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List of works by James L. Kirkland

A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues

scientific article published in 2022

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

scientific article published on 16 November 2020

Cellular senescence and senolytics: the path to the clinic

Cellular senescence drives age-dependent hepatic steatosis.

scientific article

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice.

scientific article

Growth hormone action predicts age-related white adipose tissue dysfunction and senescent cell burden in mice.

scientific article

Liver-specific GH receptor gene-disrupted (LiGHRKO) mice have decreased endocrine IGF-I, increased local IGF-I, and altered body size, body composition, and adipokine profiles

scientific article published on 11 February 2014

Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats

scientific article published on June 2003

Oleate-induced formation of fat cells with impaired insulin sensitivity

scientific article

Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice

scientific article

Senolytics improve physical function and increase lifespan in old age

scientific article published on 09 July 2018

Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation

scientific article published on 27 August 2020

The role of cellular senescence in ageing and endocrine disease

scientific article published on 11 March 2020

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice.

scientific article published on 10 August 2016

Whole-body senescent cell clearance alleviates age-related brain inflammation and cognitive impairment in mice

scientific article published on 20 January 2021

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