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List of works by Evan D Kharasch

Acute intravascular volume expansion with rapidly administered crystalloid or colloid in the setting of moderate hypovolemia

scientific article published on 01 June 2003

Add-on plasmonic patch as a universal fluorescence enhancer

Amplification of Refractometric Biosensor Response through Biomineralization of Metal–Organic Framework Nanocrystals

scientific article published in 2017

Aromatic Functionality of Target Proteins Influences Monomer Selection for Creating Artificial Antibodies on Plasmonic Biosensors

scientific article published on 09 December 2016

Assessing the utility of the utility function

scientific article published on September 2013

Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).

scientific article

Automated radiosynthesis of [11C]morphine for clinical investigation

scientific article

Bio-Enabled Gold Superstructures with Built-In and Accessible Electromagnetic Hotspots.

scientific article published on 15 May 2015

Bioavailabilities of rectal and oral methadone in healthy subjects

scientific article published in August 2004

Bioequivalence and Therapeutic Equivalence of Generic and Brand Bupropion in Adults With Major Depression: A Randomized Clinical Trial

scientific article published on 18 January 2019

Bioplasmonic Paper as a Platform for Detection of Kidney Cancer Biomarkers ⬇️

scientific article published on November 2, 2012

Bioplasmonic calligraphy for multiplexed label-free biodetection

scientific article

Bioplasmonic paper-based assay for perilipin-2 non-invasively detects renal cancer

scientific article published on 03 September 2019

Biotransformation of L-cysteine S-conjugates and N-acetyl-L-cysteine S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in human kidney in vitro: interindividual variability in N

scientific article published in February 2002

Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active

scientific article

CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease

scientific article published in August 2003

CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition

scientific article published in June 2005

Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans

scientific article

Changes: Handing Off and the Future of ANESTHESIOLOGY.

scientific article published on 6 May 2016

Changes: Thank You, Dr. Eisenach

scientific article published on 01 July 2016

Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

scientific article

Chronic epidural bupivacaine-opioid infusion in intractable cancer pain

scientific article published on June 1, 1992

Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for CYP2D6, OPRM1, and COMT genotype and select opioid therapy

scientific article published on 02 January 2021

Common Polymorphisms of CYP2B6 Influence Stereoselective Bupropion Disposition

scientific article published on 09 August 2018

Comparison of Amsorb, sodalime, and Baralyme degradation of volatile anesthetics and formation of carbon monoxide and compound a in swine in vivo

scientific article published in January 2002

Comparison of In Vitro and In Vivo Inhibition Potencies of Fluvoxamine toward CYP2C19 ⬇️

scientific article published on May 1, 2003

Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir ⬇️

scientific article published on March 15, 2011

Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir ⬇️

scientific article published on September 19, 2011

Complex Drug Interactions of the HIV Protease Inhibitors 3: Effect of Simultaneous or Staggered Dosing of Digoxin and Ritonavir, Nelfinavir, Rifampin, or Bupropion ⬇️

scientific article published on December 21, 2011

Contemporary clinical opioid use: opportunities and challenges

scientific article published on July 2009

Current Concepts in Methadone Metabolism and Transport.

scientific article published in March 2017

Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics

scientific article published on October 2013

Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics

scientific article

Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir

scientific article published on 25 September 2013

Cytotoxicity of S-conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl) vinyl ether (Compound A) in a human proximal tubular cell line ⬇️

scientific article published on November 15, 2003

Determination of morphine and morphine glucuronides in human plasma by 96-well plate solid-phase extraction and liquid chromatography–electrospray ionization mass spectrometry ⬇️

scientific article published on October 25, 2003

Development and validation of a high-throughput stereoselective LC-MS/MS assay for bupropion, hydroxybupropion, erythrohydrobupropion, and threohydrobupropion in human plasma

scientific article published on 27 February 2016

Development, validation and application of a comprehensive stereoselective LC/MS-MS assay for bupropion and oxidative, reductive, and glucuronide metabolites in human urine

scientific article published on 24 May 2016

Differences in Methadone Metabolism by CYP2B6 Variants

scientific article published on 20 April 2015

Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity

scientific article published in March 2003

Disposition of nasal, intravenous, and oral methadone in healthy volunteers

scientific article

Editor's Note: ANESTHESIOLOGY 2017: Expanding the Richness and Reach

scientific article published on 01 July 2017

Editor's Note: ANESTHESIOLOGY 2018: Inspiring Investigation and Education

scientific article published on 01 July 2018

Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry

scientific article published on 19 July 2019

Effect of HAART on Brain Organization and Function in HIV-Negative Subjects

scientific article

Effect of Rifampicin on S-ketamine and S-norketamine Plasma Concentrations in Healthy Volunteers after Intravenous S-ketamine Administration ⬇️

