List of works by Heiko Witt

A Loss of Function Polymorphism (G191R) of Anionic Trypsinogen (PRSS2) Confers Protection Against Chronic Pancreatitis

scientific article published on 01 April 2008

A Toll-like receptor 7 single nucleotide polymorphism protects from advanced inflammation and fibrosis in male patients with chronic HCV-infection

scientific article published on 12 April 2007

A common African polymorphism abolishes tyrosine sulfation of human anionic trypsinogen (PRSS2).

scientific article published on February 2009

A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis

scientific article

A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

scientific article

A recombined allele of the lipase gene CEL and its pseudogene CELP confers susceptibility to chronic pancreatitis

scientific article published on 16 March 2015

Analysis of GPRC6A variants in different pancreatitis etiologies

scientific article published on 08 August 2020

Analysis of tumour necrosis factor alpha and interleukin 10 promotor variants in patients with chronic pancreatitis ⬇️

scientific article published on November 1, 2003

Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis

scientific article published on 01 September 2009

Apolipoprotein E allele frequencies in chronic and self-limited hepatitis C suggest a protective effect of APOE4 in the course of hepatitis C virus infection

scientific article

Apolipoprotein E4 allele is associated with poor treatment response in hepatitis C virus (HCV) genotype 1.

scientific article published on December 2003

Assessing the pathological relevance of SPINK1 promoter variants

scientific article

Association of CTLA4 single nucleotide polymorphisms with viral but not autoimmune liver disease

scientific article published on November 2007

Association of IFNL3 rs12979860 and rs8099917 with biochemical predictors of interferon responsiveness in chronic hepatitis C virus infection

scientific article (publication date: 2013)

CFTR, SPINK1, CTRC and PRSS1 variants in chronic pancreatitis: is the role of mutated CFTR overestimated?

scientific article published on 17 March 2012

Chronic pancreatitis--definition, etiology, investigation and treatment

scientific article published on 31 May 2013

Chronic pancreatitis: challenges and advances in pathogenesis, genetics, diagnosis, and therapy.

scientific article published on April 2007

Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis

scientific article

Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.

scientific article

Combined effects of different interleukin-28B gene variants on the outcome of dual combination therapy in chronic hepatitis C virus type 1 infection.

scientific article published on 18 April 2012

Common CFTR haplotypes and susceptibility to chronic pancreatitis and congenital bilateral absence of the vas deferens

scientific article published on 07 June 2011

Common variants in glyoxalase I do not increase chronic pancreatitis risk

scientific article published on 29 October 2019

Common variants in the CLDN2 - MORC4 and PRSS1 - PRSS2 loci confer susceptibility to acute pancreatitis

scientific article published on 01 June 2018

Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis

scientific article

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.

scientific article published on 29 June 2016

Comprehensive functional analysis of chymotrypsin C (CTRC) variants reveals distinct loss-of-function mechanisms associated with pancreatitis risk

scientific article

Divergent roles of SPINK1 and PRSS2 variants in tropical calcific pancreatitis

scientific article

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis

scientific article published on 4 January 2018

European Guideline on IgG4-related digestive disease - UEG and SGF evidence-based recommendations

scientific article published on 18 June 2020

Evaluation of angiotensinogen c.1-44G>A and p.M268T variants as risk factors for fibrosis progression in chronic hepatitis C and liver diseases of various etiologies

scientific article

Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infection

scientific article published on 23 June 2008

Evaluation of the -26G>A CC16 polymorphism in acute respiratory distress syndrome

scientific article

Fructose malabsorption

scientific article

Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.

scientific article published on March 2013

Gender-dependent association of CTLA4 polymorphisms with resolution of hepatitis C virus infection

scientific article published on 2 November 2006

Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis

scientific article

Genetic variants of lipase activity in chronic pancreatitis

scientific article

Genetics of chronic pancreatitis

scientific article published on 01 February 2002

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis

scientific article

HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma

scientific article published on 01 July 2007

Highly Elevated Plasma γ-Glutamyltransferase Elevations: A Trait Caused by γ-Glutamyltransferase 1 Transmembrane Mutations

scientific article published on 28 October 2019

IRF5 Is Required for Bacterial Clearance in Human M1-Polarized Macrophages, and IRF5 Immune-Mediated Disease Risk Variants Modulate This Outcome

scientific article published on 28 December 2018

Identification of essential amino acids for glucose transporter 5 (GLUT5)- mediated fructose transport

scientific article published on 19 December 2017

Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection

scientific article published in October 2004

Interleukin 18 promoter variants (-137G>C and -607C>A) in patients with chronic hepatitis C: association with treatment response

scientific article published on 20 May 2009

Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer.

scientific article published on 13 October 2006

Loss of function TRPV6 variants are associated with chronic pancreatitis in nonalcoholic early-onset Polish and German patients

scientific article published in December 2021

Low-density lipoprotein receptor variants are associated with spontaneous and treatment-induced recovery from hepatitis C virus infection.

scientific article published on 14 May 2009

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

scientific article published on 26 May 2015

Mutational analysis of ATP8B1 in patients with chronic pancreatitis

scientific article

Mutational analysis of the gene encoding the zymogen granule membrane glycoprotein 2 (GP2) in patients with chronic pancreatitis

scientific article

Mutations in the human UBR1 gene and the associated phenotypic spectrum

scientific article published on 09 April 2014

Mutations of the serine protease inhibitor, Kazal type 1 gene, in patients with idiopathic chronic pancreatitis

scientific article

Myosin IXb variants and their pivotal role in maintaining the intestinal barrier: a study in Crohn's disease

scientific article published on 6 August 2014

N34S, a pancreatitis associated SPINK1 mutation, is not associated with sporadic pancreatic cancer

scientific article published on January 2003

Opie’s hypothesis revisited: Acute pancreatitis due to bile reflux into the pancreas

scientific article published on 08 December 2011

Polymorphisms at PRSS1-PRSS2 and CLDN2-MORC4 loci associate with alcoholic and non-alcoholic chronic pancreatitis in a European replication study

scientific article published on 24 September 2014

Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis

scientific article published on 01 June 2019

Rapid progression of a splenic aneurysm due to segmental arterial mediolysis: A rare cause of acute pancreatitis

scientific article published on 19 June 2013

Reassessment of GLUT7 and GLUT9 as Putative Fructose and Glucose Transporters

scientific article

Recommendations from the United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis

Relevance of endotoxin receptorCD14andTLR4gene variants in chronic liver disease

article

Sequencing of the complex CTRB1-CTRB2 locus in chronic pancreatitis

scientific article published on 29 September 2020

Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis

scientific article published on May 2007

The SPINK1 N34S variant is associated with acute pancreatitis

scientific article published on 01 August 2008

The course of genetically determined chronic pancreatitis.

scientific article

The role of epoxide hydrolase Y113H gene variant in pancreatic diseases

scientific article published in May 2009

Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations

scientific article

United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (HaPanEU).

scientific article published on 16 January 2017

Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis

scientific article published on 10 January 2020

Variants in CPA1 are strongly associated with early onset chronic pancreatitis

scientific article published on 18 August 2013

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis

scientific article

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