List of works by Shun Shimohama

"Burst and slow complexes" in nonconvulsive epileptic status

scientific article published on 01 March 2006

3-[(2,4-Dimethoxy)benzylidene]-anabaseine dihydrochloride protects against 6-hydroxydopamine-induced parkinsonian neurodegeneration through α7 nicotinic acetylcholine receptor stimulation in rats

scientific article

A Cross-Sectional Study on Socioeconomic Systems Supporting Outpatients With Parkinson's Disease in Japan.

scientific article published on 5 December 2015

A case of neuromyelitis optica presenting marked pleocytosis and hypoglycorrhachia

scientific article published on 29 July 2016

A case presenting electrophysiological and immunological characteristics of Fisher syndrome and Lambert-Eaton myasthenic syndrome

scientific article published on 08 December 2020

A heterozygous missense mutation in adolescent-onset very long-chain acyl-CoA dehydrogenase deficiency with exercise-induced rhabdomyolysis

scientific article published on January 2015

A new form of congenital proprioceptive sensory neuropathy associated with arthrogryposis multiplex.

scientific article published in November 2004

A novel lamin A/C gene mutation causing spinal muscular atrophy phenotype with cardiac involvement: report of one case

scientific article published on 20 February 2015

A novel nuclear DnaJ protein, DNAJC8, can suppress the formation of spinocerebellar ataxia 3 polyglutamine aggregation in a J-domain independent manner.

scientific article

ANCA-negative granulomatosis with polyangiitis presenting with orbital apex syndrome and recurrent pachymeningitis: A case report

scientific article published on 9 July 2016

Activity-dependent regulation of beta-catenin via epsilon-cleavage of N-cadherin

scientific article published on 6 May 2006

Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer's disease patients

scientific article

Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mous

scientific article published on 22 November 2017

Alzheimer's disease and acetylcholine receptors.

scientific article published on January 2004

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

scientific article

An Anti-PM/Scl-75 Antibody-positive Japanese Woman Who Developed Inflammatory Myopathy

scientific article published on 07 June 2019

Analysis of resources assisting in coping with swallowing difficulties for patients with Parkinson's disease: a cross-sectional study.

scientific article

Anti-ryanodine receptor-positive acetylcholine receptor-negative myasthenia gravis: evidence of impaired excitation-contraction coupling

scientific article published on 01 February 2011

Apoptotic and Oxidative Indicators in Alzheimer's Disease

scholarly article

Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?

scientific article

Association of novel and established polymorphisms in neuronal nicotinic acetylcholine receptors with sporadic Alzheimer's disease

scientific article (publication date: April 2002)

BDNF is induced by wild-type alpha-synuclein but not by the two mutants, A30P or A53T, in glioma cell line

scientific article published on May 2004

CD14 and Toll-Like Receptor 4 Promote Fibrillar Aβ42 Uptake by Microglia Through A Clathrin-Mediated Pathway

scientific article published on 01 January 2019

Characterization of sequential N-cadherin cleavage by ADAM10 and PS1.

scientific article

Clinical and Radiological Characteristics of Intracranial Artery Dissection Using Recently Proposed Diagnostic Criteria

scientific article published on 19 March 2019

Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults).

scientific article published in March 2006

Cocaine and phenylephrine eye drop test for Parkinson disease.

scientific article

Colocalization of 14-3-3 proteins with SOD1 in Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis cases and the animal model

scientific article

Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response

scientific article

Continuation of exercise is necessary to inhibit high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

scientific article

Contribution of anti-ryanodine receptor antibody to impairment of excitation-contraction coupling in myasthenia gravis

scientific article published on 01 December 2011

Copper enhances APP dimerization and promotes Aβ production

scientific article

Correlation of bite force with excitation-contraction coupling time of the masseter in myasthenia gravis

scientific article published on 12 March 2010

Development of moyamoya disease after non-herpetic acute limbic encephalitis: A case report.

