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List of works by Dean D. Metcalfe

17-Allylamino-17-demethoxygeldanamycin (17-AAG) is effective in down-regulating mutated, constitutively activated KIT protein in human mast cells

scientific article published on 9 October 2003

4. IgE, mast cells, basophils, and eosinophils

scientific article

5-hydroxytryptamine induces mast cell adhesion and migration

scientific article published on 01 November 2006

5. IgE, mast cells, basophils, and eosinophils

scientific article

A Personal Perspective on Mentoring

scientific article published on 09 October 2018

A comparison of mediators released or generated by IFN-gamma-treated human mast cells following aggregation of Fc gamma RI or Fc epsilon RI.

scientific article published in April 2001

A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis.

scientific article

A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses

scientific article

A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib

scientific article published on 24 December 2003

A pilot study of nonmyeloablative allogeneic hematopoietic stem cell transplant for advanced systemic mastocytosis

scientific article published on 01 February 2006

A proposed classification of mastocytosis incorporating molecular genetics

scientific article

A retrospective analysis of bone scan abnormalities in mastocytosis: correlation with disease category and prognosis.

scientific article

A study of the use of impulse oscillometry in the evaluation of children with asthma: analysis of lung parameters, order effect, and utility compared with spirometry

scientific article

A survey of the number and distribution of mast cells in the skin of patients with mast cell disorders

scientific article published on September 1988

A ten-year retrospective analysis of the distribution, use and phenotypic characteristics of the LAD2 human mast cell line.

scientific article

A truncated splice-variant of the FcεRIβ receptor subunit is critical for microtubule formation and degranulation in mast cells

scientific article published on 02 May 2013

Abnormal bone marrow histopathology in paediatric mastocytosis

scientific article published on 28 November 2014

Acoustic rhinometry in the practice of allergy

scientific article published on December 2006

Activated lymphocytes induce promoter activity of the TCA3 gene in mast cells following cell-to-cell contact

scientific article published on April 1996

Activated mast cells synthesize and release soluble ST2-a decoy receptor for IL-33.

scientific article published on 8 August 2015

Activation and function of the mTORC1 pathway in mast cells

scientific article published on April 2008

Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a.

scientific article published in February 2004

Activation of human mast cells through the high affinity IgG receptor

scientific article published in September 2002

Activation of mast cells by double-stranded RNA: evidence for activation through Toll-like receptor 3.

scientific article published in July 2004

Activation of transglutaminase and production of protein-bound gamma-glutamylhistamine in stimulated mouse mast cells

scientific article published on 01 November 1985

Activity of imatinib in systemic mastocytosis with chronic basophilic leukemia and a PRKG2-PDGFRB fusion

scientific article published in January 2008

Adrenomedullin is a cross-talk molecule that regulates tumor and mast cell function during human carcinogenesis

scientific article

Advanced systemic mastocytosis: from molecular and genetic progress to clinical practice

scientific article

Advances in the Classification and Treatment of Mastocytosis: Current Status and Outlook toward the Future.

scientific article

Adverse reactions to drugs and biologics in patients with clonal mast cell disorders: A Work Group Report of the Mast Cells Disorder Committee, American Academy of Allergy, Asthma & Immunology

scientific article published on 06 December 2018

Aggregation of low affinity IgG receptors induces mast cell adherence to fibronectin: requirement for the common FcR gamma-chain

scientific article published on 01 February 1997

Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria

scientific article

Aldh2 Attenuates Stem Cell Factor/Kit-Dependent Signaling and Activation in Mast Cells ⬇️

scientific article published on 10 December 2019

Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity

scientific article published on May 2009

Amplification mechanisms for the enhancement of antigen-mediated mast cell activation

scientific article published on January 2009

An association between susceptibility to experimental autoimmune uveitis and choroidal mast cell numbers ⬇️

scientific article published on October 1, 1984

An immunohistochemical study of the bone marrow lesions of systemic mastocytosis: expression of stem cell factor by lesional mast cells

scientific article published on 01 August 2002

An optimized protocol for the generation and functional analysis of human mast cells from CD34+ enriched cell populations

scientific article published on 16 June 2017

An overview of the controversy concerning questionable manifestations of food allergy

scientific article published on November 1987

Analysis of the effect of mast cell granules on lymphocyte blastogenesis in the absence and presence of mitogens: identification of heparin as a granule-associated suppressor factor

scientific article published on 01 October 1983

Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature

scientific article published in June 2005

Analysis of the wheal-and-flare reactions that follow the intradermal injection of histamine and morphine in adults with recurrent, unexplained anaphylaxis and systemic mastocytosis

