List of works - Catherine F. Clarke

A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae ⬇️

scientific article published on December 25, 2012

A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans

scientific article (publication date: April 2009)

ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment

scientific article published on 07 May 2020

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption

scientific article

Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q.

scientific article

Biochemistry: Unexpected role for vitamin B2.

scientific article

COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10

scientific article published on 23 March 2020

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

scientific article

COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae

scientific article

Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport

scientific article

Chromatin-remodeling SWI/SNF complex regulates coenzyme Q6 synthesis and a metabolic shift to respiration in yeast.

scientific article published on 24 July 2017

Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants

scientific article published on 07 January 2014

Coenzyme Q10 deficiencies: pathways in yeast and humans

scientific article published on 20 July 2018

Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2

scientific article published on 10 September 2008

Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis

scientific article

Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.

scientific article

Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli

scientific article

Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.

scientific article published on 12 April 2004

Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria

scientific article published on 24 September 2002

Evidence that ubiquinone is a required intermediate for rhodoquinone biosynthesis in Rhodospirillum rubrum

scientific article

Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants ⬇️

scientific article published on February 4, 2011

Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q ⬇️

scientific article published on January 4, 2002

Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10.

scientific article published on 07 August 2013

Folate status of gut microbiome affects Caenorhabditis eleganslifespan ⬇️

scientific article published on July 31, 2012

Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae

scientific article published on 05 May 2020

Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase

scientific article

Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae

scientific article published on 2 April 2009

Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function

scientific article published on 02 May 2019

Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome

scientific article

Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae

scientific article

Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae

scientific article published on 01 June 2020

Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress

scientific article

Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress ⬇️

scientific article published on October 16, 2010

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

scientific article published in 2017

Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid

scientific article published on September 2008

Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis

scientific article published on 27 June 2020

Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis

scientific article

Non-mitochondrial complex I proteins in a hydrogenosomal oxidoreductase complex

scientific article published in October 2004

Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway

scientific article

Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis

scientific article

Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease

scientific article

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

scientific article

Recombinant RquA catalyzes the in vivo conversion of ubiquinone to rhodoquinone in Escherichia coli and Saccharomyces cerevisiae

scientific article published on 21 May 2019

Reproductive Fitness and Quinone Content of Caenorhabditis elegans clk-1 Mutants Fed Coenzyme Q Isoforms of Varying Length ⬇️

scientific article published on October 6, 2003

Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation ⬇️

scientific article published on June 23, 2012

Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis

scientific article

Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex

scientific article

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation ⬇️

scientific article published on June 15, 2012

Target identification using drug affinity responsive target stability (DARTS)

scientific article published on 7 December 2009

The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis

The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration

scientific article

The Saccharomyces cerevisiae COQ6 Gene Encodes a Mitochondrial Flavin-dependent Monooxygenase Required for Coenzyme Q Biosynthesis ⬇️

scientific article published on April 29, 2003

The biosynthesis of ubiquinone: Synthesis and enzymatic modification of biosynthetic precursors

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

scientific article

The yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis

scientific article published on 31 October 2008

Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice

scientific article published on 08 February 2019

Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations

scientific article

Uptake of Exogenous Coenzyme Q and Transport to Mitochondria Is Required for bc1 Complex Stability in Yeast coq Mutants ⬇️

scientific article published on January 11, 2002

Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis

scientific article published on 29 December 2003

Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid

scientific article published on 23 May 2015

para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae

scientific article

List of works by Catherine F. Clarke

A conserved START domain coenzyme Q-binding polypeptide is required for efficient Q biosynthesis, respiratory electron transport, and antioxidant function in Saccharomyces cerevisiae ⬇️

A regulated response to impaired respiration slows behavioral rates and increases lifespan in Caenorhabditis elegans

ADCK4 Deficiency Destabilizes the Coenzyme Q Complex, Which Is Rescued by 2,4-Dihydroxybenzoic Acid Treatment

ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption

Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q.

Biochemistry: Unexpected role for vitamin B2.

COQ11 deletion mitigates respiratory deficiency caused by mutations in the gene encoding the coenzyme Q chaperone protein Coq10

COQ6 mutations in human patients produce nephrotic syndrome with sensorineural deafness

COQ9, a new gene required for the biosynthesis of coenzyme Q in Saccharomyces cerevisiae

Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport

Chromatin-remodeling SWI/SNF complex regulates coenzyme Q6 synthesis and a metabolic shift to respiration in yeast.

Coenzyme Q supplementation or over-expression of the yeast Coq8 putative kinase stabilizes multi-subunit Coq polypeptide complexes in yeast coq null mutants

Coenzyme Q10 deficiencies: pathways in yeast and humans

Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2

Complementation of Saccharomyces cerevisiae coq7 mutants by mitochondrial targeting of the Escherichia coli UbiF polypeptide: two functions of yeast Coq7 polypeptide in coenzyme Q biosynthesis

Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q.

Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli

Demethoxy-Q, an intermediate of coenzyme Q biosynthesis, fails to support respiration in Saccharomyces cerevisiae and lacks antioxidant activity.

