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List of works by W. Kimryn Rathmell

A Case Report of Severe Type B Lactic Acidosis Following First Dose of Nivolumab in a VHL-Mutated Metastatic Renal Cell Carcinoma

scientific article published on 26 July 2017

A Pilot Clinical Study in Characterization of Malignant Renal-cell Carcinoma Subtype with Contrast-enhanced Ultrasound

scientific article

A phase II study of lapatinib, a dual EGFR and HER-2 tyrosine kinase inhibitor, in patients with castration-resistant prostate cancer

scientific article

A tale of two cancers: Complete genetic analysis of chromophobe renal cell carcinoma contrasts with clear cell renal cell carcinoma

scientific article published on 20 January 2015

AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival.

scientific article published on April 2016

Alternate Metabolic Programs Define Regional Variation of Relevant Biological Features in Renal Cell Carcinoma Progression.

scientific article published on 19 January 2016

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

scientific article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

scientific article

Associations between Tumor Vascularity, Vascular Endothelial Growth Factor Expression and PET/MRI Radiomic Signatures in Primary Clear-Cell-Renal-Cell-Carcinoma: Proof-of-Concept Study

scientific article published on 03 March 2017

Balancing dual demands on the physician-scientist workforce

scientific article published on 16 July 2018

Basic research in kidney cancer

scientific article published on 05 July 2011

Beyond glycolysis: Hypoxia signaling as a master regulator of alternative metabolic pathways and the implications in clear cell renal cell carcinoma

scientific article published on 05 June 2020

Biological aspects and binding strategies of vascular endothelial growth factor in renal cell carcinoma

scientific article

Broad targeting of angiogenesis for cancer prevention and therapy

scientific article

CD28 costimulation drives tumor-infiltrating T cell glycolysis to promote inflammation

scientific article published on 20 August 2020

COVID-19 impact on early career investigators: a call for action

scientific article published on 05 June 2020

Carcinoma in a cadaveric transplant kidney

scientific article published on 20 October 2011

Clear cell renal cell carcinoma ontogeny and mechanisms of lethality

scientific article published on 03 November 2020

ClearCode34: A prognostic risk predictor for localized clear cell renal cell carcinoma

scientific article

Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

scientific article published on 04 June 2018

Clinical and immunologic correlates of response to PD-1 blockade in a patient with metastatic renal medullary carcinoma

scientific article published on 17 January 2017

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

article

Comprehensive Characterization of Cancer Driver Genes and Mutations

article

Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma

scientific article published on 4 November 2015

Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

scientific article

Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma.

scientific article published on 16 January 2017

Correction: SETD2 loss sensitizes cells to PI3Kβ and AKT inhibition

scientific article published on 29 October 2019

DNA hypomethylation promotes transposable element expression and activation of immune signaling in renal cell cancer

scientific article published on 04 June 2020

Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling

scientific article published on 20 March 2017

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

scientific article

Disruptions in the realm of medical science

scientific article published on 01 June 2020

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

scientific article published on 01 November 2018

Dual Chromatin and Cytoskeletal Remodeling by SETD2.

scientific article published on August 2016

Early heart development in the chick embryo: effects of isotretinoin on cell proliferation, alpha-actin synthesis, and development of contractions

scientific article published on 01 October 1992

Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation

scientific article

Emerging molecular classification in renal cell carcinoma: implications for drug development

scientific article

Empowering ASCI's support of physician-scientists through stronger institutional connections

scientific article published on 01 April 2019

Endogenous retroviral signatures predict immunotherapy response in clear cell renal cell carcinoma.

scientific article

Endogenous retrovirus expression is associated with response to immune checkpoint blockade in clear cell renal cell carcinoma

