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List of works by Nahum Sonenberg

14-3-3sigma controls mitotic translation to facilitate cytokinesis

scientific article published on March 2007

4E-BP-Dependent Translational Control of Irf8 Mediates Adipose Tissue Macrophage Inflammatory Response

scientific article published on 25 March 2020

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer

scientific article published on 20 March 2019

4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop That Controls β-Cell Mass

scientific article published on 23 May 2016

4E-BPs at the crossroads of oncogenic MAPK and AKT signaling.

scientific article

84 A homologous series of photoreactive peptidyl-tRNAs for probing the ribosomal peptidyltransferase center

scientific article published on January 1, 1977

A Novel Functional Human Eukaryotic Translation Initiation Factor 4G ⬇️

scientific article published on January 1, 1998

A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E.

scientific article

A collection of caged compounds for probing roles of local translation in neurobiology

scientific article published on 7 April 2010

A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus RNA genomes

scientific article published in January 2007

A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding

scholarly article

A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP.

scientific article

A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development

scientific article

A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A

scientific article

A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation

scientific article published on 14 October 2002

A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity

scientific article

A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay

scientific article

A photo-induced reaction of chloramphenicol with E.coli ribosomes: Covalent binding of the antibiotic and inactivation of peptidyl transferase ⬇️

scientific article published on July 24, 1974

A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA ⬇️

scientific article published on October 1, 1978

A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus

scientific article

A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay

scientific article

A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes

scientific article

ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress

scientific article

ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae ⬇️

scientific article published on August 15, 1992

ATP/Mg++-dependent cross-linking of cap binding proteins to the 5′ end of eukaryotic mRNA ⬇️

scientific article published on April 10, 1981

Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture ⬇️

scientific article published on 14 June 2010

Activation of GCN2 in UV-irradiated cells inhibits translation

scientific journal article

Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons

scientific article published on 20 May 2003

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

scientific article published on June 2004

Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism

scientific article published on 21 November 2016

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

scientific article published on 15 July 2005

Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis

scientific article published on 3 February 2012

Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species

scientific article

Aminoacylation of Proteins: New Targets for the Old ARSenal

scientific article published in January 2018

An efficient mammalian cell-free translation system supplemented with translation factors

scientific article

Analysis of terminal structures of RNA from potato virus X ⬇️

scientific article published on July 1, 1978

Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses

scientific journal article

Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3.

scientific article published on January 2011

ArabidopsisArgonaute MID domains use their nucleotide specificity loop to sort small RNAs

scientific article

Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells

scientific article published on 14 September 2011

Aster-C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

scientific article published on 09 July 2020

Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control.

scientific article published on 20 February 2005

Autism-related deficits via dysregulated eIF4E-dependent translational control

scientific article

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

scientific article published on 19 May 2021

Behavioral alterations in mice lacking the translation repressor 4E-BP2

scientific journal article

Beyond molecular tumor heterogeneity: protein synthesis takes control

scientific article published on 21 February 2018

Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins

scientific article

Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory. ⬇️

scientific article

Cancer Genomics: the post-transcriptional era ⬇️

scientific article published on 01 February 2013

Cap and cap-binding proteins in the control of gene expression

scientific article published on 28 October 2010

Cap binding complexes and cellular growth control ⬇️

scientific article published on January 1, 1995

Cap-dependent translation and control of the cell cycle

scientific article published on January 1, 2003

Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos

scientific article published on October 2006

Capped mRNAs with Reduced Secondary Structure Can Function in Extracts from Poliovirus-Infected Cells ⬇️

scientific article published on December 1, 1982

Cell biology. Burn out or fade away?

scientific article published in March 2010

Cell-free synthesis of encephalomyocarditis virus

scientific article

Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro

scientific article

Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3.

scientific article

Conserved tertiary structure elements in the 5' untranslated region of human enteroviruses and rhinoviruses ⬇️

scientific article published on 01 December 1992

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53.

scientific article published on 25 October 2007

Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase

scientific article

Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B.

scientific article published on 19 January 2010

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs

scientific article published on 30 May 2008

Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2

scientific article published on 24 October 2016

Control of synaptic plasticity and memory via suppression of poly(A)-binding protein

scientific journal article

Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q.

