List of works by Gunnar Pejler

A key role for mast cell chymase in the activation of pro-matrix metalloprotease-9 and pro-matrix metalloprotease-2.

scientific article

A role for cathepsin E in the processing of mast-cell carboxypeptidase A.

scientific article

A role for serglycin proteoglycan in granular retention and processing of mast cell secretory granule components

scientific journal article

A role for serglycin proteoglycan in mast cell apoptosis induced by a secretory granule-mediated pathway.

scientific article

ADAMTS: novel proteases expressed by activated mast cells

scientific article

Ablation of human skin mast cells in situ by lysosomotropic agents.

scientific article published on 16 April 2015

Accumulation of Ym1 and formation of intracellular crystalline bodies in alveolar macrophages lacking heparanase

scientific article published on 11 March 2010

Acidic pH is essential for maintaining mast cell secretory granule homeostasis

scientific article published on 11 May 2017

Activated mast cells promote differentiation of B cells into effector cells.

scientific article published on 5 February 2016

Active caspase-3 is stored within secretory compartments of viable mast cells

scientific article published in July 2013

Age-related enlargement of lymphoid tissue and altered leukocyte composition in serglycin-deficient mice

article

Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing

scientific article published in May 2002

Approaches for analyzing the roles of mast cells and their proteases in vivo

scientific article published on 7 February 2015

Biological implications of preformed mast cell mediators ⬇️

scientific article published on November 11, 2010

Biology of mast cell tryptase. An inflammatory mediator

scientific article

Canine uterine bacterial infection induces upregulation of proteolysis-related genes and downregulation of homeobox and zinc finger factors

scientific article (publication date: 2009)

Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase.

scientific article published on 7 February 2015

Cooperation between mast cell carboxypeptidase A and the chymase mouse mast cell protease 4 in the formation and degradation of angiotensin II

scientific journal article

Copper Regulates Maturation and Expression of an MITF:Tryptase Axis in Mast Cells.

scientific article published on 10 November 2017

Correction to: Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells

scientific article published on 03 September 2020

Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation

scientific article published on 31 August 2009

Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans

scientific article published on 4 September 2015

DNA demethylation regulates gene expression in IgE-activated mouse mast cells

scientific article published on 29 January 2020

Damnacanthal inhibits IgE receptor-mediated activation of mast cells

scientific article published on 2 February 2015

Delayed contraction of the CD8+ T cell response toward lymphocytic choriomeningitis virus infection in mice lacking serglycin

scientific journal article

Differential regulation of Nr4a subfamily nuclear receptors following mast cell activation

scientific article

Distorted secretory granule composition in mast cells with multiple protease deficiency

scientific article

Diverse bone morphogenetic protein expression profiles and smad pathway activation in different phenotypes of experimental canine mammary tumors

scientific article

Do Mast Cells Have a Role in Tendon Healing and Inflammation?

scientific article published on 04 May 2020

Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid

scientific article

Endothelin receptor antagonist macitentan or deletion of mouse mast cell protease 4 delays lesion development in atherosclerotic mice

scientific article

Excessive dietary intake of vitamin A reduces skull bone thickness in mice

scientific article

Exosome-mediated uptake of mast cell tryptase into the nucleus of melanoma cells: a novel axis for regulating tumor cell proliferation and gene expression

scientific article published on 10 September 2019

Experimental Autoimmune Encephalomyelitis Potentiates Mouse Mast Cell Protease 4-Dependent Pressor Responses to Centrally or Systemically Administered Big Endothelin-1

scientific article published on 27 June 2019

Extended substrate specificity of rat mast cell protease 5, a rodent alpha-chymase with elastase-like primary specificity

scientific journal article

Extensive expression of craniofacial related homeobox genes in canine mammary sarcomas

scientific article

Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner

scientific article

Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells

scientific article published on 20 April 2020

Granzyme D is a novel murine mast cell protease that is highly induced by multiple pathways of mast cell activation

scientific article published on 25 March 2013

Granzyme H is a novel protease expressed by human mast cells

scientific article

Heparanase affects secretory granule homeostasis of murine mast cells through degrading heparin

scientific article

Histidines are critical for heparin-dependent activation of mast cell tryptase

scientific article published on August 2004

Histone Methyltransferase Inhibition Has a Cytotoxic Impact on Transformed Mast Cells: Implications for Mastocytosis

scientific article published on 01 May 2020

Human mast cell beta-tryptase is a gelatinase

scientific article published in August 2003

IGF-1 degradation by mouse mast cell protease 4 promotes cell death and adverse cardiac remodeling days after a myocardial infarction

scientific article published on 06 June 2016

IL-6 and IL-17A degradation by mast cells is mediated by a serglycin:serine protease axis

scientific article published on 2 December 2015

Increased Bone Mass in Female Mice Lacking Mast Cell Chymase

scientific article

Increased levels of hypoxia-sensitive proteins in allergic airway inflammation

scientific article published on 19 May 2004

Increased mast cell degranulation and co-localization of mast cells with the NMDA receptor-1 during healing after Achilles tendon rupture.

