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List of works by Richard S Hotchkiss

A Quasi-Experimental, Before-After Trial Examining the Impact of an Emergency Department Mechanical Ventilator Protocol on Clinical Outcomes and Lung-Protective Ventilation in Acute Respiratory Distress Syndrome.

scientific article published on 2 February 2017

A genetically encoded multifunctional TRAIL trimer facilitates cell-specific targeting and tumor cell killing.

scientific article published on 22 June 2010

A guiding map for inflammation

scientific article published on July 2017

A prospective analysis of lymphocyte phenotype and function over the course of acute sepsis ⬇️

scientific article published on June 28, 2012

AGE DISPROPORTIONATELY INCREASES SEPSIS-INDUCED APOPTOSIS IN THE SPLEEN AND GUT EPITHELIUM

article

Abandon the mouse research ship? Not just yet!

scientific article

Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways

scientific article published on 01 April 2005

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis ⬇️

scientific article published on May 7, 2003

Adoptive transfer of dying cells causes bystander-induced apoptosis

scientific article published on 22 December 2006

Advances in the Management of Sepsis and the Understanding of Key Immunologic Defects ⬇️

scientific article published on December 1, 2011

Agonistic monoclonal antibody against CD40 receptor decreases lymphocyte apoptosis and improves survival in sepsis

scientific article published on 01 July 2006

Akt decreases lymphocyte apoptosis and improves survival in sepsis

scientific article

An anti-apoptotic peptide improves survival in lethal total body irradiation

scientific article

Anti-apoptotic peptides protect against radiation-induced cell death

scientific article published on 8 February 2007

Antibiotics improve survival and alter the inflammatory profile in a murine model of sepsis from Pseudomonas aeruginosa pneumonia

scientific article published in May 2003

Antibiotics improve survival in sepsis independent of injury severity but do not change mortality in mice with markedly elevated interleukin 6 levels

scientific article published in February 2004

Apoptosis and caspases regulate death and inflammation in sepsis

scientific article published on 13 October 2006

BTLA as a biomarker and mediator of sepsis-induced immunosuppression

scientific article

Bcl-2 inhibits gut epithelial apoptosis induced by acute lung injury in mice but has no effect on survival

scientific article published in November 2003

Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis

scientific article published on 01 August 2008

Bim-Bcl-2 homology 3 mimetic therapy is effective at suppressing inflammatory arthritis through the activation of myeloid cell apoptosis

scientific article

Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis

scientific article published on 11 May 2013

Body temperature patterns as a predictor of hospital-acquired sepsis in afebrile adult intensive care unit patients: a case-control study.

scientific article published on 12 September 2013

Both gram-negative and gram-positive experimental pneumonia induce profound lymphocyte but not respiratory epithelial cell apoptosis

scientific article published on 01 September 2006

CD4+ lymphocyte adenosine triphosphate determination in sepsis: a cohort study

scientific article

CD4+ lymphocytes control gut epithelial apoptosis and mediate survival in sepsis

scientific article published on 21 January 2009

Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis.

scientific article

Cecal ligation and puncture followed by methicillin-resistant Staphylococcus aureus pneumonia increases mortality in mice and blunts production of local and systemic cytokines

scientific article published on January 2012

Cell death

scientific article

Change in temperature profile may precede fever and be an early indicator of sepsis: a case report

scientific article published on 01 September 2011

Characterization and evaluation of two novel fluorescent sigma-2 receptor ligands as proliferation probes.

scientific article published on December 2011

Characterization and modulation of the immunosuppressive phase of sepsis

scientific article

Characterization of the systemic loss of dendritic cells in murine lymph nodes during polymicrobial sepsis

scientific article published in September 2004

Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study.

scientific article published on 20 October 2016

Counterpoint: Should antipyretic therapy be given routinely to febrile patients in septic shock? No.

scientific article published on October 2013

Deep Immune Profiling in Trauma and Sepsis: Flow Is the Way to Go!

scientific article published on 01 September 2017

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

scientific article published on 18 May 2010

Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.

scientific article

Depletion of dendritic cells, but not macrophages, in patients with sepsis

scientific article published on 01 March 2002

Desperate Times Call for Desperate Measures: Self-Cannibalism Is Protective During Sepsis

scientific article published on January 2017

Development of a new humanized mouse model to study acute inflammatory arthritis

scientific article published on 13 September 2012

Development of an immunoassay for the kidney-specific protein myo-inositol oxygenase, a potential biomarker of acute kidney injury

scientific article

Differential lymphopenia-induced homeostatic proliferation for CD4+ and CD8+ T cells following septic injury

scientific article published on 30 December 2008

Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms

scientific article

Dose-Dependent Effect of Anti-CTLA-4 on Survival in Sepsis ⬇️

scientific article published on July 1, 2011

Early antibiotic administration but not antibody therapy directed against IL-6 improves survival in septic mice predicted to die on basis of high IL-6 levels.