scientific article

Coordinated transcriptional and translational control in metabolic homeostasis in flies

scientific article published on February 2007

Correction

scholarly article published in Journal of Cell Biology

Correction: Role of 3′UTRs in the Translation of mRNAs Regulated by Oncogenic eIF4E—A Computational Inference

scientific article

Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5.

scientific article published on 25 December 2009

Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1.

scientific article published on 25 September 2009

Current status and challenges associated with targeting mTOR for cancer therapy

scientific article published on January 2009

DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation

scientific article

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice

scientific article

Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex

scientific article published on 22 April 2013

Dendritic BC1 RNA: functional role in regulation of translation initiation.

scientific article published on December 2002

Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells

scientific article

Differential stimulation of capped mRNA translation in vitro by cap binding protein ⬇️

scientific article published on May 29, 1980

Dissecting the role of mTOR: lessons from mTOR inhibitors

scientific article published on 11 December 2009

Distinct perturbation of the translatome by the antidiabetic drug metformin

scientific article

Distinct translational control in CD4+ T cell subsets

scientific article

Distinctive tRNA Repertoires in Proliferating versus Differentiating Cells

Diverse cap-binding properties of Drosophila eIF4E isoforms

scientific article published on 29 June 2016

Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis

scientific journal article

Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control

scientific article published on 25 October 2006

Elevated V-ATPase activity following PTEN loss is required for enhanced oncogenic signaling in breast cancer

scientific article published on 25 June 2020

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2

scientific journal article

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation

scientific article

Epiregulin and EGFR interactions are involved in pain processing

scientific article published on 7 August 2017

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels ⬇️

scientific article published on September 8, 1995

Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila

scientific article

Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity

scientific article published on 20 November 2017

Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP ⬇️

scientific article published on September 1, 1979

Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation

scientific article

Eukaryotic translation initiation factors and regulators

scientific article

Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis

scientific article published on 23 October 2009

FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse ⬇️

scientific article published on November 13, 2001

Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways

scientific article

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

scientific article

Fragile X syndrome

Functional and direct interaction between the RNA binding protein HuD and active Akt1.

scientific article published on 10 November 2011

G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA.

scientific article

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

scientific article

Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK

scientific article (publication date: 26 December 2003)

General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation

scientific article published on 11 December 2008

Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3

scientific article

Hepatic posttranscriptional network comprised of CCR4-NOT deadenylase and FGF21 maintains systemic metabolic homeostasis

scientific article published on 29 March 2019

Hepatitis C therapeutics: current status and emerging strategies

scientific article

High affinity RNA for mammalian initiation factor 4E interferes with mRNA-cap binding and inhibits translation

scientific article published on January 2005

Host translation at the nexus of infection and immunity

scientific article published on October 2012

HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA.

scientific article

Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A ⬇️

scientific article published on December 1, 1997

Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different

scientific article

IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells

scientific article published on 23 March 2012

Identification of a region in 23S rRNA located at the peptidyl transferase center ⬇️

scientific article published on November 1, 1975

Identification of differential translation in genome wide studies

scientific article

Identification of the 80-kDa protein that crosslinks to the cap structure of eukaryotic mRNAs as initiation factor eIF-4B ⬇️

scientific article published on July 1, 1988

Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation

scientific article published on April 2013

Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation

scientific article published on 31 January 2014

Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation?

scientific article published on 12 September 2007

Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2

scientific article published on 19 August 2019

Inhibitory properties of nucleic acid-binding ligands on protein synthesis

scientific article published on January 2005

Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells

scientific article

Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway

scientific article

Interaction of a limited set of proteins with different mRNAs and protection of 5'-caps against pyrophosphatase digestion in initiation complexes ⬇️

scientific article published on September 11, 1979

Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface

scientific article published on 24 October 2013

Introduction to Translation

scientific article published on April 2013

Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death

scientific article published on 17 October 2011

Isolation of a yeast gene encoding a protein homologous to the human Tat-binding protein TBP-1

