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List of works by Peter E Czabotar

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

scientific article published on 19 June 2020

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

scientific article

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

scientific article published on 07 October 2019

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

scientific article

BAK core dimers bind lipids and can be bridged by them

scientific article published on 14 September 2020

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

scientific article

Conformational Changes in Bcl-2 Pro-survival Proteins Determine Their Capacity to Bind Ligands

scientific article

Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis

scientific article published on 13 April 2021

Conversion of Bim-BH3 from Activator to Inhibitor of Bak through Structure-Based Design

scientific article published in November 2017

Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes

scientific article

Crystal structure of the hinge domain of Smchd1 reveals its dimerization mode and nucleic acid-binding residues

scientific article published on 16 June 2020

Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.

scientific article published on 26 June 2013

Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues

scientific article published on 19 June 2020

Enhanced antimalarial activity of plasmepsin V inhibitors by modification of the P position of PEXEL peptidomimetics

High-Resolution Structural Characterization of a Helical α/β-Peptide Foldamer Bound to the Anti-Apoptotic Protein Bcl-xL

scientific article

Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis

scientific article published on 22 November 2021

Insights into Duffy Binding-like Domains through the Crystal Structure and Function of the Merozoite Surface Protein MSPDBL2 from Plasmodium falciparum

scientific article

Ion currents through Kir potassium channels are gated by anionic lipids

scientific article published on 25 January 2022

Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

scientific article

Physiological restraint of Bak by Bcl-xL is essential for cell survival

scientific article published on 19 May 2016

Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1

scientific article

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

scientific article

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

scientific article

Structural insights into the degradation of Mcl-1 induced by BH3 domains

scientific article

Structures of BCL-2 in complex with venetoclax reveal the molecular basis of resistance mutations

scientific article published on 03 June 2019

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

scientific article published on November 2006

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

scientific article

The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

scientific article