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List of works by David Cescon

A phase I trial of ANG1/2-Tie2 inhibitor trebaninib (AMG386) and temsirolimus in advanced solid tumors (PJC008/NCI♯9041).

scientific article

A phase II randomized clinical trial of the effect of metformin versus placebo on progression-free survival in women with metastatic breast cancer receiving standard chemotherapy

scientific article published on 22 August 2019

A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease

scientific article

APOBEC3B expression in breast cancer reflects cellular proliferation, while a deletion polymorphism is associated with immune activation

scientific article

Absolute benefits of medical therapies in phase III clinical trials for breast and colorectal cancer

scientific article published on 30 November 2009

AhR controls redox homeostasis and shapes the tumor microenvironment in BRCA1-associated breast cancer

scientific article published on 07 February 2019

An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE)

scientific article published on 13 March 2019

Association between BMI, vitamin D, and estrogen levels in postmenopausal women using adjuvant letrozole: a prospective study

scientific article published on 12 June 2020

Association of MDM2 T309G and p53 Arg72Pro polymorphisms and gastroesophageal reflux disease with survival in esophageal adenocarcinoma

scientific article published in September 2013

Author Correction: Gene isoforms as expression-based biomarkers predictive of drug response in vitro.

scientific article published on 9 January 2018

BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival

scientific article published on 15 July 2013

BRM Promoter Polymorphisms and Survival of Advanced Non-Small Cell Lung Cancer Patients in the Princess Margaret Cohort and CCTG BR.24 Trial

scientific article published on 8 November 2016

Barcoded medication administration: a last line of defense

scientific article published on 01 May 2008

Benchmarking to the Gold Standard: Hyaluronan-Oxime Hydrogels Recapitulate Xenograft Models with In Vitro Breast Cancer Spheroid Culture

scientific article published on 19 July 2019

Biomarkers of outcome to weekly paclitaxel in epithelial ovarian cancer

scientific article published on 07 September 2020

Bowel loops and eyelid droops

scientific article published in October 2008

Breaking up is hard to do: PI3K isoforms on the rebound.

scientific article

CD2BP1 and CARD15 mutations are not associated with pyoderma gangrenosum in patients with inflammatory bowel disease

scientific article published in April 2004

CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours

scientific article published on 17 February 2017

Capecitabine in early breast cancer: A meta-analysis of randomised controlled trials

scientific article published on 26 March 2017

Clinical features and short-term outcomes of 144 patients with SARS in the greater Toronto area.

scientific article published on 6 May 2003

DNA replication stress: a source of APOBEC3B expression in breast cancer

scientific article

Discoloration of skin and urine after treatment with hydroxocobalamin for cyanide poisoning

scientific article published on January 2009

Disruption of the anaphase-promoting complex confers resistance to TTK inhibitors in triple-negative breast cancer.

scientific article

Epigenetic switch-induced viral mimicry evasion in chemotherapy resistant breast cancer

scientific article published on 16 June 2020

Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway

scientific article published on 24 February 2014

Evolution in sites of recurrence over time in breast cancer patients treated with adjuvant endocrine therapy

scientific article published on 24 August 2018

Evolution of the randomized controlled trial in oncology over three decades

scientific article published on 27 October 2008

Extended adjuvant tamoxifen for early breast cancer: a meta-analysis.

scientific article

Feasibility of a randomized controlled trial of vitamin D vs. placebo in women with recently diagnosed breast cancer

scientific article published on 16 June 2012

Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent

scientific article

Functional variants of OCTN cation transporter genes are associated with Crohn disease

scientific article

GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer

scientific article published on 21 August 2020

Gene Expression Analyses in Breast Cancer: Sample Matters

scientific article published on 01 April 2018

Gene isoforms as expression-based biomarkers predictive of drug response in vitro.

scientific article published on 24 October 2017

Genetic polymorphisms and head and neck cancer outcomes: a review

scientific article published on March 2008

Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression

Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression

scientific article published on 22 January 2015

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.

scientific article

If we build it they will come: targeting the immune response to breast cancer

scientific article published on 29 October 2019

Impact of multi-gene mutational profiling on clinical trial outcomes in metastatic breast cancer.

scientific article published on 24 November 2017

Influence of control group therapy on the benefit from dose-dense chemotherapy in early breast cancer: a systemic review and meta-analysis.