scientific article published on March 1989

Anaphylaxis--a practice parameter update 2015

scientific article published on 01 November 2015

Anti-IgE treatment of eosinophil-associated gastrointestinal disorders

scientific article published on September 2007

Aphidicolin-induced proliferative arrest of murine mast cells: morphological and biochemical changes are not accompanied by alterations in cytokine gene induction ⬇️

scientific article published on 01 July 1992

Arthritis and mast cell activation

scientific article published on October 1990

Assessing anaphylactic risk? Consider mast cell clonality

scientific article published on March 2009

Assessment of clinical findings, tryptase levels, and bone marrow histopathology in the management of pediatric mastocytosis

scientific article published on June 2015

Assessment of the extent of cutaneous involvement in children and adults with mastocytosis: relationship to symptomatology, tryptase levels, and bone marrow pathology

scientific article published in April 2003

Biochemical and functional characterization of proteoglycans isolated from basophils of patients with chronic myelogenous leukemia ⬇️

scientific article published on April 1, 1984

Biochemical and microscopic evidence for the internalization and degradation of heparin-containing mast cell granules by bovine endothelial cells

scientific article published on March 1985

Biomarkers of the involvement of mast cells, basophils and eosinophils in asthma and allergic diseases

scientific article

Bone marrow stromal cells use TGF-beta to suppress allergic responses in a mouse model of ragweed-induced asthma

scientific article

Btk plays a crucial role in the amplification of Fc epsilonRI-mediated mast cell activation by kit

scientific article published on 21 September 2005

Btk-dependent Rac activation and actin rearrangement following FcepsilonRI aggregation promotes enhanced chemotactic responses of mast cells

scientific article

C3a and C5a are chemotaxins for human mast cells and act through distinct receptors via a pertussis toxin-sensitive signal transduction pathway

scientific journal article

CD72 negatively regulates KIT-mediated responses in human mast cells

scientific article

CRITICAL SIGNALING EVENTS IN THE MECHANOACTIVATION OF HUMAN MAST CELLS VIA P.C492Y-ADGRE2

scientific article published on 25 March 2020

Characterization of a mast cell line that lacks the extracellular domain of membrane c-kit

scientific article published on April 1997

Characterization of adhesive interactions between mast cells and laminin isoforms: evidence of a principal role for α6 integrin ⬇️

scientific article published on December 1, 1997

Characterization of alpha 5-integrin-dependent mast cell adhesion following Fc epsilon RI aggregation

scientific article

Characterization of mast-cell tryptase-expressing peripheral blood cells as basophils

scientific article published in February 2002

Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI.

scientific article published on August 2003

Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils

scientific article

Chromogranin A is not a biomarker of mastocytosis

scientific article published on 12 October 2017

Classification and diagnosis of mastocytosis: current status

scientific article published on March 1991

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

scientific article

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions

scientific article published on 11 January 2012

Comparison of FcϵRI‐ and FcγRI‐mediated degranulation and TNF‐α synthesis in human mast cells: selective utilization of phosphatidylinositol‐3‐kinase for FcγRI‐induced degranulation ⬇️

scientific article published on May 1, 2003

Concurrent inhibition of kit- and FcepsilonRI-mediated signaling: coordinated suppression of mast cell activation

scientific article published on 09 October 2007

Consensus Opinion on Allogeneic Hematopoietic Cell Transplantation in Advanced Systemic Mastocytosis.

scientific article published on 27 April 2016

Contemporary issues in food allergy: seafood toxin-induced disease in the differential diagnosis of allergic reactions.

scientific article

Controversies in Allergy: Is a Bone Marrow Biopsy Optional or Essential in the Evaluation of the Patient with a Suspected Mast Cell Disorder?

scientific article published on 08 January 2019

Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European Academy of Allergology and Clinical Immunology

scientific article published on 15 October 2015

Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal

scientific article published on 27 October 2011

Degradation of the heparin matrix of mast cell granules by cultured fibroblasts

scientific article published on 01 September 1983

Demonstration and characterization of a transient arthritis in rats following sensitization of synovial mast cells with antigen-specific IgE and parenteral challenge with specific antigen

scientific article published in August 1988

Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with "idiopathic" anaphylaxis

scientific article

Demonstration of differential effects of cytokines on mast cells derived from murine bone marrow and peripheral blood mononuclear cells

scientific article published on 01 November 1994

Demonstration of the origin of human mast cells from CD34+ bone marrow progenitor cells ⬇️

scientific article published on March 1, 1991

Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13)