scientific article published on October 1, 1992

LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction

scientific article published on 19 July 2016

La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro

scientific article published on August 2004

Largen: a molecular regulator of mammalian cell size control

scientific article

Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection

scientific article published on April 2011

Light-regulated translational control of circadian behavior by eIF4E phosphorylation

scientific article published on 27 April 2015

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing

scientific article

MNK inhibition sensitizes KRAS-mutant colorectal cancer to mTORC1 inhibition by reducing eIF4E phosphorylation and c-MYC expression

scientific article published on 16 December 2020

MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

scientific article

Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

scientific article

Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms

scientific article

Mapping of Escherichia coli Ribosomal Components Involved in Peptidyl Transferase Activity ⬇️

scientific article published on May 1, 1973

Mapping of the gene for interferon‐inducible dsRNA‐dependent protein kinase to chromosome region 2p21‐22: A site of rearrangements in myeloproliferative disorders ⬇️

scientific article published on 01 September 1993

Mechanisms governing the control of mRNA translation

scientific article published on 12 May 2010

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

scientific article (publication date: February 2008)

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

scientific article published on 15 May 2017

Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders

scientific article published on 26 October 2018

Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice

scientific article published on 20 July 2020

Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells

scientific article published on November 2007

Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells

scientific article published on 23 October 2006

Metformin requires 4E-BPs to induce apoptosis and repress translation of Mcl-1 in hepatocellular carcinoma cells

scientific article published on 18 July 2016

Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster

scientific article published on 28 May 2013

MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans.

scientific article published in October 2014

Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing

scientific article

Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis

scientific article published on 22 October 2010

Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver

scientific article published in April 2013

Multifaceted regulation of somatic cell reprogramming by mRNA translational control.

scientific article

Muscle metabolic alterations induced by genetic ablation of 4E-BP1 and 4E-BP2 in response to diet-induced obesity

scientific article

N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density

scientific article

NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer

scientific article published on 27 July 2016

Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions

scientific article published on 20 March 2012

Neuronal Regulation of eIF2α Function in Health and Neurological Disorders.

scientific article

New modes of translational control in development, behavior, and disease

scientific article published on December 2007

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain

scientific article published on 20 November 2018

Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs

scientific article published on 15 September 2015

Novel translational control in Arc-dependent long term potentiation consolidation in vivo

scientific article published on 15 September 2009

PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse

scientific journal article

Paip1 interacts with poly(A) binding protein through two independent binding motifs

scientific article

Parallel measurement of dynamic changes in translation rates in single cells

scientific article

Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons.

scientific article published in April 2009

Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes

scientific article

Pharmacological brake-release of mRNA translation enhances cognitive memory

scientific article published in 2013

Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1.

scientific article published on April 2007

Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation

scientific article published on 14 February 2019

Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk

scientific article

Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches

scientific article published on 29 April 2015

Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein

scientific article published in January 2003

Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

scientific article

Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth

scientific article

Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation ⬇️

scientific article published on March 1, 1992

Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I

scientific article (publication date: 5 December 2003)

Photo-affinity labeling of 23 S rRNA by an analog of fMet-tRNAMet-f

scientific article published on October 18, 1976

Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2

scientific article

Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation

scientific article published on 25 August 2008

Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission

scientific article

Probing the function of the eucaryotic 5′ cap structure by using a monoclonal antibody directed against cap-binding proteins ⬇️

scientific article published on December 1, 1981

Profile of Michael N. Hall, 2017 Albert Lasker Basic Medical Research Awardee: Target of rapamycin, cell growth, and translational control

scientific article published on 19 October 2017

Proposing a mechanism of action for ataluren

scientific article published on 19 October 2016

Protein Synthesis and Translational Control: A Historical Perspective

scientific article published on 03 September 2019

Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection ⬇️

scientific article published on September 15, 1998

RAPping production of type I interferon in pDCs through mTOR.

scientific article published on October 2008

RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation

scientific article published on 14 March 2007

RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis

scientific article published in April 2003

RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes

scientific article

RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B ⬇️

scientific article published on December 1, 1991

Ras mediates translation initiation factor 4E-induced malignant transformation

scientific article published on September 1, 1992

Reconstitution reveals the functional core of mammalian eIF3

scientific article

Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression.