scientific article

Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells

scientific article published in February 2003

Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture

scientific article published in April 2003

Effects of aging on the immunopathologic response to sepsis.

scientific article published on March 2009

Endothelial cell apoptosis in sepsis

scientific article

Endothelial cell apoptosis in sepsis: a case of habeas corpus?

scientific article published in March 2004

Epidemiology of Bloodstream Infections in a Multicenter Retrospective Cohort of Liver Transplant Recipients

scientific article published on 22 February 2016

Epidermal growth factor treatment decreases mortality and is associated with improved gut integrity in sepsis.

scientific article published on July 2008

Erratum to: Is this critically ill patient immunocompromised?

scientific article published on 01 June 2016

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.

scientific article published on 26 September 2016

High-dose exogenous iron following cecal ligation and puncture increases mortality rate in mice and is associated with an increase in gut epithelial and splenic apoptosis

scientific article published in May 2004

Host-directed therapies for bacterial and viral infections.

scientific article published on 22 September 2017

IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients

scientific article published on 09 September 2019

IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.

scientific article

IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis.

scientific article

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

scientific article

Imaging Apoptosis in Sepsis--A Technology We Would Die for!

scientific article published on November 2015

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab

scientific article published on 01 October 2019

Immunoadjuvant therapy in sepsis: novel strategies for immunosuppressive sepsis coming down the pike

Immunology. Getting sepsis therapy right

scientific article published on March 2015

Immunosuppression in patients who die of sepsis and multiple organ failure

scientific article

Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach ⬇️

scientific article published on March 1, 2013

Immunotherapy - a potential new way forward in the treatment of sepsis ⬇️

scientific article published on February 20, 2013

Immunotherapy for sepsis--a new approach against an ancient foe.

scientific article published on July 2010

Immunotherapy: It is not just for cancer anymore

scientific article published on 3 January 2018

Increased lymphoid tissue apoptosis in baboons with bacteremic shock

scientific article published in June 2004

Induction of Chondrocyte Apoptosis Following Impact Load ⬇️

scientific article published on October 1, 2003

Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis

scientific article published on 01 April 2002

Inhibition of intestinal epithelial apoptosis improves survival in a murine model of radiation combined injury

scientific article (publication date: 2013)

Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia

scientific article published on 14 September 2016

Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis.

scientific article

Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis

scientific article

Interleukin-7 and anti-programmed cell death 1 antibody have differing effects to reverse sepsis-induced immunosuppression

scientific article

Interleukin-7 restores lymphocytes in septic shock: the IRIS-7 randomized clinical trial.

scientific article published on 8 March 2018

Intestine-specific overexpression of IL-10 improves survival in polymicrobial sepsis.

scientific article published on April 2008

Intravital microscopy comparing T lymphocyte trafficking to the spleen and the mesenteric lymph node

scientific article (publication date: June 2003)

Iron dysregulation combined with aging prevents sepsis-induced apoptosis

scientific article

Is this critically ill patient immunocompromised?

scientific article published on 2 December 2015

Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors

scientific article published on 23 June 2007

Leukocyte phenotyping to stratify septic shock patients.

scientific article published on 3 April 2009

Low-dose interleukin-2 reverses behavioral sensitization in multiple mouse models of headache disorders

scientific article published on 04 February 2020

Lung-Protective Ventilation Initiated in the Emergency Department (LOV-ED): A Quasi-Experimental, Before-After Trial.

scientific article published in March 2017

Lung-protective ventilation initiated in the emergency department (LOV-ED): a study protocol for a quasi-experimental, before-after trial aimed at reducing pulmonary complications

scientific article published on 11 April 2016

Lymphocyte phenotyping to distinguish septic from nonseptic critical illness.

scientific article

Mechanisms and consequences of ebolavirus-induced lymphocyte apoptosis

scientific article published on January 2010

Mechanisms of cardiac and renal dysfunction in patients dying of sepsis

scientific article published on 24 January 2013

Mechanisms of decreased intestinal epithelial proliferation and increased apoptosis in murine acute lung injury

scientific article

Modulation of the Bcl-2 family blocks sepsis-induced depletion of dendritic cells and macrophages.

scientific article published on April 2009

Molecular Diagnostics in Sepsis: From Bedside to Bench

scientific article published on 11 September 2006

Monitoring the immune response in sepsis: a rational approach to administration of immunoadjuvant therapies

scientific article

Monocyte Function and Clinical Outcomes in Febrile and Afebrile Patients with Severe Sepsis

scientific article published on 13 December 2017

Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis

scientific article published on 16 February 2007

Myeloperoxidase produces nitrating oxidants in vivo

scientific article

Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.

scientific article published on 13 March 2008

Nivolumab plus interferon-γ in the treatment of intractable mucormycosis

scientific article published on 01 January 2017

Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice

scientific article published on 01 January 2002

Parallels between cancer and infectious disease

scientific article published on July 2014

Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis

scientific article

Persistent lymphopenia after diagnosis of sepsis predicts mortality.