scientific article published on 01 October 1999

Demonstration that mast cells, T cells, and B cells bearing the activating kit mutation D816V occur in clusters within the marrow of patients with mastocytosis

scientific article published in November 2004

Description and Characterization of a Novel Human Mast Cell Line for Scientific Study

scientific article published on 06 November 2019

Detection of KIT D816V in peripheral blood of children with manifestations of cutaneous mastocytosis suggests systemic disease

scientific article published on 01 December 2018

Determination of protein phosphorylation in Fc epsilon RI-activated human mast cells by immunoblot analysis requires protein extraction under denaturing conditions

scientific article

Diagnosis and treatment of cutaneous mastocytosis in children: practical recommendations

scientific article published on August 2011

Diagnosis and treatment of systemic mastocytosis: state of the art.

scientific article

Diagnosis, Classification and Management of Mast Cell Activation Syndromes (MCAS) in the Era of Personalized Medicine

scientific article published on 27 November 2020

Diagnostic criteria and classification of mastocytosis: a consensus proposal

scientific article published in July 2001

Diminution of signal transducer and activator of transcription 3 signaling inhibits vascular permeability and anaphylaxis

scientific article

Dissociation between history and challenge in patients with physical urticaria

scientific article

Distinct PGE2-responder and non-responder phenotypes in human mast cell populations: “All or nothing” enhancement of antigen-dependent mediator release ⬇️

scientific article published on July 20, 2011

Distinct transcriptome profiles differentiate nonsteroidal anti-inflammatory drug-dependent from nonsteroidal anti-inflammatory drug-independent food-induced anaphylaxis.

scientific article

Early expression of high-affinity receptor for immunoglobulin E (Fc epsilon RI) during differentiation of mouse mast cells and human basophils

scientific article

Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells ⬇️

scientific article published on February 1, 1992

Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition

scientific article

Effects of gamma radiation on FcepsilonRI and TLR-mediated mast cell activation.

scientific article published in September 2007

Effects of tixocortol pivalate on gastrointestinal disease in systemic mastocytosis: a preliminary study

scientific article published on March 1991

Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit

scientific article published in August 2003

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

scientific article published on 17 October 2016

Elevated serum tryptase levels identify a subset of patients with a myeloproliferative variant of idiopathic hypereosinophilic syndrome associated with tissue fibrosis, poor prognosis, and imatinib responsiveness

scientific article published on 3 April 2003

Elevated tryptase levels are associated with greater bone density in a cohort of patients with mastocytosis

scientific article published on 30 January 2006

Elevation in histamine and tryptase following exercise in patients with mastocytosis

scientific article published on 23 July 2018

Endosomal trafficking of the ligated FcvarepsilonRI receptor.

scientific article

Endothelins belong to the assortment of mast cell-derived and mast cell-bound cytokines

scientific article published on February 1, 1992

Eotaxin potentiates antigen-dependent basophil IL-4 production

scientific article published on 01 September 1999

Estrogen increases the severity of anaphylaxis in female mice through enhanced endothelial nitric oxide synthase expression and nitric oxide production

scientific article published on 29 December 2014

Evidence for the involvement of a hematopoietic progenitor cell in systemic mastocytosis from single-cell analysis of mutations in the c-kit gene

scientific article published on 01 July 2002

Examination of the role of TRPM8 in human mast cell activation and its relevance to the etiology of cold-induced urticaria ⬇️

scientific article published on September 8, 2011

Exon skipping of FcεRIβ eliminates expression of the high-affinity IgE receptor in mast cells with therapeutic potential for allergy

scientific article

F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins

scientific article published on 3 March 2003

Factors affecting the determination of threshold doses for allergenic foods: how much is too much?

article

Fas (CD95, APO-1) antigen expression and function in murine mast cells ⬇️

scientific article published on October 15, 1997

FcepsilonRI- and Fcgamma receptor-mediated production of reactive oxygen species by mast cells is lipoxygenase- and cyclooxygenase-dependent and NADPH oxidase-independent

scientific article published in November 2007

Fcgamma receptors on mast cells: activatory and inhibitory regulation of mediator release

scientific article published on 10 March 2004

Fibroblasts determine the fate of Fc epsilon RI+ cell populations in vitro by selectively supporting the viability of mast cells while internalizing and degrading basophils

scientific article published on December 1994

Flow cytometric analysis for cytokine production identifies T helper 1, T helper 2, and T helper 0 cells within the human CD4+CD27- lymphocyte subpopulation

scientific article published on 01 May 1995

Functional and biochemical characterization of rat bone marrow derived mast cells.