scientific article published in February 2006

Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII

scientific journal article

Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B

scientific article

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

scientific article

Regulation of translation initiation in eukaryotes: mechanisms and biological targets

scientific article (publication date: 20 February 2009)

Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling.

scientific article published on 17 November 2006

Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins in initiation complexes ⬇️

scientific article published on October 1, 1977

Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain

scientific article published on 27 April 2010

Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap.

scientific article published on 29 December 2008

Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR

scientific journal article

Retrospective. Aaron Shatkin (1934-2012).

scientific article published in July 2012

Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period

scientific article

Role of 3'UTRs in the translation of mRNAs regulated by oncogenic eIF4E--a computational inference

scientific article

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

scientific article

S6K1 plays a critical role in early adipocyte differentiation

scientific article

Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor

scientific article published in April 2004

Selective modification of eukaryotic initiation factor 4F (eIF4F) at the onset of cell differentiation: recruitment of eIF4GII and long-lasting phosphorylation of eIF4E.

scientific article

Shared protein components of SINE RNPs

scientific article

Signal transduction and regulation of translation initiation ⬇️

scientific article published on April 1, 1992

Signaling control of mRNA translation in cancer pathogenesis

scientific article published on April 2004

Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster

scientific article

Signalling to eIF4E in cancer

scientific article

Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding

scientific article published on 5 June 2014

Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes

scientific article published on 8 May 2017

Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP.

scientific article

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

scientific article

Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP).

scientific article

Structural Analysis of the DAP5 MIF4G Domain and Its Interaction with eIF4A

scientific article

Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry

scientific article published on 27 October 2017

Structural analysis of 5′-mRNA–cap interactions with the human AGO2 MID domain

scientific article

Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2

scientific article

Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin

scientific article

Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase

scientific article

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

scientific article

Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling

scientific article

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

scientific article

Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12.

scientific article

TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction

scientific article published in April 2012

Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain

scientific article published on 21 September 2011

Targeting the eIF4F translation initiation complex: a critical nexus for cancer development

scientific article

Targeting the translation machinery in cancer

scientific article

The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes

scientific article published on 31 May 2016

The Akt of translational control

scientific article

The Distribution of eIF4E-Family Members across Insecta

scientific article (publication date: 2012)

The Drosophila poly(A) binding protein-interacting protein, dPaip2, is a novel effector of cell growth

scientific article published on February 2004

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

scientific article published on 7 July 2017

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70s6k ⬇️

scientific article published on September 1, 1997

The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene ⬇️

scientific article published on October 27, 1995

The MNK-eIF4E Signaling Axis Contributes to Injury-Induced Nociceptive Plasticity and the Development of Chronic Pain

scientific article published on 3 July 2017

The dynamics of mammalian P body transport, assembly, and disassembly in vivo

scientific article

The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior

scientific article published on 23 November 2020

The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase

scientific article published in October 2008

The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase

scientific article

The eukaryotic translation initiation factor 4E is not modified during the course of vaccinia virus replication

scientific article published on June 1, 1992

The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP

scientific article

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

scientific article

The leader of human immunodeficiency virus type 1 genomic RNA harbors an internal ribosome entry segment that is active during the G2/M phase of the cell cycle

scientific article

The long unfinished march towards understanding microRNA-mediated repression

scientific article published on April 2015

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts ⬇️

scientific article published on March 1, 1992

The mRNA 5′ cap-binding protein eIF4E and control of cell growth ⬇️

scientific article published on April 1, 1998

The mTOR Targets 4E-BP1/2 Restrain Tumor Growth and Promote Hypoxia Tolerance in PTEN-driven Prostate Cancer

scientific article published on 16 February 2018

The mTOR pathway in hepatic malignancies

scientific article published on 17 April 2013

The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity

scientific article

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC.

scientific article

The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice

scientific journal article

The protein kinase PKR: a molecular clock that sequentially activates survival and death programs

scientific article

The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation

scientific journal article

The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus

scientific journal article

Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation

scientific article

Toward a Genome-Wide Landscape of Translational Control ⬇️

scientific article published on January 1, 2013

Transcriptional induction of 4E-BP3 prolongs translation repression

scientific article published on 26 August 2016

Translation and cancer

scientific article published on 16 May 2015

Translation control during prolonged mTORC1 inhibition mediated by 4E-BP3.

