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List of works by Stuart Schreiber

6-Phosphogluconate Dehydrogenase Links Cytosolic Carbohydrate Metabolism to Protein Secretion via Modulation of Glutathione Levels

scientific article published on 13 June 2019

A Candidate Cell-Selective Anticancer Agent

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

scientific article published on 01 November 2019

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

scientific article published on 08 April 2019

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.

scientific article published in November 2017

A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells

scientific article

A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake - Probe 3 ⬇️

scientific article published on June 14, 2013

A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 1 ⬇️

scientific article published on September 18, 2014

A Small Molecule Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake—Probe 2 ⬇️

scientific article published on September 18, 2014

A Small Molecule Inhibitor of the MITF Molecular Pathway

scientific article published on 18 September 2014

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

scientific article (publication date: 21 April 2006)

A cell-based, high-throughput screen for small molecule regulators of hepatitis C virus replication

scientific article

A dataset of images and morphological profiles of 30,000 small-molecule treatments using the Cell Painting assay

scientific article

A genetic basis for the variation in the vulnerability of cancer to DNA damage

scientific article

A human islet cell culture system for high-throughput screening

scientific article

A library of spirooxindoles based on a stereoselective three-component coupling reaction.

scientific article

A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold

scientific article

A precision oncology approach to the pharmacological targeting of mechanistic dependencies in neuroendocrine tumors

scientific article published on 18 June 2018

A robust small-molecule microarray platform for screening cell lysates

scientific article published on May 2006

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

scientific article

A small molecule suppressor of FK506 that targets the mitochondria and modulates ionic balance in Saccharomyces cerevisiae

scientific article published in June 2003

A small molecule that binds Hedgehog and blocks its signaling in human cells

scientific article

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

scientific article published on 3 July 2017

A small-molecule inducer of PDX1 expression identified by high-throughput screening.

scientific article

A small-molecule probe of the histone methyltransferase G9a induces cellular senescence in pancreatic adenocarcinoma

scientific article

AACR Cancer Progress Report 2012 ⬇️

scientific article published on September 11, 2012

AAK1 identified as an inhibitor of neuregulin-1/ErbB4-dependent neurotrophic factor signaling using integrative chemical genomics and proteomics.

scientific article

Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes

scientific article

Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers

scientific article published on 26 May 2020

Allosteric inhibitors of Mycobacterium tuberculosis tryptophan synthase

scientific article published on 20 January 2020

Amino acid metabolic origin as an evolutionary influence on protein sequence in yeast

scientific article published on 09 April 2009

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

scientific article published on 24 July 2020

An Oligomer-Based Approach to Skeletal Diversity in Small-Molecule Synthesis

scientific article published on 01 November 2006

An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules.

scientific article

Antisense oligonucleotides extend survival of prion-infected mice

scientific article published on 30 July 2019

Atg16L1 T300A variant decreases selective autophagy resulting in altered cytokine signaling and decreased antibacterial defense

scientific article

Atg16l1 is required for autophagy in intestinal epithelial cells and protection of mice from Salmonella infection

scientific article published on 21 August 2013

Automated Structure-Activity Relationship Mining: Connecting Chemical Structure to Biological Profiles

scientific article published on 7 April 2014

Benzo-fused lactams from a diversity-oriented synthesis (DOS) library as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

scientific article published on April 2015

Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase

scientific article published on 01 September 2020

Binding affinity and kinetic analysis of targeted small molecule-modified nanoparticles.

scientific article

CTD2 Dashboard: a searchable web interface to connect validated results from the Cancer Target Discovery and Development Network

scientific article published in January 2017

Carbon metabolism-mediated myogenic differentiation

scientific article published on 17 January 2010

Ceestatin, a novel small molecule inhibitor of hepatitis C virus replication, inhibits 3-hydroxy-3-methylglutaryl-coenzyme A synthase

scientific article

Characterization of the Prion Protein Binding Properties of Antisense Oligonucleotides

scientific article published on 18 December 2019

ChemBank: a small-molecule screening and cheminformatics resource database

scientific article

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 1 ⬇️

scientific article published on June 3, 2011

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 2

scientific article published on 3 June 2011

Chemical Genetic Analysis of Platelet Granule Secretion-Probe 3 ⬇️

scientific article published on June 3, 2011

Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation

scientific article published in May 2003

Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

scientific article

Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling

scientific article

Chemical genomic profiling of biological networks using graph theory and combinations of small molecule perturbations

scientific article

Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation

scientific article

Chemical probes and drug leads from advances in synthetic planning and methodology.

