

scientific article published on 29 November 2020

Humoral immune responses in patients vaccinated with 1-146 HER2 protein complexed with cholesteryl pullulan nanogel

scientific article published on 15 December 2007

Immune status at pre-treatment impacts on progression-free survival of metastatic colorectal cancer patients treated with first-line chemotherapy.

scientific article published on 4 November 2015

Immunologic correlates of the abscopal effect in a patient with melanoma

scientific article (publication date: 8 March 2012)

Immunotherapy for genitourinary tumors

scientific article published on 01 February 2019

Impact of low-dose anti-thymocyte globulin on immune reconstitution after allogeneic hematopoietic cell transplantation

scientific article published on 22 October 2019

Improved survival among patients enrolled in oncology phase 1 trials in recent decades

scientific article published on 19 November 2019

Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype

scientific article

Infection risk with PI3K-AKT-mTOR pathway inhibitors and immune checkpoint inhibitors in patients with advanced solid tumours in phase I clinical trials

scientific article published on 01 April 2020

Infusion of donor lymphocytes expressing the herpes simplex virus thymidine kinase suicide gene for recurrent hematologic malignancies after allogeneic hematopoietic stem cell transplantation

scientific article published on 7 May 2015

Introduction of Clinical development of Gene-Transferred T-Cell Therapy ⬇️

scholarly article

Investigation of clinical factors associated with longer overall survival in advanced melanoma patients treated with sequential ipilimumab

scientific article published on 04 April 2019

Large-scale comprehensive immunohistochemical biomarker analyses in esophageal squamous cell carcinoma

scientific article published on 29 July 2017

Markers for anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) therapy in melanoma

Metabolic activity by (18)F-FDG-PET/CT is predictive of early response after nivolumab in previously treated NSCLC.

scientific article

Microsatellite instability and mismatch repair protein expressions in lymphocyte-predominant breast cancer

scientific article published on 24 May 2020

Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment

scientific article published on 15 December 2011

Nephrotic syndrome with extensive mesangiolysis as a clinical manifestation of chronic graft-versus-host disease (GVHD)

scientific article published on 01 October 2005

Neutrophil-to-lymphocyte ratio and histological type might predict clinical responses to eriburin-based treatment in patients with metastatic breast cancer

scientific article published on 27 February 2020

Nivolumab for advanced melanoma: pretreatment prognostic factors and early outcome markers during therapy

scientific article published on 15 October 2016

Paradoxical activation of T cells via augmented ERK signaling mediated by a RAF inhibitor

scientific article published on January 2014

Peripheral blood and tumor biomarkers in patients with advanced melanoma treated with combination nivolumab (anti-PD-1, BMS-936558, ONO-4538) and ipilimumab.

scientific article published on 7 November 2013

Phase 1 study of abemaciclib, an inhibitor of CDK 4 and 6, as a single agent for Japanese patients with advanced cancer.

scientific article published on 16 June 2016

Phase I study of the indoleamine 2,3-dioxygenase 1 inhibitor navoximod (GDC-0919) as monotherapy and in combination with the PD-L1 inhibitor atezolizumab in Japanese patients with advanced solid tumours

scientific article published on 24 May 2019

Pretreatment Immune Status Correlates with Progression-Free Survival in Chemotherapy-Treated Metastatic Colorectal Cancer Patients

scientific article published on 28 April 2016

Prognostic impact of peripheral blood neutrophil to lymphocyte ratio in advanced-stage pulmonary large cell neuroendocrine carcinoma and its association with the immune-related tumour microenvironment

scientific article published on 30 November 2020

Recent Findings in Tumor Immunology ⬇️

scholarly article

Reduced argininosuccinate synthetase expression in refractory sarcomas: Impacts on therapeutic potential and drug resistance

scientific article published on 23 September 2016

Relationship between the immune microenvironment of different locations in a primary tumour and clinical outcomes of oesophageal squamous cell carcinoma

scientific article published on 25 November 2019

Serial pseudoprogression of metastatic malignant melanoma in a patient treated with nivolumab: a case report

scientific article published on 21 November 2017

Severe colitis after PD-1 blockade with nivolumab in advanced melanoma patients: potential role of Th1-dominant immune response in immune-related adverse events: two case reports

scientific article published on 29 October 2019

The peripheral immune status of granulocytic myeloid-derived suppressor cells correlates the survival in advanced gastric cancer patients receiving cisplatin-based chemotherapy

scientific article published on 30 May 2017

Tremelimumab-associated tumor regression following after initial progression: two case reports

scientific article published on 02 October 2015

Tumor-associated CD204+ M2 macrophages is an unfavorable prognosticator in uterine cervical adenocarcinoma

scientific article published on 22 December 2017

Updates in clinical development of immune checkpoint inhibitors

scientific article published on 01 October 2017

[Clinical Significance of Ipilimumab and the Combination Therapy as Immune Checkpoint Inhibitor]

scientific article published on 01 June 2019

[III. Recent Clinical Development of Cancer Immunotherapy and Speculation for Bone and Soft Tissue Tumors].

scientific article

[Ⅲ.Cross-Organ Developmental Status and Challenges of Immune Checkpoint Inhibitors]

scientific article published on 01 August 2019

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