scientific article published on 20 June 2016

Translation initiator EIF4G1 mutations in familial Parkinson disease

scientific article (publication date: 9 September 2011)

Translational Control by the Eukaryotic Ribosome ⬇️

scientific article published on April 29, 2011

Translational control and autism-like behaviors

scientific article published on January 2013

Translational control and the cancer cell response to stress

scientific article published on 02 June 2017

Translational control by 5'-untranslated regions of eukaryotic mRNAs

scientific article

Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils

scientific article published on 20 February 2018

Translational control mechanisms in long-lasting synaptic plasticity and memory

scientific article published on 06 August 2010

Translational control of ERK signaling through miRNA/4EHP-directed silencing

scientific article published on 7 February 2018

Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency

scientific article

Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling

scientific article published on August 2013

Translational control of gene expression: a molecular switch for memory storage

scientific article

Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2

scientific journal article

Translational control of immune responses: from transcripts to translatomes

scientific article published on June 2014

Translational control of long-lasting synaptic plasticity and memory

scientific article published on January 2009

Translational control of long-term synaptic plasticity and memory storage by eIF2alpha

scientific article published on January 2006

Translational control of nociception via 4E-binding protein 1

scientific article (publication date: 18 December 2015)

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

scientific article

Translational control of the innate immune response through IRF-7

scientific article published in Nature

Translational homeostasis via the mRNA cap-binding protein, eIF4E

scientific article

Translational regulatory mechanisms in synaptic plasticity and memory storage

scientific article published on 27 October 2009

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

scientific article published on December 2004

Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection

scientific article

Tumstatin, an endothelial cell-specific inhibitor of protein synthesis

scientific article

Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1.

scientific article

UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant

scientific article

Understanding how miRNAs post-transcriptionally regulate gene expression

scientific article published on January 2010

Unique translation initiation of mRNAs-containing TISU element

scientific article published on 25 June 2011

Upstream and downstream of mTOR

scientific article

Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production

scientific article

Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation

scientific article published on 16 April 2008

Weak binding affinity of human 4EHP for mRNA cap analogs

scientific article

When translation meets metabolism: multiple links to diabetes

scientific article

XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation

scientific article

anota: Analysis of differential translation in genome-wide studies

scientific article published on 21 March 2011

eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory

scientific article

eIF2α phosphorylation controls thermal nociception

scientific article published on 03 October 2016

eIF4AIII binds spliced mRNA in the exon junction complex and is essential for nonsense-mediated decay

scientific article

eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways

scientific article published on 13 October 2010

eIF4E S209 phosphorylation licenses Myc-and stress-driven oncogenesis

scientific article published on 02 November 2020

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

scientific article

eIF4E, the mRNA cap-binding protein: from basic discovery to translational research

scientific article published on April 2008

eIF4E--from translation to transformation

scientific article published on April 2004

eIF4E/4E-BP dissociation and 4E-BP degradation in the first mitotic division of the sea urchin embryo

scientific article published in March 2003

eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies

scientific article published on 24 October 2012

eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure ⬇️

scientific article published on August 29, 1997

mRNA helicases: the tacticians of translational control

scientific article published on April 2011

mTOR Controls Mitochondrial Dynamics and Cell Survival via MTFP1.

scientific article published on 13 September 2017

mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio ⬇️

scientific article published on December 1, 2012

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons

scientific article

mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction

scientific article published on 19 March 2018

mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation.

scientific article

mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK.

scientific article

mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs

scientific article

mTORC1-mediated translational elongation limits intestinal tumour initiation and growth

scientific article

miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock

scientific article

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT

scientific article

p53-dependent translational control of senescence and transformation via 4E-BPs.

scientific article published in November 2009

μ-Opioid Receptor Activates Signaling Pathways Implicated in Cell Survival and Translational Control ⬇️

scientific article published on September 4, 1998

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