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List of works by Martín E Fernández-Zapico

"Enjoy glass of wine before eating:" a randomized trial to test the orexigenic effects of this advice in advanced cancer patients

scientific article published on 2 April 2016

4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells.

scientific article published on 25 February 2016

A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma

scientific article

A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth

scientific article

A novel epigenetic CREB‐miR‐373 axis mediates ZIP4‐induced pancreatic cancer growth ⬇️

scientific article published on July 16, 2013

A novel functional interaction between the Sp1-like protein KLF13 and SREBP-Sp1 activation complex underlies regulation of low density lipoprotein receptor promoter function

scientific article

A preoperative serum signature of CEA+/CA125+/CA19-9 ≥ 1000 U/mL indicates poor outcome to pancreatectomy for pancreatic cancer

scientific article published on 18 October 2014

Aberrant nuclear accumulation of glycogen synthase kinase-3beta in human pancreatic cancer: association with kinase activity and tumor dedifferentiation

scientific article published on September 2006

Aberrant signaling pathways in pancreatic cancer: a two compartment view

scientific article published on January 2012

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

scientific journal article

Activation of the transforming growth factor-β/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma

scientific article

Adrenomedullin is up-regulated in patients with pancreatic cancer and causes insulin resistance in β cells and mice

scientific article published on 06 September 2012

An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation

scientific article

Antianoikis effect of nuclear factor-kappaB through up-regulated expression of osteoprotegerin, BCL-2, and IAP-1.

scientific article published on 5 January 2006

Back to the drawing board: Re-thinking the role of GLI1 in pancreatic carcinogenesis

scientific article

Biology and prognostic impact of clonal plasmacytoid dendritic cells in chronic myelomonocytic leukemia

scientific article published on 20 March 2019

Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism

scientific article

CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations

scientific article published on 23 July 2018

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)-a study of 1084 patients

scientific article published on 13 December 2019

Comprehensive analysis of tumor microenvironment cytokines in Waldenstrom macroglobulinemia identifies CCL5 as a novel modulator of IL-6 activity ⬇️

scientific article published on September 14, 2011

Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation.

scientific article published in June 2019

Corrigendum to “Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis” [Cancer Lett. 328 (2) (2012) 212–221]

scholarly article published in Cancer Letters

Derivation of adult canine intestinal organoids for translational research in gastroenterology

scientific article published on 11 April 2019

Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins

scientific article published on 25 February 2019

Discovering and targeting the epigenetic pathways to treat muscle loss: working toward a paradigm shift in cancer therapeutics

scientific article

Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid

scientific article

Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.

scientific article

Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis

scientific article

E3 ubiquitin ligase PARK2, an inhibitor of melanoma cell growth, is repressed by the oncogenic ERK1/2-ELK1 transcriptional axis

scientific article published on 16 September 2020

Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis

scientific article

Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistance

scientific article

Epigenetic control of the tumor microenvironment

scientific article

Epigenetics of cancer-associated muscle catabolism

scientific article

Epigenetics of gastrointestinal diseases: notes from a workshop

scientific article published on 30 July 2018

Estrogen receptor beta repurposes EZH2 to suppress oncogenic NFκB/p65 signaling in triple negative breast cancer

scientific article published on 17 February 2022

Experience with precision genomics and tumor board, indicates frequent target identification, but barriers to delivery.

scientific article

Expression profiling in pancreatic cancer research: the initial steps and the road ahead

scientific article published in September 2003

Fundamentals of transcription factors and their impact on pancreatic development and cancer

scientific article

GLI1 finds a new role in cancer stem cell biology ⬇️

scientific article published on March 18, 2013

GLI1 inhibition promotes epithelial-to-mesenchymal transition in pancreatic cancer cells

scientific article

GLI1/GLI2 functional interplay is required to control Hedgehog/GLI targets gene expression

scientific article published on 07 August 2020

GLI2 transcription factor mediates cytokine cross-talk in the tumor microenvironment.

scientific article

Gemcitabine Activates Natural Killer Cells to Attenuate Pancreatic Cancer Recurrence.

