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List of works by Olivier De Wever

A 3D CFD model of the interstitial fluid pressure and drug distribution in heterogeneous tumor nodules during intraperitoneal chemotherapy

article

A nanobody targeting the F-actin capping protein CapG restrains breast cancer metastasis

scientific article published on 13 December 2013

A novel missense mutation (G43S) in the switch I region of Rab27A causing Griscelli syndrome

scientific article

A supporting ecosystem to mature extracellular vesicles into clinical application

scientific article published on 11 April 2019

ALK positively regulates MYCN activity through repression of HBP1 expression

scientific article published on 11 December 2018

APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma

scientific article

Abstract 4300: Comparative assessment of cell viability and motility kinetics by novel real-time technology and classic endpoint assays

Activation of the FAK-src molecular scaffolds and p130Cas-JNK signaling cascades by alpha1-integrins during colon cancer cell invasion.

scientific article published on December 2007

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study

scientific article published on 21 October 2019

Age and cellular context influence rectal prolapse formation in mice with caecal wall colorectal cancer xenografts.

scientific article published on 28 September 2016

An ex(o)citing machinery for invasive tumor growth ⬇️

scientific article published on November 23, 2010

An immunohistochemical analysis of Rab27B distribution in fetal and adult tissue

scientific article published in January 2012

Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization

scientific article published on 27 November 2019

Anti-angiogenic effects of mangiferin and mechanism of action in metastatic melanoma

scientific article published on 01 February 2020

Assessment of the trifluoromethyl ketone functionality as an alternative zinc-binding group for selective HDAC6 inhibition

scientific article published on 18 May 2018

Biological properties of extracellular vesicles and their physiological functions.

scientific article published on 14 May 2015

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.

scientific article

Bone marrow-derived mesenchymal stem cells promote colorectal cancer progression through paracrine neuregulin 1/HER3 signalling ⬇️

scientific article published on April 25, 2012

CCN5, a Novel Transcriptional Repressor of the Transforming Growth Factor β Signaling Pathway ⬇️

scientific article published on January 24, 2011

Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Microparticles in View of Personalized Antitumor Vaccination

Cancer-associated adipose tissue promotes breast cancer progression by paracrine oncostatin M and Jak/STAT3 signaling.

scientific article published on 24 September 2014

Cancer-associated fibroblasts as target and tool in cancer therapeutics and diagnostics.

scientific article published on 11 August 2015

Cancer-associated fibroblasts connect metastasis-promoting communication in colorectal cancer

scientific article published on 23 March 2015

Carcinoma-associated fibroblasts provide operational flexibility in metastasis

scientific article published on 07 January 2014

Cell surface clicking of antibody-recruiting polymers to metabolically azide-labeled cancer cells

scientific article published on 01 September 2019

Chick Heart Invasion Assay for Testing the Invasiveness of Cancer Cells and the Activity of Potentially Anti-invasive Compounds.

scientific article

Chitosan/γ-PGA nanoparticles-based immunotherapy as adjuvant to radiotherapy in breast cancer

scientific article published on 07 July 2020

Combined inhibition of rho-associated protein kinase and EGFR suppresses the invasive phenotype in EGFR-dependent lung cancer cells.

scientific article published on 20 August 2015

Combined targeting of EGFR/HER promotes anti-tumor efficacy in subsets of KRAS mutant lung cancer resistant to single EGFR blockade

scientific article

Commutators of PAR-1 signaling in cancer cell invasion reveal an essential role of the Rho-Rho kinase axis and tumor microenvironment

scientific article published in December 2005

Comparative Profiling of Metastatic 4T1- vs. Non-metastatic Py230-Based Mammary Tumors in an Intraductal Model for Triple-Negative Breast Cancer

scientific article published on 17 December 2019

Confounding factors of ultrafiltration and protein analysis in extracellular vesicle research

scientific article

Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding

scientific article published on 25 August 2004

Data on in vivo selection of SK-OV-3 Luc ovarian cancer cells and intraperitoneal tumor formation with low inoculation numbers.

