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List of works by Alexei Degterev

A HPLC method for the quantitative determination of N-(2-hydroxy-5-nitrophenylcarbamothioyl)-3,5-dimethylbenzamide in biological samples ⬇️

scientific article published on April 6, 2011

A computational framework for studying neuron morphology from in vitro high content neuron-based screening

scientific article

A decade of caspases

scientific article published on November 2003

A genome-wide RNAi screen reveals multiple regulators of caspase activation

scientific article

A novel tracing algorithm for high throughput imaging Screening of neuron-based assays.

scientific article published on 20 September 2006

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors

scientific article

Activity assays for receptor-interacting protein kinase 1:a key regulator of necroptosis

scientific article published in January 2013

Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis

scientific article

An Image Based System Biology Approach for Alzheimer's Disease Pathway Analysis

scientific article published on 01 April 2009

Antigen-mediated T cell expansion regulated by parallel pathways of death

scholarly article

Assays for necroptosis and activity of RIP kinases

scientific article

Automated neurite extraction using dynamic programming for high-throughput screening of neuron-based assays.

scientific article published on 27 January 2007

Automated neurite labeling and analysis in fluorescence microscopy images

scientific article published in June 2006

Caspase-dependent suppression of type I interferon signaling promotes KSHV lytic replication

scientific article published on 7 March 2018

Chemical Library Screens to Identify Pharmacological Modulators of Necroptosis

scientific article published on 01 January 2018

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

scientific article (publication date: July 2005)

Combination Nanopreparations of a Novel Proapoptotic Drug - NCL-240, TRAIL and siRNA.

scientific article published on 07 March 2016

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice ⬇️

scientific article published on September 21, 2011

Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis

scientific article published on 23 January 2017

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

scientific article published on 01 January 2020

Correction to: Phenytoin inhibits necroptosis.

scientific article published on 24 May 2018

Cytotoxicity of PEGylated liposomes co-loaded with novel pro-apoptotic drug NCL-240 and the MEK inhibitor cobimetinib against colon carcinoma in vitro

scientific article

Diversity in the mechanisms of neuronal cell death.

scientific article published on October 2003

Emerging Roles for RIPK1 and RIPK3 in Pathogen-Induced Cell Death and Host Immunity

scientific article published on 19 September 2015

Expansion and evolution of cell death programmes

scientific article published on May 2008

Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system

scientific article published on 21 March 2013

Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1 ⬇️

scientific article published on May 29, 2012

Generation of small molecules to interfere with regulated necrosis

scientific article published on 5 April 2016

Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice

scientific article published in August 2017

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Identification of RIP1 kinase as a specific cellular target of necrostatins

scientific article (publication date: May 2008)

Identification of a molecular signaling network that regulates a cellular necrotic cell death pathway

scientific article

Identification of small molecule inhibitors of neurite loss induced by Aβ peptide using high content screening.

scientific article

In vitro cytotoxicity of novel pro-apoptotic agent DM-PIT-1 in PEG-PE-based micelles alone and in combination with TRAIL.

scientific article

Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.

scientific article

Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases

scientific article published on 29 July 2013

Is SIRT2 required for necroptosis?

scientific article published on February 2014

KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients

scientific article

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.

scientific article published on May 2017

Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor–related apoptosis-inducing ligand and induces an alternative cell death pathway ⬇️

scientific article published on July 13, 2011

Methods to analyze cellular necroptosis

scientific article

Micellar formulations of pro-apoptotic DM-PIT-1 analogs and TRAIL in vitro and in vivo

scientific article published on February 2013

Molecular pathways involved in cell death after chemically induced DNA damage

scientific article published on January 2009

Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model

scientific article published in May 2010

Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice

scientific article

Optimization of the anti-cancer activity of phosphatidylinositol-3 kinase pathway inhibitor PITENIN-1: switching a thiourea with 1,2,3-triazole

scientific article

Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability.

scientific article

Phenytoin inhibits necroptosis.

scientific article published on 2 March 2018

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4.

scientific article published on July 2016

Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

scientific article

Retinal ganglion cell (RGC) programmed necrosis contributes to ischemia-reperfusion-induced retinal damage.

scientific article

Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice

scientific article

Role of phosphatidylinositol 3,4,5-trisphosphate in cell signaling

scientific article published on January 2013

Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains ⬇️

scientific article published on November 16, 2010

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

scientific article published on 19 July 2018

Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G

scientific article

Small-molecule inhibitors of the PI3K signaling network

scientific article

Structural basis of RIP1 inhibition by necrostatins

scientific article

Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1.

scientific article published in March 2015

Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5

scientific article published on 21 November 2006

Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors

scientific article published on 25 April 2008

Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors

scientific article

Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7

scientific article published on 22 August 2008

Structure-activity relationship study of novel necroptosis inhibitors

scientific article

Structure-activity relationship study of tricyclic necroptosis inhibitors

scientific article published on 16 March 2007

Targeting RIPK1 for the treatment of human diseases

scientific article published on 02 May 2019

Targeting RIPK1,2,3 to combat inflammation

scientific article published on 13 October 2015

Targeting energy metabolism of cancer cells: Combined administration of NCL-240 and 2-DG.

scientific article published on 24 August 2017

Targeting of Micelles and Liposomes Loaded with the Pro-Apoptotic Drug, NCL-240, into NCI/ADR-RES Cells in a 3D Spheroid Model.

scientific article published on 28 June 2016

Targeting phospshatidylinositol 3-kinase signaling with novel phosphatidylinositol 3,4,5-triphosphate antagonists ⬇️

scientific article published on June 1, 2011

Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice

scientific article

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