scientific article

Induction of Human Lung Mast Cell Apoptosis by Granule Permeabilization: A Novel Approach for Targeting Mast Cells

scientific article published on 27 November 2017

Induction of Mast Cell Apoptosis by a Novel Secretory Granule-Mediated Pathway

scientific article published on 01 January 2015

Infection of mast cells with live streptococci causes a toll-like receptor 2- and cell-cell contact-dependent cytokine and chemokine response

scientific article

Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells

scientific article published on 13 March 2017

Live Staphylococcus aureus Induces Expression and Release of Vascular Endothelial Growth Factor in Terminally Differentiated Mouse Mast Cells

scientific article published on 23 June 2016

Lysosomotropic challenge of mast cells causes intra-granular reactive oxygen species production

scientific article published on 15 May 2019

Mast Cell Chymase Decreases The Severity Of Group B Streptococcus Infections

scientific article published on 12 September 2017

Mast Cell Degranulation Exacerbates Skin Rejection by Enhancing Neutrophil Recruitment

Mast Cell β-Tryptase Is Enzymatically Stabilized by DNA

scientific article published on 17 July 2020

Mast Cells and MCPT4 Chymase Promote Renal Impairment after Partial Ureteral Obstruction.

scientific article

Mast cell accumulation in glioblastoma with a potential role for stem cell factor and chemokine CXCL12.

scientific article

Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist

scientific article

Mast cell cathepsins C and S control levels of carboxypeptidase A and the chymase, mouse mast cell protease 5.

scientific article published in October 2003

Mast cell chymase contributes to the antibody response and the severity of autoimmune arthritis

scientific article

Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

scientific article published on 10 October 2019

Mast cell chymase protects against renal fibrosis in murine unilateral ureteral obstruction

scientific article

Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice

scientific article

Mast cell differentiation and activation is closely linked to expression of genes coding for the serglycin proteoglycan core protein and a distinct set of chondroitin sulfate and heparin sulfotransferases

scientific article published on 13 November 2009

Mast cell proteases

scientific article published on January 2007

Mast cell proteases: multifaceted regulators of inflammatory disease

scientific article published on 16 March 2010

Mast cell secretory granules: armed for battle

scientific article

Mast cell-dependent activation of pro matrix metalloprotease 2: A role for serglycin proteoglycan-dependent mast cell proteases

scientific journal article

Mast cells are activated by Staphylococcus aureus in vitro but do not influence the outcome of intraperitoneal S. aureus infection in vivo

scientific article published on 01 October 2014

Mast cells can enhance resistance to snake and honeybee venoms

scientific article

Mast cells contribute to bleomycin-induced lung inflammation and injury in mice through a chymase/mast cell protease 4-dependent mechanism

scientific article published on 22 January 2014

Mast cells express tyrosine hydroxylase and store dopamine in a serglycin-dependent manner

scientific article published on 01 January 2012

Mast cells limit extracellular levels of IL-13 via a serglycin proteoglycan-serine protease axis.

scientific article published in December 2012

Mast cells promote melanoma colonization of lungs

scientific article published on 02 September 2016

Mast cells promote scar remodeling and functional recovery after spinal cord injury via mouse mast cell protease 6.

scientific article

Mast cells protect from post-traumatic brain inflammation by the mast cell-specific chymase mouse mast cell protease-4.

scientific article published on 27 November 2012

Mast cells protect from post-traumatic spinal cord damage in mice by degrading inflammation-associated cytokines via mouse mast cell protease 4.

scientific article published on 26 September 2013

Mast cells regulate homeostatic intestinal epithelial migration and barrier function by a chymase/Mcpt4-dependent mechanism

scientific article

Mastitis Pathogens with High Virulence in a Mouse Model Produce a Distinct Cytokine Profile In Vivo.

scientific article

Mefloquine, an anti-malaria agent, causes reactive oxygen species-dependent cell death in mast cells via a secretory granule-mediated pathway

scientific article

Mitogen-Activated Protein Kinase Signaling Regulates Proteoglycan Composition of Mast Cell Secretory Granules.

scientific article published on 19 July 2018

Mouse Mast Cell Protease 4 Deletion Protects Heart Function and Survival After Permanent Myocardial Infarction

scholarly article by Martin Houde et al published 2018 in Frontiers in Pharmacology

Mouse Mast Cell Protease-4 Recruits Leukocytes in the Inflammatory Phase of Surgically Wounded Skin

scientific article published on 21 August 2019

Mouse connective tissue mast cell proteases tryptase and carboxypeptidase A3 play protective roles in itch induced by endothelin-1

scientific article published on 22 April 2020

Mouse mast cell protease 4 is the major chymase in murine airways and has a protective role in allergic airway inflammation

scientific article published on 19 October 2009

Mouse mast cell protease 4 suppresses scar formation after traumatic spinal cord injury

scientific article published on 06 March 2019

Mouse mast cell protease-4 deteriorates renal function by contributing to inflammation and fibrosis in immune complex-mediated glomerulonephritis

scientific article

Mouse mast cell proteases 4 and 5 mediate epidermal injury through disruption of tight junctions

scientific article published on 12 February 2014

Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis

scientific article

Neutrophil elastase depends on serglycin proteoglycan for localization in granules

scientific article published on 01 February 2007

Novel Insight into the in vivo Function of Mast Cell Chymase: Lessons from Knockouts and Inhibitors

scientific article published on 04 June 2020

Novel aspects of mast cell and basophil function: Highlights from the 9th meeting of the European Mast Cell and Basophil Research Network (EMBRN)-A Marcus Wallenberg Symposium

scientific article published on 18 October 2019

Novel insights into the biological function of mast cell carboxypeptidase A.