Epigenetic modifiers: activities in renal cell carcinoma

scientific article published on 01 October 2018

Epstein-Barr virus latent membrane protein 1 is not associated with vessel density nor with hypoxia inducible factor 1 alpha expression in nasopharyngeal carcinoma tissue

scientific article published on 12 November 2009

Ethical challenges: managing oncology drug shortages

scientific article published on March 2013

Ethical considerations for the clinical oncologist in an era of oncology drug shortages

scientific article published on 21 January 2014

Evaluation, diagnosis and surveillance of renal masses in the setting of VHL disease

scientific article published on 16 September 2020

Expression of Ror2 mediates invasive phenotypes in renal cell carcinoma

scientific article

Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination

scientific article

Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis

article

Fine-Needle Aspiration-Based Patient-Derived Cancer Organoids

scientific article published on 24 July 2020

Genomic investigation of etiologic heterogeneity: methodologic challenges

scientific article

HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcoma.

scientific article published in January 2004

HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma

scientific article published on December 2008

HIF1α and HIF2α exert distinct nutrient preferences in renal cells

scientific article

HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas

scientific article published on 14 August 2017

Haploinsufficiency for Microtubule Methylation Is an Early Driver of Genomic Instability in Renal Cell Carcinoma

scientific article published on 03 May 2018

High Frequency of Ovarian Cyst Development in Vhl2B/+;Snf5+/- Mice

scientific article published on 20 April 2018

High-dose-intensity MVAC for Advanced Renal Medullary Carcinoma: Report of Three Cases and Literature Review

scientific article

Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers

scientific article published on 07 January 2019

Identification of Ror2 as a hypoxia-inducible factor target in von Hippel-Lindau-associated renal cell carcinoma

scientific article

Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma

scientific article

In vitro and in vivo models analyzing von Hippel-Lindau disease-specific mutations

scientific article

In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation

scientific article published on March 2013

Individualised axitinib regimen for patients with metastatic renal cell carcinoma after treatment with checkpoint inhibitors: a multicentre, single-arm, phase 2 study

scientific article published on 16 August 2019

Insights into the Genetic Basis of the Renal Cell Carcinomas from The Cancer Genome Atlas

scientific article published on 21 June 2016

Integrative radiomics expression predicts molecular subtypes of primary clear cell renal cell carcinoma

scientific article published on 23 May 2018

Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks

scientific article published on August 1994

Kidney cancer

scientific article

Kidney cancer: Rest ASSUREd, much can be learned from adjuvant studies in renal cancer

scientific article published on 25 April 2016

Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants

scientific article published on April 1996

Ligand-independent integrin β1 signaling supports lung adenocarcinoma development

scientific article published in 2022

Looking beyond inhibition of VEGF/mTOR: emerging targets for renal cell carcinoma drug development

scientific article published on August 2011

Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

scientific article

Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 (Signal Transducer and Activator of Transcription 3) Splicing

scientific article published on 16 April 2020

Management and outcomes of patients with renal medullary carcinoma: a multicentre collaborative study.

scientific article published on 8 November 2016

Management of Indeterminate Cystic Kidney Lesions: Review of Contrast-enhanced Ultrasound as a Diagnostic Tool.

scientific article

Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology

scientific article published on 18 October 2011

Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets

scientific article published on January 2017

Metabolic Pathways in Kidney Cancer: Current Therapies and Future Directions

scientific article published on 29 October 2018

Methylated α-tubulin antibodies recognize a new microtubule modification on mitotic microtubules.

scientific article published on 3 September 2016

Mitochondrial dysregulation and glycolytic insufficiency functionally impair CD8 T cells infiltrating human renal cell carcinoma

scientific article

Modeling clear cell renal cell carcinoma and therapeutic implications

scientific article published on 02 March 2020

Molecular Stratification of Clear Cell Renal Cell Carcinoma by Consensus Clustering Reveals Distinct Subtypes and Survival Patterns

scientific article

Molecular Subtypes Improve Prognostic Value of International Metastatic Renal Cell Carcinoma Database Consortium Prognostic Model

