List of works - Jacob D Estes

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

scientific article

Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques

scientific article published on 08 April 2022

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

scientific article

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy

scientific article

Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice

scientific article

Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

scientific article published on 01 February 2020

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants

scientific article published on 9 July 2019

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

scientific article

CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells

scientific article (publication date: October 2014)

CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.

scientific article published on September 2016

CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells

scientific article

CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

scientific article

CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles

scientific article published on 3 August 2016

CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering

scientific article published on 15 March 2017

Central Nervous System Inflammation and Infection During Early, Non-Accelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.

scientific article published on 21 March 2018

Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.

scientific article

Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV

scientific article published on 20 September 2018

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques"

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

scholarly article published by Elena Chertova in 2018

Corrigendum: Zika viral dynamics and shedding in rhesus and cynomolgus macaques

scientific article published on February 2017

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

scientific article

Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4+ T Cells in African Green Monkeys

scientific article published on 24 April 2017

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

scientific article

Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration

scientific article published on 30 January 2014

Defining HIV and SIV Reservoirs in Lymphoid Tissues.

scientific article published on January 2016

Defining total-body AIDS-virus burden with implications for curative strategies

scientific article published on 2 October 2017

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

scientific article

Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection

scientific article published on 13 July 2016

Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques.

scientific article published on 10 June 2015

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy.

scientific article published on 19 April 2018

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

scientific article

Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals

scientific article

Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate

article

Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection

scientific article

Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques

scientific article

Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques

scientific article published on May 2008

Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques

scientific article

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

scientific article published on 28 December 2015

Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells

scientific article published on 01 December 2019

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

scientific article published on 31 May 2016

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

scientific article

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

scientific article published on January 2017

Follicular dendritic cell contributions to HIV pathogenesis

scientific article

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

scientific article published on 12 July 2018

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.

scientific article

Glycerol monolaurate prevents mucosal SIV transmission

scientific article

Gut epithelial barrier and systemic inflammation during chronic HIV infection

scientific article published on January 2015

HIV-1-induced AIDS in monkeys

scientific article

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

scientific article published in Nature Communications

Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1β.

scientific article

Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection

scientific article (publication date: December 2014)

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.

scientific article published on 20 June 2016

Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence

scientific article

Immune clearance of highly pathogenic SIV infection

scientific article

Impact of early cART in the gut during acute HIV infection

scientific article published on July 2016

Inadequate T follicular cell help impairs B cell immunity during HIV infection.

scientific article published on 10 March 2013

Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease

scientific article

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

scientific article

Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease

scientific article

Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation

scientific article

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

scientific article

Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction

scientific article published on 03 September 2019

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

scientific article

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity.

scientific article

Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21

scientific article (publication date: 2013)

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

scientific article

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

scientific article

Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue microenvironments

scientific article published on 9 January 2018

One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates

scientific article

Paucity of IL-21–producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques ⬇️

scientific article published on September 18, 2012

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

scientific article published on 16 January 2013

Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques

scientific article published on 11 February 2013

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

scientific article published on 07 September 2020

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection

scientific article published on 19 October 2012

Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques

scientific article published on 11 January 2012

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

scientific article published on 22 January 2020

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

scientific article

SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.

scientific article published on 29 September 2011

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage

scientific article

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins

scientific article

Short-lived infected cells support virus replication in sooty mangabeys naturally infected with simian immunodeficiency virus: implications for AIDS pathogenesis

scientific article

Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques

scholarly article by Maud Mavigner et al published 15 September 2018 in Journal of Virology

Systemic administration of antiretrovirals prior to exposure prevents rectal and intravenous HIV-1 transmission in humanized BLT mice

scientific article

Telmisartan Does Not Improve Lymph Node or Adipose Tissue Fibrosis More Than Continued ART Alone

scientific article published in February 2018

The human IL-15 superagonist N-803 promotes migration of virus-specific CD8+ T and NK cells to B cell follicles but does not reverse latency in ART-suppressed, SHIV-infected macaques

scientific article published on 12 March 2020

Three-dimensional imaging of HIV-1 virological synapses reveals membrane architectures involved in virus transmission.

scientific article

Tissue myeloid cells in SIV-infected primates acquire viral DNA through phagocytosis of infected T cells

scientific article

Tissue-specific transcriptional profiling of plasmacytoid dendritic cells reveals a hyperactivated state in chronic SIV infection

scientific article published on 28 June 2021

Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts

scientific article

Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission

scientific article (publication date: 2014)