scientific article published in December 1988

Functional and phenotypic studies of two variants of a human mast cell line with a distinct set of mutations in the c-kit proto-oncogene

scientific article published on January 2003

Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms

scientific article

GATA-2-deficient mast cells limit IgE-mediated immediate hypersensitivity reactions in human subjects

scientific article published on 15 May 2019

Gene expression analysis in mastocytosis reveals a highly consistent profile with candidate molecular markers

scientific article

Generalized erythematous macules and plaques associated with flushing, repeated syncope, and refractory anemia

scientific article

Genetically modified crops and allergenicity

scientific article

Glucocorticoids decrease tissue mast cell number by reducing the production of the c-kit ligand, stem cell factor, by resident cells: in vitro and in vivo evidence in murine systems

scientific article published on April 1997

Glycogen synthase kinase 3beta activation is a prerequisite signal for cytokine production and chemotaxis in human mast cells

scientific article

Glycogen synthase kinase-3β is a prosurvival signal for the maintenance of human mast cell homeostasis

scientific article published on 28 October 2011

Glycomic analysis of human mast cells, eosinophils and basophils

scientific article

Glycosaminoglycan profiles in cloned granulated lymphocytes with natural killer function and in cultured mast cells: their potential use as biochemical markers

scientific article published on 01 April 1984

Growth of human mast cells from bone marrow and peripheral blood-derived CD34(+) pluripotent hematopoietic cells.

scientific article published on January 2015

Growth of human mast cells from bone marrow and peripheral blood-derived CD34+ pluripotent progenitor cells

scientific article published in January 2006

Hematologic manifestations of systemic mast cell disease: A prospective study of laboratory and morphologic features and their relation to prognosis ⬇️

scientific article published on December 1, 1991

Hepatic involvement in mastocytosis: clinicopathologic correlations in 41 cases

scientific article published in October 1995

Heritable risk for severe anaphylaxis associated with increased α-tryptase-encoding germline copy number at TPSAB1

scientific article published on 24 July 2020

Heterogeneity of mast cells in the tissues of the respiratory tract and other organ systems

scientific article

High-resolution tracking of cell division demonstrates differential effects of TH1 and TH2 cytokines on SCF-dependent human mast cell production in vitro: correlation with apoptosis and Kit expression

scientific article published on 14 September 2004

Human dendritic cell 1 and dendritic cell 2 subsets express FcepsilonRI: correlation with serum IgE and allergic asthma

scientific article published in December 2003

Human macrophages cultured on agar but not agarose resemble mast cells

scientific article published on 01 September 1989

Human mast cells are capable of serotonin synthesis and release

scientific article published on 13 October 2006

Human mast cells express functional TrkA and are a source of nerve growth factor.

scientific article published on September 1997

Human mast cells express the hyaluronic-acid-binding isoform of CD44 and adhere to hyaluronic acid

scientific article published on 01 March 2000

Human mast cells produce the CD4+ T lymphocyte chemoattractant factor, IL-16 ⬇️

scientific article published on September 15, 1997

Human mast cells synthesize and release angiogenin, a member of the ribonuclease A (RNase A) superfamily

scientific article published on 22 July 2009

Human tissue mast cells are an inducible reservoir of persistent HIV infection

scientific article published on 9 March 2007

IL-3-dependent growth of basophil-like cells and mastlike cells from human bone marrow

scientific article published on 01 April 1989

IL-3-dependent mast cells attach to plate-bound vitronectin. Demonstration of augmented proliferation in response to signals transduced via cell surface vitronectin receptors

scientific article

IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand ⬇️

scientific article published on October 1, 1993

IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.

scientific article published on 17 December 2012

IL-5 receptor α levels in patients with marked eosinophilia or mastocytosis

scientific article

IL-6 levels predict disease variant and extent of organ involvement in patients with mastocytosis

scientific article published on 01 May 2005

IL-6 promotes an increase in human mast cell numbers and reactivity through suppression of suppressor of cytokine signaling 3.

scientific article published on 07 January 2016

Identification and Categorization of Inducible Mast Cell Genes in a Subtraction Library ⬇️

scientific article published on January 6, 1998

Identification and characterization of the inducible murine mast cell gene, imc-415.

scientific article

Identification of Fyn-binding proteins in MC/9 mast cells using mass spectrometry ⬇️

scientific article published on October 10, 2003

Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

scientific article

Identification of a polymorphism in the transmembrane domain of the protooncogene c-kit in healthy subjects

scientific article published on 01 January 1996

Identification of an amino acid sequence in the laminin A chain mediating mast cell attachment and spreading.

