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List of works by Alistair S Brown

A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening

scientific article published on 25 March 2023

A sensitive single-enzyme assay system using the non-ribosomal peptide synthetase BpsA for measurement of L-glutamine in biological samples

scientific article published on 31 January 2017

Bioactivity-Guided Metabolite Profiling of Feijoa ( Acca sellowiana) Cultivars Identifying 4-Cyclopentene-1,3-dione as a Potent Antifungal Inhibitor of Chitin Synthesis.

scientific article published on 16 March 2018

Crystal structure of the essential Mycobacterium tuberculosis phosphopantetheinyl transferase PptT, solved as a fusion protein with maltose binding protein

scientific article

Directed Evolution of the Nonribosomal Peptide Synthetase BpsA to Enable Recognition by the Human Phosphopantetheinyl Transferases for Counter-Screening Antibiotic Candidates

scientific article published on 29 October 2020

Engineering the indigoidine-synthesising enzyme BpsA for diverse applications in biotechnology

2018 doctoral thesis by Alistair Brown at Victoria University of Wellington

High-Throughput Screening for Inhibitors of the SARS-CoV-2 Protease Using a FRET-Biosensor

scientific article published on 13 October 2020

Inhibition of Indigoidine Synthesis as a High-Throughput Colourimetric Screen for Antibiotics Targeting the Essential Phosphopantetheinyl Transferase PptT

scientific article published on 12 July 2021

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

scientific article published on 15 September 2020

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

scientific article published on 25 April 2020

Metagenomic Exploration of the Marine Sponge Mycale hentscheli Uncovers Multiple Polyketide-Producing Bacterial Symbionts

scientific article published on 24 March 2020

Structural, functional and evolutionary perspectives on effective re-engineering of non-ribosomal peptide synthetase assembly lines

scientific article published on 01 November 2018

The indigoidine synthetase BpsA provides a colorimetric ATP assay that can be adapted to quantify the substrate preferences of other NRPS enzymes

scientific article published on 17 July 2020

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