scientific article published on 13 April 2018

Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation

scientific article published on 18 April 2004

Chemoproteomics quantifies complexity ⬇️

scientific article published on 01 March 2011

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

scientific article published on 20 March 2012

Cinnamides as selective small-molecule inhibitors of a cellular model of breast cancer stem cells

scientific article

Complex alpha-pyrones synthesized by a gold-catalyzed coupling reaction

scientific article published on January 2007

Control of Olefin Geometry in Macrocyclic Ring-Closing Metathesis Using a Removable Silyl Group ⬇️

scientific article published on May 27, 2011

Copper-mediated amidation of heterocyclic and aromatic C-H bonds

scientific article

Correction: GW8510 Increases Insulin Expression in Pancreatic Alpha Cells through Activation of p53 Transcriptional Activity

scientific article published on 7 March 2012

Correlating chemical sensitivity and basal gene expression reveals mechanism of action.

scientific article

Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity

scientific article

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

scientific article published on 17 February 2020

DNA Barcoding a Complete Matrix of Stereoisomeric Small Molecules

scientific article published on 25 June 2019

DNA-Compatible [3 + 2] Nitrone-Olefin Cycloaddition Suitable for DEL Syntheses

scientific article published on 14 February 2019

Deacetylase enzymes: biological functions and the use of small-molecule inhibitors

scientific article

Decoding Products of Diversity Pathways from Stock Solutions Derived from Single Polymeric Macrobeads H.E.B. and L.P. contributed equally to this work. We thank the National Institute of General Medical Sciences (GM-52067) for the support of this re

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

scientific article

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity.

scientific article

Development and validation of a T7 based linear amplification for genomic DNA ⬇️

scientific article published on May 9, 2003

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo

scientific article published on 25 May 2016

Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia

scientific article

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

scientific article

DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets

scientific article published on 24 March 2016

Diacylfuroxans Are Masked Nitrile Oxides That Inhibit GPX4 Covalently

scientific article published on 16 December 2019

Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts

scientific article published on 14 September 2011

Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).

scientific article

Direct control of mitochondrial function by mTOR.

scientific article

Discovering Small Molecules that Overcome Differentiation Arrest in Acute Myeloid Leukemia

Discovery and Evaluation of Fungicidal Anti-Cryptococcal Molecules

Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.

scientific article

Discovery of 8-Membered Ring Sulfonamides as Inhibitors of Oncogenic Mutant Isocitrate Dehydrogenase 1.

scientific article published on 18 August 2016

Discovery of Antimalarial Azetidine-2-carbonitriles That Inhibit P. falciparum Dihydroorotate Dehydrogenase

scientific article (publication date: 13 April 2017)

Discovery of Inhibitors of Anti-Apoptotic Protein A1 ⬇️

scientific article published on July 27, 2012

Discovery of Potent and Highly Selective Inhibitors of GSK3b ⬇️

scientific article published on May 13, 2014

Discovery of a Small Molecule Activator of the Hypoxia Inducible Factor Pathway

Discovery of a Small-Molecule Probe for V-ATPase Function

scientific article published on 20 April 2015

Discovery of a small-molecule inhibitor and cellular probe of Keap1–Nrf2 protein–protein interaction ⬇️

scientific article published on March 14, 2013

Discovery of an inhibitor of a transcription factor using small molecule microarrays and diversity-oriented synthesis

scientific article

Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake

scientific article published on 11 April 2015

Discovery of histone deacetylase 8 selective inhibitors ⬇️

scientific article published on February 2, 2011

Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myeloma

scientific article

Discovery of small molecule probe that shows anti-tubercular activity via Mtb bioA (DAPA synthase) enzyme inhibition

Discovery of small-molecule enhancers of reactive oxygen species that are nontoxic or cause genotype-selective cell death.

scientific article

Discovery of small-molecule modulators of the Sonic Hedgehog pathway.

scientific article

Disease allele-dependent small-molecule sensitivities in blood cells from monogenic diabetes ⬇️

scientific article published on December 23, 2010

Distinct biological network properties between the targets of natural products and disease genes

scientific article published on July 2010

Divergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives

scientific article

Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway

scientific article published on 30 May 2008

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

scientific article

Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform

scientific article

Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors

scientific article

Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease

scientific article

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

scientific article (publication date: 7 September 2016)

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents

scientific article

Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation

scholarly article

Domain-specific Quantification of Prion Protein in Cerebrospinal Fluid by Targeted Mass Spectrometry

scientific article published on 26 September 2019

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition.

