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List of works by Carolyn Calfee

A Research Agenda for Precision Medicine in Sepsis and Acute Respiratory Distress Syndrome: An Official American Thoracic Society Research Statement

scientific article published on 15 October 2021

A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome.

scientific article published on 3 August 2016

A living WHO guideline on drugs for covid-19

scientific article published on 04 September 2020

A new frontier in ARDS trials: phenotyping before randomisation

scientific article published on 06 August 2019

A simple classification model for hospital mortality in patients with acute lung injury managed with lung protective ventilation

scientific article published on December 2011

ANGPT2 genetic variant is associated with trauma-associated acute lung injury and altered plasma angiopoietin-2 isoform ratio.

scientific article

ARDS Subphenotypes: Understanding a Heterogeneous Syndrome

scientific article published on 24 March 2020

ARDS in 2015: new clinical directions, new biological insights

scientific article published in December 2015

ARDS: new mechanistic insights, new therapeutic directions

scientific article published on 12 November 2014

Active and Passive Cigarette Smoking and Acute Lung Injury after Severe Blunt Trauma ⬇️

scientific article published on March 18, 2011

Acute Respiratory Distress Syndrome Phenotypes

scientific article published on 01 February 2019

Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy.

scientific article

Acute Respiratory Distress Syndrome Subphenotypes beyond the Syndrome: A Step toward Treatable Traits?

scientific article published in 2021

Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death

scientific article

Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis

scientific article

Acute respiratory distress syndrome

Acute respiratory distress syndrome subphenotypes and differential response to simvastatin: secondary analysis of a randomised controlled trial

article by Carolyn Calfee et al published September 2018 in The Lancet. Respiratory medicine

Acute respiratory distress syndrome subphenotypes and therapy responsive traits among preclinical models: protocol for a systematic review and meta-analysis

scientific article published on 07 April 2020

Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis

scientific article published on 23 March 2020

Aerosolized beta-adrenergic agonist therapy reduces pulmonary edema following lung surgery

scientific article published in April 2008

Alternative Tobacco Product Use in Critically Ill Patients

scientific article published on 24 November 2020

Assessment of industry data on pulmonary and immunosuppressive effects of IQOS

scientific article published on 29 August 2018

Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis

scientific article published on 01 September 2018

Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome

scientific article published on 23 May 2016

Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome

scientific article published on 01 November 2018

Biomarkers and Precision Medicine: State of the Art

scientific article published on 22 October 2019

Biomarkers increase detection of active smoking and secondhand smoke exposure in critically ill patients

scientific article

Biomarkers of ARDS: what's new?

scientific article published on 15 July 2015

Biomarkers of lung epithelial injury and inflammation distinguish severe sepsis patients with acute respiratory distress syndrome

scientific article

Biomarkers of lung injury in primary graft dysfunction following lung transplantation

scientific article published on August 2007

COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone

COVID-19-associated acute respiratory distress syndrome: is a different approach to management warranted?

scientific article published on 06 July 2020

Characterization of distinct coagulopathic phenotypes in injury: Pathway-specific drivers and implications for individualized treatment

scientific article published on 23 March 2017

Characterizing the gut microbiome in trauma: significant changes in microbial diversity occur early after severe injury

scientific article published on 23 October 2017

Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice.

scientific article

Cigarette Smoke Exposure and the Acute Respiratory Distress Syndrome

scientific article published on 22 May 2015

Cigarette Smoking and ARDS After Blunt Trauma: The Influence of Changing Smoking Patterns and Resuscitation Practices

scientific article published on 20 June 2020

Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice

scientific article published on 15 March 2018

Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation.

scientific article published on 2 February 2016

Clara cell protein (CC16), a marker of lung epithelial injury, is decreased in plasma and pulmonary edema fluid from patients with acute lung injury

scientific article published on 02 February 2009

Clearing the air. Smoking and incident asthma in adults

scientific article published in January 2015

Clinical Evidence of Early Acute Lung Injury Often Precedes the Diagnosis of ALI ⬇️

scientific article published on June 24, 2012

Clinical Predictors of Hospital Mortality Differ Between Direct and Indirect ARDS.

scientific article published on 20 September 2016

Clinical immunology: Culprits with evolutionary ties

scientific article published on March 2010

Clinical problem-solving. Anchors away.

