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List of works by Eric P. Skaar

A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus.

scientific article published on 19 October 2016

A Staphylococcus aureus regulatory system that responds to host heme and modulates virulence

scientific article

A Superoxide Dismutase Capable of Functioning with Iron or Manganese Promotes the Resistance of Staphylococcus aureus to Calprotectin and Nutritional Immunity.

scientific article

A battle for iron: host sequestration and Staphylococcus aureus acquisition

scientific article

A precious metal heist

scientific article

A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis

scientific article published on June 2013

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

scientific article published on 5 April 2017

Acinetobacter baumannii Coordinates Urea Metabolism with Metal Import To Resist Host-Mediated Metal Limitation

scientific article published on 27 September 2016

Acinetobacter baumannii can use multiple siderophores for iron acquisition, but only acinetobactin is required for virulence

scientific article published on 19 October 2020

Acinetobacter baumannii increases tolerance to antibiotics in response to monovalent cations

scientific article

Acinetobacter baumannii response to host-mediated zinc limitation requires the transcriptional regulator Zur

scientific article

Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus.

scientific article published on 29 April 2013

Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili

scientific article (publication date: March 2015)

Advanced mass spectrometry technologies for the study of microbial pathogenesis.

scientific article

Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen ⬇️

article published in the Proceedings of the National Academy of Sciences of the United States of America

An Integrated, High-Throughput Strategy for Multiomic Systems Level Analysis

scientific article published on 30 August 2018

An Iron-Regulated Autolysin Remodels the Cell Wall To Facilitate Heme Acquisition in Staphylococcus lugdunensis

scientific article

Analysis of the Piv recombinase-related gene family of Neisseria gonorrhoeae.

scientific article

Analysis of the Staphylococcus aureus abscess proteome identifies antimicrobial host proteins and bacterial stress responses at the host-pathogen interface

scientific article published on 11 July 2013

Antibacterial photosensitization through activation of coproporphyrinogen oxidase.

scientific article

Arachidonic Acid Kills Staphylococcus aureus through a Lipid Peroxidation Mechanism

scientific article published on 01 October 2019

Bacillithiol has a role in Fe-S cluster biogenesis in Staphylococcus aureus

scientific article

Bacillus anthracis HssRS signalling to HrtAB regulates haem resistance during infection

scientific article

Bacillus anthracis IsdG, a heme-degrading monooxygenase

scientific article

Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis

scientific article published on 31 March 2020

Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress

scientific article published on 7 July 2016

Binding of transition metals to S100 proteins

scientific article

Broad-spectrum suppression of bacterial pneumonia by aminoglycoside-propagated Acinetobacter baumannii

scientific article published on 13 March 2020

Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections.

scientific article published on 6 July 2015

Cdc42 promotes host defenses against fatal infection

scientific article published on 20 May 2013

Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase

scientific article

Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation.

scientific article

Control of copper resistance and inorganic sulfur metabolism by paralogous regulators in Staphylococcus aureus

scientific article

Correction: Competing for Iron: Duplication and Amplification of the isd Locus in Staphylococcus lugdunensis HKU09-01 Provides a Competitive Advantage to Overcome Nutritional Limitation

scientific article published on 27 July 2018

Correction: Identification of an Acinetobacter baumannii Zinc Acquisition System that Facilitates Resistance to Calprotectin-mediated Zinc Sequestration.

scientific article published on 11 January 2013

Crossed Wires: Interspecies Interference Blocks Pathogen Colonization

scientific article

CtaM Is Required for Menaquinol Oxidase aa3 Function in Staphylococcus aureus.

scientific article published on 12 July 2016

Cuts Both Ways: Proteases Modulate Virulence of Enterohemorrhagic

scientific article published in 2019

Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus

scientific article published on 18 February 2016

Defining the interaction of the protease CpaA with its type II secretion chaperone CpaB and its contribution to virulence in Acinetobacter species

scientific article

Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection.

scientific article published on 26 September 2016

Differential activation of Staphylococcus aureus heme detoxification machinery by heme analogues

scientific article published on 17 January 2014

Directed evolution reveals the mechanism of HitRS signaling transduction in Bacillus anthracis

scientific article published on 23 December 2020

Drug-Resistant Staphylococcus aureus Strains Reveal Distinct Biochemical Features with Raman Microspectroscopy

scientific article published on 25 June 2018

Erratum: Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection

scientific article

Existence of a Colonizing Staphylococcus aureus Strain Isolated in Diabetic Foot Ulcers.

scientific article published on 21 April 2015

Fur regulation of Staphylococcus aureus heme oxygenases is required for heme homeostasis.

scientific article published in February 2018

Genetic Determinants of Intrinsic Colistin Tolerance in Acinetobacter baumannii.