scientific article published on 29 June 2016

Genome-wide screen identifies a novel p97/CDC-48-dependent pathway regulating ER-stress-induced gene transcription

scientific article

Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas

scientific article published on 14 September 2020

Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis

scientific article

Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells

scientific article

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

scientific article

Hedgehog inhibition promotes a switch from Type II to Type I cell death receptor signaling in cancer cells

scientific article

Hedgehog takes a new "RHOad" to angiogenesis

scientific article published on 15 February 2010

IKBKE Is Required during KRAS-Induced Pancreatic Tumorigenesis

scientific article published on 9 January 2017

Identification and characterization of a novel promoter for the human ANO1 gene regulated by the transcription factor signal transducer and activator of transcription 6 (STAT6)

scientific article

Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.

scientific article published on 22 March 2014

Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease

scientific article published on 05 October 2020

Inactivation of the transcription factor GLI1 accelerates pancreatic cancer progression.

scientific article

Induction of Lysosome-associated Protein Transmembrane 4 Beta via Sulfatase 2 Enhances Autophagic Flux in Liver Cancer Cells

scientific article published on 25 September 2019

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

scientific article published on 2 April 2014

Inhibition of glycogen synthase kinase-3 activity leads to epigenetic silencing of nuclear factor kappaB target genes and induction of apoptosis in chronic lymphocytic leukemia B cells

scientific article published on 26 April 2007

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis

scientific article published on 13 October 2012

It Takes a Village to Overcome KRAS Dependence in Pancreatic Cancer

scientific article published on 01 July 2020

KLF11-mediated repression antagonizes Sp1/sterol-responsive element-binding protein-induced transcriptional activation of caveolin-1 in response to cholesterol signaling

scientific article

Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias

scientific article published on September 2006

Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young

scientific article published on 15 April 2013

LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth

scientific article published on 16 November 2017

Loss of the Transcription Factor GLI1 Identifies a Signaling Network in the Tumor Microenvironment Mediating KRAS Oncogene-induced Transformation ⬇️

scientific article published on March 12, 2013

MODY7 gene, KLF11, is a novel p300-dependent regulator of Pdx-1 (MODY4) transcription in pancreatic islet beta cells

scientific article published on 20 October 2009

Mechanistic Insights into Self-Reinforcing Processes Driving Abnormal Histogenesis During the Development of Pancreatic Cancer ⬇️

scientific article published on January 31, 2013

Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells.

scientific article

Molecular Modeling and Functional Analysis of Exome Sequencing-Derived Variants of Unknown Significance Identify a Novel, Constitutively Active FGFR2 Mutant in Cholangiocarcinoma

scientific article published in 2017

NFAT transcription factors, the potion mediating "Dr. Jekyll-Mr. Hyde" transformation of the TGFβ pathway in cancer cells ⬇️

scientific article published on October 23, 2010

NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells

scientific article

NFkappaB p50-CCAAT/enhancer-binding protein beta (C/EBPbeta)-mediated transcriptional repression of microRNA let-7i following microbial infection

scientific article

New Aspects of the Epigenetics of Pancreatic Carcinogenesis

scientific article published on 31 August 2020

Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells

scientific article

Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs

scientific article

Novel roles of the unfolded protein response in the control of tumor development and aggressiveness.

scientific article published on 05 May 2015

Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid

scientific article

Oncogenic transcription factors: cornerstones of inflammation-linked pancreatic carcinogenesis ⬇️

scientific article published on October 13, 2011

Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy

scientific article published in April 2015

Pancreatic cancer microenvironment, to target or not to target?

scientific article

Pancreatic cancer research: challenges, opportunities, and recent developments.

scientific article published on September 2002

Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer

scientific article published on 21 November 2019

Phenotypic correlates and prognostic outcomes of TET2 mutations in myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: A comprehensive study of 504 adult patients

scientific article published on 10 January 2020

Pivotal role of Harakiri in the induction and prevention of gentamicin-induced hearing loss

scientific article

Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα.

scientific article published on 10 June 2013

Primers on molecular pathways--the NFAT transcription pathway in pancreatic cancer

scientific article published on 19 August 2010

RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

scientific article published on 18 May 2021

Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer

scientific article published on 29 April 2019

Regulation of GLI Underlies a Role for BET Bromodomains in Pancreatic Cancer Growth and the Tumor Microenvironment.