scientific article

Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus

scientific article published on 16 October 2006

Differential expression profiles of PLC-beta1 and -delta1 in primary cultured rat cortical neurons treated with N-methyl-D-aspartate and peroxynitrite

scientific article

Disease model: Parkinson's disease.

scientific article

Dopamine facilitates alpha-synuclein oligomerization in human neuroblastoma SH-SY5Y cells

scientific article

Dopamine is involved in selectivity of dopaminergic neuronal death by rotenone

scientific article

Dopamine receptors and Parkinson's disease

scientific article published on 13 June 2011

Early administration of galantamine from preplaque phase suppresses oxidative stress and improves cognitive behavior in APPswe/PS1dE9 mouse model of Alzheimer's disease

scientific article published on 16 September 2019

Early effect of tacrolimus in improving excitation-contraction coupling in myasthenia gravis

scientific article published on 03 March 2012

Effect of local cooling on excitation-contraction coupling in myasthenic muscle: Another mechanism of ice-pack test in myasthenia gravis

scientific article

Effects of a DJ-1-Binding Compound on Spatial Learning and Memory Impairment in a Mouse Model of Alzheimer's Disease.

scientific article published on 21 September 2016

Effects of hyperoxia and acrylonitrile on the phospholipase C isozyme protein levels in rat heart and brain

scientific journal article

Effects of mitochondrial dysfunction on glutamate receptor-mediated neurotoxicity in cultured rat spinal motor neurons.

scientific article

Enhancement of nicotinic receptors alleviates cytotoxicity in neurological disease models

scientific article published on May 2011

Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice

scientific article

Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: a case report.

scientific article published on 21 June 2006

Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function

scientific article published in January 2018

Estradiol protects dopaminergic neurons in a MPP+Parkinson's disease model.

scientific article

Estrogens and Parkinson disease: novel approach for neuroprotection.

scientific article

Evaluation of Mitochondrial Oxidative Stress in the Brain of a Transgenic Mouse Model of Alzheimer's Disease by in vitro Electron Paramagnetic Resonance Spectroscopy

scientific article published on 01 January 2019

Evaluation of oxidative stress in the brain of a transgenic mouse model of Alzheimer disease by in vivo electron paramagnetic resonance imaging

scientific article

Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice

scientific article

Fingolimod induces BAFF and expands circulating transitional B cells without activating memory B cells and plasma cells in multiple sclerosis

scientific article published on 24 October 2017

Fingolimod suppresses bone resorption in female patients with multiple sclerosis

scientific article published on 24 June 2016

Fisher syndrome with delayed facial weakness and taste impairment: a case report

scientific article published on 28 September 2016

GSK3beta activity modifies the localization and function of presenilin 1.

scientific article published on 27 March 2007

Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling

scientific article published on 23 April 2012

Galantamine modulates nicotinic receptor and blocks Abeta-enhanced glutamate toxicity

scientific article published in December 2004

Galantamine-induced amyloid-{beta} clearance mediated via stimulation of microglial nicotinic acetylcholine receptors

scientific article

Generation of striatal neurons from human induced pluripotent stem cells by controlling extrinsic signals with small molecules

Gluten sensitivity in Japanese patients with adult-onset cerebellar ataxia.

scientific article published in March 2006

Heat shock protein-90-induced microglial clearance of exogenous amyloid-beta1-42 in rat hippocampus in vivo

scientific article

Heat-shock protein 105 interacts with and suppresses aggregation of mutant Cu/Zn superoxide dismutase: clues to a possible strategy for treating ALS.

scientific article published on 30 March 2007

High Fat Diet Enhances β-Site Cleavage of Amyloid Precursor Protein (APP) via Promoting β-Site APP Cleaving Enzyme 1/Adaptor Protein 2/Clathrin Complex Formation.

