List of works - John Kappler

A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas

scientific article

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

scientific article

A closer look at TCR germline recognition

scientific article published on 14 June 2012

A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling

scientific article

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

scientific article published on June 2002

Alternate interactions define the binding of peptides to the MHC molecule IA(b).

scientific article

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

scientific article

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

scientific article

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

scientific article published on 6 April 2004

Anti-Ia inhibits the activity of B cells but not a T cell-derived helper mediator

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

scientific article published on October 2016

Apoptosis and the homeostatic control of immune responses

scientific article

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

scientific article

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

scientific article published on 27 February 2017

Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity

scientific article

Bax does not have to adopt its final form to drive T cell death

scientific article

Bcl-xl does not have to bind Bax to protect T cells from death

scientific article

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

scientific article published in Nature

C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes

scientific article published on 18 December 2017

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

scientific article published on June 2015

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

scientific article

CD4 memory T cells divide poorly in response to antigen because of their cytokine profile

scholarly article

CD4 memory T cells: what are they and what can they do?

scientific article published on 09 March 2009

CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells

CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome

scientific article published on 2 January 2007

CD8 T cell competition for dendritic cells in vivo is an early event in activation

scholarly article

Characterization and mode of action of a nonspecific T-cell-derived helper mediator

Chromogranin A is an autoantigen in type 1 diabetes

scientific article

Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors

scientific article published on September 2016

Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4+ T cell response to a rheumatoid arthritis-associated antigen

article

Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.

scientific article published on 28 August 2017

Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation

scientific journal article

Components of the ligand for a Ni++ reactive human T cell clone

scientific article

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

scientific journal article

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines

scientific article published on 29 June 2016

Control of Bcl-2 expression by reactive oxygen species

scientific article

Control of T cell viability

scientific article published on January 2004

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

scientific article

Crystal structure of HLA-DP2 and implications for chronic beryllium disease

scientific article

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands

scientific article

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

scientific article

Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?

scientific article

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

scientific article published on 16 December 2013

Epitope dominance, competition and T cell affinity maturation

scientific article

Evolutionarily conserved amino acids that control TCR-MHC interaction

scientific article published on January 2008

Evolutionarily conserved features contribute to αβ T cell receptor specificity

scientific article published on 29 September 2011

Expression of the Antigen-Specific MHC-Restricted T Cell Receptor

Functions of Helper T Cell Hybridomas in B Cell Antibody Responses

article

Genetic and hormonal factors in female-biased autoimmunity

scientific article

Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection

scientific article (publication date: 23 April 2009)

Germline-encoded recognition of diverse glycolipids by natural killer T cells

article

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses

scientific article

Helper T-cells recognize antigen and components of the macrophage surface membrane simultaneously

article published in 1976

Homeostasis of the memory T cell pool

scientific article

Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model

scientific article published on May 2007

Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

scientific article

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes

scientific article published on 01 April 2019

How the T Cell Repertoire Becomes Peptide and MHC Specific

article

IR GENES AND I REGION RESTRICTION

article

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease

scientific article

Identification of multiple public TCR repertoires in chronic beryllium disease

scientific article

Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties

scholarly article

IgG Autoantibodies against Deposited C3 Inhibit Macrophage-Mediated Apoptotic Cell Engulfment in Systemic Autoimmunity ⬇️

scientific article published on August 3, 2011

Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line

scientific article published on 27 December 2012

Immune mechanisms of protection: can adjuvants rise to the challenge?

scientific article

Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor

scientific article

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence

scientific article

Interaction of JMJD6 with single-stranded RNA ⬇️

scientific article published on August 2, 2010

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

scientific article published on 15 October 2006

Is Tall-1 a trimer or a virus-like cluster?

scientific article published in Nature

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

scientific article published on 5 December 2016

JMJD5 couples with CDK9 to release the paused RNA polymerase II

scientific article published on 03 August 2020

Ligand-receptor binding revealed by the TNF family member TALL-1

scientific article (publication date: May 2003)