scientific article

Clinically relevant model of pneumococcal pneumonia, ARDS, and nonpulmonary organ dysfunction in mice

scientific article published on 11 September 2019

Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time

scientific article published on 17 April 2020

Comparison of chest radiograph scoring to lung weight as a quantitative index of pulmonary edema in organ donors

scientific article published on 10 February 2012

Comparison of machine learning clustering algorithms for detecting heterogeneity of treatment effect in acute respiratory distress syndrome: A secondary analysis of three randomised controlled trials

scientific article published on 01 December 2021

Comparison of thermodilution measured extravascular lung water with chest radiographic assessment of pulmonary oedema in patients with acute lung injury ⬇️

scientific article published on August 11, 2013

Critical Role of Activated Protein C in Early Coagulopathy and Later Organ Failure, Infection and Death in Trauma Patients ⬇️

scientific article published on February 1, 2012

Cytokine elevation in severe and critical COVID-19: a rapid systematic review, meta-analysis, and comparison with other inflammatory syndromes

scientific article published on 16 October 2020

Derivation and validation of a two-biomarker panel for diagnosis of ARDS in patients with severe traumatic injuries

scientific article published on 28 August 2017

Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome

scientific article

Detection of Pneumonia Pathogens from Plasma Cell-Free DNA

scientific article published on 01 February 2020

Determining the aetiology of pulmonary oedema by the oedema fluid-to-plasma protein ratio

scientific article

Development and validation of parsimonious algorithms to classify acute respiratory distress syndrome phenotypes: a secondary analysis of randomised controlled trials

scientific article published on 13 January 2020

Diagnostic workup for ARDS patients

scientific article published on 23 March 2016

Differences in degree, differences in kind: characterizing lung injury in trauma

scientific article

Distinct molecular phenotypes of direct vs indirect ARDS in single-center and multicenter studies

scientific article published on June 2015

Donor smoking is associated with pulmonary edema, inflammation and epithelial dysfunction in ex vivo human donor lungs

scientific article

Dose-Dependent Pulmonary Toxicity of Aerosolized Vitamin E Acetate

scientific article published on 21 August 2020

Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome

scientific article published on 01 January 2019

Early acute lung injury: criteria for identifying lung injury prior to the need for positive pressure ventilation*.

scientific article published on August 2013

Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion

scientific article

Early release of soluble receptor for advanced glycation endproducts after severe trauma in humans.

scientific article

Effect of simvastatin on physiological and biological outcomes in patients undergoing esophagectomy: a randomized placebo-controlled trial

scientific article published in January 2014

Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs

scientific article

Elevated plasma levels of TIMP-3 are associated with a higher risk of acute respiratory distress syndrome and death following severe isolated traumatic brain injury

scientific article published on 27 June 2018

Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study

scientific article published on 14 December 2015

Environmental risk factors for acute respiratory distress syndrome

scientific article

Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

scientific article

Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

scientific article published on 21 November 2019

Exposing the bidirectional effects of alcohol on coagulation in trauma: Impaired clot formation and decreased fibrinolysis in rotational thromboelastometry

scientific article published in January 2018

External validation of a biomarker and clinical prediction model for hospital mortality in acute respiratory distress syndrome

scientific article published on 7 June 2017

Extracorporeal Membrane Oxygenation during Respiratory Pandemics: Past, Present, and Future

scientific article published on 25 February 2022

FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study

scientific article

FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences

scientific article published on 01 August 2019

Fibrinogen and platelet contributions to clot formation: implications for trauma resuscitation and thromboprophylaxis

scientific article

Fixing the leak: targeting the vascular endothelium in sepsis.

scientific article published on 21 November 2012

Fluid administration and monitoring in ARDS: which management?

scientific article published on 09 November 2020

Focusing on the alveolar epithelium: Alveolar fluid clearance in diffuse versus focal acute respiratory distress syndrome

scientific article

Gender Differences in Authorship of Critical Care Literature

scientific article published on 01 April 2020

Gender Parity in Critical Care Medicine.

scientific article published on 27 February 2017

Genome wide association identifies PPFIA1 as a candidate gene for acute lung injury risk following major trauma

scientific article

Global Absence and Targeting of Protective Immune States in Severe COVID-19

scientific article published on 28 October 2020

Global Absence and Targeting of Protective Immune States in Severe COVID-19

scientific article published on 29 October 2020

Global absence and targeting of protective immune states in severe COVID-19

scientific article published on 25 January 2021

Health Care Utilization and the Cost of Post-Traumatic ARDS Care.

scientific article published on 2 April 2018

Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days

scientific article published on 17 February 2017

Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis

scientific article published on 19 July 2018

Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis.

scientific article published on 27 April 2017

Identification of Acute Kidney Injury Sub-phenotypes with Differing Molecular Signatures and Response to Vasopressin Therapy

scientific article published on 01 April 2019

Identification of early acute lung injury at initial evaluation in an acute care setting prior to the onset of respiratory failure

scientific article published on 02 February 2009

Identifying Clinical Research Priorities in Adult Pulmonary and Critical Care: NHLBI Working Group Report

scientific article published on 09 March 2020

Incorporating Inflammation into Mortality Risk in Pediatric Acute Respiratory Distress Syndrome.