scientific article published on 28 September 2015

High mobility group box protein-1 inhibits microglial Abeta clearance and enhances Abeta neurotoxicity

scientific article published in December 2004

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

scientific article published on 3 December 2001

Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.

scientific article

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

scientific article published in February 2002

Hyperbilirubinemia protects against focal ischemia in rats

scientific article published in February 2003

Hyperemesis-induced Wernicke-Korsakoff Syndrome due to Hypergastrinemia during Long-term Treatment with Proton Pump Inhibitors

scientific article published on 14 July 2020

Hypersomnia caused by isolated angiitis of the CNS.

scientific article published in August 2005

Idiopathic normal pressure hydrocephalus has a different cerebrospinal fluid biomarker profile from Alzheimer's disease

scientific article published in January 2015

Impaired post-tetanic potentiation of muscle twitch in myasthenia gravis

scientific article published on 23 October 2015

Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells

scientific article published on 7 September 2006

Inhibitory effects of antiparkinsonian drugs and caspase inhibitors in a parkinsonian flatworm model

scientific article published in June 2003

Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease

scientific article

Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease

scientific article

Intravenous mesenchymal stem cell administration exhibits therapeutic effects against 6-hydroxydopamine-induced dopaminergic neurodegeneration and glial activation in rats

scientific article published in November 2014

Involvement of WAVE accumulation in Abeta/APP pathology-dependent tangle modification in Alzheimer's disease

scientific article published on 04 June 2009

Involvement of Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE) and Rac1 in the phagocytosis of amyloid-beta(1-42) in rat microglia

scientific article

Iron accelerates the conversion of dopamine-oxidized intermediates into melanin and provides protection in SH-SY5Y cells

scientific article published on October 2005

Ischemic Stroke with Protein S Deficiency Treated by Apixaban

scientific article published on 13 January 2020

Isolation of a diterpenoid substance with potent neuroprotective activity from fetal calf serum

scientific article

Latitude and HLA-DRB1 alleles independently affect the emergence of cerebrospinal fluid IgG abnormality in multiple sclerosis

scientific article

Latitude and HLA-DRB1*04:05 independently influence disease severity in Japanese multiple sclerosis: a cross-sectional study

scientific article published on 06 September 2016

Load effect on background rhythms during motor execution: A magnetoencephalographic study

scientific article published on 25 June 2016

Long-term clinical and radiological improvement of chronic acquired hepatocerebral degeneration after obliteration of portosystemic shunt: Report of a case

scientific article

Mesenchymal stem cells transmigrate across brain microvascular endothelial cell monolayers through transiently formed inter-endothelial gaps

scientific article published on 20 July 2011

Microglial Amyloid-β1-40 Phagocytosis Dysfunction Is Caused by High-Mobility Group Box Protein-1: Implications for the Pathological Progression of Alzheimer's Disease

scientific article

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins

scientific article published in April 2002

Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats

scientific article

Morphological change by overexpression of D385A dominant negative presenilin 1 in human neuroblastoma SH-SY5Y cells

scientific article published on 10 November 2006

Mouse Bone Marrow-derived Microglia-like Cells Secrete Transforming Growth Factor-β1 and Promote Microglial Aβ Phagocytosis and Reduction of Brain Aβ

scientific article published on 01 July 2020

Mutations in LGI1 gene in Japanese families with autosomal dominant lateral temporal lobe epilepsy: the first report from Asian families

scientific article published on 22 September 2009

Myopericarditis in a case of anti-signal recognition particle (anti-SRP) antibody-positive myopathy.

scientific article

N-cadherin enhances APP dimerization at the extracellular domain and modulates Aβ production

scientific article

N-cadherin regulates p38 MAPK signaling via association with JNK-associated leucine zipper protein: implications for neurodegeneration in Alzheimer disease

scientific article

N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio

scientific article published on 25 November 2008

Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

scientific article

Neuronal Survival and Death in Alzheimer Disease

Neuroprotective mechanisms of antiparkinsonian dopamine D2-receptor subfamily agonists

scientific article published in July 2003

Neuroprotective properties of Bcl-w in Alzheimer disease

scientific article

Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models

scientific article

Novel neuroprotective mechanisms of pramipexole, an anti-Parkinson drug, against endogenous dopamine-mediated excitotoxicity.