scientific article published on 11 May 2016

Response to erythropoiesis-stimulating agents in patients with WHO-defined myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)

scientific article published on 03 March 2020

Restricted heterochromatin formation links NFATc2 repressor activity with growth promotion in pancreatic cancer

scientific article published on 10 November 2011

Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis

scientific article

Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function

scientific article

ST3GAL1 is a target of the SOX2-GLI1 transcriptional complex and promotes melanoma metastasis through AXL

scientific article published on 17 November 2020

Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases

scientific article published on 8 February 2012

Sequential Activation of Snail1 and N-Myc Modulates Sonic Hedgehog–Induced Transformation of Neural Cells ⬇️

scientific article published on June 6, 2011

Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation

scientific article

Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling

scientific article

Stromal Gli signaling regulates the activity and differentiation of prostate stem and progenitor cells

scientific article published on 17 May 2018

Stromal deactivation by CSF1: a new feature of the aggressive pancreatic cancer microenvironment

scientific article published on 23 April 2020

Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

scientific article

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

scientific article

T1385 Adrenomedullin: A Biomarker of Pancreatic Cancer-Associated Diabetes?

TCR/CD28-stimulated actin dynamics are required for NFAT1-mediated transcription of c-rel leading to CD28 response element activation

scientific article published on 01 July 2007

TFII-I-mediated polymerase pausing antagonizes GLI2 induction by TGFβ

scientific article published on 16 June 2020

Targeting Pancreatic Cancer Metastasis by Inhibition of Vav1, a Driver of Tumor Cell Invasion

scientific article published on 14 May 2015

Targeting epigenetic pathways in acute myeloid leukemia and myelodysplastic syndrome: a systematic review of hypomethylating agents trials

scientific article

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor-stroma crosstalk.

scientific article published on 3 April 2018

Targeting of the Hedgehog/GLI and mTOR pathways in advanced pancreatic cancer, a phase 1 trial of Vismodegib and Sirolimus combination

scientific article published on 14 July 2020

Targeting tumour microenvironment, a FAKtual challenge in pancreatic cancer

scientific article published on 03 October 2019

The Structure-Specific Recognition Protein 1 Associates with Lens Epithelium-Derived Growth Factor Proteins and Modulates HIV-1 Replication

scientific article published on 21 May 2016

The diurnal periodicity of hexose transporter mRNA and protein levels in the rat jejunum: role of vagal innervation

scientific article

The extracellular sulfatase SULF2 promotes liver tumorigenesis by stimulating assembly of a promoter-looping GLI1-STAT3 transcriptional complex

scientific article published on 27 January 2020

The first initiative targeted to increase the training of African-American scientists in pancreatic cancer research: the Mayo Clinic College of Medicine-Oakwood College alliance.

scientific article

The oncogenic effect of sulfatase 2 in human hepatocellular carcinoma is mediated in part by glypican 3-dependent Wnt activation

scientific article published on November 2010

The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma

scientific article published on April 2015

The transcription factor GLI1 cooperates with the chromatin remodeler SMARCA2 to regulate chromatin accessibility at distal DNA regulatory elements

scientific article published on 06 May 2020

The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor β-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner

scientific article

The transcription factor GLI1 mediates TGFβ1 driven EMT in hepatocellular carcinoma via a SNAI1-dependent mechanism

scientific article

The transcription factor GLI1 modulates the inflammatory response during pancreatic tissue remodeling

scientific article

Toward personalized TGFβ inhibition for pancreatic cancer

scientific article published on 22 October 2019

Transcriptional Control of Gene Expression in Pancreatic Cancer: From Sequence-Specific Transcription Factors to Nuclear Architecture ⬇️

scientific article published on 01 June 2011

Transcriptional Induction of Periostin by a Sulfatase 2-TGFβ1-SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma.

scientific article published on 21 November 2016

Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB.

scientific article

Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma.

scientific article

When developmental signaling pathways go wrong and their impact on pancreatic cancer development

scientific article

ZIP4 Increases Expression of Transcription Factor ZEB1 to Promote Integrin α3β1 Signaling and Inhibit Expression of the Gemcitabine Transporter ENT1 in Pancreatic Cancer Cells

scientific article published on 09 November 2019

ZIP4 Promotes Muscle Wasting and Cachexia in Mice with Orthotopic Pancreatic Tumors by Stimulating RAB27B-Regulated Release of Extracellular Vesicles From Cancer Cells

scientific article published on 17 October 2018

ZIP4 Promotes Pancreatic Cancer Progression by Repressing ZO-1 and claudin-1 through a ZEB1-Dependent Transcriptional Mechanism.

scientific article published on 3 April 2018

mTOR-Dependent ARID1A Degradation: A New Twist in the Genetic–Epigenetic Interplay Driving Hepatocellular Carcinoma

scientific article published in 2021

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