scientific article published on June 1, 2011

Effects of parecoxib, a parenteral COX-2-specific inhibitor, on the pharmacokinetics and pharmacodynamics of propofol

scientific article

Enantiomeric metabolic interactions and stereoselective human methadone metabolism

scientific article

Environmental Stability of Plasmonic Biosensors Based on Natural versus Artificial Antibody

scientific article published on 13 June 2018

Errors and Integrity in Seeking and Reporting Apparent Research Misconduct

scientific article published on 21 August 2017

Estimation of the contribution of norketamine to ketamine-induced acute pain relief and neurocognitive impairment in healthy volunteers

scientific article

Evaluation of Urine Aquaporin-1 and Perilipin-2 Concentrations as Biomarkers to Screen for Renal Cell Carcinoma: A Prospective Cohort Study

scientific article

Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination

scientific article published in January 2005

Every breath you take, we'll be watching you.

scientific article published in April 2007

Expanded studies of the pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers.

scientific article

Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury

scientific article published on 11 January 2016

Frontiers in Opioid Pharmacology

scientific article published on 01 May 2018

Gene expression profiling of nephrotoxicity from the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether ("compound A") in rats

scientific article published on 29 December 2005

Getting Oil and Water to Mix ⬇️

scientific article published on March 1, 2012

Gold nanocages with built-in artificial antibodies for label-free plasmonic biosensing

scientific article published on 22 November 2013

Halogen Substitution Influences Ketamine Metabolism by Cytochrome P450 2B6: In Vitro and Computational Approaches

scientific article published on 10 January 2019

Headache outcomes following treatment of unruptured intracranial aneurysms: a prospective analysis.

scientific article published on 11 March 2011

High-sensitivity analysis of buprenorphine, norbuprenorphine, buprenorphine glucuronide, and norbuprenorphine glucuronide in plasma and urine by liquid chromatography-mass spectrometry

scientific article published on 08 September 2013

Hot Spot-Localized Artificial Antibodies for Label-Free Plasmonic Biosensing

scientific article published on April 2013

How central is central post-stroke pain? The role of afferent input in post-stroke neuropathic pain: a prospective open-label pilot study.

scientific article published on 21 March 2018

Human Kidney Methoxyflurane and Sevoflurane Metabolism

scientific article (publication date: March 1995)

In Reply

In vitro metabolism of cyclosporine A by human kidney CYP3A5.

scientific article published in November 2004

Influence of HIV antiretrovirals on methadone N-demethylation and transport

scientific article

Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial

scientific article published on 01 March 2020

Influence of age on the pharmacokinetics and pharmacodynamics of oral transmucosal fentanyl citrate

scientific article published in September 2004

Influence of hepatic and intestinal cytochrome P4503A activity on the acute disposition and effects of oral transmucosal fentanyl citrate

scientific article published in September 2004

Influence of sevoflurane on the metabolism and renal effects of compound A in rats

scientific article published in December 2005

Initial pharmacokinetic, safety and efficacy evaluation of nasal morphine gluconate for breakthrough pain in cancer patients

scientific article

Innovation in Clinical Research Regulation

scientific article published on 01 January 2020

Intraoperative Methadone in Same-Day Ambulatory Surgery: A Randomized, Double-Blinded, Dose-Finding Pilot Study

scientific article published on 01 April 2019

Intraoperative methadone: rediscovery, reappraisal, and reinvigoration?

scientific article published in January 2011

Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis

scientific article published in November 2004

Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo

scientific article

Journal-related Activities and Other Special Activities at the 2020 American Society of Anesthesiologists Meeting

scientific article published on 04 September 2020

Journal-related and other special activities at the 2008 American Society of Anesthesiologists Annual Meeting

scientific article published in September 2008

Lack of Indinavir Effects on Methadone Disposition Despite Inhibition of Hepatic and Intestinal Cytochrome P4503A (CYP3A) ⬇️

scientific article published on February 1, 2012

Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression

scientific article published on 22 January 2019

Low-flow sevoflurane compared with low-flow isoflurane anesthesia in patients with stable renal insufficiency

scientific article

Mechanism of autoinduction of methadone N-demethylation in human hepatocytes

scientific article published on 03 June 2013

Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes

scientific article published on 22 November 2004

Metal-Organic Framework Encapsulation Preserves the Bioactivity of Protein Therapeutics

scientific article published on 19 October 2018

Metal-Organic Framework as a Protective Coating for Biodiagnostic Chips.