scientific article published on 28 February 2017

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

scientific article published on 20 March 2015

Inflammasomes Assemble: Cytoplasmic Guardians or Fallen Heroes?

scientific article published on 01 August 2019

Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults

article published in the Proceedings of the National Academy of Sciences of the United States of America

Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study.

scientific article published on July 2014

Interstitial lung diseases in the hospitalized patient

scientific article published on 25 September 2015

Is a "Cytokine Storm" Relevant to COVID-19?

scientific article published on 30 June 2020

Is there still a role for the lung injury score in the era of the Berlin definition ARDS?

scientific article published on 18 February 2014

Keratinocyte growth factor promotes epithelial survival and resolution in a human model of lung injury

scientific article

Lack of Clinical Benefit of Interferon β-1a Among Patients With Severe Acute Respiratory Distress Syndrome: Time to Overhaul Drug Trials in ARDS?

scientific article published on 17 February 2020

Latent Class Analysis Reveals COVID-19-related Acute Respiratory Distress Syndrome Subgroups with Differential Responses to Corticosteroids

scientific article published on 01 December 2021

Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study

scientific article published on 05 October 2018

Long-Term Ozone Exposure Increases the Risk of Developing the Acute Respiratory Distress Syndrome.

scientific article published on 17 December 2015

Long-term ozone exposure is positively associated with telomere length in critically ill patients

scientific article published on 08 May 2020

Low to Moderate Air Pollutant Exposure and Acute Respiratory Distress Syndrome after Severe Trauma

scientific article published on 01 January 2019

Lung Microbiota is Related to Smoking Status and to Development of ARDS in Critically Ill Trauma Patients.

scientific article published on 16 October 2017

MSC extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS

scientific article published on 17 December 2020

Machine Learning Classifier Models Can Identify ARDS Phenotypes Using Readily Available Clinical Data

scientific article published on 18 June 2020

Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury

scientific article published on 8 February 2018

Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial

scientific article

Metagenomic comparison of tracheal aspirate and mini-bronchial alveolar lavage for assessment of respiratory microbiota

scientific article published on 17 January 2019

Misclassification of acute respiratory distress syndrome after traumatic injury: The cost of less rigorous approaches

scientific article

NIH Workshop Report: E-cigarette or Vaping Product Use Associated Lung Injury (EVALI): Developing a Research Agenda

scientific article published on 03 April 2020

New Insights into Clinical and Mechanistic Heterogeneity of the Acute Respiratory Distress Syndrome: Summary of the Aspen Lung Conference 2021

scientific article published in 2022

Nonventilatory treatments for acute lung injury and ARDS.

scientific article published on March 2007

Novel translational approaches to the search for precision therapies for acute respiratory distress syndrome

scientific article

One-year mortality and predictors of death among hospital survivors of acute respiratory distress syndrome

scientific article published on 17 January 2014

Opening the Debate on the New Sepsis Definition. Precision Medicine: An Opportunity to Improve Outcomes of Patients with Sepsis

scientific article published on 11 May 2016

Peeking under the Hood of Acute Respiratory Distress Syndrome Phenotypes: Deeper Insights into Biological Heterogeneity

scientific article published on 01 July 2019

Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults.

scientific article

Perhaps it's not the platelet: Ristocetin uncovers the potential role of von Willebrand factor in impaired platelet aggregation following traumatic brain injury

scientific article published on 01 November 2018

Peripheral blood leukocyte telomere length is associated with survival of sepsis patients

scientific article published on 16 January 2020

Personalized medicine for ARDS: the 2035 research agenda

scientific article published on 04 April 2016

Phenotypes and personalized medicine in the acute respiratory distress syndrome

scientific article published on 18 November 2020

Phenotypes in acute respiratory distress syndrome: moving towards precision medicine

scientific article published on 01 February 2019

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

scientific article published in 2022

Physiologic Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome

scientific article published on 01 February 2019

Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis

article

Plasma angiopoietin-2 in clinical acute lung injury: prognostic and pathogenetic significance

scientific article

Plasma angiopoietin-2 outperforms other markers of endothelial injury in prognosticating pediatric ARDS mortality.

scientific article

Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients

scientific article published on April 2013

Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis

scientific article

Plasma granulocyte colony-stimulating factor levels correlate with clinical outcomes in patients with acute lung injury

scientific article

Plasma interleukin-8 is not an effective risk stratification tool for adults with vasopressor-dependent septic shock

scientific article

Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury

scientific article published on 19 June 2008

Plasma receptor for advanced glycation end-products predicts duration of ICU stay and mechanical ventilation in patients after lung transplantation

scientific article published on July 2007

Plasma sRAGE Acts as a Genetically Regulated Causal Intermediate in Sepsis-associated Acute Respiratory Distress Syndrome

scientific article published on 01 January 2020

Plasma sRAGE is independently associated with increased mortality in ARDS: a meta-analysis of individual patient data

article

Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study

scientific article published on 09 December 2019

Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome.