scientific article

Identification of chondroitin sulfate E in human lung mast cells ⬇️

scientific article published on April 15, 1988

IgE(+), Kit(-), I-A/I-E(-) myeloid cells are the initial source of Il-4 after antigen challenge in a mouse model of allergic pulmonary inflammation

scientific article published in July 2002

IgE, mast cells, basophils, and eosinophils

scientific article

IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells

scientific article published on May 2009

Immortalization of Mouse Bone Marrow-Derived Mast Cells with Ad12-SV40 Virus ⬇️

scientific article published on January 1, 1993

Immune surveillance by mast cells during dengue infection promotes natural killer (NK) and NKT-cell recruitment and viral clearance

scientific article

Immunophenotypic and Ultrastructural Analysis of Mast Cells in Hermansky-Pudlak Syndrome Type-1: A Possible Connection to Pulmonary Fibrosis

scientific article

Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia

scientific article published on 23 July 2019

Impaired function of bone marrow stromal cells in systemic mastocytosis

scientific article

Impulse oscillometry identifies peripheral airway dysfunction in children with adenosine deaminase deficiency

scientific article published on 18 December 2015

Impulse oscillometry in the evaluation of diseases of the airways in children ⬇️

scientific article published on January 6, 2011

Induction and enhancement of Fc(epsilon)RI-dependent mast cell degranulation following coculture with activated T cells: dependency on ICAM-1- and leukocyte function-associated antigen (LFA)-1-mediated heterotypic aggregation ⬇️

scientific article published on April 15, 1998

Inhibition of Allergic Reactivity through Targeting FcεRI-Bound IgE with Humanized Low-Affinity Antibodies

scientific article published on 21 October 2019

Inhibition of IgE-mediated mast cell degranulation by sulphasalazine

scientific article

Inhibition of the growth of IL-3-dependent mast cells from murine bone marrow by recombinant granulocyte macrophage-colony-stimulating factor.

scientific article

Interaction of DJ-1 with Lyn is essential for IgE-mediated stimulation of human mast cells

scientific article published on 12 October 2017

Interaction of mast cells with extracellular matrix proteins

scientific article published on May 1995

Interactions between mast cells, fibroblasts and connective tissue components

scientific article

Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.

scientific article published on 19 August 2015

International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis.

scientific article published on 16 January 2013

Introduction: what are the issues in addressing the allergenic potential of genetically modified foods?

scientific article

Isolation and Characterization of Heparin from Human Lung ⬇️

scientific article published on December 1, 1979

Isolation and characterization of sulphated mucopolysaccharides from rat leukaemic (RBL-1) basophils

scientific article published on February 1980

Isolation of Tissue Mast Cells ⬇️

scientific article published on 01 August 2010

KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities

scientific article published on 12 July 2007

KIT GNNK splice variants: expression in systemic mastocytosis and influence on the activating potential of the D816V mutation in mast cells

scientific article published on 04 June 2013

KIT signaling regulates MITF expression through miRNAs in normal and malignant mast cell proliferation ⬇️

scientific article published on January 27, 2011

Kinetics of the appearance of Fc epsilon RI-bearing cells in interleukin-3-dependent mouse bone marrow cultures: correlation with histamine content and mast cell maturation

scientific article published in February 1992

Kit and FcepsilonRI mediate unique and convergent signals for release of inflammatory mediators from human mast cells

scientific article

Kit- and Fc epsilonRI-induced differential phosphorylation of the transmembrane adaptor molecule NTAL/LAB/LAT2 allows flexibility in its scaffolding function in mast cells

scientific journal article

Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-α production ⬇️

scientific article published on March 13, 2013

Laminin promotes mast cell attachment

Levels of mast-cell growth factors in plasma and in suction skin blister fluid in adults with mastocytosis: correlation with dermal mast-cell numbers and mast-cell tryptase

scientific article published on January 2002

Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation.

scientific article

Maculopapular Cutaneous Mastocytosis in a Diverse Population

scientific article published on 02 May 2019

Mast Cell Biology: Introduction and Overview ⬇️

scientific article published on January 1, 2011

Mast Cells Signal their Importance in Health and Disease

scientific article published on 15 February 2018

Mast cell activation syndrome: Importance of consensus criteria and call for research

scientific article published on 19 June 2018

Mast cell activation syndrome: Proposed diagnostic criteria.

scientific article

Mast cell adhesion to fibronectin.

scientific article published on August 1991

Mast cell biology in evolution

scientific article published on 11 May 2006

Mast cell dependent vascular changes associated with an acute response to cold immersion in primary contact urticaria

scientific article (publication date: 2013)