scientific article published on 07 December 2016

Methadone Disposition: Implementing Lessons Learned

scientific article published on 01 May 2019

Methadone N-Demethylation by the Common CYP2B6 Allelic Variant CYP2B6.6 ⬇️

scientific article published on January 8, 2013

Methadone Pharmacogenetics: CYP2B6 Polymorphisms Determine Plasma Concentrations, Clearance, and Metabolism

scientific article

Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

scientific article published on 18 February 2009

Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir

scientific article

Misidentification of Bupropion Glucuronide Metabolites and Re-evaluation of Metabolite Pharmacokinetics

scientific article published on November 2016

Molecular characterization of CYP2B6 substrates

scientific article

More than polymorphism

scientific article published on 01 June 2007

Mutations in a molecule: the virtues of antagonism

scientific article published on October 2008

New Insights into the Mechanism of Methoxyflurane Nephrotoxicity and Implications for Anesthetic Development (Part 1)

scientific article (publication date: October 2006)

New Insights into the Mechanism of Methoxyflurane Nephrotoxicity and Implications for Anesthetic Development (Part 2)

scientific article (publication date: October 2006)

New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway

scientific article

New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites

scientific article

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes

article published in 2019

Ninety-six hour ketamine infusion with co-administered clonidine for treatment-resistant depression: A pilot randomised controlled trial

scientific article published on 26 February 2016

Nitrous Oxide Anesthesia and Plasma Homocysteine in Adolescents ⬇️

scientific article published on June 16, 2011

Novel Coronavirus 2019 and Anesthesiology

scientific article published on 26 March 2020

Observations and Observational Research

scientific article published on 01 July 2019

Opioid Half-lives and Hemlines: The Long and Short of Fashion

scientific article

Opioid Sensitivity in Children with and without Obstructive Sleep Apnea

scientific article published on 01 June 2019

P-glycoprotein is a major determinant of norbuprenorphine brain exposure and antinociception

scientific article

PEGylated Artificial Antibodies: Plasmonic Biosensors with Improved Selectivity.

scientific article published on 19 August 2016

Paradoxical role of cytochrome P450 3A in the bioactivation and clinical effects of levo-alpha-acetylmethadol: importance of clinical investigations to validate in vitro drug metabolism studies

scientific article published in January 2005

Peer Review Matters: Research Quality and the Public Trust

scientific article published on 01 January 2021

Peptide Functionalized Gold Nanorods for the Sensitive Detection of a Cardiac Biomarker Using Plasmonic Paper Devices

scientific article

Perioperative COX-2 inhibitors: knowledge and challenges

scientific article published on 01 January 2004

Perioperative Gabapentinoids: Deflating the Bubble

scientific article published on 01 August 2020

Perioperative Opioids and Public Health

scientific article

Perioperative Pharmacokinetics of Methadone in Adolescents ⬇️

scientific article published on December 1, 2011

Persistent Postoperative Opioid Use: Perception, Progress, and Promise

scientific article published on 31 March 2020

Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.

scientific article published in March 2005

Pharmacokinetic interactions between buprenorphine and antiretroviral medications

scientific article published on December 2006

Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease

scientific article published on 30 August 2016

Pharmacokinetics and clinical effects of multidose sublingual triazolam in healthy volunteers

scientific article published in February 2006

Pharmacokinetics and pharmacodynamics of oral oxycodone in healthy human subjects: role of circulating active metabolites

scientific article

Pharmacokinetics and tissue penetration of cefoxitin in obesity: implications for risk of surgical site infection

scientific article published on 03 June 2011

Plasma and cerebrospinal fluid pharmacokinetics of ondansetron in humans

scientific article published on 04 June 2020

Postoperative Brain Function: Toward a Better Understanding and the American Society of Anesthesiologists Perioperative Brain Health Initiative

article

Pressure waveform monitoring during central venous catheterization

scientific article published on 01 December 2009

Quinidine as a probe for the role of p-glycoprotein in the intestinal absorption and clinical effects of fentanyl

scientific article published in March 2004

Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir

scientific article published on 19 February 2008

Rapid, Point-of-Care, Paper-Based Plasmonic Biosensor for Zika Virus Diagnosis

scientific article published on 10 August 2017

Rational Perioperative Opioid Management in the Era of the Opioid Crisis

scientific article published on 01 April 2020

Rational Perioperative Opioid Management in the Era of the Opioid Crisis: Reply

scientific article published on 04 August 2020

Reply to comment on: Pharmacokinetics and analgesic effects of methadone in children and adults with sickle cell disease

scientific article published on 10 November 2016

Reporting Laboratory and Animal Research in ANESTHESIOLOGY: The Importance of Sex as a Biologic Variable

scientific article published on 01 November 2019

Role of CYP2B6 in stereoselective human methadone metabolism

scientific article

Role of Cytochrome P4502B6 Polymorphisms in Ketamine Metabolism and Clearance

scientific article published on 20 October 2016

Role of Cytochrome P4502B6 in Methadone Metabolism and Clearance ⬇️

scientific article published on 07 January 2013

Role of P-glycoprotein in the intestinal absorption and clinical effects of morphine

scientific article published on December 2003

Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats

scientific article published in September 2004

Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone

scientific article

Ru-Rong Ji, Ph.D., Recipient of the 2020 Excellence in Research Award

scientific article published on 04 September 2020

Sensitivity and Specificity of Urinary Neutrophil Gelatinase-Associated Lipocalin and Kidney Injury Molecule-1 for the Diagnosis of Renal Cell Carcinoma ⬇️

scientific article published on September 7, 2011

Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity

scientific article published in October 2005

Sevoflurane formulation water content influences degradation by Lewis acids in vaporizers.

