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List of works by Ari M Melnick

<i>BCL10</i> Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL

scientific article published in 2022

A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters

scientific article published on August 2013

Aberrant epigenetic and genetic marks are seen in myelodysplastic leukocytes and reveal Dock4 as a candidate pathogenic gene on chromosome 7q

scientific article

An "EZ" Epigenetic Road to Leukemia Stem Cell Metabolic Reprogramming?

scientific article published on 01 September 2019

An Aged/Autoimmune B-cell Program Defines the Early Transformation of Extranodal Lymphomas ⬇️

scientific article published on 20 October 2022

Author Correction: ChromaFold predicts the 3D contact map from single-cell chromatin accessibility ⬇️

scientific article published on 15 January 2025

ChromaFold predicts the 3D contact map from single-cell chromatin accessibility ⬇️

scientific article published in November 2024

Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures

publication published on 04 February 2021

Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL

scientific article published on 23 April 2019

Critical residues within the BTB domain of PLZF and Bcl-6 modulate interaction with corepressors.

scientific article

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation

scientific article published on 13 September 2021

ETO protein of t(8;21) AML is a corepressor for Bcl-6 B-cell lymphoma oncoprotein.

scientific article published on 9 October 2003

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

scientific journal article

Emerging epigenetic-modulating therapies in lymphoma

scientific article published on 01 August 2019

Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression

scientific article published on 11 December 2012

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia

scientific article published on 11 June 2015

Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis

scientific journal article

Germinal center-derived lymphomas: The darkest side of humoral immunity

scientific article published on 01 March 2019

H1 histones control the epigenetic landscape by local chromatin compaction

scientific article published on 09 December 2020

Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture ⬇️

scientific article published on 9 December 2020

Histone demethylase LSD1 is required for germinal center formation and BCL6-driven lymphomagenesis.

scientific article published on 10 December 2018

Long non-coding RNAs discriminate the stages and gene regulatory states of human humoral immune response

article

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment ⬇️

scientific article published on 3 April 2024

Meta-analysis of microarray studies reveals a novel hematopoietic progenitor cell signature and demonstrates feasibility of inter-platform data integration

scientific article published on 13 August 2008

Oncogene-mediated alterations in chromatin conformation

scientific article

PD-1/PD-L1 immune checkpoint and p53 loss facilitate tumor progression in activated B-cell diffuse large B-cell lymphomas

scientific article published on 11 April 2019

Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma

scientific article published on 28 April 2016

Selective Inhibition of HDAC3 Targets Synthetic Vulnerabilities and Activates Immune Surveillance in Lymphoma

scientific article published on 08 January 2020

Shotgun transcriptome, spatial omics, and isothermal profiling of SARS-CoV-2 infection reveals unique host responses, viral diversification, and drug interactions

scientific article published on 12 March 2021

Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia

scientific article published on 23 March 2015

Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation

scientific article published on 11 January 2021

Somatic mutations drive specific, but reversible epigenetic heterogeneity states in AML

scientific article published on 16 September 2020

Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer

scientific article

Synergistic antitumor effect of combined EZH2 and DOT1L inhibition in B-cell lymphoma ⬇️

scientific article published on 26 February 2025

Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps

scientific article published on 9 March 2021

TET2 deficiency reprograms the germinal center B cell epigenome and silences genes linked to lymphomagenesis

scientific article published on 17 June 2020

The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight

scientific article

The therapeutic landscape for cells engineered with chimeric antigen receptors

scientific article published on 06 January 2020

Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma

scientific article published on 01 May 2022

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