scientific article

Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments

scientific article published on 12 August 2016

Elucidation of the physiology of non-replicating, drug tolerant Mycobacterium tuberculosis with the aid of the small molecule probe ML338

scholarly article published 22 November 2013

Empirical Bayes analysis of quantitative proteomics experiments

scientific article

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

scientific article published in Nature

Erratum: Corrigendum: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

scientific article published on 16 September 2015

Erratum: Corrigendum: The promise and peril of chemical probes

scientific article published in November 2015

Evaluating drug targets through human loss-of-function genetic variation

scientific article published on 27 May 2020

Evaluating potential drug targets through human loss-of-function genetic variation

scientific article

Evolutionarily conserved optimization of amino acid biosynthesis.

scientific article published on 7 August 2007

Expanding Stereochemical and Skeletal Diversity Using Petasis Reactions and 1,3-Dipolar Cycloadditions ⬇️

scientific article published on October 26, 2010

Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

scientific article

Fluorous-based small-molecule microarrays for the discovery of histone deacetylase inhibitors

scientific article published on January 2007

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity

scientific article

Gene Expression-Based Screen for Parkinson's Disease Identifies GW8510 as a Neuroprotective Agent.

scientific article

Genetic basis of individual differences in the response to small-molecule drugs in yeast

article

Global approaches to chromatin

scientific article

Global nucleosome occupancy in yeast

scientific article

Gold(I)-catalyzed coupling reactions for the synthesis of diverse small molecules using the build/couple/pair strategy

scientific article published in April 2009

HDAC6 inhibitors modulate Lys49 acetylation and membrane localization of β-catenin in human iPSC-derived neuronal cells

scientific article

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset.

scientific article

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth

scientific article published on 28 August 2018

High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission

scientific article

High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria

scientific article

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

scientific article

Histone Variant H2A.Z Marks the 5′ Ends of Both Active and Inactive Genes in Euchromatin

article

Identification and characterization of small molecule inhibitors of a class I histone deacetylase from Plasmodium falciparum

scientific article (publication date: 23 April 2009)

Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection

scientific article

Identification of Small Molecule Inhibitors that Suppress Cytokine-Induced Apoptosis in Human Pancreatic Islet Cells ⬇️

scientific article published on November 4, 2011

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3 ⬇️

scientific article published on July 27, 2012

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection

scientific article published on 3 June 2011

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 1

Identification of Small-Molecule Inhibitors of Trypansoma cruzi Infection - Probe 3

Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells - Probe 3

Identification of a Selective Small-Molecule Inhibitor of Breast Cancer Stem Cells—Probe 2

Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe

scholarly article published 4 April 2015

Identification of a selective small molecule inhibitor of breast cancer stem cells

scientific article

Identification of a small molecule that selectively activates alpha-synuclein translational expression

scientific article published on 3 June 2011

Identification of a small molecule that selectively inhibits alpha-synuclein translational expression ⬇️

scientific article published on June 3, 2011

Identification of a small-molecule inhibitor of class Ia PI3Ks with cell-based screening

scientific article published on April 2007

Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.

scientific article

Identification of regulators of polyploidization presents therapeutic targets for treatment of AMKL

scientific article

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence ⬇️

scientific article published on June 14, 2013

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2 ⬇️

scientific article published on July 27, 2012

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 1 ⬇️

scientific article published on July 8, 2011

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 2 ⬇️

scientific article published on July 8, 2011

Identification of small molecules that selectively inhibit streptokinase expression without suppression of viability in Group A streptococci - Probe 3 ⬇️

scientific article published on July 8, 2011

Identification of small-molecule inhibitors of Trypansoma cruzi replication

scientific article

Identifying Cellular Targets of Small-Molecule Probes and Drugs with Biochemical Enrichment and SILAC ⬇️

scientific article published on January 1, 2012

Identifying the proteins to which small-molecule probes and drugs bind in cells

scholarly article

Indolinyl-Thiazole Based Inhibitors of Scavenger Receptor-BI (SR-BI)-Mediated Lipid Transport

scientific article published on 2 February 2015

Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.

scientific article

Inhibition of Histone Deacetylase 3 Protects Beta Cells from Cytokine-Induced Apoptosis ⬇️

scientific article published on June 22, 2012

Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile.

scientific article published on 29 April 2016

Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects

scientific article

Integrated genetic and pharmacologic interrogation of rare cancers

scientific article

Integration of Growth Factor and Nutrient Signaling

scientific article (publication date: August 2003)

Integration of growth factor and nutrient signaling: implications for cancer biology

scientific article (publication date: August 2003)