Mast cell heterogeneity in higher animals: a comparison of the properties of autologous lung and intestinal mast cells from nonhuman primates.

scientific article published in September 1986

Mast cell mediators with emphasis on intestinal mast cells

scientific article

Mast cell migratory response to interleukin-8 is mediated through interaction with chemokine receptor CXCR2/Interleukin-8RB.

scientific article published on May 1999

Mast cell ontogeny and apoptosis

scientific article published on August 1995

Mast cell proliferative disorders: current view on variants recognized by the World Health Organization

scientific article published on October 2003

Mast cell-T cell interactions

scientific article

Mast cells and arthritis

scientific article published on December 1988

Mast cells and mastocytosis

scientific article published on August 2008

Mast cells chemotax to laminin with enhancement after IgE-mediated activation

scientific article published on December 1989

Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc epsilon RI- cell population ⬇️

scientific article published on October 15, 1994

Mast cells in allergy and host defense

scientific article

Mast cells in cutaneous mastocytosis: accumulation of the MCTC type

scientific article published in January 1990

Mast cells in innate immunity

scientific article

Mast cells, basophils and mastocytosis

Mast cells, which interact with Escherichia coli, up-regulate genes associated with innate immunity and become less responsive to Fc(epsilon)RI-mediated activation.

scientific article published on 10 November 2005

Mastocytosis

scientific article published on 7 October 2013

Mastocytosis

scientific article published on 01 January 1989

Mastocytosis

scientific article published on 01 January 2005

Mastocytosis

scientific article published on 01 June 2010

Mastocytosis and disorders of mast cell proliferation

scientific article

Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype

scientific article

Mastocytosis complicating pregnancy

scientific article

Mastocytosis in infants and children: recognition of patterns of skin disease

scientific article published on 01 January 1989

Mastocytosis-derived extracellular vesicles exhibit a mast cell signature, transfer KIT to stellate cells, and promote their activation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

scientific article published on 28 December 2016

Mastocytosis: current concepts in diagnosis and treatment

scientific article

Mastocytosis: current treatment concepts

scientific article

Mastocytosis: pathology, genetics, and current options for therapy

scientific article

Mechanisms of mast cell signaling in anaphylaxis

scientific article published on October 2009

Molecular remission and reversal of myelofibrosis in response to imatinib mesylate treatment in patients with the myeloproliferative variant of hypereosinophilic syndrome

scientific article

Mouse heparin proteoglycan. Synthesis by mast cell-fibroblast monolayers during lymphocyte-dependent mast cell proliferation.

scientific article

Multiple bidirectional alterations of phenotype and changes in proliferative potential during the in vitro and in vivo passage of clonal mast cell populations derived from mouse peritoneal mast cells ⬇️

scientific article published on 01 September 1988

Murine mast cells synthesize basement membrane components. A potential role in early fibrosis

scientific article

NTAL phosphorylation is a pivotal link between the signaling cascades leading to human mast cell degranulation following Kit activation and Fc epsilon RI aggregation

scientific article (publication date: July 2004)

Nitric oxide inhibits IgE-dependent cytokine production and Fos and Jun activation in mast cells

scientific article

Office-based management of urticaria

scientific article

Omalizumab for the treatment of unprovoked anaphylaxis in patients with systemic mastocytosis

scientific article published on 03 May 2007

On the way to targeted therapy of mast cell neoplasms: identification of molecular targets in neoplastic mast cells and evaluation of arising treatment concepts.

scientific article published in August 2004

Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production

scientific article published on 04 April 2019

Paediatric mastocytosis

scientific article published on May 2002

Passive cutaneous anaphylaxis in mouse skin is associated with local accumulation of interleukin-6 mRNA and immunoreactive interleukin-6 protein

scientific article published on November 1, 1992

Pathogenesis and Pathology of Mastocytosis

scientific article published on January 2017

Patterns of skeletal scintigraphy and their relationship to plasma and urinary histamine levels in systemic mastocytosis ⬇️

scientific article published on 01 August 1984

Pediatric mastocytosis

scientific article

Pediatric mastocytosis

scientific article published on 01 March 1991

Pediatric mastocytosis

scientific article published on 01 September 1994

Pediatric mastocytosis: routine anesthetic management for a complex disease

scientific article published on August 2008

Pediatric-onset mastocytosis: a long term clinical follow-up and correlation with bone marrow histopathology