scientific article published on 14 November 2006

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients

scientific article published on 29 July 2016

PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model

scientific article published on 24 July 2006

PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity

scientific article

Pharmacological characteristics of rotational behavior in hemiparkinsonian rats transplanted with mouse embryonic stem cell-derived neurons

scientific article published on 4 September 2004

Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons

scientific article

Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-Δ12,14 Prostaglandin J2-Sensitive Microglial Activation

scientific article published on April 1, 2003

Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease

scientific article

Possible involvement of both mitochondria- and endoplasmic reticulum-dependent caspase pathways in rotenone-induced apoptosis in human neuroblastoma SH-SY5Y cells

scientific article published in November 2002

Possible involvement of group I mGluRs in neuroprotective effect of theanine

scientific article

Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane ⬇️

scientific article published on October 15, 2003

Presenilin 1 is involved in the maturation of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1).

scientific article published on January 2007

Presenilin 1 mediates retinoic acid-induced differentiation of SH-SY5Y cells through facilitation of Wnt signaling

scientific article published in July 2003

Progressive multifocal leukoencephalopathy after autologous peripheral blood stem cell transplantation in a patient with multiple myeloma treated with combination therapy

scientific article published on 22 July 2016

Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease

scientific article published on 08 December 2006

Proteasome inhibitors protect against degeneration of nigral dopaminergic neurons in hemiparkinsonian rats.

scientific article

Proteasome mediates dopaminergic neuronal degeneration, and its inhibition causes alpha-synuclein inclusions

scientific article published on 12 December 2003

Protective effect of dopamine D2 agonists in cortical neurons via the phosphatidylinositol 3 kinase cascade.

scientific article published in November 2002

Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons.

scientific article published on 25 April 2005

Protein trafficking and Alzheimer's disease

scientific article

Proteome analysis of brain proteins in Alzheimer's disease: subproteomics following sequentially extracted protein preparation.

scientific article

Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates

scientific article published in July 2007

Recovery of focal brain ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia

scientific article

Relationship between dysphagia and depressive states in patients with Parkinson's disease

scientific article published on 01 April 2011

Respiratory insufficiency with preserved diaphragmatic function in amyotrophic lateral sclerosis

scientific article

Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study

scientific article published in March 2010

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

scientific article

Role of Suppressor of Cytokine Signaling 3 (SOCS3) in Altering Activated Microglia Phenotype in APPswe/PS1dE9 Mice

scientific article published on 3 November 2016

Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis

scientific article published in February 2003

Roles of Nicotinic Acetylcholine Receptors in the Pathology and Treatment of Alzheimer’s and Parkinson’s Diseases

SIRT1 deficiency interferes with membrane resealing after cell membrane injury

scientific article published on 26 June 2019

Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemi-parkinsonian rats

scientific article published on 31 August 2005

Severe Mononeuritis Multiplex due to Rheumatoid Vasculitis in Rheumatoid Arthritis in Sustained Clinical Remission for Decades

scientific article published on 18 November 2019

Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimer's and Parkinson's diseases

scientific article published on January 2011

Stimulation of nicotinic acetylcholine receptors protects motor neurons.