scientific article

Developmental and cancer research on the mammary gland nowadays ⬇️

scientific article published on January 1, 2011

Developments and future clinical outlook of taxane nanomedicines

scientific article published on 20 March 2017

Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion

scientific article

Differential regulation of extracellular matrix protein expression in carcinoma-associated fibroblasts by TGF-β1 regulates cancer cell spreading but not adhesion.

scientific article published on 15 October 2014

Differential secretome analysis of cancer-associated fibroblasts and bone marrow-derived precursors to identify microenvironmental regulators of colon cancer progression

scientific article published on 06 January 2013

Discovery of (S)-3'-hydroxyblebbistatin and (S)-3'-aminoblebbistatin: polar myosin II inhibitors with superior research tool properties.

scientific article published on 21 February 2017

Disruption of STAT3 signaling leads to tumor cell invasion through alterations of homotypic cell-cell adhesion complexes

scientific article published in April 2004

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research.

scientific article published on February 2017

Effect of the secretory small GTPase Rab27B on breast cancer growth, invasion, and metastasis

scientific article

Engineered 3D microporous gelatin scaffolds to study cell migration

scientific article published on 29 February 2012

Establishment and characterization of a cell line and patient-derived xenograft (PDX) from peritoneal metastasis of low-grade serous ovarian carcinoma

scientific article published on 21 April 2020

Estrogen receptor alpha (ERalpha) and insulin-like growth factor I receptor (IGF-IR) cross-talk in the gonadotropic alphaT3-1 cell line.

scientific article published on September 2007

Estrogen receptor signaling is an unstable feature of the gonadotropic LbetaT2 cell line.

scientific article

Expression profiling of migrated and invaded breast cancer cells predicts early metastatic relapse and reveals Krüppel-like factor 9 as a potential suppressor of invasive growth in breast cancer

scientific article

FHL2: a scaffold protein of carcinogenesis, tumour-stroma interactions and treatment response

scientific article published on 17 December 2015

Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes

scientific article published on 29 July 2020

Fibroblast-induced matrix remodeling paves the path for invasion.

scientific article published in January 2015

Frondoside a suppressive effects on lung cancer survival, tumor growth, angiogenesis, invasion, and metastasis

scientific article

Function of extracellular vesicle-associated miRNAs in metastasis

scientific article

Genipin-crosslinked gelatin microspheres as a strategy to prevent postsurgical peritoneal adhesions: In vitro and in vivo characterization

scientific article published on 22 April 2016

Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts.

scientific article published on 28 November 2017

Growth factor modulation of fibroblast proliferation, differentiation, and invasion: implications for tissue valve engineering

scientific article published in October 2006

Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo.

scientific article published on 23 December 2017

Histopathological characterization of ductal carcinoma in situ (DCIS) of the breast according to HER2 amplification status and molecular subtype.

scientific article

Hypoxia imaging using 18F-FAZA PET/CT to predict radioresistance and guide hypoxic modification with nimorazole in esophageal adenocarcinoma xenografts

scientific article published on 01 June 2017

Hypoxia imaging with 18F-FAZA PET/CT predicts radiotherapy response in esophageal adenocarcinoma xenografts.

scientific article

Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands

scientific article published in March 2003

Identification of a GαGβγ, AKT and PKCα signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition

scientific article published on 30 April 2012

Identification of a novel HER3 activating mutation homologous to EGFR-L858R in lung cancer.

scientific article published on 9 December 2015

Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells.

scientific article published on 14 September 2010

Improved xenograft efficiency of esophageal adenocarcinoma cell lines through in vivo selection.

scientific article published on 15 May 2017

Increased levels of systemic LPS-positive bacterial extracellular vesicles in patients with intestinal barrier dysfunction

scientific article published on 05 December 2018

Invasion of retinal pigment epithelial cells: N-cadherin, hepatocyte growth factor, and focal adhesion kinase

scientific article

Krüppel-like factors in cancer progression: three fingers on the steering wheel

scientific article published on January 2014

Localization and Expression of Nuclear Factor of Activated T-Cells 5 in Myoblasts Exposed to Pro-inflammatory Cytokines or Hyperosmolar Stress and in Biopsies from Myositis Patients.

