List of works - Christina J. Sigurdson

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

scientific article

A molecular switch controls interspecies prion disease transmission in mice

scientific article

A prion disease of cervids: chronic wasting disease

scientific article published on 03 April 2008

A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC.

scientific article

A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA Receptor

scientific article published on 11 August 2020

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

scientific article

Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-β and prion plaques in brain

scientific article published on 22 August 2012

Antiprion immunotherapy: to suppress or to stimulate?

scientific article published in September 2004

Asparagine and glutamine ladders promote cross-species prion conversion

scientific article published on 20 September 2017

Bacterial colitis increases susceptibility to oral prion disease

scientific article

Biochemical properties of highly neuroinvasive prion strains

scientific article

Cell-to-cell transmission of non-prion protein aggregates.

scientific article published on 12 October 2010

Cellular and Molecular Mechanisms of Prion Disease

scientific article published on 24 October 2018

Chronic wasting disease

scientific article

Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein

scientific article

Cross-species transmission of CWD prions

scientific article

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue

scientific article published on 29 October 2019

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

scientific article

De novo prion aggregates trigger autophagy in skeletal muscle

scientific article published on 04 December 2013

Defining the Conformational Features of Anchorless, Poorly Neuroinvasive Prions ⬇️

scientific article published on April 18, 2013

Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice

scientific article

Enhanced neuroinvasion by smaller, soluble prions

scientific article

Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets ⬇️

scientific article published on September 14, 2011

Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus) ⬇️

scientific article published on June 18, 2012

Generation of novel neuroinvasive prions following intravenous challenge

scientific article published on 5 March 2018

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Human prion protein sequence elements impede cross-species chronic wasting disease transmission

scientific article published on 11 May 2015

Human prion protein sequence elements impede cross-species chronic wasting disease transmission. ⬇️

scientific article

Infectious prions in the saliva and blood of deer with chronic wasting disease

scientific article

Letters to the Editor

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

scientific article published on 25 January 2004

Lymphotoxin-Dependent Prion Replication in Inflammatory Stromal Cells of Granulomas

Molecular mechanisms of prion pathogenesis

scientific article published on January 2008

Mucosal transmission and pathogenesis of chronic wasting disease in ferrets

scientific article published on 24 October 2012

Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands

scientific article published on November 2014

Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death

scientific article published on 05 May 2015

Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines

scientific article published on 16 June 2016

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses

scientific article

Other animal prion diseases

scientific article published on January 2003

PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP

scientific article

Polymorphism of Amyloid Fibrils In Vivo.

scientific article published on 8 March 2016

Post-translational modifications in PrP expand the conformational diversity of prions in vivo

scientific article

PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer

scientific article published in October 2002

PrPSc in mammary glands of sheep affected by scrapie and mastitis

Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy

scientific article published in October 2002

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients

scientific article published in 2018

Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice ⬇️

scientific article published on April 1, 2012

Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease

scientific article published on 01 March 2020

Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease

scientific article published on 23 May 2020

Prion strain discrimination using luminescent conjugated polymers

Prion strain interactions are highly selective

scientific article

Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC

scientific article published on January 2014

Prions in skeletal muscles of deer with chronic wasting disease

scientific article published on 26 January 2006

Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats

scientific article

Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes

scientific article

Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication

scientific article

Recent advances on the molecular pathogenesis of prion diseases

scientific article published on 01 March 2019

Reconstructing prions: fibril assembly from simple yeast to complex mammals

scientific article published on January 2005

Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

scientific article published on 01 October 2020

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

scientific article published on 20 December 2018

Sheep with scrapie and mastitis transmit infectious prions through the milk

scientific article

Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions

scientific article published on 31 October 2019

Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids.

scientific article

Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein

scientific article

Strain fidelity of chronic wasting disease upon murine adaptation ⬇️

scientific article

Structure of the β2-α2 loop and interspecies prion transmission

scientific article

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes

scientific article

The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates

scientific article

Tracking protein aggregate interactions

scientific article

List of works by Christina J. Sigurdson

A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates.