scientific article published in May 2005

Streptococcus oralis Meningitis with Gingival Bleeding in a Patient: A Case Report and Review of the Literature

scientific article published on 30 September 2020

Successful intervention for overwhelming postsplenectomy infection caused by non-vaccine pneumococcal serotype 23A

scientific article published on 01 March 2020

Synergistic effect of galantamine on nicotine-induced neuroprotection in hemiparkinsonian rat model

scientific article

Temporal changes of CD68 and α7 nicotinic acetylcholine receptor expression in microglia in Alzheimer's disease-like mouse models

scientific article published in January 2015

The Japanese Early-Stage Trial of High-Dose Methylcobalamin for Amyotrophic Lateral Sclerosis (JETALS): Protocol for a Randomized Controlled Trial

scientific article published on 21 December 2018

The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease

scientific article

The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities

scientific article

The spectrum of clinicopathological features in pure autonomic neuropathy

scientific article published on 24 February 2012

Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice.

scientific article

Therapy for Alzheimer-type dementia-status quo and future considerations

scientific article published in April 2013

Thyrotoxic myopathy mimicking myasthenic syndrome associated with thymic hyperplasia

scientific article

Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept

scientific article published on January 2003

Toxin-induced and genetic animal models of Parkinson's disease

scientific article published on 22 December 2010

Transient oculomotor palsy correlated with nerve enhancement on MRI in chronic inflammatory demyelinating polyneuropathy

scientific article published on 16 November 2009

Transplantation of Mesenchymal Stem Cells Improves Amyloid-β Pathology by Modifying Microglial Function and Suppressing Oxidative Stress

scientific article published on 01 January 2019

Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats

scientific article published on October 2005

Transport and toxic mechanism for aluminum citrate in human neuroblastoma SH-SY5Y cells

scientific article published on 27 January 2006

Variations in the BDNF gene in autopsy-confirmed Alzheimer's disease and dementia with Lewy bodies in Japan

scientific article published on 7 August 2006

[A case of Marchiafava-Bignami disease suggesting vasogenic edema].

scientific article published on 30 November 2015

[A case of atypical Tolosa-Hunt syndrome with a contrast enhanced lesion of the oculomotor and trigeminal nerves on MRI]

scientific article published on 01 January 2014

[A case of dural arteriovenous fistula of right cavernous sinus presenting bilateral eye symptoms]

scientific article published on 19 September 2015

[A case with temporal lobe epilepsy associated with hypocalcemia due to primary hypoparathyroidism]

scientific article published on 01 July 2006

[Anti-dementia drugs].

scientific article published in August 2012

[Current concepts regarding cortical dementia].

scientific article

[Dementia: progress in diagnosis and treatment; Topics, I. Basic knowledge of dementia and pathophysiology; 1. The concept and pathophysiology of dementia of Alzheimer-type].

scientific article published in August 2011

[Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions].

scientific article

[Dramatic seizure reduction with levetiracetam in adult Dravet syndrome: a case report]

scientific article published on 01 January 2015

[Focal cortical dysplasia at the primary somatosensory cortex could manifest both intractable partial epilepsy and cortical reflex myoclonus]

scientific article published on 01 May 2006

[Galantamine]

scientific article published on 01 December 2011

[Lewy bodies: neuroprotective?]

scientific article published on 01 November 2006

[Nucleus basalis of Meynert and cholinergic neurotransmission].

scientific article published in October 2011

[Sporadic adult-onset neuronal intranuclear inclusion disease with abnormal electroretinogram, nerve conduction studies and somatosensory evoked potential]

scientific article published on 01 June 2018

[Treatment outcome of patients with cranial base lesions of unknown etiology: focusing on infectious cases with multiple cranial nerve disorders]

scientific article published on 01 January 2013

[Two cases of photosensitive seizure induced by barcode readers with red flashing lights]

scientific article published on 29 September 2018

[Unilateral ptosis induced by pure midbrain infarction: a case report]

scientific article published on 07 July 2020

p-Quinone mediates 6-hydroxydopamine-induced dopaminergic neuronal death and ferrous iron accelerates the conversion of p-quinone into melanin extracellularly.

scientific article published on March 2005

α4 nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior

scientific article

α7 nicotinic acetylcholine receptor mediated neuroprotection in Parkinson's disease

scientific article published on May 2012

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