scientific article

MIFlowCyt-EV: a framework for standardized reporting of extracellular vesicle flow cytometry experiments

scientific article published on 03 February 2020

MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity

scientific article published on 01 November 2021

Mathematical modeling of intraperitoneal drug delivery: simulation of drug distribution in a single tumor nodule

scientific article published in November 2017

Mesenchymal stem cell secreted platelet derived growth factor exerts a pro-migratory effect on resident Cardiac Atrial appendage Stem Cells

scientific article published on 8 December 2013

Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines

scientific article published on 23 November 2018

Modeling and quantification of cancer cell invasion through collagen type I matrices

scientific article published on January 2010

Modifications of cell signalling and redox balance by targeting protein acetylation using natural and engineered molecules: implications in cancer therapy.

scientific article

Molecular and pathological signatures of epithelial-mesenchymal transitions at the cancer invasion front

scientific article published on 22 July 2008

Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers

scientific article published on 20 August 2008

Nanoscopic tumor tissue distribution of platinum after intraperitoneal administration in a xenograft model of ovarian cancer

scientific article

Netrin-1 induces apoptosis in human cervical tumor cells via the TAp73alpha tumor suppressor

scientific article published in October 2008

OMO-1 reduces progression and enhances cisplatin efficacy in a 4T1-based non-c-MET addicted intraductal mouse model for triple-negative breast cancer

scientific article published on 17 March 2021

Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy

scientific article

Preclinical evaluation of local prolonged release of paclitaxel from gelatin microspheres for the prevention of recurrence of peritoneal carcinomatosis in advanced ovarian cancer

scientific article published on 16 October 2019

Pretreatment with VEGF(R)-inhibitors reduces interstitial fluid pressure, increases intraperitoneal chemotherapy drug penetration, and impedes tumor growth in a mouse colorectal carcinomatosis model

scientific article published on 7 September 2015

Quantitative and Functional Requirements for Bioluminescent Cancer Models

scientific article published on January 2016

Rab27 GTPases Distribute Extracellular Nanomaps for Invasive Growth and Metastasis: Implications for Prognosis and Treatment ⬇️

scientific article published on May 10, 2013

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

scientific article

Radiation-induced myosin IIA expression stimulates collagen type I matrix reorganization.

scientific article published on 3 June 2013

Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF-1R activation

scientific article published on 7 December 2017

Recent exposure to ultrafine particles in school children alters miR-222 expression in the extracellular fraction of saliva

scientific article published on 26 July 2016

Requirement of both mucins and proteoglycans in cell-cell dissociation and invasiveness of colon carcinoma HT-29 cells

scientific article published on May 2003

Resident and bone marrow-derived mesenchymal stem cells in head and neck squamous cell carcinoma

scientific article published on 09 March 2010

Role of WISP-2/CCN5 in the maintenance of a differentiated and noninvasive phenotype in human breast cancer cells

scientific article

SMARCAD1 knockdown uncovers its role in breast cancer cell migration, invasion, and metastasis

scientific article published on 27 May 2016

Secretome analysis of breast cancer-associated adipose tissue to identify paracrine regulators of breast cancer growth.

scientific article published on 3 May 2017

Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

scientific article published on 20 February 2019

Single cell and spheroid collagen type I invasion assay

scientific article published on January 2014

Soluble N-cadherin in human biological fluids

scientific article published in December 2006

Soluble cadherins as cancer biomarkers

scientific article published on 19 October 2007

Some diffuse large B-cell lymphomas (DLBCLs) present with clone-dependent TTF-1 positivity

scientific article published on 2 February 2018

Species-dependent extracranial manifestations of a brain seeking breast cancer cell line

scientific article published in PLoS ONE

Splenic 18F-FDG uptake on baseline PET/CT is associated with oncological outcomes and tumor immune state in uterine cervical cancer

scientific article published on 25 August 2020

Splenic hematopoietic and stromal cells in cancer progression

scientific article published on 30 September 2020

Stromal architecture and periductal decorin are potential prognostic markers for ipsilateral locoregional recurrence in ductal carcinoma in situ of the breast.

