List of works by Lorenzo Moretta

2B4 (CD244) is expressed and functional on human eosinophils

scientific article published in January 2005

A non-canonical adenosinergic pathway led by CD38 in human melanoma cells induces suppression of T cell proliferation

scientific article published on 25 July 2015

Activating KIRs and NKG2C in Viral Infections: Toward NK Cell Memory?

scientific article

Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells

scientific article published on 01 March 2002

Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function.

scientific article published on 24 August 2006

Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)

scientific article

Anti-leukemia activity of alloreactive NK cells in KIR ligand-mismatched haploidentical HSCT for pediatric patients: evaluation of the functional role of activating KIR and redefinition of inhibitory KIR specificity

scientific article

Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity.

scientific article

CD56(bright)perforin(low) noncytotoxic human NK cells are abundant in both healthy and neoplastic solid tissues and recirculate to secondary lymphoid organs via afferent lymph.

scientific article published on 19 March 2014

CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity

scientific article (publication date: December 2003)

Cellular ligands of activating NK receptors.

scientific article

Classification of current anticancer immunotherapies

scientific article

Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression

scientific article

Crystallization and preliminary crystallographic characterization of the extracellular Ig-like domain of human natural killer cell activating receptor NKp44.

scientific article

Dendritic cell editing by activated natural killer cells results in a more protective cancer-specific immune response

scientific article

Dendritic cell editing by natural killer cells

scientific article

Dissecting CD56dim human NK cells ⬇️

scientific article published on November 11, 2010

Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs

scholarly article

Dual-functional capability of CD3+CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity.

scientific article

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation

scientific article

Early liaisons between cells of the innate immune system in inflamed peripheral tissues.

scientific article

Effector and regulatory events during natural killer-dendritic cell interactions

scientific article published on December 2006

Efficacy of third-party chimeric antigen receptor modified peripheral blood natural killer cells for adoptive cell therapy of B-cell precursor acute lymphoblastic leukemia

scientific article published on 19 November 2019

Expression and crystallographic characterization of the extracellular domain of human natural killer cell triggering receptor NKp46.

scientific article published on 27 November 2003

Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction

scientific article

Functional characterization of natural killer cells in type I leukocyte adhesion deficiency

scientific article published on 01 February 2007

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells.

scientific article published in June 2004

Human NK Cell Subsets Redistribution in Pathological Conditions: A Role for CCR7 Receptor

scientific article

Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice

scientific article published on 11 April 2007

Human NK cells: surface receptors, inhibitory checkpoints, and translational applications

scientific article published on 18 February 2019

Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells

scientific article

Human natural killer cell function and their interactions with dendritic cells

scientific article

Human natural killer cells: their origin, receptors and function

scientific article (publication date: May 2002)

IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors

scientific article

IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors

scientific article

Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis

scientific article

Identification of HLA-E-specific alloreactive T lymphocytes: a cell subset that undergoes preferential expansion in mixed lymphocyte culture and displays a broad cytolytic activity against allogeneic cells

scientific article

Identification of PVR (CD155) and Nectin-2 (CD112) as cell surface ligands for the human DNAM-1 (CD226) activating molecule

scientific article

Identification of a subset of human natural killer cells expressing high levels of programmed death 1: A phenotypic and functional characterization

scientific article published on 27 May 2016

Inhibitory 2B4 contributes to NK cell education and immunological derangements in XLP1 patients.

scientific article published on 6 April 2017

Killer Ig–like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation ⬇️

scientific article published on January 20, 2011

M-CSF induces the expression of a membrane-bound form of IL-18 in a subset of human monocytes differentiating in vitro toward macrophages

scientific article published in June 2012

Markers and function of human NK cells in normal and pathological conditions

scientific article published on 5 January 2017

Melanoma cells inhibit natural killer cell function by modulating the expression of activating receptors and cytolytic activity

scientific article published on 18 January 2012

Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

scientific article

Mesenchymal stromal cells induce peculiar alternatively activated macrophages capable of dampening both innate and adaptive immune responses.

scientific article

Modulation of CD112 by the alphaherpesvirus gD protein suppresses DNAM-1-dependent NK cell-mediated lysis of infected cells

scientific article

Molecular definition of group 1 innate lymphoid cells in the mouse uterus

scientific article published in Nature Communications

NK Cells and Other Innate Lymphoid Cells in Hematopoietic Stem Cell Transplantation

scientific article

NK cells provide helper signal for CD8+ T cells by inducing the expression of membrane-bound IL-15 on DCs.

scientific article published on 26 March 2009

NK cells recognize and kill human glioblastoma cells with stem cell-like properties

scientific article

NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor

scientific article (publication date: 15 July 2005)

Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction.

scientific article

Natural killer cells and neuroblastoma: tumor recognition, escape mechanisms, and possible novel immunotherapeutic approaches

scientific article

Natural killer cells in HIV-1 infection: dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

scientific article

Neuroblastoma-derived TGF-β1 modulates the chemokine receptor repertoire of human resting NK cells.

scientific article published on 10 April 2013

Nidogen-1 is a novel extracellular ligand for the NKp44 activating receptor

scientific article published on 11 July 2018

PD-1 in human NK cells: evidence of cytoplasmic mRNA and protein expression

scientific article published on 25 December 2018

PD-L1 expression in metastatic neuroblastoma as an additional mechanism for limiting immune surveillance

scientific article published on 15 July 2015

PMN-MDSC are a new target to rescue graft-versus-leukemia activity of NK cells in haplo-HSC transplantation

scientific article published on 04 October 2019

PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis

scientific article

Presence of innate lymphoid cells in pleural effusions of primary and metastatic tumors: Functional analysis and expression of PD-1 receptor

scientific article published on 26 March 2019

Recognition of adult and pediatric acute lymphoblastic leukemia blasts by natural killer cells

scientific article

Selective cross-talk among natural cytotoxicity receptors in human natural killer cells

scientific article (publication date: May 2003)

Structure of the human NK cell triggering receptor NKp46 ectodomain

scientific article

Structure of the saccharide-binding domain of the human natural killer cell inhibitory receptor p75/AIRM1

scientific article

Sub-lingual administration of a polyvalent mechanical bacterial lysate (PMBL) in patients with moderate, severe, or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD spirometric classification: A multicentre, double-blin

scientific article published on 4 May 2015

Surface NK receptors and their ligands on tumor cells

scientific article

Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells

scientific article

TCRαβ/CD19 depleted hematopoietic stem cell transplantation from haploidentical donors: dissecting the GvL/GvHD conundrum

scientific article published on 14 April 2020

TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells

scientific article

TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.

scientific article

The Innate Immune Cross Talk between NK Cells and Eosinophils Is Regulated by the Interaction of Natural Cytotoxicity Receptors with Eosinophil Surface Ligands

scientific article published on 28 April 2017

The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells

scientific article

The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils

scientific article

The interaction of human natural killer cells with either unpolarized or polarized macrophages results in different functional outcomes

scientific article

The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity

scientific article

The yin-yang of the interaction between myelomonocytic cells and NK cells

scientific article published on 19 August 2018

Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells

scientific article

Update on natural killer cells: cross-talk with dendritic cells and role in the cure of acute myeloid leukemias

scientific article

Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction

scientific article published on 11 September 2009

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