List of works - Dimitri Y Chirgadze

5-Formylcytosine alters the structure of the DNA double helix

scientific article published on 15 December 2014

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

scientific article

A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping

scientific article

A new look at sodium channel β subunits

scientific article published on January 2015

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.

scientific article published on 5 May 2015

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

scientific article published on 11 May 2017

Asymmetry in the Multiprotein Systems of Molecular Biology

scholarly article by Tom Blundell published in January 2015

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain ⬇️

scientific article published on 21 August 2017

Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis.

scientific article

Crystal Structure and Molecular Imaging of the Nav Channel 3 Subunit Indicates a Trimeric Assembly

scientific article

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

scientific article

Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity

scientific article

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

scientific article

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

scientific article

Crystal structure of the PepSY-containing domain of the YpeB protein involved in germination of bacillus spores

scientific article

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

scientific article

Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein

scientific article published in November 2005

Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate

scientific article published on 11 January 2006

Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis

scientific article published on 01 October 2006

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

scientific article published on 2 February 2017

DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.

scientific article

Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.

scientific article

Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa

scientific article published on 20 July 2018

High-resolution crystal structure of the human Notch 1 ankyrin domain

scientific article

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

scientific article

Knowledge-based real-space explorations for low-resolution structure determination.

scientific article

Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)

scientific article

Nanostructured films from hierarchical self-assembly of amyloidogenic proteins

scientific article published on 28 February 2010

Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions

scientific article published in October 2011

Nucleophile Selectivity of Chorismate-Utilizing Enzymes

scholarly article by Olivier Kerbarh published in April 2007

Snapshot of protein structure evolution reveals conservation of functional dimerization through intertwined folding.

scientific article

Spatial and Temporal Organisation of Multiprotein Systems of Cell Regulation and Signalling: What Can We Learn from NHEJ System of Double-Strand Break Repair?

scientific article published on 17 October 2011

Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems

scientific article published in June 2012

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK

scientific article

Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

scientific article published on 3 July 2012

Structural and functional analysis of SleL, a peptidoglycan lysin involved in germination of Bacillus spores

scientific article

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

scientific article

Structural basis for collagen recognition by the immune receptor OSCAR.

scientific article published on 9 November 2015

Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining

scientific article published on 25 August 2010

Structural constraints on protein self-processing in L-aspartate- -decarboxylase

scientific article

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

scientific article

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

article

Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.

scientific article published on 8 April 2015

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode

scientific article published on 18 January 2006

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

scientific article published on 17 March 2020

The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination

scientific article

The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores

scientific article

The effect of protein-precipitant interfaces and applied shear on the nucleation and growth of lysozyme crystals

scientific article published on 22 October 2009

Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways

scientific article published on 20 April 2019

List of works by Dimitri Y Chirgadze

5-Formylcytosine alters the structure of the DNA double helix

A Nanobody Binding to Non-Amyloidogenic Regions of the Protein Human Lysozyme Enhances Partial Unfolding but Inhibits Amyloid Fibril Formation

A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping

A new look at sodium channel β subunits

Achieving high signal-to-noise in cell regulatory systems: Spatial organization of multiprotein transmembrane assemblies of FGFR and MET receptors.

Amyloid-like Fibrils from an α-Helical Transmembrane Protein

Asymmetry in the Multiprotein Systems of Molecular Biology

Characterization and structural determination of a new anti-MET function-blocking antibody with binding epitope distinct from the ligand binding domain ⬇️

Coupling growth-factor engineering with nanotechnology for therapeutic angiogenesis.

Crystal Structure and Molecular Imaging of the Nav Channel 3 Subunit Indicates a Trimeric Assembly

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ

Crystal structure of the PepSY-containing domain of the YpeB protein involved in germination of bacillus spores

Crystal structure of the TSH receptor in complex with a thyroid-stimulating autoantibody

Crystal structure of the beta-chain of human hepatocyte growth factor-like/macrophage stimulating protein

Crystal structures of Yersinia enterocolitica salicylate synthase and its complex with the reaction products salicylate and pyruvate

Crystal structures of the PLP- and PMP-bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

DNA-PKcs, Allostery, and DNA Double-Strand Break Repair: Defining the Structure and Setting the Stage.

Expanding the solvent chemical space for self-assembly of dipeptide nanostructures.

Gluconeogenic precursor availability regulates flux through the glyoxylate shunt in Pseudomonas aeruginosa

High-resolution crystal structure of the human Notch 1 ankyrin domain

Inhibition ofMycobacterium tuberculosisPantothenate Synthetase by Analogues of the Reaction Intermediate

Knowledge-based real-space explorations for low-resolution structure determination.

Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1)

Nanostructured films from hierarchical self-assembly of amyloidogenic proteins

Non-homologous end-joining partners in a helical dance: structural studies of XLF-XRCC4 interactions

Nucleophile Selectivity of Chorismate-Utilizing Enzymes

Snapshot of protein structure evolution reveals conservation of functional dimerization through intertwined folding.

Spatial and Temporal Organisation of Multiprotein Systems of Cell Regulation and Signalling: What Can We Learn from NHEJ System of Double-Strand Break Repair?

Spatial and temporal organization of multi-protein assemblies: achieving sensitive control in information-rich cell-regulatory systems

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK

Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

Structural and functional analysis of SleL, a peptidoglycan lysin involved in germination of Bacillus spores

Structural and functional insights into the role of the N-terminal Mps1 TPR domain in the SAC (spindle assembly checkpoint)

Structural basis for collagen recognition by the immune receptor OSCAR.

Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining

Structural constraints on protein self-processing in L-aspartate- -decarboxylase

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

Structure of a Blinkin-BUBR1 Complex Reveals an Interaction Crucial for Kinetochore-Mitotic Checkpoint Regulation via an Unanticipated Binding Site

Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression.

Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode

The Influence of Pathogenic Mutations in α-Synuclein on Biophysical and Structural Characteristics of Amyloid Fibrils

The crystal structure of Clostridium perfringens SleM, a muramidase involved in cortical hydrolysis during spore germination

The crystal structure of the N-terminal region of BUB1 provides insight into the mechanism of BUB1 recruitment to kinetochores

The effect of protein-precipitant interfaces and applied shear on the nucleation and growth of lysozyme crystals

Understanding the structure and role of DNA-PK in NHEJ: How X-ray diffraction and cryo-EM contribute in complementary ways