Linking genetic susceptibility and T cell activation in beryllium-induced disease

scientific article published on May 2010

Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model

scientific article published on 29 August 2002

Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7

scientific article

Loss of the proapoptotic protein, Bim, breaks B cell anergy

scientific article

Lower TCR repertoire diversity in Traj18-deficient mice

scientific article published on 19 July 2012

MAIT cell recognition of MR1 on bacterially infected and uninfected cells

scientific article

Many different Vbeta CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions

scholarly article

Mast cell-dependent migration of effector CD8+ T cells through production of leukotriene B4.

scientific article published on 31 August 2003

Memory CD4 T cells that express CXCR5 provide accelerated help to B cells

scientific article

Memory CD4 T cells: generation, reactivation and re-assignment

scientific article published on 16 March 2010

Mimotopes for alloreactive and conventional T cells in a peptide-MHC display library

scientific article

Molecular mechanisms of activated T cell death in vivo

scientific article

Molecular targeting of islet autoantigens

scientific article published on April 2010

Molecules in medicine mini review: the αβ T cell receptor

scientific article

Monoclonal antibody blocking the recognition of an insulin peptide-MHC complex modulates type 1 diabetes

scientific article published on 03 February 2014

Multiple mechanisms of T cell tolerance to Mls-1a

scientific article published on January 1991

Mutagenesis of Beryllium-Specific TCRs Suggests an Unusual Binding Topology for Antigen Recognition ⬇️

scientific article published on August 26, 2011

N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes

scientific article

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation

scientific journal article

Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells

scientific article

Negative selection imparts peptide specificity to the mature T cell repertoire

scientific article

Non-malignant clonal expansions of CD8+ memory T cells in aged individuals

scientific article

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990.

scientific article published on May 2010

Not all CD4+ memory T cells are long lived

scientific article published on June 2006

Observation of Antigen-Dependent CD8+ T-Cell/ Dendritic Cell Interactions in Vivo

article

Peptide sequences of T-cell receptor δ and γ chains are identical to predicted X and γ proteins

scientific article published in Nature

Peptide vaccines prevent tumor growth by activating T cells that respond to native tumor antigens

scientific article

Pillars Article: Characterization of a Monoclonal Antibody Which Detects All Murine αβ T Cell Receptors. J. Immunol. 1989. 142: 2736-2742.

scientific article

Production and characterization of T cell hybridomas

scientific article

Promotion of B cell immune responses via an alum-induced myeloid cell population

scientific article published in June 2004

Properties of Antigen-Specific H-2 Restricted T Cell Hybridomas

Recognition of self and altered self by T cells in autoimmunity and allergy

scientific article published on 11 January 2013

Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease

journal article published in 2014

Regulatory vs. inflammatory cytokine T-cell responses to mutated insulin peptides in healthy and type 1 diabetic subjects

scientific article

Residues of the variable region of the T-cell-receptor β-chain that interact with S. aureus toxin superantigens

scientific article published in Nature

SOLUBLE EFFECTORS, MEDIATORS, AND FACTORS AND THEIR MECHANISMS OF ACTION

Specific Recognition of Arginine Methylated Histone Tails by JMJD5 and JMJD7.

scientific article published on 19 February 2018

Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouse

scientific article

Staging and resetting T cell activation in SMACs

scientific article (publication date: October 2002)