scientific article

Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis

scientific article published on 01 December 2006

Prevention of immune cell apoptosis as potential therapeutic strategy for severe infections

scientific article published on February 2007

Prevention of lymphocyte apoptosis--a potential treatment of sepsis?

scientific article

Probiotics for preventing ventilator-associated pneumonia

scientific article

Probiotics for preventing ventilator-associated pneumonia

scientific article (published 2011-04-13)

Pulmonary contusion is associated with toll-like receptor 4 upregulation and decreased susceptibility to pseudomonas pneumonia in a mouse model.

scientific article published on June 2012

Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.

scientific article published on 26 October 2011

Reactivation of multiple viruses in patients with sepsis

scientific article

Rebuttal From Drs Drewry and Hotchkiss.

scientific article

Reducing the burden of acute respiratory distress syndrome: the case for early intervention and the potential role of the emergency department

scientific article

Reply: The role of arrhythmias in defining cardiac dysfunction during sepsis

scientific article

Restoration of T Cell function in multi-drug resistant bacterial sepsis after interleukin-7, anti-PD-L1, and OX-40 administration.

scientific article published on 26 June 2018

Role of apoptotic cell death in sepsis

scientific article published on January 2003

Selective sigma-2 ligands preferentially bind to pancreatic adenocarcinomas: applications in diagnostic imaging and therapy ⬇️

scientific article published on 15 July 2007

Sepsis and septic shock

Sepsis from Pseudomonas aeruginosa pneumonia decreases intestinal proliferation and induces gut epithelial cell cycle arrest*

scientific article published on 01 June 2003

Sepsis gene expression profiling: murine splenic compared with hepatic responses determined by using complementary DNA microarrays

scholarly article

Sepsis induces apoptosis and profound depletion of splenic interdigitating and follicular dendritic cells

scientific article published on 01 July 2003

Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study

scientific article published on 02 February 2009

Sepsis-induced apoptosis leads to active suppression of delayed-type hypersensitivity by CD8+ regulatory T cells through a TRAIL-dependent mechanism

scientific article

Sepsis-induced disseminated intravascular coagulation, symmetrical peripheral gangrene, and amputations

scientific article

Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice

scientific article published on 15 April 2009

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

scientific article

Sepsis: Preventing organ failure in sepsis - the search continues

scientific article published on 21 November 2016

Sepsis: Revising definitions of sepsis

scientific article

Sequence makes a difference: paradoxical effects of stress in vivo

scientific article published in September 2004

Sigma-2 receptor ligands potentiate conventional chemotherapies and improve survival in models of pancreatic adenocarcinoma

scientific article

Splenic CD4+ T Cells Have a Distinct Transcriptional Response Six Hours after the Onset of Sepsis

article

Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses

scientific article

Stress-induced fractal rearrangement of the endothelial cell cytoskeleton causes apoptosis

Subcellular Localization of Sigma-2 Receptors in Breast Cancer Cells Using Two-Photon and Confocal Microscopy

article

Surviving sepsis: bcl-2 overexpression modulates splenocyte transcriptional responses in vivo

scientific article published on 18 January 2007

T cells from patients with Candida sepsis display a suppressive immunophenotype

scientific article

TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo

scientific article published on 01 May 2006

TAT-Bim induces extensive apoptosis in cancer cells

scientific article published on 06 January 2007

TLR3 agonist improves survival to secondary pneumonia in a double injury model ⬇️

scientific article published on October 11, 2012

Targeted delivery of siRNA to cell death proteins in sepsis.

scientific article published on August 2009

Targeting AKT with the proapoptotic peptide, TAT-CTMP: a novel strategy for the treatment of human pancreatic adenocarcinoma.

scientific article

Targeting the programmed cell death 1: programmed cell death ligand 1 pathway reverses T cell exhaustion in patients with sepsis

scientific article

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

scientific article

The authors reply

scientific article published on 01 November 2015

The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?

scientific article published on 25 September 2013

The first step in utilizing immune-modulating therapies: immune status determination.

scientific article published on 24 January 2011

The new normal: immunomodulatory agents against sepsis immune suppression

scientific article published on 30 January 2014

The presence of hypothermia within 24 hours of sepsis diagnosis predicts persistent lymphopenia

scientific article

The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis

scientific article published on 01 December 2006

The sepsis seesaw: tilting toward immunosuppression

scientific article published on May 2009

Tolerance and Cross-Tolerance following Toll-Like Receptor (TLR)-4 and -9 Activation Are Mediated by IRAK-M and Modulated by IL-7 in Murine Splenocytes

scientific article (publication date: 2015)

Understanding why clinicians should care about danger-associated molecular patterns

scientific article published on 24 February 2016

Use of multifunctional sigma-2 receptor ligand conjugates to trigger cancer-selective cell death signaling

scientific article published on 7 November 2011

Widespread Down-Regulation of Cardiac Mitochondrial and Sarcomeric Genes in Patients With Sepsis

scientific article published on 6 January 2017

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