List of works - Jennifer A. Pietenpol

A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Respons

scientific article

A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments

scientific article published on 12 May 2015

A gene signature-based approach identifies mTOR as a regulator of p73.

scientific article published on 4 August 2008

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling

scientific article published on May 2007

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

scientific article published on 4 May 2015

Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes

scientific article published on 31 August 2021

Analysis of cell-cycle checkpoint pathways in head and neck cancer cell lines: implications for therapeutic strategies

scientific article published in February 2002

Analysis of high-throughput RNAi screening data in identifying genes mediating sensitivity to chemotherapeutic drugs: statistical approaches and perspectives ⬇️

scientific article published on December 17, 2012

BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition

scientific article

Cell cycle-dependent transduction of cell-permeant Cre recombinase proteins

scientific article published on 01 July 2003

Cell-cycle dysregulation and anticancer therapy

scientific article

Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators

scientific article published in November 2005

Clinical implications of molecular heterogeneity in triple negative breast cancer.

scientific article

Combined modality management of breast cancer: development of predictive markers through proteomics

scientific article

Comparative study of exome copy number variation estimation tools using array comparative genomic hybridization as control

scientific article published on 4 November 2013

Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue.

scientific article

Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells

scientific article

Corrigendum to "Comparative Study of Exome Copy Number Variation Estimation Tools Using Array Comparative Genomic Hybridization as Control".

scientific article published on 18 July 2017

Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway.

scientific article published on 10 October 2003

DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis

scientific article published on 06 March 2009

Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.

scientific article published on December 2016

Detection of internal exon deletion with exon Del.

scientific article

Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

scientific article

Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis

scientific article

Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes

scientific article published on 15 August 2013

Diverse, Biologically Relevant, and Targetable Gene Rearrangements in Triple-Negative Breast Cancer and Other Malignancies

scientific article published on 26 May 2016

Dominant negative p63 isoform expression in head and neck squamous cell carcinoma

scientific article published in December 2004

EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

scientific article

Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells

scientific article

Erratum to: Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

scientific article published on 18 April 2016

Evaluation of p63 and p73 antibodies for cross-reactivity

scientific article published on 9 November 2009

Expression of p63 and 14-3-3sigma in normal and hyperdifferentiated mucosa of the upper aerodigestive tract

scientific article published in June 2002

Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients.

scientific article

Head and neck cancer: meeting summary and research opportunities.

scientific article

IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium

scientific article

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.

scientific article

Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes

scientific article

Identification of Targetable Recurrent MAP3K8 Rearrangements in Melanomas Lacking Known Driver Mutations

scientific article published on 11 June 2019

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

scientific article (publication date: July 2011)

Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation.

scientific article

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1

scientific article

Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer

scientific article published on 2 April 2013

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro

scientific article

Inhibition of epidermal growth factor receptor signaling decreases p63 expression in head and neck squamous carcinoma cells

scientific article published on June 2003

Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems

scientific article published on 14 January 2003

Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis

scientific article published on August 2006

Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer

scientific article

Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data.

scientific article

Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets

scientific article published on 19 December 2013

Multi-perspective quality control of Illumina exome sequencing data using QC3.

scientific article

Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer

scientific article published in March 2006

New strategies for triple-negative breast cancer--deciphering the heterogeneity

scientific article published on February 2014

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors

scientific article

Patient-derived breast tumor xenografts facilitating personalized cancer therapy

scientific article published on 22 January 2013

Practicality of identifying mitochondria variants from exome and RNAseq data.

scientific article published on 23 October 2015

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival

scientific article published on 29 September 2010

Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes

scientific article

Protein arginine methyltransferase I: substrate specificity and role in hnRNP assembly

scientific journal article

RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells.

scientific article

RNAseq by Total RNA Library Identifies Additional RNAs Compared to Poly(A) RNA Library

scientific article published on 12 October 2015

Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis

scientific article published on 01 April 2005

Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection.

scientific article

Significance of p63 amplification and overexpression in lung cancer development and prognosis.

scientific article published in November 2003

Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein

scientific article

Subtyping of triple-negative breast cancer: implications for therapy

scientific article

TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer

scientific article published on 10 December 2019

TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer.

scientific article

Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

scientific article published on 01 March 2020

Targeting mutant p53 in human tumors

scientific article published on 10 September 2012

The DNA binding activity of p53 displays reaction-diffusion kinetics.

scientific article

The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

scientific article

The jury is in: p73 is a tumor suppressor after all.

scientific article published on October 2008

Transcriptional programs regulated by p63 in normal epithelium and tumors

scientific article published on 3 February 2007

Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.

scientific article

Triple-negative breast cancer: molecular subtypes and new targets for therapy.

scientific article published on January 2015

Tyramide Signal-Amplified Immunofluorescence of MYCN and MYC in Human Tissue Specimens and Cell Line Cultures

publication published on 05 July 2020

Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha

scientific article

mTOR regulates autophagy-associated genes downstream of p73.

scientific article published on 30 January 2009

p53 family members: similar biochemistry, different biology

scientific article published on 27 April 2005

p63 and epithelial biology

scientific article

p63: Molecular complexity in development and cancer

scientific article published on 19 March 2004

p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network.

scientific article

p73 Is Required for Ovarian Follicle Development and Regulates a Gene Network Involved in Cell-to-Cell Adhesion

p73 Is Required for pIgR Expression in the Respiratory Epithelium

article published in 2018

p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton

scientific article published on 05 December 2018

p73 regulates epidermal wound healing and induced keratinocyte programming.

scientific article published on 19 June 2019

List of works by Jennifer A. Pietenpol

A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Respons

A Synthetic Lethal Screen Identifies DNA Repair Pathways that Sensitize Cancer Cells to Combined ATR Inhibition and Cisplatin Treatments

A gene signature-based approach identifies mTOR as a regulator of p73.

