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List of works by Gabi Dachs

5-Fluoroindole-3-acetic acid: a prodrug activated by a peroxidase with potential for use in targeted cancer therapy

scientific article published in January 2002

A profile of prognostic and molecular factors in European and Māori breast cancer patients

scientific article

Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels

scientific article published on 3 April 2019

Analysis of the horseradish peroxidase/indole-3-acetic acid combination in a three-dimensional tumor model

scientific article published in July 2004

Anti-vascular agent Combretastatin A-4-P modulates hypoxia inducible factor-1 and gene expression

scientific article

Ascorbate availability affects tumor implantation-take rate and increases tumor rejection in Gulo-/- mice

scientific article published on 8 April 2016

Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells

scientific article published on 15 May 2019

Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer

scientific article

Body mass index (BMI): association with clinicopathological factors and outcome of women with newly diagnosed breast cancer in New Zealand

scientific article

Bystander or no bystander for gene directed enzyme prodrug therapy

scientific article

Cancer disparities in indigenous Polynesian populations: Māori, Native Hawaiians, and Pacific people

scientific article published in May 2008

Cancer gene therapy: 'delivery, delivery, delivery'

scientific article

Characterisation of a Mouse Model of Breast Cancer with Metabolic Syndrome

scholarly article

Characterisation of enzyme prodrug gene therapy combinations in coated spheroids and vascular networks in vitro

scientific article

Consumption of vitamin C is below recommended daily intake in many cancer patients and healthy volunteers in Christchurch

scientific article published on 7 March 2014

Current limitations of murine models in oncology for ascorbate research

scientific article

Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid

scientific article published in November 2000

Diflavin oxidoreductases activate the bioreductive prodrug PR-104A under hypoxia

scientific article published on 7 October 2011

Direct visualization of electroporation-assisted in vivo gene delivery to tumors using intravital microscopy - spatial and time dependent distribution

scientific article

Effect of post-implant exercise on tumour growth rate, perfusion and hypoxia in mice

scientific article published on 18 March 2020

Effective gene transfer to solid tumors using different nonviral gene delivery techniques: Electroporation, liposomes, and integrin-targeted vector

article

Effects of Exercise on the Tumour Microenvironment

scientific article published on 1 January 2020

Enhanced response to radiotherapy in tumours deficient in the function of hypoxia-inducible factor-1

scientific article

Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals

scientific article published on 6 February 2020

From bench to bedside for gene-directed enzyme prodrug therapy of cancer

scientific article

Gene delivery to hypoxic cells in vitro

scientific article published on September 2000

Gulonolactone Addition to Human Hepatocellular Carcinoma Cells with Gene Transfer of Gulonolactone Oxidase Restores Ascorbate Biosynthesis and Reduces Hypoxia Inducible Factor 1

scientific article published on 5 March 2014

Hypoxia response elements

article

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

scientific article

Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5

scientific article published on 15 August 2014

Immunohistochemical analysis of cancer stem cell markers in invasive breast carcinoma and associated ductal carcinoma in situ: relationships with markers of tumor hypoxia and microvascularity

scientific article published on 1 October 2012

In vivo characterization of horseradish peroxidase with indole-3-acetic acid and 5-bromoindole-3-acetic acid for gene therapy of cancer

scientific article

Increased Tumor Ascorbate is Associated with Extended Disease-Free Survival and Decreased Hypoxia-Inducible Factor-1 Activation in Human Colorectal Cancer

scientific article published on 4 February 2014

Intracellular ascorbate enhances hypoxia-inducible factor (HIF)-hydroxylase activity and preferentially suppresses the HIF-1 transcriptional response

scholarly article

Low Vitamin C Status in Patients with Cancer Is Associated with Patient and Tumor Characteristics

scientific article published on 5 August 2020

Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer

scientific article published on 22 June 2010

Marginal effects of glucose, insulin and insulin-like growth factor on chemotherapy response in endothelial and colorectal cancer cells

scientific article

Mechanisms of cytotoxicity induced by horseradish peroxidase/indole-3-acetic acid gene therapy

scientific article published in January 2002

Modulation of hypoxia-inducible factor-1 alpha in cultured primary cells by intracellular ascorbate

scientific article published on 30 November 2006

Novel chimeric gene promoters responsive to hypoxia and ionizing radiation.

scientific article published in October 2002

Optimizing transfection of primary human umbilical vein endothelial cells using commercially available chemical transfection reagents

scientific article published in July 2010

Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice

scientific article published on 24 August 2016

Recombinant horseradish peroxidase variants for targeted cancer treatment

scientific article published on 15 March 2016

Regulation of the 2-oxoglutarate-dependent dioxygenases and implications for cancer

scientific article

Restoring physiological levels of ascorbate slows tumor growth and moderates HIF-1 pathway activity in Gulo(-/-) mice

scientific article

Targeting cancer with gene therapy using hypoxia as a stimulus

scientific article published in January 2004

Targeting gene expression to hypoxic tumor cells

article

Targeting gene therapy to cancer: a review

scientific article published on January 1, 1997

The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein

scientific article published on 30 November 2018

The Christchurch Tissue Bank to support cancer research

scientific article

The Role of Exercise and Hyperlipidaemia in Breast Cancer Progression

scientific article published in January 2018

The bioreductive prodrug PR-104A is activated under aerobic conditions by human aldo-keto reductase 1C3

scientific article

The influence of oxygen tension and pH on the expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast tumor cells grown in vitro and in vivo.

scientific article published on February 1997

The molecular response of mammalian cells to hypoxia and the potential for exploitation in cancer therapy

scientific article

Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics

scientific article

Use of horseradish peroxidase for gene-directed enzyme prodrug therapy with paracetamol

scientific article published on May 2004

Vitamin C Transporters in Cancer: Current Understanding and Gaps in Knowledge

scientific article

Voluntary exercise slows breast tumor establishment and reduces tumor hypoxia in ApoE-/- mice

scientific article published on 14 December 2017

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