Integrative radiogenomic profiling of squamous cell lung cancer

scientific article published on 26 August 2013

KRAS Genomic Status Predicts the Sensitivity of Ovarian Cancer Cells to Decitabine

scientific article

Kinase-Independent Small-Molecule Inhibition of JAK-STAT Signaling

scientific article

Large-scale chemical dissection of mitochondrial function

scientific article

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

scientific article

Ligand-Enabled β-Methylene C(sp3 )-H Arylation of Masked Aliphatic Alcohols

scientific article published on 12 February 2020

Linking tumor mutations to drug responses via a quantitative chemical-genetic interaction map.

scientific article published on 12 December 2014

MB-103DiSCoVERing INNOVATIVE THERAPIES: COMBINING GENETICALLY ACCURATE DISEASE MODELS OF MEDULLOBLASTOMA WITH ADVANCED IN SILICO ANALYSIS TO IDENTIFY NOVEL THERAPEUTIC TARGETS.

scientific article published on 30 May 2016

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans ⬇️

scientific article published on July 26, 2013

ML238: An Antimalarial Small Molecule of a Unique Structural Class

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

scientific article published on 30 August 2012

Macrocycloadditions leading to conformationally restricted small molecules

scientific article published on 01 May 2006

Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors

scientific article

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

scientific article published on 25 September 2019

Methylation of Histone H3 K4 Mediates Association of the Isw1p ATPase with Chromatin

scientific article published on 07 June 2018

Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin

scientific article published in November 2003

Methylation of histone H3 Lys 4 in coding regions of active genes

scientific article

Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

scientific article

Modular, Stereocontrolled Cβ–H/Cα–C Activation of Alkyl Carboxylic Acids

scientific article published on 30 January 2019

Modular, stereocontrolled C-H/C-C activation of alkyl carboxylic acids

scientific article published on 17 April 2019

Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays

scientific article

Multimodal small-molecule screening for human prion protein binders

scientific article published on 28 July 2020

Multiplex cytological profiling assay to measure diverse cellular states

scientific article (publication date: 2013)

NAMPT is the cellular target of STF-31-like small-molecule probes

scientific article published on 7 August 2014

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors.

scientific article published on 4 February 2015

Niche-based screening identifies small-molecule inhibitors of leukemia stem cells

scientific article

Optimization of PDE3A Modulators for SLFN12-Dependent Cancer Cell Killing

scientific article published on 18 October 2019

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

scientific article

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

scientific article

Perturbational profiling of nanomaterial biologic activity

scholarly article

Phosphorylation-Inducing Chimeric Small Molecules

scientific article published on 04 August 2020

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

scientific article

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

scientific article published on 16 September 2020

Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints

scientific article published on 10 August 2020

Prion protein quantification in cerebrospinal fluid as a tool for prion disease drug development

article

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development

scientific article published on 01 April 2019

Quantifying fitness distributions and phenotypic relationships in recombinant yeast populations

scholarly article

Quantifying structure and performance diversity for sets of small molecules comprising small-molecule screening collections ⬇️

scientific article published on April 11, 2011

Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming

scientific article (publication date: 2014)

RETRACTED: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

RETRACTED scientific article

RWEN: response-weighted elastic net for prediction of chemosensitivity of cancer cell lines

scientific article published on 01 October 2018

Real-Time Biological Annotation of Synthetic Compounds.

scientific article

Recent achievements and current trajectories of diversity-oriented synthesis

scientific article published on 14 October 2019

Regulation of ferroptotic cancer cell death by GPX4

scientific article

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

scientific article published on 01 November 2004

Renal medullary carcinomas depend upon loss and are sensitive to proteasome inhibition

scientific article published on 12 March 2019

Retraction Note: Selective killing of cancer cells by a small molecule targeting the stress response to ROS

scientific article published in Nature

Revealing complex traits with small molecules and naturally recombinant yeast strains

scientific article published in March 2006

Rhabdoid Tumors Are Sensitive to the Protein-Translation Inhibitor Homoharringtonine

scientific article published on 06 July 2020

Ring-opening and ring-closing reactions of a shikimic acid-derived substrate leading to diverse small molecules

scientific article published on 01 March 2007

Rpd3p relocation mediates a transcriptional response to rapamycin in yeast

scientific article

SIR1, an upstream component in auxin signaling identified by chemical genetics

scientific article

STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability ⬇️

scientific article published on February 9, 2012

Screen for Inhibitors of STK33 Kinase Activity ⬇️

scientific article published on May 13, 2014

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 1 ⬇️

scientific article published on June 3, 2011

Screen for RAS-Selective Lethal Compounds and VDAC Ligands - Probe 2 ⬇️

scientific article published on July 27, 2012

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

scientific article published on March 2017

Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

scientific article published on 30 March 2020

Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules

scientific article

Short synthesis of skeletally and stereochemically diverse small molecules by coupling petasis condensation reactions to cyclization reactions

scientific article (publication date: 26 May 2006)