scientific article

Genomic and functional analysis of the type VI secretion system in Acinetobacter

scientific article

Haemin represses the haemolytic activity of Staphylococcus aureus in an Sae-dependent manner.

scientific article

Helicobacter pylori Resists the Antimicrobial Activity of Calprotectin via Lipid A Modification and Associated Biofilm Formation

scientific article

Heme Synthesis and Acquisition in Bacterial Pathogens.

scientific article published on 24 March 2016

Heme sensing and detoxification by HatRT contributes to pathogenesis during Clostridium difficile infection

scientific article published on 21 December 2018

Host-microbe interactions that shape the pathogenesis of Acinetobacter baumannii infection

scientific article published on 14 June 2012

Human VH1-69 Gene-Encoded Human Monoclonal Antibodies against Staphylococcus aureus IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis

scientific article published on 22 October 2019

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S-Sulfhydration and Global Virulence Regulation in Staphylococcus aureus

scientific article

Identification of a S. aureus virulence factor by activity-based protein profiling (ABPP)

scientific article published on 16 May 2018

Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration

scientific article

Imaging mass spectrometry for assessing temporal proteomics: analysis of calprotectin in Acinetobacter baumannii pulmonary infection

scientific article

In vivo bioluminescence imaging of labile iron accumulation in a murine model of Acinetobacter baumannii infection.

scientific article

Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis

scientific article

Inhibition of bacterial superoxide defense: a new front in the struggle between host and pathogen.

scientific article

Integrated molecular imaging reveals tissue heterogeneity driving host-pathogen interactions

scientific article published in March 2018

Integrated molecular imaging technologies for investigation of metals in biological systems: A brief review

scientific article published on 19 February 2020

Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action.

scientific article

Inter- and intraspecies metabolite exchange promotes virulence of antibiotic-resistant Staphylococcus aureus

scientific article

Intracellular metalloporphyrin metabolism in Staphylococcus aureus

scientific article published on 27 March 2007

Iron in infection and immunity

scientific article published on May 2013

Iron-regulated surface determinants (Isd) of Staphylococcus aureus: stealing iron from heme

scientific article published on April 2004

Iron-source preference of Staphylococcus aureus infections

scientific article published on 01 September 2004

IsdB-dependent hemoglobin binding is required for acquisition of heme by Staphylococcus aureus

scientific article

IsdG and IsdI, heme-degrading enzymes in the cytoplasm of Staphylococcus aureus

scientific article published on 21 October 2003

Link between the membrane-bound pyridine nucleotide transhydrogenase and glutathione-dependent processes in Rhodobacter sphaeroides

scientific article

Loss of mitochondrial protein Fus1 augments host resistance to Acinetobacter baumannii infection

scientific journal article

MALDI FTICR IMS of Intact Proteins: Using Mass Accuracy to Link Protein Images with Proteomics Data

scientific article

Manganese homeostasis and utilization in pathogenic bacteria

scientific article

Mechanisms of pyocyanin toxicity and genetic determinants of resistance in Staphylococcus aureus

scientific article published on 12 June 2017

Medically Relevant Acinetobacter Species Require a Type II Secretion System and Specific Membrane-Associated Chaperones for the Export of Multiple Substrates and Full Virulence

scientific article

Membrane damage elicits an immunomodulatory program in Staphylococcus aureus

scientific article

Menaquinone biosynthesis potentiates haem toxicity in Staphylococcus aureus.

scientific article

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

scientific article published in Science

Metal ion acquisition in Staphylococcus aureus: overcoming nutritional immunity

scientific article

Metal limitation and toxicity at the interface between host and pathogen

scientific article

Metalloregulation of Gram-positive pathogen physiology

scientific article published on 10 December 2011

Metals in Host–Microbe Interaction

article

Metals in infectious diseases and nutritional immunity

scientific article published on 28 May 2015

Miniature on-chip detection of unpurified methicillin-resistant Staphylococcus aureus (MRSA) DNA using real-time PCR.

scientific article

MntABC and MntH contribute to systemic Staphylococcus aureus infection by competing with calprotectin for nutrient manganese

scientific article published on July 2013

Molecular Basis for the Evolution of Species-Specific Hemoglobin Capture by Staphylococcus aureus

scientific article published in 2018

Molecular Mechanisms of Staphylococcus aureus Iron Acquisition ⬇️

scientific article published on January 1, 2011

Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

scientific article

Monitoring the inflammatory response to infection through the integration of MALDI IMS and MRI

scientific article

Myeloid-related protein-8/14 facilitates bacterial growth during pneumococcal pneumonia

scientific article published on September 2014

Neutrophil extracellular traps enhance macrophage killing of bacterial pathogens

scientific article published on 10 September 2021

Neutrophil microbicides induce a pathogen survival response in community-associated methicillin-resistant Staphylococcus aureus.