scientific article published on 20 February 2017

Molecularly targeted therapy in renal cell carcinoma

scientific article

Neoadjuvant chemotherapy administration and time to cystectomy for muscle-invasive bladder cancer: An evaluation of transitions between academic and community settings

scientific article published on 26 June 2015

Neoadjuvant clinical trial with sorafenib for patients with stage II or higher renal cell carcinoma

scientific article published on 16 February 2010

Neoadjuvant docetaxel/estramustine prior to radical prostatectomy or external beam radiotherapy in high risk localized prostate cancer: a phase II trial

scientific article published on 21 December 2009

Neoadjuvant treatment of renal cell carcinoma

scientific article published on January 2010

PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma

scientific article published on 01 May 2020

PET/CT with (124)I-cG250: great potential and some open questions

scientific article

Patients with ClearCode34-identified molecular subtypes of clear cell renal cell carcinoma represent unique populations with distinct comorbidities

scientific article published on 3 November 2015

Phase I study of concurrent weekly docetaxel, high-dose intensity-modulated radiation therapy (IMRT) and androgen-deprivation therapy (ADT) for high-risk prostate cancer

scientific article published on 27 September 2012

Phase II Study of Two Weeks on, One Week off Sunitinib Scheduling in Patients With Metastatic Renal Cell Carcinoma

scientific article published on 11 April 2018

Phase II trial of 5-fluorouracil and leucovorin in combination with interferon-alpha and interleukin-2 for advanced renal cell cancer

scientific article published in April 2004

Phase II trial of sorafenib plus interferon alfa-2b as first- or second-line therapy in patients with metastatic renal cell cancer

scientific article published in August 2007

Physician and stakeholder perceptions of conflict of interest policies in oncology

scientific article published on 25 March 2013

Pilot Study of [18F] Fluorodeoxyglucose Positron Emission Tomography (FDG-PET)/Magnetic Resonance Imaging (MRI) for Staging of Muscle-invasive Bladder Cancer (MIBC)

scientific article published on 05 March 2020

Pleiotropic effects of the trichloroethylene-associated P81S VHL mutation on metabolism, apoptosis, and ATM-mediated DNA damage response

scientific article published on 29 August 2013

Positron emission tomography in renal cell carcinoma: an imaging biomarker in development

scientific article published on July 2012

Preoperative tyrosine kinase inhibition as an adjunct to debulking nephrectomy

scientific article published on 5 August 2008

Publisher Correction: Clinical activity and molecular correlates of response to atezolizumab alone or in combination with bevacizumab versus sunitinib in renal cell carcinoma

scientific article published on 01 December 2018

Racial difference in histologic subtype of renal cell carcinoma

scientific article published on 06 August 2013

Recent updates in renal cell carcinoma

scientific article

Receptor tyrosine kinase-like orphan receptor 2 (Ror2) expression creates a poised state of Wnt signaling in renal cancer.

scientific article published on 26 July 2013

Regulation of KLF4 Turnover Reveals an Unexpected Tissue-Specific Role of pVHL in Tumorigenesis

scholarly article by Armin M. Gamper published in October 2015

Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis

scientific article published on January 2012

Renal Medullary Carcinoma: Establishing Standards in Practice

scientific article published on July 2017

Renal cancer subtypes: Should we be lumping or splitting for therapeutic decision making?

scientific article published on 14 November 2016

Renal cell carcinoma

Renal cell carcinoma

scientific article published on 01 May 2004

Renal cell carcinoma

scientific article published on 01 May 2007

Renal cell carcinoma

scientific article published on 01 May 2005

Renal cell carcinoma

scientific article published on 01 May 2006

Renal cell carcinoma

scientific article published on 10 November 2014

Renal cell carcinoma: where will the state-of-the-art lead us?

scientific article

Reply to Alexander S. Parker, Brad C. Leibovich, Jeanette E. Eckel-Passow, John C. Cheville's letter to the editor re: Samira A. Brooks, A. Rose Brannon, Joel S. Parker, et al. ClearCode34: a prognostic risk predictor for localized clear cell renal

scientific article published on 15 July 2014

Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA.