Signaling network model of chromatin

scientific article (publication date: 13 December 2002)

Skeletal diversity in small-molecule synthesis using ligand-controlled catalysis

scientific article published on 26 October 2007

Small molecule enhancers of rapamycin-induced TOR inhibition promote autophagy, reduce toxicity in Huntington's disease models and enhance killing of mycobacteria by macrophages

scientific article

Small molecule modulation of the human chromatid decatenation checkpoint

scientific article published on December 2003

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models.

scientific article

Small molecules of different origins have distinct distributions of structural complexity that correlate with protein-binding profiles ⬇️

scientific article published on October 18, 2010

Small molecules, big players: the National Cancer Institute's Initiative for Chemical Genetics

scientific article published in September 2006

Small-Molecule Suppressors of Cytokine-Induced beta-Cell Apoptosis.

scientific article

Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

scientific article published on 01 August 2019

Small-molecule control of cytokine function: new opportunities for treating immune disorders

scientific article

Small-molecule diversity using a skeletal transformation strategy

scientific article published on 01 June 2005

Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics

scientific article published on 20 July 2015

Small-molecule fluorophores to detect cell-state switching in the context of high-throughput screening

scientific article

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

scientific article

Small-molecule inhibition of proteasome and aggresome function induces synergistic antitumor activity in multiple myeloma

scientific article

Small-molecule inhibitors directly target CARD9 and mimic its protective variant in inflammatory bowel disease

scientific article

Small-molecule reagents for cellular pull-down experiments

scientific article

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

scientific article

Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells.

scientific article published on 14 August 2017

Small-molecule targeting of brachyury transcription factor addiction in chordoma

scientific article published on 21 January 2019

SpectralNET--an application for spectral graph analysis and visualization

scientific article

Stereochemical and skeletal diversity arising from amino propargylic alcohols

scientific article published on June 2010

Stereospecific Palladium-Catalyzed C-H Arylation of Pyroglutamic Acid Derivatives at the C3 Position Enabled by 8-Aminoquinoline as a Directing Group

scientific article published on 15 August 2017

Structural Biasing Elements for In-Cell Histone Deacetylase Paralog Selectivity ⬇️

scientific article published on May 14, 2003

Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines.

article by Manmohan Sharma et al published 12 January 2021 in Nature Communications

Structure-activity relationships of GPX4 inhibitor warheads

scientific article published on 10 September 2020

Synergistic Effects of Stereochemistry and Appendages on the Performance Diversity of a Collection of Synthetic Compounds

scientific article published on 06 September 2018

Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog

scientific article

Syntheses of stereochemically diverse nine-membered ring-containing biaryls

scientific article published in October 2004

Syntheses of α-Pyrones Using Gold-Catalyzed Coupling Reactions ⬇️

scientific article published on May 2, 2011

Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole

scientific article

Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold

scientific article published on March 2009

Synthesis of a Bicyclic Azetidine with In Vivo Antimalarial Activity Enabled by Stereospecific, Directed C(sp3)-H Arylation

scientific article published on 21 July 2017

Synthesis of calcineurin-resistant derivatives of FK506 and selection of compensatory receptors

scientific article published in January 2002

Synthesis of oxazocenones via gold(I)-catalyzed 8-endo-dig hydroalkoxylation of alkynamides

scientific article published on 8 January 2015

Synthesis of piperlogs and analysis of their effects on cells

scientific article published on September 2013

Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs ⬇️

scientific article published on September 4, 2012

Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis

scientific article

Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

scientific article published on 19 January 2021

Targeting Dependency on the GPX4 Lipid Peroxide Repair Pathway for Cancer Therapy

scientific article published on 27 March 2018

The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells

scientific article published on 15 September 2011

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

scientific article (publication date: 13 March 2008)

The NIH's role in accelerating translational sciences ⬇️

scientific article published on January 9, 2012

The Power of Sophisticated Phenotypic Screening and Modern Mechanism-of-Action Methods

scientific article

The identification and characterization of non-reactive inhibitor of Keap1-Nrf2 interaction through HTS using a fluorescence polarization assay

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

scientific article published on 22 May 2015

The landscape of cancer cell line metabolism

scientific article published on 08 May 2019

The promise and peril of chemical probes

scientific article

The use of chromatin immunoprecipitation assays in genome-wide analyses of histone modifications

scientific article published on January 2004

Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor

scientific article

Toward performance-diverse small-molecule libraries for cell-based phenotypic screening using multiplexed high-dimensional profiling

scientific article

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