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List of works by Felix Hoppe-Seyler

A novel peptide motif binding to and blocking the intracellular activity of the human papillomavirus E6 oncoprotein

scientific article

A rapid microscale procedure for the simultaneous preparation of cytoplasmic RNA, nuclear DNA binding proteins and enzymatically active luciferase extracts ⬇️

scientific article published on September 25, 1991

Activation of human papillomavirus type 18 E6-E7 oncogene expression by transcription factor Sp1 ⬇️

scientific article published on December 25, 1992

Activation of the enhancer of zeste homologue 2 gene by the human papillomavirus E7 oncoprotein

scientific article

Binding proteins internalized by PTD-fused ligands allow the intracellular sequestration of selected targets by ligand exchange

scientific article published in April 2010

Cellular growth inhibition by FK778 is linked to G1 arrest or S phase accumulation, dependent on the functional status of the retinoblastoma protein

scientific article published in March 2009

Cellular responses of HPV-positive cancer cells to genotoxic anti-cancer agents: repression of E6/E7-oncogene expression and induction of apoptosis

scientific article published on 01 November 1996

Correlation between shiftide activity and HIV-1 integrase inhibition by a peptide selected from a combinatorial library

scientific article

Dependence of intracellular and exosomal microRNAs on viral E6/E7 oncogene expression in HPV-positive tumor cells

scientific article

Determination of chymotrypsin in stool by a new photometric method

scientific article published on 01 December 1986

Development of peptide aptamer microarrays for detection of HPV16 oncoproteins in cell extracts

scientific article published on 6 November 2010

EZH2 depletion blocks the proliferation of colon cancer cells

scientific article

Effects of the antifungal agent ciclopirox in HPV-positive cancer cells: Repression of viral E6/E7 oncogene expression and induction of senescence and apoptosis

scientific article published on 31 October 2019

Emerging topics in human tumor virology ⬇️

scientific article published on 05 May 2011

Endogenous BTG2 expression stimulates migration of bladder cancer cells and correlates with poor clinical prognosis for bladder cancer patients ⬇️

scientific article published on January 8, 2013

Enhancer of zeste homolog 2 (EZH2) expression is an independent prognostic factor in renal cell carcinoma ⬇️

scientific article published on October 4, 2010

Expression of inhibitor of apoptosis protein Livin in renal cell carcinoma and non-tumorous adult kidney.

scientific article published on 30 October 2007

Growth suppression induced by downregulation of E6-AP expression in human papillomavirus-positive cancer cell lines depends on p53

scientific article

High nuclear Livin expression is a favourable prognostic indicator in renal cell carcinoma

scientific article published on 18 September 2008

Identification of E6/E7-Dependent MicroRNAs in HPV-Positive Cancer Cells.

scientific article

Identification of cellular targets for the human papillomavirus E6 and E7 oncogenes by RNA interference and transcriptome analyses

scientific article

Induction of apoptosis in human papillomaviruspositive cancer cells by peptide aptamers targeting the viral E6 oncoprotein

scientific article published on June 2000

Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene

scientific article (publication date: 13 November 2003)

Induction of dormancy in hypoxic human papillomavirus-positive cancer cells.

scientific article published on 23 January 2017

Inhibition of Bax activity is crucial for the antiapoptotic function of the human papillomavirus E6 oncoprotein

scientific article

Intracellular Analysis of the Interaction between the Human Papillomavirus Type 16 E6 Oncoprotein and Inhibitory Peptides

scientific article published on 7 July 2015

Isoform-specific silencing of the Livin gene by RNA interference defines Livin beta as key mediator of apoptosis inhibition in HeLa cells

scientific article

Isolation of peptides blocking the function of anti-apoptotic Livin protein

scientific article

Membrane partitioning of peptide aggregates: coarse-grained molecular dynamics simulations

scientific article published on 27 February 2019

Molecular mechanisms of virus-induced carcinogenesis: the interaction of viral factors with cellular tumor suppressor proteins

scientific article published on November 1995

Mutational analysis of adeno-associated virus Rep protein-mediated inhibition of heterologous and homologous promoters ⬇️

scientific article published on September 1, 1995

Oncogenic human papillomaviruses activate the tumor-associated lens epithelial-derived growth factor (LEDGF) gene

scientific article

Oncogenic human papillomaviruses block expression of the B-cell translocation gene-2 tumor suppressor gene

scientific article published in November 2009

PI3K/AKT/mTOR Signaling Regulates the Virus/Host Cell Crosstalk in HPV-Positive Cervical Cancer Cells ⬇️

scientific article published on 03 May 2019

Peptide aptamer-mediated inhibition of target proteins by sequestration into aggresomes

scientific article published on 22 May 2006

Peptide aptamers targeting the hepatitis B virus core protein: a new class of molecules with antiviral activity ⬇️

scientific article published on October 4, 2001

Peptide aptamers: specific inhibitors of protein function

scientific article published in August 2004

Repression of Human Papillomavirus Oncogene Expression under Hypoxia Is Mediated by PI3K/mTORC2/AKT Signaling

scientific article published on 12 February 2019

Repression of endogenous p53 transactivation function in HeLa cervical carcinoma cells by human papillomavirus type 16 E6, human mdm-2, and mutant p53

scientific article published on June 1993

Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1 ⬇️

scientific article published on October 1, 1991

Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells.

scientific article

Silencing of human papillomavirus (HPV) E6/E7 oncogene expression affects both the contents and the amounts of extracellular microvesicles released from HPV‐positive cancer cells ⬇️

scientific article published on April 30, 2013

Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells

scientific article

The E6AP binding pocket of the HPV16 E6 oncoprotein provides a docking site for a small inhibitory peptide unrelated to E6AP, indicating druggability of E6

scientific article

The HPV E6/E7 Oncogenes: Key Factors for Viral Carcinogenesis and Therapeutic Targets.

scientific article published on 17 August 2017

The anti-apoptotic livin gene is an important determinant for the apoptotic resistance of non-small cell lung cancer cells

scientific article

The enhancer of zeste homolog 2 gene contributes to cell proliferation and apoptosis resistance in renal cell carcinoma cells

scientific article

The inhibitors of nucleotide biosynthesis leflunomide, FK778, and mycophenolic acid activate hepatitis B virus replication in vitro

scientific article published on June 2012

The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells

scientific article

Transtactin: a universal transmembrane delivery system for Strep-tag II-fused cargos

scientific article

Tumor suppressor genes in molecular medicine

scientific article published on August 1994

Uncoupling of p21WAF1/CIP1/SDI1 mRNA and protein expression upon genotoxic stress ⬇️

scientific article published on August 13, 1998

Viral E6/E7 oncogene and cellular hexokinase 2 expression in HPV-positive cancer cell lines.

scientific article published on 15 November 2017

Virus/Host Cell Crosstalk in Hypoxic HPV-Positive Cancer Cells

scientific article published on 5 July 2017

p53 mutations are rare events in recurrent cervical cancer

scientific article published on 01 June 2001

siRNA targeting of the viral E6 oncogene efficiently kills human papillomavirus-positive cancer cells

scientific article

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