A molecular switch controls interspecies prion disease transmission in mice

A prion disease of cervids: chronic wasting disease

A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC.

A soluble derivative of PrPC activates cell-signaling and regulates cell physiology through LRP1 and the NMDA Receptor

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

Aminonaphthalene 2-cyanoacrylate (ANCA) probes fluorescently discriminate between amyloid-β and prion plaques in brain

Antiprion immunotherapy: to suppress or to stimulate?

Asparagine and glutamine ladders promote cross-species prion conversion

Bacterial colitis increases susceptibility to oral prion disease

Biochemical properties of highly neuroinvasive prion strains

Cell-to-cell transmission of non-prion protein aggregates.

Cellular and Molecular Mechanisms of Prion Disease

Chronic wasting disease

Chronic wasting disease prions are not transmissible to transgenic mice overexpressing human prion protein

Cross-species transmission of CWD prions

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer's brain tissue

De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis

De novo prion aggregates trigger autophagy in skeletal muscle

Defining the Conformational Features of Anchorless, Poorly Neuroinvasive Prions ⬇️

Electron microscopic and confocal laser microscopy analysis of amyloid plaques in chronic wasting disease transmitted to transgenic mice

Enhanced neuroinvasion by smaller, soluble prions

Evidence for distinct chronic wasting disease (CWD) strains in experimental CWD in ferrets ⬇️

Experimental Oral Transmission of Chronic Wasting Disease to Reindeer (Rangifer tarandus tarandus) ⬇️

Generation of novel neuroinvasive prions following intravenous challenge

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Human prion protein sequence elements impede cross-species chronic wasting disease transmission

Human prion protein sequence elements impede cross-species chronic wasting disease transmission. ⬇️

Infectious prions in the saliva and blood of deer with chronic wasting disease

Letters to the Editor

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

Lymphotoxin-Dependent Prion Replication in Inflammatory Stromal Cells of Granulomas

Molecular mechanisms of prion pathogenesis

Mucosal transmission and pathogenesis of chronic wasting disease in ferrets

Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands

Multiple Mechanisms of Unfolded Protein Response-Induced Cell Death

Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines

Novel pentameric thiophene derivatives for in vitro and in vivo optical imaging of a plethora of protein aggregates in cerebral amyloidoses

Other animal prion diseases

PK-sensitive PrP is infectious and shares basic structural features with PK-resistant PrP

Polymorphism of Amyloid Fibrils In Vivo.

Post-translational modifications in PrP expand the conformational diversity of prions in vivo

PrP(CWD) lymphoid cell targets in early and advanced chronic wasting disease of mule deer

PrPSc in mammary glands of sheep affected by scrapie and mastitis

Preclinical diagnosis of chronic wasting disease in captive mule deer (Odocoileus hemionus) and white-tailed deer (Odocoileus virginianus) using tonsillar biopsy

Prion Seeds Distribute throughout the Eyes of Sporadic Creutzfeldt-Jakob Disease Patients

Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice ⬇️

Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease

Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease

Prion strain discrimination using luminescent conjugated polymers

Prion strain interactions are highly selective

Prion transmission prevented by modifying the β2-α2 loop structure of host PrPC

Prions in skeletal muscles of deer with chronic wasting disease

Protein profiling of isolated uterine AA amyloidosis causing fetal death in goats

Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes

Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication

Recent advances on the molecular pathogenesis of prion diseases

Reconstructing prions: fibril assembly from simple yeast to complex mammals

Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns

Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease

Sheep with scrapie and mastitis transmit infectious prions through the milk

Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions

Solvation-Guided Design of Fluorescent Probes for Discrimination of Amyloids.

Spongiform encephalopathy in transgenic mice expressing a point mutation in the β2-α2 loop of the prion protein

Strain fidelity of chronic wasting disease upon murine adaptation ⬇️

Structure of the β2-α2 loop and interspecies prion transmission

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes

The structural basis for optimal performance of oligothiophene-based fluorescent amyloid ligands: conformational flexibility is essential for spectral assignment of a diversity of protein aggregates

Tracking protein aggregate interactions