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List of works by Peter Dervan

1,1-Di-tert-butyldiazene

scientific article published in 1982

A C-14 labeled Py-Im polyamide localizes to a subcutaneous prostate cancer tumor

scientific article

A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity

scientific article published on 22 January 2016

A Pyrrole-Imidazole Polyamide Is Active against Enzalutamide-Resistant Prostate Cancer

scientific article published on 30 March 2017

A Pyrrole-Imidazole Polyamide Motif for Recognition of Eleven Base Pair Sequences in the Minor Groove of DNA

A sequence-specific DNA binding small molecule triggers the release of immunogenic signals and phagocytosis in a model of B-cell lymphoma

scientific article

A two-hit mechanism for pre-mitotic arrest of cancer cell proliferation by a polyamide-alkylator conjugate

scientific article published on 17 July 2006

Accessibility of Nuclear Chromatin by DNA Binding Polyamides ⬇️

scientific article published on September 1, 2003

Activity of a Py-Im polyamide targeted to the estrogen response element

scientific article published on 26 February 2013

Addressing single molecules on DNA nanostructures

scientific article

Ahmed H. Zewail (1946-2016).

scientific article published in September 2016

Allosteric inhibition of protein--DNA complexes by polyamide--intercalator conjugates

scientific article published in July 2003

Allosteric inhibition of zinc-finger binding in the major groove of DNA by minor-groove binding ligands

scientific article published in April 2004

Allosteric modulation of DNA by small molecules

scientific article

Alpha-diaminobutyric acid-linked hairpin polyamides

scientific article

Alternative Heterocycles for DNA Recognition: The Benzimidazole/Imidazole Pair ⬇️

scientific article published on May 9, 2003

An HRE-Binding Py-Im Polyamide Impairs Hypoxic Signaling in Tumors

scientific article published on 30 December 2015

Analysis of hairpin polyamide complexes having DNA binding sites in close proximity

scientific article published in October 2002

Animal toxicity of hairpin pyrrole-imidazole polyamides varies with the turn unit

scientific article published on 09 September 2013

Antitumor activity of a pyrrole-imidazole polyamide

scientific article

Arresting cancer proliferation by small-molecule gene regulation

scientific article

Blocking transcription through a nucleosome with synthetic DNA ligands

scientific article published on 01 August 2002

Cell-free and cellular activities of a DNA sequence selective hairpin polyamide-CBI conjugate

scientific article (publication date: 8 November 2002)

Cellular uptake of N-methylpyrrole/N-methylimidazole polyamide-dye conjugates

scientific article

Characterization and solubilization of pyrrole-imidazole polyamide aggregates

scientific article

Chromatin structure determines accessibility of a hairpin polyamide–chlorambucil conjugate at histone H4 genes in pancreatic cancer cells ⬇️

scientific article published on April 25, 2012

Completion of a Programmable DNA-Binding Small Molecule Library

scientific article

Crystal structures of nucleosome core particles in complex with minor groove DNA-binding ligands

scientific article (publication date: 14 February 2003)

Cyclic pyrrole-imidazole polyamides targeted to the androgen response element

scientific article published on May 2009

DNA crosslinking and biological activity of a hairpin polyamide-chlorambucil conjugate

scientific article (publication date: 15 February 2003)

DNA damage effects of a polyamide-CBI conjugate in SV40 virions

scientific article published on 2 December 2004

DNA minor-groove recognition by 3-methylthiophene/pyrrole pair

scientific article published in June 2004

DNA sequence selectivity of hairpin polyamide turn units

scientific article

DNA sequence-specific polyamides alleviate transcription inhibition associated with long GAA.TTC repeats in Friedreich's ataxia

scholarly article

DNA-templated dimerization of hairpin polyamides

scientific article published in December 2003

Defining the sequence-recognition profile of DNA-binding molecules

scientific article

Design of a sequence-specific DNA bisintercalator

scientific article

Design of artificial transcriptional activators with rigid poly-L-proline linkers

scientific article published in November 2002

Design of sequence-specific DNA binding molecules for DNA methyltransferase inhibition

scientific article

Enhancing the cellular uptake of Py-Im polyamides through next-generation aryl turns

scientific article published on 12 November 2011

Expanding the repertoire of heterocycle ring pairs for programmable minor groove DNA recognition

scientific article

Expanding the repertoire of natural product-inspired ring pairs for molecular recognition of DNA.

scientific article

Exploring the limits of benzimidazole DNA-binding oligomers for the hypoxia inducible factor (HIF) site.

scientific article published on 12 September 2006

Fluorescent sequence-specific dsDNA binding oligomers

scientific article

Gene expression changes in a tumor xenograft by a pyrrole-imidazole polyamide

scientific article

Guiding the design of synthetic DNA-binding molecules with massively parallel sequencing

scientific article

Imidazopyridine/Pyrrole and Hydroxybenzimidazole/Pyrrole Pairs for DNA Minor Groove Recognition ⬇️

scientific article published on May 14, 2003

Improved nuclear localization of DNA-binding polyamides

scientific article

In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography

scholarly article

Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates

scientific article

Inhibition of DNA binding by NF-kappa B with pyrrole-imidazole polyamides.

scientific article

Inhibition of DNA binding by human estrogen-related receptor 2 and estrogen receptor alpha with minor groove binding polyamides

scientific article

Inhibition of Moloney murine leukemia virus integration using polyamides targeting the long-terminal repeat sequences

scientific article published in May 2003

Inhibition of vascular endothelial growth factor with a sequence-specific hypoxia response element antagonist

scholarly article

Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

scientific article published in May 2018

Microwave assisted synthesis of Py-Im polyamides

scientific article

Minimization of a protein-DNA dimerizer

scientific article

Modifications at the C-terminus to improve pyrrole-imidazole polyamide activity in cell culture

scientific article

Modulating hypoxia-inducible transcription by disrupting the HIF-1-DNA interface

scientific article published on August 2007

Modulation of NF-κB-dependent gene transcription using programmable DNA minor groove binders

scientific article published on 27 December 2011

Molecular basis of antibiotic multiresistance transfer in Staphylococcus aureus

scientific article

Molecular recognition of the nucleosomal "supergroove".