Structural Basis of Chronic Beryllium Disease: Linking Allergic Hypersensitivity and Autoimmunity

scientific article

Structural Basis of Cytochrome c Presentation by IE k

scientific article

Structural basis of the recognition of a methylated histone tail by JMJD2A

scientific article

Superantigens and their potential role in human disease

scientific article published on January 1993

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

scientific article

T cell allorecognition via molecular mimicry

scientific article

T cell apoptosis and reactive oxygen species

scientific article

T cell receptor specificity for major histocompatibility complex proteins

scientific article

T cells and their eons-old obsession with MHC

scientific article

T cells down-modulate peptide-MHC complexes on APCs in vivo

scientific article

T-box transcription factor T-bet, a key player in a unique type of B-cell activation essential for effective viral clearance

scientific article published on 06 August 2013

T-cell receptor (TCR) interaction with peptides that mimic nickel offers insight into nickel contact allergy

scientific article published on 6 November 2012

T-cells with different functions have different sensitivities to antigen

TCR hypervariable regions expressed by T cells that respond to effective tumor vaccines ⬇️

scientific article published on February 21, 2012

TCR-MHC/peptide interactions: kissing-cousins or a shotgun wedding?

scientific article

THE ROLE OF ANTIGEN-PRESENTING CELLS IN EFFECTOR HELPER T CELL ACTION

article

TLR7 drives accumulation of ABCs and autoantibody production in autoimmune-prone mice

scientific article published on March 2013

TWO T CELL SIGNALS ARE REQUIRED FOR THE B CELL RESPONSE TO PROTEIN-BOUND ANTIGENS

scholarly article published 1979

The Advantages of Limiting the T Cell Repertoire for Antigen & MHC

scholarly article published 1990

The Epstein-Barr virus Bcl-2 homolog, BHRF1, blocks apoptosis by binding to a limited amount of Bim

scholarly article

The Ikaros transcription factor regulates responsiveness to IL-12 and expression of IL-2 receptor alpha in mature, activated CD8 T cells

scientific article

The Murine T Cell Receptor

The T Cell Receptors

The T Cell and its Receptor

The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

scientific article published in Nature

The domestic cat antibody response to feline herpesvirus-1 increases with age.

scientific article published on 4 May 2017

The major histocompatibility complex-restricted antigen receptor on T cells: Distribution on thymus and peripheral T cells

article

The somatically generated T cell receptor CDR3a contributes to the MHC allele specificity of the T cell receptor

The somatically generated portion of T cell receptor CDR3α contributes to the MHC allele specificity of the T cell receptor

scientific article

The structure of HLA-DR52c: Comparison to other HLA-DRB3 alleles

scientific article

The structure of a Bcl-xL/Bim fragment complex: implications for Bim function

scientific article

The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR.

scientific article

Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains

scientific article

Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation

scientific article

Toll-like receptor 7 (TLR7)-driven accumulation of a novel CD11c⁺ B-cell population is important for the development of autoimmunity

scientific article

Transgenic Bcl-3 slows T cell proliferation

scientific article published on 10 February 2009

Use of baculovirus MHC/peptide display libraries to characterize T-cell receptor ligands

scientific article published in April 2006

Using a baculovirus display library to identify MHC class I mimotopes

scientific article

Vaccination of mice with baculovirus-infected insect cells expressing antigenic proteins

scientific article

Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells

scientific article

Yeast surface display of a noncovalent MHC class II heterodimer complexed with antigenic peptide

scientific article published in November 2005

List of works by John Kappler

A Rapid Method to Characterize Mouse IgG Antibodies and Isolate Native Antigen Binding IgG B Cell Hybridomas

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

A closer look at TCR germline recognition

A conserved CXXC motif in CD3epsilon is critical for T cell development and TCR signaling

Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim.

Alternate interactions define the binding of peptides to the MHC molecule IA(b).

Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder

Anti-Ia inhibits the activity of B cells but not a T cell-derived helper mediator

Antiviral CD8+ T Cells Restricted by Human Leukocyte Antigen Class II Exist during Natural HIV Infection and Exhibit Clonal Expansion

Apoptosis and the homeostatic control of immune responses

Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetes

B cells expressing the transcription factor T-bet drive lupus-like autoimmunity

Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity

Bax does not have to adopt its final form to drive T cell death

Bcl-xl does not have to bind Bax to protect T cells from death

Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking

C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes

CD11c-Expressing B Cells Are Located at the T Cell/B Cell Border in Spleen and Are Potent APCs

CD25+CD4+ T cells contribute to the control of memory CD8+ T cells

CD4 memory T cells divide poorly in response to antigen because of their cytokine profile

CD4 memory T cells: what are they and what can they do?