scientific article

Platelet Aggregation After Blunt Trauma Is Associated with the Acute Respiratory Distress Syndrome and Altered by Cigarette Smoke Exposure

scientific article published on 14 November 2017

Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury

scientific article published on 01 April 2019

Possible hepatotoxicity of IQOS.

scientific article published on 21 August 2018

Practitioner's Guide to Latent Class Analysis: Methodological Considerations and Common Pitfalls

scientific article published on 09 November 2020

Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply

scientific article published on 01 April 2019

Predictors of postinjury acute respiratory distress syndrome: Lung injury persists in the era of hemostatic resuscitation

scientific article published on 01 August 2019

Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome.

scientific article

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

scientific article published on 27 August 2020

Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention

scientific article published on 17 June 2020

Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure

scientific article published on 01 March 2019

Pulmonary Dead Space Monitoring: Identifying Subjects With ARDS at Risk of Developing Right Ventricular Dysfunction

scientific article published on 28 May 2019

Pulmonary toxicity of e-cigarettes

scientific article

Recent advances in mechanical ventilation

scientific article

Reply to "Letter to the Editor: Pulmonary toxicity of electronic cigarettes: more doubts than certainties".

scientific article published in November 2017

Reply: Next Step to Understanding Subphenotypes of Acute Respiratory Distress Syndrome

scientific article published on 13 April 2017

Severe COVID-19 Infections-Knowledge Gained and Remaining Questions

scientific article published on 18 September 2020

Severity scoring of lung oedema on the chest radiograph is associated with clinical outcomes in ARDS

scientific article published on 14 June 2018

Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury

scientific article

Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury

scientific article

Sonographic B-lines, Fluid Resuscitation, and Hypoxemia in Malawian Patients with Suspected Sepsis

scientific article published on 14 April 2020

Stability of ARDS subphenotypes over time in two randomised controlled trials.

scientific article published on 24 February 2018

Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials

scientific article

Subphenotypes in critical care: translation into clinical practice

scientific article published on 01 June 2020

The ABO Histo-Blood Group, endothelial activation, and acute respiratory distress syndrome risk in critical illness

scientific article published on 15 September 2020

The Canary in the Coal Mine Is Coughing: Electronic Cigarettes and Respiratory Symptoms in Adolescents

scientific article

The acute respiratory distress syndrome following isolated severe traumatic brain injury

scientific article

The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury

scientific article published on 29 December 2011

The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial

scientific article

The attributable mortality of acute respiratory distress syndrome

scientific article published on 25 May 2020

The authors reply

scientific article published on 01 April 2019

The authors reply

The authors reply

The authors reply

scientific article published in April 2019

The influence of perceived control of asthma on health outcomes

scientific article published in November 2006

The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia

scientific article published on 7 January 2016

The search for diagnostic markers in sepsis: many miles yet to go.

scientific article published in July 2012

Therapeutic potential of mesenchymal stem cells for severe acute lung injury

scientific article

Therapeutic strategies for severe acute lung injury

scientific article published in August 2010

Therapeutic value of a lung protective ventilation strategy in acute lung injury

scientific article

Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment

scientific article published on 03 December 2019

Timing of Intubation and Clinical Outcomes in Adults With Acute Respiratory Distress Syndrome

scientific article published on 15 October 2015

Toward Smarter Lumping and Smarter Splitting: Rethinking Strategies for Sepsis and Acute Respiratory Distress Syndrome Clinical Trial Design

scientific article published on 31 May 2016

Towards a biological definition of ARDS: are treatable traits the solution?

scientific article published in 2022

Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS

scientific article published on 26 August 2021

Trauma-associated lung injury differs clinically and biologically from acute lung injury due to other clinical disorders

scientific article published on October 2007

Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial

scientific article published on 16 November 2018

Twenty-Four-Hour Cardiovascular Effects of Electronic Cigarettes Compared With Cigarette Smoking in Dual Users

scientific article published on 19 November 2020

Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19

scientific article published on 24 August 2021

Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate immune responses by SARS-CoV-2

scientific article published on 20 May 2020

Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses

scientific article published on 17 November 2020

Use of risk reclassification with multiple biomarkers improves mortality prediction in acute lung injury

scientific article

Using Best Subsets Regression to Identify Clinical Characteristics and Biomarkers Associated with Sepsis-Associated Acute Kidney Injury

scientific article published on 12 October 2020

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