scientific article published on October 1994

Roadmap for the development of the University of North Carolina at Chapel Hill Genitourinary OncoLogy Database--UNC GOLD

scientific article

Ror2 as a therapeutic target in cancer

scientific article

Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma

scientific article

Seeing the forest for the trees: kidney oncogenomes in relation to therapeutic outcomes

scientific article

Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity

scientific article published on 23 December 2017

State of the science: an update on renal cell carcinoma

scientific article

Strategies to overcome therapeutic resistance in renal cell carcinoma

scientific article published on 11 January 2017

Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation

scientific article published on 15 August 2016

Summary from the First Kidney Cancer Research Summit, September 12-13, 2019: A Focus on Translational Research

scientific article published on 02 May 2020

Systematic Review: ClearCode 34 - A Validated Prognostic Signature in Clear Cell Renal Cell Carcinoma (ccRCC)

article

The 2019 Nobel Prize honors fundamental discoveries in hypoxia response

scientific article published on 01 January 2020

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

scientific article published in April 2018

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

article

The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase

scientific article published on 02 October 2020

The loss of radiographic enhancement in primary renal cell carcinoma tumors following multitargeted receptor tyrosine kinase therapy is an additional indicator of response

scientific article published on 20 November 2009

The molecular biology of renal cell carcinoma

scientific article published on August 2013

The somatic genomic landscape of chromophobe renal cell carcinoma

scientific article (publication date: 8 September 2014)

The tumor microenvironment as a metabolic barrier to effector T cells and immunotherapy

scientific article published on 05 May 2020

Transformation to Academic Leadership: The Role of Mentorship and Executive Coaching

scientific article published on 01 September 2019

Tumor Mutational Load and Immune Parameters across Metastatic Renal Cell Carcinoma Risk Groups

scientific article published on 18 August 2016

Tumor suppressive activity of prolyl isomerase Pin1 in renal cell carcinoma.

scientific article

Tyrosine Kinase Signaling in Clear Cell and Papillary Renal Cell Carcinoma Revealed by Mass Spectrometry-Based Phosphotyrosine Proteomics

scientific article published on 24 May 2016

Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-angiogenic Therapy in Renal Cell Carcinoma

scientific article published on 27 July 2018

Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy

scientific article published in January 2018

Untangling ccRCC prognosis with SLINKY.

scientific article published on 20 February 2017

Updated Recommendations on the Diagnosis, Management, and Clinical Trial Eligibility Criteria for Patients With Renal Medullary Carcinoma

scientific article published on 12 September 2018

Using Molecular Biology to Develop Drugs for Renal Cell Carcinoma

scientific article published on March 2008

VHL Type 2B gene mutation moderates HIF dosage in vitro and in vivo

scientific article published on 02 March 2009

VHL and PTEN loss coordinate to promote mouse liver vascular lesions

scientific article

VHL gene mutations in renal cell carcinoma: role as a biomarker of disease outcome and drug efficacy

scientific article published on March 2009

VHL inactivation in renal cell carcinoma: implications for diagnosis, prognosis and treatment

scientific article published on January 2008

VHL substrate transcription factor ZHX2 as an oncogenic driver in clear cell renal cell carcinoma

scientific article

VHL type 2B mutations retain VBC complex form and function

scientific article

VHL: oxygen sensing and vasculogenesis

scientific article

Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects

scientific article published on 24 October 2013

Von Hippel-Lindau mutations disrupt vascular patterning and maturation via Notch.

scientific article published on 22 February 2018

Von Hippel-Lindau status influences phenotype of liver cancers arising from PTEN loss.

scientific article published on February 2015

loss sensitizes cells to PI3Kβ and AKT inhibition

von Hippel-Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2alpha signaling and splenic erythropoiesis

scientific article

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