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List of works by Jose Carlos Alves-Filho

-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

scientific article published on 02 October 2018

15d-PGJ-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

scientific article published in Scientific Reports

5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality

scientific article published on 31 October 2013

9The PI3Kγ/AKT signaling pathway mediates peripheral antinociceptive action of dipyrone

scientific article published on 26 September 2020

Apocynin and Nox2 regulate NF-κB by modifying thioredoxin-1 redox-state.

scientific article published on 04 October 2016

Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice

scientific article

Budlein A, a Sesquiterpene Lactone From , Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

scholarly article by Victor Fattori et al published 2018 in Frontiers in Pharmacology

CCR2 Expression in Neutrophils Plays a Critical Role in Their Migration Into the Joints in Rheumatoid Arthritis

scientific article published in July 2015

CCR2-deficient mice are protected to sepsis by the disruption of the inflammatory monocytes emigration from the bone marrow

scientific article published on 05 October 2020

CCR4-dependent reduction in the number and suppressor function of CD4Foxp3 cells augments IFN-γ-mediated pulmonary inflammation and aggravates tuberculosis pathogenesis

scientific article published on 21 December 2018

CCR5-Positive Inflammatory Monocytes are Crucial for Control of Sepsis

scientific article published on 01 November 2019

Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

scientific article published on 17 April 2018

Cinnamoyloxy-mammeisin Isolated from Geopropolis Attenuates Inflammatory Process by Inhibiting Cytokine Production: Involvement of MAPK, AP-1, and NF-κB.

scientific article published in July 2016

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice

scientific article published on 28 May 2019

Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

scientific article

DF2755A, a novel non-competitive allosteric inhibitor of CXCR1/2, reduces inflammatory and post-operative pain

scientific article published on 16 November 2015

DMH-CBD, a cannabidiol analog with reduced cytotoxicity, inhibits TNF production by targeting NF-kB activity dependent on A2A receptor

scientific article published on 20 February 2019

Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice

scientific article published on 24 October 2016

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice

scientific article published on 15 June 2017

Frontline Science: Blood-circulating leukocytes fail to infiltrate the spinal cord parenchyma after spared nerve injury

scientific article published on 31 May 2019

Fructose 1,6-bisphosphate, a high-energy intermediate of glycolysis, attenuates experimental arthritis by activating anti-inflammatory adenosinergic pathway

scientific article

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

scientific article published on 13 June 2018

Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels

scientific article published in September 2008

IL-1α promotes liver inflammation and necrosis during blood-stage Plasmodium chabaudi malaria

scientific article published on 20 May 2019

IL-27 Counteracts Neuropathic Pain Development Through Induction of IL-10

scientific article published on 01 January 2019

IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis

scientific article published on 04 September 2020

IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy

scientific article published on 14 May 2010

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

scientific article published on 01 March 2021

Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis

scientific article published in Nature Communications

Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice

scientific article

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis

scientific article

Lapachol, a compound targeting pyrimidine metabolism, ameliorates experimental autoimmune arthritis

scientific article published on 7 March 2017

Lipopolysaccharide induces inflammatory hyperalgesia triggering a TLR4/MyD88-dependent cytokine cascade in the mice paw

scientific article

Low expression of CD39 on regulatory T cells as a biomarker for resistance to methotrexate therapy in rheumatoid arthritis

scientific article

MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression

scientific article published on 03 August 2020

Mechanisms underlying the hyperalgesic responses triggered by joint activation of TLR4.

scientific article published on 24 August 2016

Medial plantar nerve ligation as a novel model of neuropathic pain in mice: pharmacological and molecular characterization

scientific article published on 27 May 2016

Molecular basis of carrageenan-induced cytokines production in macrophages

scientific article published on 07 September 2020

Morphological, cellular, and molecular basis of brain infection in COVID-19 patients

scientific article published in 2022

NLRP12 controls arthritis severity by acting as a checkpoint inhibitor of Th17 cell differentiation

scientific article published on 07 July 2020

Naringenin mitigates titanium dioxide (TiO)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F Manchope et al published 28 October 2018 in Inflammation Research

Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F. Manchope et al published 28 October 2018 in Inflammation Research

Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia

scientific article published on 2 June 2017

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis

scientific article

Neutrophil extracellular traps mediate joint hyperalgesia induced by immune inflammation

scientific article published on 26 December 2020

Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

scientific article

PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation

scientific article published on 01 October 2020

Paclitaxel Reduces Tumor Growth by Reprogramming Tumor-Associated Macrophages to an M1 Profile in a TLR4-Dependent Manner

scientific article published on 13 August 2018

Pericytes modulate myelination in the central nervous system

scientific article published on 7 December 2017

Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production

scientific article published on 10 May 2017

Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects

scientific article published on 6 April 2017

Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress

scientific article published on 09 May 2016

Regulation of type 17 helper T-cell function by nitric oxide during inflammation

scientific article

Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury

scientific article published on 26 March 2020

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

scientific article published on 31 March 2019

S100A9 plays a pivotal role in a mouse model of herpetic neuralgia via TLR4/TNF pathway

scientific article published on 31 March 2020

SARS-CoV-2 triggered neutrophil extracellular traps (NETs) mediate COVID-19 pathology

scientific article published on 9 June 2020

SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology

scientific article published on 01 December 2020

STING regulates metabolic reprogramming in macrophages via HIF-1α during Brucella infection

scientific article published on 14 May 2021

Spinal cord oligodendrocyte-derived alarmin IL-33 mediates neuropathic pain

scientific article published on 26 August 2015

Succinate receptor deficiency attenuates arthritis by reducing dendritic cell traffic and expansion of Th17 cells in the lymph nodes

scientific article published on 12 June 2018

Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice

scientific article published on 18 August 2015

TGF-β signalling defect is linked to low CD39 expression on regulatory T cells and methotrexate resistance in rheumatoid arthritis.

scientific article published on 6 February 2018

TGFβ1 signaling sustains aryl hydrocarbon receptor (AHR) expression and restrains the pathogenic potential of T17 cells by an AHR-independent mechanism

scientific article published on 13 November 2018

Targeting IL-33/ST2 signaling: regulation of immune function and analgesia

scientific article

Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice

scientific article

Targeting nitric oxide as a key modulator of sepsis, arthritis and pain

scientific article published on 30 April 2019

The Atypical Chemokine Receptor ACKR2 is Protective Against Sepsis

scientific article published on 24 August 2017

The NOD2 signaling in peripheral macrophages contributes to neuropathic pain development

scientific article published on 01 January 2019

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

scientific article published in April 2016

The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain

scientific article published on 7 June 2016

Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome

scientific article published in September 2012

Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.

scientific article published on 14 May 2015

α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice

scientific article published on 13 March 2012

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