A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling

Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer

Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes

Analysis of cell-cycle checkpoint pathways in head and neck cancer cell lines: implications for therapeutic strategies

Analysis of high-throughput RNAi screening data in identifying genes mediating sensitivity to chemotherapeutic drugs: statistical approaches and perspectives ⬇️

BRAF fusions define a distinct molecular subset of melanomas with potential sensitivity to MEK inhibition

Cell cycle-dependent transduction of cell-permeant Cre recombinase proteins

Cell-cycle dysregulation and anticancer therapy

Chromatin immunoprecipitation-based screen to identify functional genomic binding sites for sequence-specific transactivators

Clinical implications of molecular heterogeneity in triple negative breast cancer.

Combined modality management of breast cancer: development of predictive markers through proteomics

Comparative study of exome copy number variation estimation tools using array comparative genomic hybridization as control

Comparison of triple-negative breast cancer molecular subtyping using RNA from matched fresh-frozen versus formalin-fixed paraffin-embedded tissue.

Constitutively active K-cyclin/cdk6 kinase in Kaposi sarcoma-associated herpesvirus-infected cells

Corrigendum to "Comparative Study of Exome Copy Number Variation Estimation Tools Using Array Comparative Genomic Hybridization as Control".

Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway.

DeltaNp63 antagonizes p53 to regulate mesoderm induction in Xenopus laevis

Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.

Detection of internal exon deletion with exon Del.

Development of a RSK Inhibitor as a Novel Therapy for Triple-Negative Breast Cancer

Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis

Differential response to neoadjuvant chemotherapy among 7 triple-negative breast cancer molecular subtypes

Diverse, Biologically Relevant, and Targetable Gene Rearrangements in Triple-Negative Breast Cancer and Other Malignancies

Dominant negative p63 isoform expression in head and neck squamous cell carcinoma

EGFR Kinase Domain Duplication (EGFR-KDD) Is a Novel Oncogenic Driver in Lung Cancer That Is Clinically Responsive to Afatinib

Epidermal growth factor receptor plays a significant role in hepatocyte growth factor mediated biological responses in mammary epithelial cells

Erratum to: Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients

Evaluation of p63 and p73 antibodies for cross-reactivity

Expression of p63 and 14-3-3sigma in normal and hyperdifferentiated mucosa of the upper aerodigestive tract

Generation of an algorithm based on minimal gene sets to clinically subtype triple negative breast cancer patients.

Head and neck cancer: meeting summary and research opportunities.

IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy.

Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes

Identification of Targetable Recurrent MAP3K8 Rearrangements in Melanomas Lacking Known Driver Mutations

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation.

Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1

Identification of prognosis-relevant subgroups in patients with chemoresistant triple-negative breast cancer

Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro

Inhibition of epidermal growth factor receptor signaling decreases p63 expression in head and neck squamous carcinoma cells

Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems

Loss of p63 leads to increased cell migration and up-regulation of genes involved in invasion and metastasis

Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer

Mitochondria sequence mapping strategies and practicability of mitochondria variant detection from exome and RNA sequencing data.

Molecular profiling of the residual disease of triple-negative breast cancers after neoadjuvant chemotherapy identifies actionable therapeutic targets

Multi-perspective quality control of Illumina exome sequencing data using QC3.

Neoadjuvant concurrent paclitaxel and radiation in stage II/III breast cancer

New strategies for triple-negative breast cancer--deciphering the heterogeneity

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors

Patient-derived breast tumor xenografts facilitating personalized cancer therapy

Practicality of identifying mitochondria variants from exome and RNAseq data.

Preoperative concurrent paclitaxel-radiation in locally advanced breast cancer: pathologic response correlates with five-year overall survival

Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes

Protein arginine methyltransferase I: substrate specificity and role in hnRNP assembly

RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells.

RNAseq by Total RNA Library Identifies Additional RNAs Compared to Poly(A) RNA Library

Reduced p53 in peripheral blood mononuclear cells from patients with rheumatoid arthritis is associated with loss of radiation-induced apoptosis

Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection.

Significance of p63 amplification and overexpression in lung cancer development and prognosis.

Stabilization and functional impairment of the tumor suppressor p53 by the human papillomavirus type 16 E7 oncoprotein

Subtyping of triple-negative breast cancer: implications for therapy

TBCRC 032 IB/II Multicenter Study: Molecular Insights to AR Antagonist and PI3K Inhibitor Efficacy in Patients with AR+ Metastatic Triple-Negative Breast Cancer

TNBCtype: A Subtyping Tool for Triple-Negative Breast Cancer.

Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

Targeting mutant p53 in human tumors

The DNA binding activity of p53 displays reaction-diffusion kinetics.

The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

The jury is in: p73 is a tumor suppressor after all.

Transcriptional programs regulated by p63 in normal epithelium and tumors

Transforming growth factor beta receptor type III is a tumor promoter in mesenchymal-stem like triple negative breast cancer.

Triple-negative breast cancer: molecular subtypes and new targets for therapy.

Tyramide Signal-Amplified Immunofluorescence of MYCN and MYC in Human Tissue Specimens and Cell Line Cultures

Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha

mTOR regulates autophagy-associated genes downstream of p73.

p53 family members: similar biochemistry, different biology