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.

scientific article

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

scientific article published on 9 July 2014

Zika viral dynamics and shedding in rhesus and cynomolgus macaques

scientific article (publication date: December 2016)

List of works by Jacob D Estes

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

Ad26.COV2.S prevents upregulation of SARS-CoV-2 induced pathways of inflammation and thrombosis in hamsters and rhesus macaques

An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy

Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice

Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

Autologous, Gene-Modified Hematopoietic Stem and Progenitor Cells Repopulate the Central Nervous System with Distinct Clonal Variants

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

CD4 depletion in SIV-infected macaques results in macrophage and microglia infection with rapid turnover of infected cells

CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.

CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells

CTLA-4+PD-1- Memory CD4+ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles

CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering

Central Nervous System Inflammation and Infection During Early, Non-Accelerated Simian-Human Immunodeficiency Virus Infection in Rhesus Macaques.

Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.

Combination anti-PD-1 and antiretroviral therapy provides therapeutic benefit against SIV

Correction for Mavigner et al., "Simian Immunodeficiency Virus Persistence in Cellular and Anatomic Reservoirs in Antiretroviral Therapy-Suppressed Infant Rhesus Macaques"

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

Corrigendum: Zika viral dynamics and shedding in rhesus and cynomolgus macaques

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

Cytotoxic T Cell Functions Accumulate When CD4 Is Downregulated by CD4+ T Cells in African Green Monkeys

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration

Defining HIV and SIV Reservoirs in Lymphoid Tissues.

Defining total-body AIDS-virus burden with implications for curative strategies

Depletion of CD4⁺ T cells abrogates post-peak decline of viremia in SIV-infected rhesus macaques

Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection

Differential Impact of In Vivo CD8+ T Lymphocyte Depletion in Controller versus Progressor Simian Immunodeficiency Virus-Infected Macaques.

Differential impact of transplantation on peripheral and tissue-associated viral reservoirs: Implications for HIV gene therapy.

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

Disruption of intestinal CD4+ T cell homeostasis is a key marker of systemic CD4+ T cell activation in HIV-infected individuals

Disruption of latent HIV in vivo during the clearance of actinic keratosis by ingenol mebutate

Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection

Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques

Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques

Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

Elite control of HIV is associated with distinct functional and transcriptional signatures in lymphoid tissue CD8+ T cells

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies

Follicular dendritic cell contributions to HIV pathogenesis

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.

Glycerol monolaurate prevents mucosal SIV transmission

Gut epithelial barrier and systemic inflammation during chronic HIV infection

HIV-1-induced AIDS in monkeys

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells

Homeostatic tissue responses in skin biopsies from NOMID patients with constitutive overproduction of IL-1β.

Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection

IL-15 promotes activation and expansion of CD8+ T cells in HIV-1 infection.

Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence

Immune clearance of highly pathogenic SIV infection

Impact of early cART in the gut during acute HIV infection

Inadequate T follicular cell help impairs B cell immunity during HIV infection.

Increased intestinal permeability correlates with sigmoid mucosa alpha-synuclein staining and endotoxin exposure markers in early Parkinson's disease

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease

Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

Intestinal proteomic analysis of a novel non-human primate model of experimental colitis reveals signatures of mitochondrial and metabolic dysfunction

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

MRSA Infections in HIV-Infected People Are Associated with Decreased MRSA-Specific Th1 Immunity.

Maintenance of intestinal Th17 cells and reduced microbial translocation in SIV-infected rhesus macaques treated with interleukin (IL)-21

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

Next-generation in situ hybridization approaches to define and quantify HIV and SIV reservoirs in tissue microenvironments

One percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates

Paucity of IL-21–producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques ⬇️

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

Rate of AIDS progression is associated with gastrointestinal dysfunction in simian immunodeficiency virus-infected pigtail macaques

Recommendations for measuring HIV reservoir size in cure-directed clinical trials

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection

Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

SARS-CoV-2 infection protects against rechallenge in rhesus macaques

SIV infection of rhesus macaques results in dysfunctional T- and B-cell responses to neo and recall Leishmania major vaccination.

SIV-induced Translocation of Bacterial Products in the Liver Mobilizes Myeloid Dendritic and Natural Killer Cells Associated With Liver Damage