CD8 Clonal Expansions in Mice: An Age-associated Alteration of CD8 Memory T-cells

CD8 T cell clonal expansions & aging: a heterogeneous phenomenon with a common outcome

CD8 T cell competition for dendritic cells in vivo is an early event in activation

Characterization and mode of action of a nonspecific T-cell-derived helper mediator

Chromogranin A is an autoantigen in type 1 diabetes

Class II major histocompatibility complex mutant mice to study the germ-line bias of T-cell antigen receptors

Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4+ T cell response to a rheumatoid arthritis-associated antigen

Clipping of arginine-methylated histone tails by JMJD5 and JMJD7.

Complex and dynamic redistribution of NF-kappaB signaling intermediates in response to T cell receptor stimulation

Components of the ligand for a Ni++ reactive human T cell clone

Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

Contamination of DNase Preparations Confounds Analysis of the Role of DNA in Alum-Adjuvanted Vaccines

Control of Bcl-2 expression by reactive oxygen species

Control of T cell viability

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

Crystal structure of HLA-DP2 and implications for chronic beryllium disease

Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

Do MHCII-presented neoantigens drive type 1 diabetes and other autoimmune diseases?

Effective functional maturation of invariant natural killer T cells is constrained by negative selection and T-cell antigen receptor affinity

Epitope dominance, competition and T cell affinity maturation

Evolutionarily conserved amino acids that control TCR-MHC interaction

Evolutionarily conserved features contribute to αβ T cell receptor specificity

Expression of the Antigen-Specific MHC-Restricted T Cell Receptor

Functions of Helper T Cell Hybridomas in B Cell Antibody Responses

Genetic and hormonal factors in female-biased autoimmunity

Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection

Germline-encoded recognition of diverse glycolipids by natural killer T cells

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses

Helper T-cells recognize antigen and components of the macrophage surface membrane simultaneously

Homeostasis of the memory T cell pool

Homeostatically proliferating CD4 T cells are involved in the pathogenesis of an Omenn syndrome murine model

Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells

How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes

How the T Cell Repertoire Becomes Peptide and MHC Specific

IR GENES AND I REGION RESTRICTION

Identification of beryllium-dependent peptides recognized by CD4+ T cells in chronic beryllium disease

Identification of multiple public TCR repertoires in chronic beryllium disease

Identification of two major types of age-associated CD8 clonal expansions with highly divergent properties

IgG Autoantibodies against Deposited C3 Inhibit Macrophage-Mediated Apoptotic Cell Engulfment in Systemic Autoimmunity ⬇️

Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line

Immune mechanisms of protection: can adjuvants rise to the challenge?

Improving antigenic peptide vaccines for cancer immunotherapy using a dominant tumor-specific T cell receptor

Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza A virus that expresses an altered nucleoprotein sequence

Interaction of JMJD6 with single-stranded RNA ⬇️

Interface-disrupting amino acids establish specificity between T cell receptors and complexes of major histocompatibility complex and peptide

Is Tall-1 a trimer or a virus-like cluster?

Islet-Derived CD4 T Cells Targeting Proinsulin in Human Autoimmune Diabetes

JMJD5 couples with CDK9 to release the paused RNA polymerase II

Ligand-receptor binding revealed by the TNF family member TALL-1

Linking genetic susceptibility and T cell activation in beryllium-induced disease

Liposomal clodronate as a novel agent for treating autoimmune hemolytic anemia in a mouse model

Loss of Bim allows precursor B cell survival but not precursor B cell differentiation in the absence of interleukin 7

Loss of the proapoptotic protein, Bim, breaks B cell anergy

Lower TCR repertoire diversity in Traj18-deficient mice

MAIT cell recognition of MR1 on bacterially infected and uninfected cells