scientific article published on 26 July 2013

Stromal integrin α11 regulates PDGFR-β signaling and promotes breast cancer progression

scientific article published on 09 July 2019

Stromal myofibroblasts are drivers of invasive cancer growth

scientific article

Synthesis of C-ring-modified blebbistatin derivatives and evaluation of their myosin II ATPase inhibitory potency

scholarly article by Bart I Roman published in July 2018

Targeted liposome-loaded microbubbles for cell-specific ultrasound-triggered drug delivery.

scientific article published on 5 June 2013

Targeting Polo-like kinase 1 and TRAIL enhances apoptosis in non-small cell lung cancer.

scientific article published on 19 June 2018

Targeting the Tumor Microenvironment in Colorectal Peritoneal Metastases

scientific article published on 16 January 2020

Tenascin-C and SF/HGF produced by myofibroblasts in vitro provide convergent pro-invasive signals to human colon cancer cells through RhoA and Rac.

scientific article published on April 2004

The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness

scientific article published on 14 January 2020

The extracellular matrix regulates cancer progression and therapy response: implications for prognosis and treatment

scientific article published on January 2009

The generation and use of recombinant extracellular vesicles as biological reference material

scientific article published on 23 July 2019

The impact of disparate isolation methods for extracellular vesicles on downstream RNA profiling

scientific article published on 18 September 2014

The proinvasive activity of Wnt-2 is mediated through a noncanonical Wnt pathway coupled to GSK-3beta and c-Jun/AP-1 signaling

scientific article

The role of non-muscle myosin IIA in aggregation and invasion of human MCF-7 breast cancer cells.

scientific article

The secretory small GTPase Rab27B as a marker for breast cancer progression

scientific article

The tandem PDZ domains of syntenin promote cell invasion

scientific article published on 24 March 2007

The transcriptome of lung tumor-infiltrating dendritic cells reveals a tumor-supporting phenotype and a microRNA signature with negative impact on clinical outcome

scientific article (publication date: 8 November 2016)

The transforming functions of PI3-kinase-gamma are linked to disruption of intercellular adhesion and promotion of cancer cell invasion

scientific article published on September 2008

The tumor ecosystem regulates the roads for invasion and metastasis

scientific article published on 14 June 2011

Transiently Responsive Block Copolymer Micelles Based on N-(2-Hydroxypropyl)methacrylamide Engineered with Hydrolyzable Ethylcarbonate Side Chains

scientific article published on 9 December 2015

Transparent reporting of experimental parameters in assays measuring phenotypic steps in metastasis

Tumor grafts derived from sarcoma patients retain tumor morphology, viability, and invasion potential and indicate disease outcomes in the chick chorioallantoic membrane model

scientific article published on 24 July 2012

Tumor-environment biomimetics delay peritoneal metastasis formation by deceiving and redirecting disseminated cancer cells.

scientific article published on 2 April 2015

Tumour tissue transport after intraperitoneal anticancer drug delivery

scientific article published on 28 March 2017

Tunable self-assembled nanogels composed of well-defined thermoresponsive hyaluronic acid–polymer conjugates

scientific article published on 09 July 2013

Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine

scientific article published on 11 March 2020

Urinary extracellular vesicle biomarkers in urological cancers: From discovery towards clinical implementation

scientific article published in 2018

Use of Tamoxifen Before and During Pregnancy ⬇️

scientific article published on October 21, 2011

Vacuolar H+ ATPase expression and activity is required for Rab27B-dependent invasive growth and metastasis of breast cancer

scientific article

When Neighbors Talk: Colon Cancer Cell Invasion and Tumor Microenvironment Myofibroblasts

scientific article published on 28 October 2016

When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer

scientific article published on 08 July 2015

miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells

scientific article published on 12 February 2013

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