scientific article published on 28 July 2009

Nuclear receptor 4a3 (nr4a3) regulates murine mast cell responses and granule content

scientific journal article

Pivotal role of mouse mast cell protease 4 in the conversion and pressor properties of Big-endothelin-1.

scientific article

Polyamines are present in mast cell secretory granules and are important for granule homeostasis

scientific article

Polycationic peptides as inhibitors of mast cell serine proteases

scientific article published in April 2003

Protective role of mouse mast cell tryptase Mcpt6 in melanoma

scientific article published on 01 January 2020

Proteolytic histone modification by mast cell tryptase, a serglycin proteoglycan-dependent secretory granule protease

scientific article published on 29 January 2014

Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation.

scientific article published on 13 May 2016

Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

scientific article published on 14 January 2020

Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile

scientific journal article

Reduction with dithiothreitol causes serglycin-specific defects in secretory granule integrity of bone marrow derived mast cells

scientific article published on 6 December 2008

Secretion of macrophage urokinase plasminogen activator is dependent on proteoglycans ⬇️

scientific article published on October 1, 2003

Serglycin Is a Major Proteoglycan in Polarized Human Endothelial Cells and Is Implicated in the Secretion of the Chemokine GROα/CXCL1 ⬇️

scientific article published on November 12, 2010

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

scientific article published on 12 January 2016

Serglycin is essential for maturation of mast cell secretory granule

scientific journal article

Serglycin is the major secreted proteoglycan in macrophages and has a role in the regulation of macrophage tumor necrosis factor-alpha secretion in response to lipopolysaccharide

scientific journal article

Serglycin protects against high fat diet-induced increase in serum LDL in mice

scientific article published on 21 September 2015

Serglycin proteoglycan deletion induces defects in platelet aggregation and thrombus formation in mice

scientific article published on 19 December 2007

Serglycin proteoglycan is not implicated in localizing exocrine pancreas enzymes to zymogen granules.

scientific article published on 14 May 2009

Serglycin proteoglycan is required for secretory granule integrity in mucosal mast cells

scientific article published on April 2007

Serglycin proteoglycan promotes apoptotic versus necrotic cell death in mast cells

scientific article

Serglycin proteoglycan: regulating the storage and activities of hematopoietic proteases

scientific article published on January 2009

Serglycin-deficient cytotoxic T lymphocytes display defective secretory granule maturation and granzyme B storage

scientific journal article

Serglycin: the master of the mast cell

scientific article published on 01 January 2012

Serotonin and histamine storage in mast cell secretory granules is dependent on serglycin proteoglycan

scientific article published on 30 January 2008

Significant Contribution of Mouse Mast Cell Protease 4 in Early Phases of Experimental Autoimmune Encephalomyelitis

scientific article

Streptococcal sagA activates a proinflammatory response in mast cells by a sublytic mechanism

scientific article published on 07 July 2019

The Absence of Tryptase Mcpt6 Causes Elevated Cellular Stress in Response to Modulation of the Histone Acetylation Status in Mast Cells

scientific article published on 02 October 2019

The Effect of Lipopolysaccharide-Induced Experimental Bovine Mastitis on Clinical Parameters, Inflammatory Markers, and the Metabolome: A Kinetic Approach.

scientific article published on 25 June 2018

The Role of Mast Cells in Bacterial Infection

scientific article published on 15 October 2015

The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis

scientific article

The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover

scientific journal article

The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung

scientific article

The controversial role of mast cells in fibrosis

scientific article published in March 2018

The emerging role of mast cell proteases in asthma

scientific article published on 31 October 2019

The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.

scientific article

The role of mouse mast cell proteases in the proliferative phase of wound healing in microdeformational wound therapy.

scientific article published in September 2014

Tryptase-catalyzed core histone truncation: A novel epigenetic regulatory mechanism in mast cells

scientific article published on 17 January 2017

Tumor-mast cell interactions: induction of pro-tumorigenic genes and anti-tumorigenic 4-1BB in MCs in response to Lewis Lung Carcinoma

scientific article

Urticaria: Collegium Internationale Allergologicum (CIA) Update 2020

scientific article published on 30 March 2020

Vitamin a is a negative regulator of osteoblast mineralization

scientific article

[EXPRESS] Mouse mast cells and mast cell proteases do not play a significant role in acute tissue injury pain induced by formalin

scientific article published on 01 January 2018

[The mast cell--both evil and good. Time to reconsider the role of the mast cell in health and disease]

scientific article published on 01 March 2009

Paulina is supported by:

About Paulina

Help