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List of works by Russell William Jenkins

3D microfluidic ex vivo culture of organotypic tumor spheroids to model immune checkpoint blockade

article

A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade

article

A novel mechanism of lysosomal acid sphingomyelinase maturation: requirement for carboxyl-terminal proteolytic processing.

scientific article

A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.

scientific article published on 13 August 2007

Accumulation of long-chain glycosphingolipids during aging is prevented by caloric restriction.

scientific article

Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid

scientific article

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase

scientific article

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

scientific article published on 26 June 2018

Autophagy Inhibition Dysregulates TBK1 Signaling and Promotes Pancreatic Inflammation.

scientific article published on 11 April 2016

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

scientific article published on 3 November 2017

Ceramide synthase-dependent ceramide generation and programmed cell death: involvement of salvage pathway in regulating postmitochondrial events

scientific article

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.

scientific article published on August 2017

Defective acid sphingomyelinase pathway with Pseudomonas aeruginosa infection in cystic fibrosis

scientific article published on 23 January 2009

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 November 2018

Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

scientific article published on 01 January 2019

Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane

scientific article

Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low‐density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release ⬇️

scientific article published on May 1, 2012

Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases ⬇️

scientific article published on June 1, 2011

Dynamic single-cell RNA sequencing identifies immunotherapy persister cells following PD-1 blockade

scientific article published on 05 November 2020

Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis

scientific article

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids.

scientific article published on 3 November 2017

Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation

scientific article

Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration

scientific article published on 13 July 2015

Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease ⬇️

scientific article published on August 31, 2012

Mapping the immune environment in clear cell renal carcinoma by single-cell genomics

scientific article published on 27 January 2021

Mechanisms of Resistance to Immune Checkpoint Blockade

scientific article published on 01 February 2019

Mechanisms of resistance to immune checkpoint inhibitors

scientific article published on 2 January 2018

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in Cancer

scientific article published on 3 November 2017

Molecular targeting of acid ceramidase: implications to cancer therapy.

scientific article published on August 2008

Neutral Sphingomyelinase-2 Mediates Growth Arrest by Retinoic Acid through Modulation of Ribosomal S6 Kinase ⬇️

scientific article published on May 2, 2011

Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.

scientific article published on 9 October 2006

Refining Targeted Therapy Opportunities for BRAF-Mutant Melanoma

scientific article

Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation.

scientific article

Regulation of CC Ligand 5/RANTES by Acid Sphingomyelinase and Acid Ceramidase ⬇️

scientific article published on February 18, 2011

Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway

scientific article published on April 2008

Response to Crizotinib in a Patient With Lung Adenocarcinoma Harboring a MET Splice Site Mutation

scientific article published on 7 February 2015

Roles and regulation of secretory and lysosomal acid sphingomyelinase

scientific article published on June 2009

Safety Study of Adeno-Associated Virus Serotype 2-Mediated Human Acid Sphingomyelinase Expression in the Nonhuman Primate Brain ⬇️

scientific article published on August 1, 2012

Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism

scientific article

Targeting TANK-binding kinase 1 (TBK1) in cancer

scientific article published on 22 September 2020

Treatment of Advanced Melanoma in 2020 and Beyond

scientific article published on 05 April 2020

Tumor innate immunity primed by specific interferon-stimulated endogenous retroviruses.

scientific article

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