scientific article published in June 2009

Significance of lipid composition in a blood-brain barrier-mimetic PAMPA assay

scientific article

Silk-Encapsulated Plasmonic Biochips with Enhanced Thermal Stability.

scientific article published on 20 July 2016

Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil

scientific article

Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry ⬇️

scientific article published on March 5, 2011

Simultaneous measurement of in vivo P-glycoprotein and cytochrome P450 3A activities

scientific article

Single Molecule Force Spectroscopy to Compare Natural versus Artificial Antibody-Antigen Interaction

scientific article published on 21 March 2017

Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam

scientific article published in November 2005

Sleeping to survive?: The impact of volatile anesthetics on mortality in sepsis

scientific article published on October 2013

Stereochemical aspects of itraconazole metabolism in vitro and in vivo

scientific article

Stereoselective Ketamine Metabolism by Genetic Variants of Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase

scientific article published on 01 October 2018

Stereoselective analysis of bupropion and hydroxybupropion in human plasma and urine by LC/MS/MS

scientific article published on 10 July 2007

Stereoselective bupropion hydroxylation as an in vivo phenotypic probe for cytochrome P4502B6 (CYP2B6) activity

scientific article

Stereoselective bupropion hydroxylation by cytochrome P450 CYP2B6 and cytochrome P450 oxidoreductase genetic variants

scientific article published on 01 April 2020

Stereoselective determination of methadone and the primary metabolite EDDP in human plasma by automated on-line extraction and liquid chromatography mass spectrometry

scientific article

Stereoselective metabolism of bupropion by cytochrome P4502B6 (CYP2B6) and human liver microsomes

scientific article published on June 2008

Stereoselective steady-state disposition and bioequivalence of brand and generic bupropion in adults

scientific article published on 09 May 2020

Steroid Anesthesia Revisited: Again

scientific article published on May 2015

Strain-specific altered nicotine metabolism in 3,3'-diindolylmethane (DIM) exposed mice

scientific article published on 20 May 2019

Sulfoxidation of cysteine and mercapturic acid conjugates of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A).

scientific article published in March 2004

The Challenges of Translation

scientific article published on 01 April 2018

The Specificity of Urinary Aquaporin 1 and Perilipin 2 to Screen for Renal Cell Carcinoma ⬇️

scientific article published on November 12, 2012

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans

scientific article

The effect of quinidine, used as a probe for the involvement of P-glycoprotein, on the intestinal absorption and pharmacodynamics of methadone

scientific article published in May 2004

The hematological effects of nitrous oxide anesthesia in pediatric patients

scientific article

The influence of parecoxib, a parenteral cyclooxygenase-2 specific inhibitor, on the pharmacokinetics and clinical effects of midazolam

scientific article published in September 2002

The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects

scientific article published on 01 January 2020

The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine

scientific article

Toward precision prescribing for methadone: Determinants of methadone deposition

scientific article published on 17 April 2020

Toxicity during tumescent lipoplasty: a commentary

scientific article published on 01 July 2004

Trusted Evidence: Discovery to Practice

scientific article published on 01 January 2019

Ultrarobust Biochips with Metal-Organic Framework Coating for Point-of-Care Diagnosis.

scientific article published on 16 January 2018

Uncertainty and Certainty

scientific article published on 26 May 2020

Uncertainty and Certainty: Reply

scientific article published on 14 September 2020

Understanding Research Methods and the Readers' Toolbox: A New Article Type

scientific article published on 01 February 2019

Urinary aquaporin 1 and perilipin 2: Can these novel markers accurately characterize small renal masses and help guide patient management?

scientific article published on 22 November 2018

Urinary biomarkers for the early diagnosis of kidney cancer

scientific article

Urinary concentrations of aquaporin-1 and perilipin-2 in patients with renal cell carcinoma correlate with tumor size and stage but not grade

scientific article

Urine aquaporin 1 and perilipin 2 differentiate renal carcinomas from other imaged renal masses and bladder and prostate cancer

scientific article

Use of enantiomeric bupropion and hydroxybupropion to assess CYP2B6 activity in glomerular kidney diseases

scientific article published on 26 January 2010

Wherefore Gabapentinoids?: Was There Rush Too Soon to Judgment?

scientific article

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