scientific article published on October 2009

Phagocytosis of mast cell granules by cultured fibroblasts

scientific article published on 01 January 1983

Polydispersity of rat mast cell heparin. Implications for proteoglycan assembly

scientific article published on 01 December 1980

Preclinical human models and emerging therapeutics for advanced systemic mastocytosis

scientific article published on 05 July 2018

Prevention of F-actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells

scientific article

Production of granulocyte-macrophage colony-stimulating factor by primary cultures of unstimulated rat microvascular endothelial cells

scientific article

Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome

scientific article published on 05 February 2019

Proposed Terminology and Classification of Pre-Malignant Neoplastic Conditions: A Consensus Proposal

scientific article published on 26 November 2017

Prostaglandin E2 activates and utilizes mTORC2 as a central signaling locus for the regulation of mast cell chemotaxis and mediator release ⬇️

scientific article published on October 27, 2010

Providing the TORC for cell cycle progression in neoplastic mast cells

scientific article published on 15 January 2012

Pulmonary and ovarian manifestations of systemic mastocytosis

scientific article published on 01 April 1996

Radiotherapy of refractory bone pain due to systemic mast cell disease

scientific article

Receptor-mediated modulation of murine mast cell function by alpha-melanocyte stimulating hormone.

scientific article published on September 1999

Refinements in response criteria in systemic mastocytosis: reply to a proposal

scientific article published on 26 April 2010

Regression of urticaria pigmentosa in adult patients with systemic mastocytosis: correlation with clinical patterns of disease

scientific article published on 01 June 2002

Regulation of Reactive Oxygen Species and the Antioxidant Protein DJ-1 in Mastocytosis

scientific article

Regulation of adhesion of mouse bone marrow-derived mast cells to laminin

scientific article published on 01 November 1990

Regulation of normal and neoplastic human mast cell development in mastocytosis.

scientific article published on January 2005

Reply

Reply: To PMID 25553642.

scientific article

Rictor negatively regulates high-affinity receptors for IgE-induced mast cell degranulation

scientific article

Risk and Management of Patients with Mastocytosis and MCAS in the SARS-CoV-2 (COVID-19) Pandemic: Expert Opinions

scientific article published on 16 June 2020

Risk assessment in anaphylaxis: current and future approaches

scientific article published on July 2007

Rodent and human mast cells produce functionally significant intracellular reactive oxygen species but not nitric oxide

scientific article published on 10 September 2004

Roles of adaptor molecules in mast cell activation

scientific article

S1P₄ Regulates Passive Systemic Anaphylaxis in Mice but Is Dispensable for Canonical IgE-Mediated Responses in Mast Cells.

scientific article

Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

scientific article

Second symposium on the definition and management of anaphylaxis: summary report--second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium.

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Secretion of Interleukin-1 Receptor Antagonist from Human Mast Cells after Immunoglobulin E–Mediated Activation and after Segmental Antigen Challenge ⬇️

scientific article published on December 1, 2001

Sequential Appearance of Basophils and Mast Cells from Human Bone Marrow in Long-Term Suspension Culture ⬇️

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Serum tryptase levels in atopic and nonatopic children

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Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies

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Silica-directed mast cell activation is enhanced by scavenger receptors

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Skewed Lymphocyte Subpopulations and Associated Phenotypes in Patients with Mastocytosis

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Slowly progressive systemic mastocytosis with high mast-cell burden and no evidence of a non-mast-cell hematologic disorder: an example of a smoldering case?

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Smouldering mastocytosis: a novel subtype of systemic mastocytosis with slow progression

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Solar Urticaria.

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Soluble stem cell factor receptor (CD117) and IL-2 receptor alpha chain (CD25) levels in the plasma of patients with mastocytosis: relationships to disease severity and bone marrow pathology

scientific article published on 01 August 2000

Standards and standardization in mastocytosis: consensus statements on diagnostics, treatment recommendations and response criteria

scientific article published on June 2007

Stem cell factor induces mast cell adhesion to fibronectin.

scientific article published on January 1994

Stem cell factor programs the mast cell activation phenotype

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Subvisible Particle Content, Formulation, and Dose of an Erythropoietin Peptide Mimetic Product Are Associated With Severe Adverse Postmarketing Events

scientific article published on 03 February 2016

Surrogate markers of disease in mastocytosis.

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Symposium on the definition and management of anaphylaxis: summary report.

