List of works - Michelle L. Hastings

A big score for RNA.

scientific article

A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.

scientific article

A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.

scientific article published in October 2018

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease

scientific article on April 2011

Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1

scientific article

An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites

scientific article published on 19 December 2004

An exonic splicing enhancer within a bidirectional coding sequence regulates alternative splicing of an antisense mRNA

scientific article

Antisense Oligonucleotides for the Treatment of Inner Ear Dysfunction

scientific article published on 01 April 2019

Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice

scientific article published on 13 October 2017

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

scientific article published on 10 June 2020

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse

scientific article

Authors' reply

Biogenesis of mammalian microRNAs by a non-canonical processing pathway

scientific article

Comprehensive splice-site analysis using comparative genomics

scientific article

Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)

scientific article

Corticosteroid sensitization drives opioid addiction

scholarly article

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

scientific article

Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

scientific article

Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice

scientific article published on 05 August 2020

Drosha promotes splicing of a pre-microRNA-like alternative exon

scientific article

Dual-specificity splice sites function alternatively as 5' and 3' splice sites

scholarly article

Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the Drosha cleavage site.

scientific article published on 18 January 2013

Expression and purification of splicing proteins from mammalian cells

scientific article published on 01 January 2014

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction

scientific article published on 06 April 2020

Fetal gene therapy and pharmacotherapy to treat congenital hearing loss and vestibular dysfunction

scientific article published on 05 March 2020

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

scientific article

Identification of SRSF10 as a regulator of SMN2 ISS-N1

scientific article published on 10 December 2020

Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation

scientific article published on September 2011

MicroRNAs are exported from malignant cells in customized particles

scientific article

Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts

scientific article published on 01 October 2019

Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis

scientific article

Neurite Collapse and Altered ER Ca Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

scientific article published on 27 December 2018

Open reading frame correction using antisense oligonucleotides for the treatment of cystic fibrosis caused by CFTR-W1282X

scholarly article

Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis

scholarly article

Plasma components affect accuracy of circulating cancer-related microRNA quantitation

scientific article published on 30 November 2011

RNA localization and co-translational interactions control RAB13 GTPase function and cell migration

scientific article published on 18 September 2020

RNA therapeutics

scholarly article

Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment

scientific article published on 12 October 2017

Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness

scientific article

Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide

scientific article published on 19 June 2017

SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant

scientific article published on 17 October 2013

Searching for novel biomarkers using a mouse model of CLN3-Batten disease

scientific article published in PLoS ONE

Selective release of microRNA species from normal and malignant mammary epithelial cells

scientific article

Sensitive PCR-based quantitation of cell-free circulating microRNAs

scientific article

Spatial Disorientation Under Dark Conditions Across Development in an Alzheimer’s Disease Mouse Model

scholarly article

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

scientific article published on 27 June 2020

Splice-switching antisense oligonucleotides as therapeutic drugs

scientific article published on 10 June 2016

Targeting Alternative Splicing for Therapeutic Interventions

scholarly article

Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production.

scientific article published on 6 March 2018

Targeting RNA splicing for disease therapy

scientific article published on 19 March 2013

Targeting SR proteins improves SMN expression in spinal muscular atrophy cells

scientific article

Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy

scientific article

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

scientific article published on 22 February 2016

Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease

scientific article published on 27 July 2020

List of works by Michelle L. Hastings

A big score for RNA.

A feedback loop regulates splicing of the spinal muscular atrophy-modifying gene, SMN2.

A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.

Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease

Alternative splicing regulation by interaction of phosphatase PP2Cgamma with nucleic acid-binding protein YB-1

An LKB1 AT-AC intron mutation causes Peutz-Jeghers syndrome via splicing at noncanonical cryptic splice sites

An exonic splicing enhancer within a bidirectional coding sequence regulates alternative splicing of an antisense mRNA

Antisense Oligonucleotides for the Treatment of Inner Ear Dysfunction

Antisense oligonucleotide therapy rescues disruptions in organization of exploratory movements associated with Usher syndrome type 1C in mice

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse

Authors' reply

Biogenesis of mammalian microRNAs by a non-canonical processing pathway

Comprehensive splice-site analysis using comparative genomics

Control of pre-mRNA splicing by the general splicing factors PUF60 and U2AF(65)

Corticosteroid sensitization drives opioid addiction

Determinants of exon 7 splicing in the spinal muscular atrophy genes, SMN1 and SMN2.

Differential 3' splice site recognition of SMN1 and SMN2 transcripts by U2AF and U2 snRNP

Direct Delivery of Antisense Oligonucleotides to the Middle and Inner Ear Improves Hearing and Balance in Usher Mice

Drosha promotes splicing of a pre-microRNA-like alternative exon

Dual-specificity splice sites function alternatively as 5' and 3' splice sites

Ensemble analysis of primary microRNA structure reveals an extensive capacity to deform near the Drosha cleavage site.

Expression and purification of splicing proteins from mammalian cells

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction

Fetal gene therapy and pharmacotherapy to treat congenital hearing loss and vestibular dysfunction

Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c.

Identification of SRSF10 as a regulator of SMN2 ISS-N1

Induction of antagonistic soluble decoy receptor tyrosine kinases by intronic polyA activation

MicroRNAs are exported from malignant cells in customized particles

Mitochondrial clearance and maturation of autophagosomes are compromised in LRRK2 G2019S familial Parkinson's disease patient fibroblasts

Moving towards effective therapeutic strategies for Neuronal Ceroid Lipofuscinosis

Neurite Collapse and Altered ER Ca Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

Open reading frame correction using antisense oligonucleotides for the treatment of cystic fibrosis caused by CFTR-W1282X

Open reading frame correction using splice-switching antisense oligonucleotides for the treatment of cystic fibrosis

Plasma components affect accuracy of circulating cancer-related microRNA quantitation

RNA localization and co-translational interactions control RAB13 GTPase function and cell migration

RNA therapeutics

Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment

Rescue of hearing and vestibular function by antisense oligonucleotides in a mouse model of human deafness

Rescue of peripheral vestibular function in Usher syndrome mice using a splice-switching antisense oligonucleotide

SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant

Searching for novel biomarkers using a mouse model of CLN3-Batten disease

Selective release of microRNA species from normal and malignant mammary epithelial cells

Sensitive PCR-based quantitation of cell-free circulating microRNAs

Spatial Disorientation Under Dark Conditions Across Development in an Alzheimer’s Disease Mouse Model

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

Splice-switching antisense oligonucleotides as therapeutic drugs

Targeting Alternative Splicing for Therapeutic Interventions

Targeting Amyloid-β Precursor Protein, APP, Splicing with Antisense Oligonucleotides Reduces Toxic Amyloid-β Production.

Targeting RNA splicing for disease therapy

Targeting SR proteins improves SMN expression in spinal muscular atrophy cells

Tetracyclines that promote SMN2 exon 7 splicing as therapeutics for spinal muscular atrophy

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides.

Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease