List of works - Gerold Schuler

A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor

scientific article

A fast and robust method to clone and functionally validate T-cell receptors

scientific article

An improved method for RNA isolation and removal of melanin contamination from melanoma tissue: implications for tumor antigen detection and amplification

scientific article published on 16 May 2006

BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy

scientific article published on 18 January 2018

CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC?

scientific article published on 10 October 2013

CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia

scientific article published on 05 June 2019

Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

scientific article published on 16 August 2019

Combining a chimeric antigen receptor and a conventional T-cell receptor to generate T cells expressing two additional receptors (TETARs) for a multi-hit immunotherapy of melanoma.

scientific article published in June 2016

Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.

scientific article

Curatopes Melanoma: A Database of Predicted T-cell Epitopes from Overly Expressed Proteins in Metastatic Cutaneous Melanoma

scientific article published on 15 August 2019

Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection

scientific article published in September 2007

Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells.

scientific article published on 28 December 2015

Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DC

scientific article published on 03 December 2018

Generation of CD8(+) T cells expressing two additional T-cell receptors (TETARs) for personalised melanoma therapy.

scientific article published on 15 July 2015

Generation of HIV-1-specific T cells by electroporation of T-cell receptor RNA.

scientific article published in August 2008

Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes

scientific article published on 16 September 2011

Human adenovirus-specific γ/δ and CD8+ T cells generated by T-cell receptor transfection to treat adenovirus infection after allogeneic stem cell transplantation

scientific article

Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a

scientific article published on 07 March 2019

Introduction of functional chimeric E/L-selectin by RNA electroporation to target dendritic cells from blood to lymph nodes

scientific article published on 02 September 2007

Just one position-independent lysine residue can direct MelanA into proteasomal degradation following N-terminal fusion of ubiquitin

scientific article

Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes

scientific article published on 14 March 2017

NF-κB activation triggers NK-cell stimulation by monocyte-derived dendritic cells

scientific article published on 11 December 2019

Nonviral RNA transfection to transiently modify T cells with chimeric antigen receptors for adoptive therapy.

scientific article published on January 2013

Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination.

scientific article

RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.

scientific article published on 17 August 2017

Sarcoidosis Under Dendritic Cell Vaccination Immunotherapy in Long-term Responding Patients with Metastatic Melanoma

scientific article published in June 2017

Stability and activity of MCSP-specific chimeric antigen receptors (CARs) depend on the scFv antigen-binding domain and the protein backbone.

scientific article published on 29 October 2015

Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation

scientific article published on 21 June 2010

Triggering of NF-κB in cytokine-matured human DCs generates superior DCs for T-cell priming in cancer immunotherapy

scientific article published on 16 September 2014

List of works by Gerold Schuler

A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor

A fast and robust method to clone and functionally validate T-cell receptors

An improved method for RNA isolation and removal of melanin contamination from melanoma tissue: implications for tumor antigen detection and amplification

BRAF and MEK Inhibitors Influence the Function of Reprogrammed T Cells: Consequences for Adoptive T-Cell Therapy

CD8(+) T-cell priming and boosting: more antigen-presenting DC, or more antigen per DC?

CSPG4-Specific CAR T Cells for High-Risk Childhood B Cell Precursor Leukemia

Clinical-Scale Production of CAR-T Cells for the Treatment of Melanoma Patients by mRNA Transfection of a CSPG4-Specific CAR under Full GMP Compliance

Combining a chimeric antigen receptor and a conventional T-cell receptor to generate T cells expressing two additional receptors (TETARs) for a multi-hit immunotherapy of melanoma.

Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango.

Curatopes Melanoma: A Database of Predicted T-cell Epitopes from Overly Expressed Proteins in Metastatic Cutaneous Melanoma

Effective clinical-scale production of dendritic cell vaccines by monocyte elutriation directly in medium, subsequent culture in bags and final antigen loading using peptides or RNA transfection

Electroporated Antigen-Encoding mRNA Is Not a Danger Signal to Human Mature Monocyte-Derived Dendritic Cells.

Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DC

Generation of CD8(+) T cells expressing two additional T-cell receptors (TETARs) for personalised melanoma therapy.

Generation of HIV-1-specific T cells by electroporation of T-cell receptor RNA.

Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes

Human adenovirus-specific γ/δ and CD8+ T cells generated by T-cell receptor transfection to treat adenovirus infection after allogeneic stem cell transplantation

Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a

Introduction of functional chimeric E/L-selectin by RNA electroporation to target dendritic cells from blood to lymph nodes

Just one position-independent lysine residue can direct MelanA into proteasomal degradation following N-terminal fusion of ubiquitin

Multiepitope tissue analysis reveals SPPL3-mediated ADAM10 activation as a key step in the transformation of melanocytes

NF-κB activation triggers NK-cell stimulation by monocyte-derived dendritic cells

Nonviral RNA transfection to transiently modify T cells with chimeric antigen receptors for adoptive therapy.

Preclinical evaluation of NF-κB-triggered dendritic cells expressing the viral oncogenic driver of Merkel cell carcinoma for therapeutic vaccination.

RNA-transfection of γ/δ T cells with a chimeric antigen receptor or an α/β T-cell receptor: a safer alternative to genetically engineered α/β T cells for the immunotherapy of melanoma.

Sarcoidosis Under Dendritic Cell Vaccination Immunotherapy in Long-term Responding Patients with Metastatic Melanoma

Stability and activity of MCSP-specific chimeric antigen receptors (CARs) depend on the scFv antigen-binding domain and the protein backbone.

Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation

Triggering of NF-κB in cytokine-matured human DCs generates superior DCs for T-cell priming in cancer immunotherapy