scientific article

NMR structure of a cyclic polyamide-DNA complex

scientific article

Next generation hairpin polyamides with (R)-3,4-diaminobutyric acid turn unit

scientific article

Nuclear localization of pyrrole–imidazole polyamide–fluorescein conjugates in cell culture ⬇️

scientific article published on September 30, 2003

Nucleosomes in solution exist as a mixture of twist-defect states

scientific article published in January 2005

Oligomerization route to Py-Im polyamide macrocycles

scientific article published on August 2009

Paradoxical effects of DNA binding polyamides on HTLV-1 transcription

scientific article published on September 2004

Parallel Synthesis of H-pin Polyamides by Alkene Metathesis on Solid Phase ⬇️

scientific article published on April 23, 2003

Pharmacokinetics of Py-Im Polyamides Depend on Architecture: Cyclic versus Linear ⬇️

scientific article published on April 24, 2012

Polyamides reveal a role for repression in latency within resting T cells of HIV-infected donors

scientific article published on 15 September 2004

Programmable DNA binding oligomers for control of transcription

scientific article

Programmable oligomers for minor groove DNA recognition

scientific article published on July 2006

Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition

scientific article published on 26 October 2006

Programming multiple protein patterns on a single DNA nanostructure

scientific article

Promoter scanning for transcription inhibition with DNA-binding polyamides

scientific article

Pyrrole-imidazole polyamides distinguish between double-helical DNA and RNA.

scientific article published on 14 September 2012

Quantitating the concentration of Py-Im polyamide-fluorescein conjugates in live cells

scientific article

Quantitative detection of small molecule/DNA complexes employing a force-based and label-free DNA-microarray

scientific article published on June 2009

Quantitative microarray profiling of DNA-binding molecules

scientific article

RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

scientific article published on 17 October 2016

Recognition of "mirror-image" DNA by small molecules

scientific article published in January 2007

Recognition of ten base pairs of DNA by head-to-head hairpin dimers

scientific article (publication date: 19 June 2002)

Recognition of the DNA minor groove by pyrrole-imidazole polyamides

scientific article (publication date: June 2003)

Replication stress by Py-Im polyamides induces a non-canonical ATR-dependent checkpoint response

scientific article

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

scientific article published on 15 September 2009

Role of Mismatch Repair Enzymes in GAA·TTC Triplet-repeat Expansion in Friedreich Ataxia Induced Pluripotent Stem Cells ⬇️

scientific article published on July 13, 2012

Search for the optimal linker in tandem hairpin polyamides

scientific article (publication date: October 2002)

Sequence specific fluorescence detection of double strand DNA.

scientific article

Sequence specific suppression of androgen receptor-DNA binding in vivo by a Py-Im polyamide

Sequence-specific fluorescence detection of DNA by polyamide-thiazole orange conjugates.

scientific article published in November 2005

Shape selective recognition of T.A base pairs by hairpin polyamides containing N-terminal 3-methoxy (and 3-chloro) thiophene residues

scientific article published in October 2003

Single position substitution of hairpin pyrrole-imidazole polyamides imparts distinct DNA-binding profiles across the human genome

scientific article published on 22 December 2020

Single-dose pharmacokinetic and toxicity analysis of pyrrole–imidazole polyamides in mice ⬇️

scientific article published on August 21, 2012

Small molecule transcription factor mimic

scientific article published in December 2004

Small molecules targeting histone H4 as potential therapeutics for chronic myelogenous leukemia

scientific article published on April 2008

Solid-phase synthesis of DNA binding polyamides on oxime resin

scientific article

Stalled DNA Replication Forks at the Endogenous GAA Repeats Drive Repeat Expansion in Friedreich's Ataxia Cells

scientific article published on 14 July 2016

Structural Basis for Cyclic Py-Im Polyamide Allosteric Inhibition of Nuclear Receptor Binding ⬇️

scientific article published on October 20, 2010

Structural basis for the initiation of eukaryotic transcription-coupled DNA repair

scientific article published on 22 November 2017

Structure of a beta-alanine-linked polyamide bound to a full helical turn of purine tract DNA in the 1:1 motif

scientific article

Suppression of androgen receptor-mediated gene expression by a sequence-specific DNA-binding polyamide

scientific article

Synthesis of cyclic Py-Im polyamide libraries

scientific article

Targeted chemical wedges reveal the role of allosteric DNA modulation in protein-DNA assembly

scientific article published on April 2008

Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides

scientific article

Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide

scientific article published on 10 November 2011

Temperature-sensitive protein-DNA dimerizers

scientific article

The reach of linear protein-DNA dimerizers

scientific article published on 20 October 2007

Toward Artificial Developmental Regulators ⬇️

scientific article published on November 5, 2003

Tumor Repression of VCaP Xenografts by a Pyrrole-Imidazole Polyamide

scientific article published on 16 November 2015

Tumor xenograft uptake of a pyrrole-imidazole (Py-Im) polyamide varies as a function of cell line grafted

scientific article

U-pin polyamide motif for recognition of the DNA minor groove

scientific article

Unanticipated differences between alpha- and gamma-diaminobutyric acid-linked hairpin polyamide-alkylator conjugates

scientific article published on 14 December 2006

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