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Synergistic activation of phospholipases Cgamma and Cbeta: a novel mechanism for PI3K-independent enhancement of FcepsilonRI-induced mast cell mediator release

scientific article published on 22 January 2008

Systemic mastocytosis

scientific article published on 01 January 2004

Systemic mastocytosis

scientific article published on 01 January 2006

Systemic mastocytosis: CT and US features of abdominal manifestations

scientific article published on 01 February 1997

TLR-mediated signaling pathways circumvent the requirement for DAP12 in mast cells for the induction of inflammatory mediator release

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Targeting Sphingosine Kinase Isoforms Effectively Reduces Growth and Survival of Neoplastic Mast Cells With D816V-KIT.

scientific article published on 28 March 2018

Targeting kit activation: a potential therapeutic approach in the treatment of allergic inflammation

scientific article published on March 2007

Telangiectasia macularis eruptiva perstans or highly vascularized urticaria pigmentosa?

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The CD20 homologue MS4A4 directs trafficking of KIT toward clathrin-independent endocytosis pathways and thus regulates receptor signaling and recycling

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The FcεRIβ homologue, MS4A4A, promotes FcεRI signal transduction and store-operated Ca2+ entry in human mast cells

scientific article published on 30 March 2020

The Kit-activating mutation D816V enhances stem cell factor--dependent chemotaxis

scientific article published in August 2001

The biology of Kit in disease and the application of pharmacogenetics

scientific article published in July 2004

The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations

scientific article published on March 2002

The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non-mast cell lineage disease (SM-AHNMD)

scientific article published on August 2010

The effects of aspartame on mast cells and basophils

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The effects of stem cell factor on the ultrastructure of Fc epsilon RI+ cells developing in IL-3-dependent murine bone marrow-derived cell cultures ⬇️

scientific article published on November 1, 1993

The high-affinity immunoglobulin-E receptor (FcepsilonRI) is endocytosed by an AP-2/clathrin-independent, dynamin-dependent mechanism

scientific article published on June 2006

The histologic and functional characterization of enzymatically dispersed intestinal mast cells of nonhuman primates: effects of secretagogues and anti-allergic drugs on histamine secretion.

scientific article published on September 1985

The liver, spleen, and lymph nodes in mastocytosis

scientific article published on March 1991

The mast cell

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The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

scientific article published on December 2008

The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase

scientific article published on 16 September 2003

The protooncogene c-kit and c-kit ligand in human disease☆☆☆★ ⬇️

scientific article published on October 1, 1997

The role of c-Kit and its ligand, stem cell factor, in mast cell apoptosis

scientific article published on May 1995

The role of reactive oxygen species and nitric oxide in mast cell-dependent inflammatory processes

scientific article published on June 2007

The treatment of mastocytosis: an overview

scientific article published on March 1991

Thrombopoietin alone or in the presence of stem cell factor supports the growth of KIT(CD117)low/ MPL(CD110)+ human mast cells from hematopoietic progenitor cells

scientific article published on 01 April 2005

Transcriptional regulation of the TCA3 gene in mast cells after Fc epsilon RI cross-linking

scientific article published on July 1994

Transforming growth factor-beta prevents stem cell factor-mediated rescue of mast cells from apoptosis after IL-3 deprivation

scientific article published on September 1994

Treatment of systemic mastocytosis

scientific article published on August 2006

Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels

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Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis

scientific article published in June 1987

Twelve-year follow-up of omalizumab therapy for anaphylaxis in 2 patients with systemic mastocytosis

scientific article published on 24 August 2018

Two different negative regulatory elements control the transcription of T-cell activation gene 3 in activated mast cells

scientific article published on April 1997

Ultrastructural localization of heparin to human mast cells of the MCTC and MCT types by labeling with antithrombin III-gold.

scientific article published on November 1993

Ultrastructural, biochemical, and functional characteristics of histamine-containing cells cloned from mouse bone marrow: tentative identification as mucosal mast cells

scientific article published on 01 August 1983

Understanding the mechanisms of anaphylaxis

scientific article published on August 2008

Vibratory Urticaria Associated with a Missense Variant in ADGRE2.

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Vibratory Urticaria and ADGRE2

scientific article published on 01 July 2016

Vocal cord dysfunction as demonstrated by impulse oscillometry

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WAO International Scientific Conference (WISC 2016) Abstracts: Jerusalem, Israel. 6–9 December 2016.

scientific article published on 20 June 2017

What is food to one ...

scientific article published on 01 August 1984

Why the 20% + 2 Tryptase Formula Is a Diagnostic Gold Standard for Severe Systemic Mast Cell Activation and Mast Cell Activation Syndrome

scientific article published on 28 June 2019

mTORC1 and mTORC2 differentially regulate homeostasis of neoplastic and non-neoplastic human mast cells

scientific article published on 3 November 2011

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