Development and fertility in Caenorhabditis elegans clk-1 mutants depend upon transport of dietary coenzyme Q8 to mitochondria

Evidence that ubiquinone is a required intermediate for rhodoquinone biosynthesis in Rhodospirillum rubrum

Expression of the human atypical kinase ADCK3 rescues coenzyme Q biosynthesis and phosphorylation of Coq polypeptides in yeast coq8 mutants ⬇️

Extension of Life-Span in Caenorhabditis elegans by a Diet Lacking Coenzyme Q ⬇️

Focal segmental glomerulosclerosis is associated with a PDSS2 haplotype and, independently, with a decreased content of coenzyme Q10.

Folate status of gut microbiome affects Caenorhabditis eleganslifespan ⬇️

Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae

Genetic evidence for a multi-subunit complex in coenzyme Q biosynthesis in yeast and the role of the Coq1 hexaprenyl diphosphate synthase

Genetic evidence for the requirement of the endocytic pathway in the uptake of coenzyme Q6 in Saccharomyces cerevisiae

Human COQ10A and COQ10B are distinct lipid-binding START domain proteins required for coenzyme Q function

Human COQ9 Rescues a coq9 Yeast Mutant by Enhancing Coenzyme Q Biosynthesis from 4-Hydroxybenzoic Acid and Stabilizing the CoQ-Synthome

Identification of Coq11, a new coenzyme Q biosynthetic protein in the CoQ-synthome in Saccharomyces cerevisiae

Intragenic suppressor mutations of the COQ8 protein kinase homolog restore coenzyme Q biosynthesis and function in Saccharomyces cerevisiae

Isotope-reinforced polyunsaturated fatty acids protect mitochondria from oxidative stress

Isotope-reinforced polyunsaturated fatty acids protect yeast cells from oxidative stress ⬇️

Kaempferol increases levels of coenzyme Q in kidney cells and serves as a biosynthetic ring precursor

Lipids including cholesteryl linoleate and cholesteryl arachidonate contribute to the inherent antibacterial activity of human nasal fluid

Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis

Molecular characterization of the human COQ5 C-methyltransferase in coenzyme Q10 biosynthesis

Non-mitochondrial complex I proteins in a hydrogenosomal oxidoreductase complex

Overexpression of the Coq8 kinase in Saccharomyces cerevisiae coq null mutants allows for accumulation of diagnostic intermediates of the coenzyme Q6 biosynthetic pathway

Paraoxonase 2 deficiency alters mitochondrial function and exacerbates the development of atherosclerosis

Primary coenzyme Q deficiency in Pdss2 mutant mice causes isolated renal disease

Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

Recombinant RquA catalyzes the in vivo conversion of ubiquinone to rhodoquinone in Escherichia coli and Saccharomyces cerevisiae

Reproductive Fitness and Quinone Content of Caenorhabditis elegans clk-1 Mutants Fed Coenzyme Q Isoforms of Varying Length ⬇️

Restoring de novo coenzyme Q biosynthesis in Caenorhabditis elegans coq-3 mutants yields profound rescue compared to exogenous coenzyme Q supplementation ⬇️

Resveratrol and para-coumarate serve as ring precursors for coenzyme Q biosynthesis

Saccharomyces cerevisiae Coq9 polypeptide is a subunit of the mitochondrial coenzyme Q biosynthetic complex

Small amounts of isotope-reinforced polyunsaturated fatty acids suppress lipid autoxidation ⬇️

Target identification using drug affinity responsive target stability (DARTS)

The Endoplasmic Reticulum-Mitochondria Encounter Structure Complex Coordinates Coenzyme Q Biosynthesis

The Saccharomyces cerevisiae COQ10 gene encodes a START domain protein required for function of coenzyme Q in respiration

The Saccharomyces cerevisiae COQ6 Gene Encodes a Mitochondrial Flavin-dependent Monooxygenase Required for Coenzyme Q Biosynthesis ⬇️

The biosynthesis of ubiquinone: Synthesis and enzymatic modification of biosynthetic precursors

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.

The yeast Coq4 polypeptide organizes a mitochondrial protein complex essential for coenzyme Q biosynthesis

Treatment with 2,4-Dihydroxybenzoic Acid Prevents FSGS Progression and Renal Fibrosis in Podocyte-Specific Coq6 Knockout Mice

Unusual kinetic isotope effects of deuterium reinforced polyunsaturated fatty acids in tocopherol-mediated free radical chain oxidations

Uptake of Exogenous Coenzyme Q and Transport to Mitochondria Is Required for bc1 Complex Stability in Yeast coq Mutants ⬇️

Yeast Coq5 C-methyltransferase is required for stability of other polypeptides involved in coenzyme Q biosynthesis

Yeast Coq9 controls deamination of coenzyme Q intermediates that derive from para-aminobenzoic acid

para-Aminobenzoic acid is a precursor in coenzyme Q6 biosynthesis in Saccharomyces cerevisiae