Search filters

List of works by Deborah A Tweddle

A multilocus technique for risk evaluation of patients with neuroblastoma

scientific article published on February 2011

A systematic review of re-induction chemotherapy for children with relapsed high-risk neuroblastoma

scholarly article by Fiona Herd et al published April 2019 in European Journal of Cancer

A tailored molecular profiling programme for children with cancer to identify clinically actionable genetic alterations

scientific article published on 19 September 2019

ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms

scientific article published on 28 April 2020

Accelerating drug development for neuroblastoma - New Drug Development Strategy: an Innovative Therapies for Children with Cancer, European Network for Cancer Research in Children and Adolescents and International Society of Paediatric Oncology Euro

scientific article published on 12 June 2017

Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN-Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group

scientific article published on 09 September 2020

COX2 expression in neuroblastoma increases tumorigenicity but does not affect cell death in response to the COX2 inhibitor celecoxib

scientific article

Carboplatin therapeutic monitoring in preterm and full-term neonates.

scientific article

Cell cycle regulation targets of MYCN identified by gene expression microarrays

scientific article published on May 2007

Central nervous system penetration and enhancement of temozolomide activity in childhood medulloblastoma models by poly(ADP-ribose) polymerase inhibitor AG-014699.

scientific article

Characterisation of the p53 pathway in cell lines established from TH-MYCN transgenic mouse tumours

scientific article published on 31 January 2018

DNA damage checkpoint kinases in cancer

scientific article published on 08 June 2020

Detection of Circulating and Disseminated Neuroblastoma Cells Using the ImageStream Flow Cytometer for Use as Predictive and Pharmacodynamic Biomarkers

scientific article published on 25 November 2019

Development of a real-time polymerase chain reaction assay for prediction of the uptake of meta-[(131)I]iodobenzylguanidine by neuroblastoma tumors.

scientific article published on August 2003

Differentiation of Human Embryonic Stem Cells to Sympathetic Neurons: A Potential Model for Understanding Neuroblastoma Pathogenesis

scientific article published on 01 November 2018

Evidence for the development of p53 mutations after cytotoxic therapy in a neuroblastoma cell line

scientific article

Factors associated with recurrence and survival length following relapse in patients with neuroblastoma ⬇️

scientific article published on 4 October 2016

High Frequency of p53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma

scientific article

High-resolution analysis of allelic imbalance in neuroblastoma cell lines by single nucleotide polymorphism arrays

scientific article published on January 2007

Histological profile of tumours from MYCN transgenic mice.

scientific article

Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data.

scientific article

Identification of different ALK mutations in a pair of neuroblastoma cell lines established at diagnosis and relapse

scientific article

Increased frequency of aberrations in the p53/MDM2/p14(ARF) pathway in neuroblastoma cell lines established at relapse

scientific article published on February 2006

Influence of segmental chromosome abnormalities on survival in children over the age of 12 months with unresectable localised peripheral neuroblastic tumours without MYCN amplification.

scientific article published on 4 November 2014

Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.

scientific article

Large cell neuroblastoma: a distinct phenotype of neuroblastoma with aggressive clinical behavior

scientific article

MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance

scientific article published on January 2014

MYCN amplification remains prognostically strong 20 years after its “clinical debut”

scientific article published on 01 December 2004

MYCN oncoprotein targets and their therapeutic potential

scientific article published on 13 February 2010

MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63.

scientific article published on 04 July 2011

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma

scientific article published on 6 December 2015

Neonatal neuroblastoma.

scientific article

Outcome of the p53-mediated DNA damage response in neuroblastoma is determined by morphological subtype and MYCN expression.

scientific article

Percentage Tumor Necrosis Following Chemotherapy in Neuroblastoma Correlates withMYCNStatus but not Survival ⬇️

scientific article published on 08 January 2011

Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma

scientific article

Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma

scientific article published on 09 January 2019

SKP2 is a direct transcriptional target of MYCN and a potential therapeutic target in neuroblastoma

scientific article published on 2 April 2015

Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study).

scientific article published on 10 November 2011

Structurally diverse MDM2-p53 antagonists act as modulators of MDR-1 function in neuroblastoma

scientific article

Targeting the DNA Damage Response for the Treatment of High Risk Neuroblastoma

scientific article published on 03 April 2020

Temporal clustering of neuroblastic tumours in children and young adults from Northern England

scientific article

Temporal clustering of neuroblastic tumours in children and young adults from Ontario, Canada

scientific article published in 2022

The p53 codon 72 Pro/Pro genotype identifies poor-prognosis neuroblastoma patients: correlation with reduced apoptosis and enhanced senescence by the p53-72P isoform.

scientific article

The p53 pathway and its inactivation in neuroblastoma.

scientific article

The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage

scientific article published on 15 November 2006

The use of pharmacokinetically guided carboplatin chemotherapy in a pre-term infant with neuroblastoma-associated spinal cord compression

scientific article published on 28 May 2019

Vincristine dosing, drug exposure and therapeutic drug monitoring in neonate and infant cancer patients

scientific article published on 14 October 2021

p53 cellular localization and function in neuroblastoma: evidence for defective G(1) arrest despite WAF1 induction in MYCN-amplified cells

scientific article published on June 2001

p53 is a direct transcriptional target of MYCN in neuroblastoma

scientific article published on 09 February 2010

p53 is nuclear and functional in both undifferentiated and differentiated neuroblastoma

scientific article

p53, SKP2, and DKK3 as MYCN Target Genes and Their Potential Therapeutic Significance ⬇️

scientific article published on November 28, 2012

Paulina is supported by:

About Paulina

Help