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List of works by Roger G Ptak

A novel anti-HIV active integrase inhibitor with a favorable in vitro cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase metabolism profile.

scientific article

A sensitive virus yield assay for evaluation of Antivirals against Zika Virus

scientific article (publication date: December 2016)

Albumin-conjugated C34 peptide HIV-1 fusion inhibitor: equipotent to C34 and T-20 in vitro with sustained activity in SCID-hu Thy/Liv mice

scientific article published on 22 September 2008

Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication

scientific article published on 17 October 2016

An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.

scientific article published on 4 November 2016

Application of the synthetic aminosugars for glycodiversification: synthesis and antimicrobial studies of pyranmycin

scientific article published in March 2004

Cataloguing the HIV type 1 human protein interaction network

scientific article

Correlation of Naturally Occurring HIV-1 Resistance to DEB025 with Capsid Amino Acid Polymorphisms ⬇️

scientific article published on March 22, 2013

Cross-reactive HIV-1-neutralizing activity of serum IgG from a rabbit immunized with gp41 fused to IgG1 Fc: possible role of the prolonged half-life of the immunogen

scientific article

Development of Indole Compounds as Small Molecule Fusion Inhibitors Targeting HIV-1 Glycoprotein-41 ⬇️

scientific article published on October 3, 2011

Development of a comprehensive human immunodeficiency virus type 1 screening algorithm for discovery and preclinical testing of topical microbicides.

scientific article published on 3 March 2008

Development of hexadecyloxypropyl tenofovir (CMX157) for treatment of infection caused by wild-type and nucleoside/nucleotide-resistant HIV.

scientific article

Development of real-time PCR array for simultaneous detection of eight human blood-borne viral pathogens

scientific article

Dimer initiation signal of human immunodeficiency virus type 1: its role in partner selection during RNA copackaging and its effects on recombination

scientific article published on 31 January 2007

Dimeric RNA recognition regulates HIV-1 genome packaging

scientific article

Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement

scientific article published on December 2014

Discovery of a small-molecule antiviral targeting the HIV-1 matrix protein.

scientific article published on 29 November 2012

Effector memory differentiation increases detection of replication-competent HIV-l in resting CD4+ T cells from virally suppressed individuals

scientific article published on 14 October 2019

Enhanced potency of bivalent small molecule gp41 inhibitors

scientific article

Evaluation of PD 404,182 as an anti-HIV and anti-herpes simplex virus microbicide

scientific article

Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs

scientific article published on 6 July 2017

Exploring Modifications of an HIV-1 Capsid Inhibitor: Design, Synthesis, and Mechanism of Action

article

HIV integrase inhibitors with nucleobase scaffolds: discovery of a highly potent anti-HIV agent

scientific article published on January 2006

HIV-1 regulatory proteins: targets for novel drug development

scientific article

HIV-1, human interaction database: current status and new features

scientific article

Heterocyclic compounds that inhibit Rev-RRE function and human immunodeficiency virus type 1 replication

scientific article

Highly Potent Chimeric Inhibitors Targeting Two Steps of HIV Cell Entry ⬇️

scientific article published on June 9, 2011

Human immunodeficiency virus type 1, human protein interaction database at NCBI.

scientific article

IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro

scientific article published on 05 December 2020

Identification of a novel HIV-1 inhibitor targeting Vif-dependent degradation of human APOBEC3G protein

scientific article

Identification of a small-molecule inhibitor of HIV-1 assembly that targets the phosphatidylinositol (4,5)-bisphosphate binding site of the HIV-1 matrix protein.

scientific article

Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid

scientific article published on 30 May 2012

Inhibition of HIV-1 Replication by Amphotericin B Methyl Ester

scientific article published in Journal of Biological Chemistry

Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms

scientific article published on October 2004

Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef

scientific article

Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent

scientific article

Mechanisms of human immunodeficiency virus type 2 RNA packaging: efficient trans packaging and selection of RNA copackaging partners.

scientific article

Molecular evidence of HIV-1 transmission in a criminal case

scientific article

Moloney leukemia virus 10 (MOV10) protein inhibits retrovirus replication

scientific article

Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication

scientific article published on 23 October 2009

Nucleosides with self-complementary hydrogen-bonding motifs: synthesis and base-pairing studies of two nucleosides containing the imidazo[4,5-d]pyridazine ring system

scientific article published on 9 June 2006

Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formation

scientific article published on April 2006

Phosphorylation of beta-D-ribosylbenzimidazoles is not required for activity against human cytomegalovirus

scientific article

Potent Strategy To Inhibit HIV-1 by Binding both gp120 and gp41 ⬇️

scientific article published on October 18, 2010

Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1.

scientific article

Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1. ⬇️

scientific article published on 30 June 2015

Resistance of human cytomegalovirus to the benzimidazole L-ribonucleoside maribavir maps to UL27

scientific article

Structure-activity relationship studies of indole-based compounds as small molecule HIV-1 fusion inhibitors targeting glycoprotein 41.

scientific article

Structure-activity relationships of a novel capsid targeted inhibitor of HIV-1 replication

scientific article published on 28 October 2014

Suboptimal inhibition of protease activity in human immunodeficiency virus type 1: effects on virion morphogenesis and RNA maturation

scientific article published on 26 July 2008

Synergistic Antiviral activity of Sofosbuvir and Type -I Interferons (α and β) against Zika virus

scientific article

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