scientific article

Neutrophil-generated oxidative stress and protein damage in Staphylococcus aureus

scientific article published on 27 June 2016

Next-generation technologies for spatial proteomics: Integrating ultra-high speed MALDI-TOF and high mass resolution MALDI FTICR imaging mass spectrometry for protein analysis

scientific article published on 06 April 2016

Nfu facilitates the maturation of iron-sulfur proteins and participates in virulence in Staphylococcus aureus.

scientific article published on 20 December 2014

Nonconventional Therapeutics against Staphylococcus aureus

scientific article published on 01 November 2018

Nonsteroidal Anti-inflammatory Drugs Alter the Microbiota and Exacerbate Colitis while Dysregulating the Inflammatory Response

scientific article published on 08 January 2019

Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus

scientific article published on August 2011

Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface.

scientific article published on 8 June 2015

Nutritional immunity beyond iron: a role for manganese and zinc.

scientific article

Nutritional immunity: transition metals at the pathogen-host interface

scientific article

Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens

scientific article

OxyR regulates the transcriptional response to hydrogen peroxide

article

Passage of heme-iron across the envelope of Staphylococcus aureus.

scientific article

Pathogenic Helicobacter pylori strains translocate DNA and activate TLR9 via the cancer-associated cag type IV secretion system.

scientific article published on 09 May 2016

Peptidoglycan editing provides immunity to Acinetobacter baumannii during bacterial warfare

scientific article published on 22 July 2020

Powerful Genetic Resource for the Study of Methicillin-Resistant Staphylococcus aureus ⬇️

scientific article published on April 2, 2013

Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus

scientific article

RAGE-Mediated Suppression of Interleukin-10 Results in Enhanced Mortality in a Murine Model of Acinetobacter baumannii Sepsis

scientific article published on 4 January 2017

Recent advances in experimental models of osteomyelitis

scientific article

Recombination, repair and replication in the pathogenic Neisseriae: the 3 R′s of molecular genetics of two human‐specific bacterial pathogens ⬇️

scientific article published on October 1, 2003

Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system

scientific article published on 30 August 2013

Repurposing the Nonsteroidal Anti-inflammatory Drug Diflunisal as an Osteoprotective, Antivirulence Therapy for Staphylococcus aureus Osteomyelitis.

scientific article published on 20 June 2016

Restriction of arginine induces antibiotic tolerance in Staphylococcus aureus

scientific article published in 2024

Roles of the recJ and recN genes in homologous recombination and DNA repair pathways of Neisseria gonorrhoeae

scientific article

Ruffling of Metalloporphyrins Bound to IsdG and IsdI, Two Heme-degrading Enzymes in Staphylococcus aureus

scientific article

S100 Proteins in the Innate Immune Response to Pathogens

scientific article published on 01 January 2019

Salmonella Mitigates Oxidative Stress and Thrives in the Inflamed Gut by Evading Calprotectin-Mediated Manganese Sequestration.

scientific article published on June 2016

Siderophore-mediated zinc acquisition enhances enterobacterial colonization of the inflamed gut

scientific article published in 2021

Signaling and DNA-binding activities of the Staphylococcus aureus HssR-HssS two-component system required for heme sensing

scientific article published on 16 July 2007

Simultaneous Exposure to Intracellular and Extracellular Photosensitizers for the Treatment of Staphylococcus aureus Infections

scientific article published on 13 September 2021

Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis

scientific article

Specificity for human hemoglobin enhances Staphylococcus aureus infection

scientific article

Staphylococcus aureus HemX Modulates Glutamyl-tRNA Reductase Abundance To Regulate Heme Biosynthesis.

scientific article published on 6 February 2018

Staphylococcus aureus HrtA is an ATPase required for protection against heme toxicity and prevention of a transcriptional heme stress response.

scientific article published on 7 March 2008

Staphylococcus aureus IsdB is a hemoglobin receptor required for heme iron utilization.

scientific article

Staphylococcus aureus exhibits heterogeneous siderophore production within the vertebrate host

scientific article published on 14 October 2019

Staphylococcus aureus fur regulates the expression of virulence factors that contribute to the pathogenesis of pneumonia

scientific article

Staphylococcus aureus growth using human hemoglobin as an iron source

scientific article published on 7 February 2013

Staphylococcus aureus haem oxygenases are differentially regulated by iron and haem.

scientific article published on 10 July 2008

Staphylococcus aureus redirects central metabolism to increase iron availability

scientific article

Staphylococcus lugdunensis IsdG liberates iron from host heme

scientific article

Structural Basis for Hemoglobin Capture by Staphylococcus aureus Cell-surface Protein, IsdH

scientific article

Subcellular localization of the Staphylococcus aureus heme iron transport components IsdA and IsdB.