scientific article published on 8 February 2018

Integrative Pharmacogenomics Analysis of Patient-Derived Xenografts

scientific article published on 29 May 2019

Invasive pulmonary aspergillosis associated with marijuana use in a man with colorectal cancer

scientific article published in May 2008

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

article

MicroSPECT/CT Imaging of Cell-Line and Patient-Derived EGFR-Positive Tumor Xenografts in Mice with Panitumumab Fab Modified with Hexahistidine Peptides To Enable Labeling with 99mTc(I) Tricarbonyl Complex

scientific article published on 11 July 2019

Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

scientific article published on May 2013

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.

scientific article published on 9 July 2016

NRF2 Pathway Activation and Adjuvant Chemotherapy Benefit in Lung Squamous Cell Carcinoma

scientific article

Noncoding somatic and inherited single-nucleotide variants converge to promote ESR1 expression in breast cancer.

scientific article published on 29 August 2016

On the Road to Precision: Understanding the Biology Driving Genomic Assays

scientific article published on 11 December 2020

PIK3CA genotype and treatment decisions in human epidermal growth factor receptor 2-positive breast cancer.

scientific article published on 5 January 2015

PRMT5 is an actionable therapeutic target in CDK4/6 inhibitor-resistant ER+/RB-deficient breast cancer

scientific article published in 2024

Pembrolizumab monotherapy for previously treated metastatic triple-negative breast cancer: cohort A of the phase II KEYNOTE-086 study

scientific article published on 01 March 2019

Pembrolizumab monotherapy for previously untreated, PD-L1-positive, metastatic triple-negative breast cancer: cohort B of the phase II KEYNOTE-086 study

scientific article published on 01 March 2019

Pembrolizumab plus chemotherapy versus placebo plus chemotherapy for previously untreated locally recurrent inoperable or metastatic triple-negative breast cancer (KEYNOTE-355): a randomised, placebo-controlled, double-blind, phase 3 clinical trial

scientific article published on 01 December 2020

Pharmacogenetic and Germline Prognostic Markers of Lung Cancer

article

Pharmacology and in vivo efficacy of pyridine-pyrimidine amides that inhibit microtubule polymerization

scientific article published on 9 February 2018

Phase 2 study of pembrolizumab (pembro) monotherapy for previously treated metastatic triple-negative breast cancer (mTNBC): KEYNOTE-086 cohort A

Phase 2 study of pembrolizumab as first-line therapy for PD-L1–positive metastatic triple-negative breast cancer (mTNBC): Preliminary data from KEYNOTE-086 cohort B

Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

scientific article published on 6 February 2018

Presentation of nonfinal results of randomized controlled trials at major oncology meetings

scientific article published on 20 July 2009

Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1

scientific article published on 15 February 2019

Reply to Oegema et al.: CFI-400945 and Polo-like kinase 4 inhibition

article published in the Proceedings of the National Academy of Sciences of the United States of America

Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial

scientific article published on 15 July 2019

Targeting the cell cycle in breast cancer: towards the next phase

scientific article published on 11 September 2018

The Antiarrhythmic Drug, Dronedarone, Demonstrates Cytotoxic Effects in Breast Cancer Independent of Thyroid Hormone Receptor Alpha 1 (THRα1) Antagonism

scientific article published in Scientific Reports

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 1: Late Recurrence: Current Understanding, Clinical Considerations

scientific article published on 10 August 2019

Toronto Workshop on Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Part 2: Approaches to Predict and Identify Late Recurrence, Research Directions

scientific article published on 10 August 2019

Toxicity of Extended Adjuvant Therapy With Aromatase Inhibitors in Early Breast Cancer: A Systematic Review and Meta-analysis

scientific article published in January 2018

Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer

scientific article published on 08 October 2019

Tyrosine Threonine Kinase Inhibition Eliminates Lung Cancers by Augmenting Apoptosis and Polyploidy

scientific article published on 29 July 2019

W4R variant in CSRP3 encoding muscle LIM protein in a patient with hypertrophic cardiomyopathy

scientific article published on 22 January 2005

p53 Arg72Pro and MDM2 T309G polymorphisms, histology, and esophageal cancer prognosis

scientific article

p53 Arg72Pro, MDM2 T309G and CCND1 G870A polymorphisms are not associated with susceptibility to esophageal adenocarcinoma

scientific article

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