scientific article published on 27 April 2009

Sulfide Homeostasis and Nitroxyl Intersect via Formation of Reactive Sulfur Species in Staphylococcus aureus

scientific article

Synthesis of the Siderophore Coelichelin and Its Utility as a Probe in the Study of Bacterial Metal Sensing and Response

scientific article published on 15 January 2019

TLR9 activation suppresses inflammation in response to Helicobacter pylori infection.

scientific article published on 6 October 2016

Taste for Blood: Hemoglobin as a Nutrient Source for Pathogens ⬇️

scientific article published on March 8, 2012

The Acinetobacter baumannii Znu System Overcomes Host-Imposed Nutrient Zinc Limitation

scientific article published on 18 November 2019

The CsoR-like sulfurtransferase repressor (CstR) is a persulfide sensor in Staphylococcus aureus

scientific article

The Human Antimicrobial Protein Calgranulin C Participates in Control of Helicobacter pylori Growth and Regulation of Virulence

scientific article published on 11 May 2015

The Immune Protein Calprotectin Impacts Clostridioides difficile Metabolism through Zinc Limitation

scientific article published on 19 November 2019

The Impact of Dietary Transition Metals on Host-Bacterial Interactions

scientific article published on 01 June 2018

The Innate Immune Protein S100A9 Protects from T-Helper Cell Type 2-mediated Allergic Airway Inflammation

scientific article published on 01 October 2019

The IsdG-family of haem oxygenases degrades haem to a novel chromophore

scientific article

The Manganese-Responsive Transcriptional Regulator MumR Protects Acinetobacter baumannii from Oxidative Stress

scientific article published on 20 February 2020

The Response of Acinetobacter baumannii to Zinc Starvation.

scientific article published on June 2016

The battle for iron between bacterial pathogens and their vertebrate hosts

scientific article

The capability of Pseudomonas aeruginosa to recruit zinc under conditions of limited metal availability is affected by inactivation of the ZnuABC transporter

scientific article published on June 2015

The chlorite dismutase (HemQ) from Staphylococcus aureus has a redox-sensitive heme and is associated with the small colony variant phenotype

scientific article

The contribution of nutrient metal acquisition and metabolism to Acinetobacter baumannii survival within the host

scientific article published on 12 December 2013

The evolution of a superbug: how Staphylococcus aureus overcomes its unique susceptibility to polyamines

scientific article published on 2 September 2011

The flexible loop of Staphylococcus aureus IsdG is required for its degradation in the absence of heme

scientific article

The heme sensor system of Staphylococcus aureus

scientific article published on 02 June 2009

The host protein calprotectin modulates the Helicobacter pylori cag type IV secretion system via zinc sequestration

scientific article

The impact of metal sequestration on Staphylococcus aureus metabolism

scientific article published on 05 December 2011

The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction.

scientific article published on 15 June 2016

The misidentification of bacterial genes as human cDNAs: was the human D-1 tumor antigen gene acquired from bacteria?

scientific article

The outer membrane localization of the Neisseria gonorrhoeae MsrA/B is involved in survival against reactive oxygen species

scientific article

The role of zinc and nutritional immunity in Clostridium difficile infection

scientific article

Time-resolved Studies of IsdG Protein Identify Molecular Signposts along the Non-canonical Heme Oxygenase Pathway

scientific article

Toll-Like Receptor 9 Contributes to Defense against Acinetobacter baumannii Infection.

scientific article

Total Synthesis of Hinduchelins A-D, Stereochemical Revision of Hinduchelin A, and Biological Evaluation of Natural and Unnatural Analogues

scientific article published on 08 May 2019

Transferrin iron starvation therapy for lethal bacterial and fungal infections

scientific article

Transition Metals and Virulence in Bacteria

scientific article published on 07 September 2016

Two heme-dependent terminal oxidases power Staphylococcus aureus organ-specific colonization of the vertebrate host.

scientific article published on 30 July 2013

Two-component system cross-regulation integrates Bacillus anthracis response to heme and cell envelope stress

scientific article (publication date: March 2014)

Zinc and Manganese Chelation by Neutrophil S100A8/A9 (Calprotectin) Limits Extracellular Aspergillus fumigatus Hyphal Growth and Corneal Infection.

scientific article

Zinc sequestration by the neutrophil protein calprotectin enhances Salmonella growth in the inflamed gut.

scientific article published in March 2012

ZupT Facilitates Clostridioides difficile Resistance to Host-Mediated Nutritional Immunity

scientific article published on 11 March 2020

genetic determinants of intrinsic colistin tolerance in Acinetobacter baumannii

scientific article

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