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List of works by Justin M. Balko

A Critical Need for Better Cancer Immunotherapy Models: Are Organotypic Tumor Spheroid Cultures the Answer?

scientific article published in February 2018

A case report of clonal EBV-like memory CD4+ T cell activation in fatal checkpoint inhibitor-induced encephalitis

scientific article published on 22 July 2019

A gene expression predictor of response to EGFR-targeted therapy stratifies progression-free survival to cetuximab in KRAS wild-type metastatic colorectal cancer

scientific article

A gene expression signature from human breast cancer cells with acquired hormone independence identifies MYC as a mediator of antiestrogen resistance

scientific article published on 23 February 2011

A genetic mouse model recapitulates immune checkpoint inhibitor-associated myocarditis and supports a mechanism-based therapeutic intervention

scientific article published on 30 November 2020

A kinome-wide screen identifies the insulin/IGF-I receptor pathway as a mechanism of escape from hormone dependence in breast cancer

scientific article published on 9 September 2011

A prognostic signature based on three-genes expression in triple-negative breast tumours with residual disease.

scientific article published on 3 February 2016

A tumor-intrinsic PD-L1-NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy ⬇️

scientific article published on 04 February 2020

Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer

scientific article published on 26 March 2019

Abstract 4875: Human HER2 and PI3K H1047R cooperate to promote mammary tumorigenesis in vivo

Abstract A007: Mutant PIK3CA accelerates HER2-driven transgenic mammary tumor progression, enhances cancer stem cell features, and induces resistance to combinations of anti-HER2 therapies

Activation of MAPK pathways due to DUSP4 loss promotes cancer stem cell-like phenotypes in basal-like breast cancer

scientific article

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

scientific article published on 19 September 2017

Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Ca

scientific article published on 2 August 2017

Assessing Tumor-infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method From the International Immunooncology Biomarkers Working Group: Part 1: Assessing the Host Immune Response, TILs in I

scientific article published in September 2017

Association of FGFR1 with ERαmaintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer.

scientific article

Biological Consequences of MHC-II Expression by Tumor Cells in Cancer

scientific article published on 21 November 2018

Biomarkers for Immunotherapy Toxicity: Are Cytokines the Answer?

scientific article published on 26 December 2018

Biomarkers for assessing the effectiveness of immunotherapy in breast cancer

scientific article published on 17 January 2018

Biomarkers for immune therapy in melanoma

scientific article published on 01 June 2018

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study

scientific article published on 12 November 2018

Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer

scientific article published on 21 August 2020

Combined Dusp4 and p53 loss with Dbf4 amplification drives tumorigenesis via cell cycle restriction and replication stress escape in breast cancer

scientific article published on 18 July 2022

Comparative analysis of the GNAQ, GNA11, SF3B1, and EIF1AX driver mutations in melanoma and across the cancer spectrum.

scientific article published on 18 April 2016

Conditional loss of ErbB3 delays mammary gland hyperplasia induced by mutant PIK3CA without affecting mammary tumor latency, gene expression, or signaling.

scientific article published on 30 April 2013

Correction to: Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

scientific article published on 29 July 2019

Correction: Association of FGFR1 with ERα Maintains Ligand-Independent ER Transcription and Mediates Resistance to Estrogen Deprivation in ER+ Breast Cancer

scientific article published on 01 February 2019

Correction: Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer

scientific article published on 01 February 2019

Correction: PIK3CA C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors

scientific article published on 01 February 2019

Correction: RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

scientific article published on 01 February 2019

DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

scientific article published on 16 January 2018

Dead-box or black-box: is DDX1 a potential biomarker in breast cancer? ⬇️

scientific article published on August 8, 2010

Deep exploration of the immune infiltrate and outcome prediction in testicular cancer by quantitative multiplexed immunohistochemistry and gene expression profiling

scientific article published on 20 March 2017

Demographic factors associated with toxicity in patients treated with anti-programmed cell death-1 therapy

scientific article published on 29 April 2020

Deregulation of DUSP activity in EGFR-mutant lung cancer cell lines contributes to sustained ERK1/2 signaling

scientific article published on 20 October 2009

Discordant cellular response to presurgical letrozole in bilateral synchronous ER+ breast cancers with a KRAS mutation or FGFR1 gene amplification

scientific article published on 09 August 2012

Do the genes tell us the path of most resistance? ⬇️

scientific article published on January 15, 2011

Dual specificity phosphatase 4 gene expression in association with triple-negative breast cancer outcome

scientific article

EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer

scientific article published on 7 January 2016

ERα-dependent E2F transcription can mediate resistance to estrogen deprivation in human breast cancer

scientific article

Efferocytosis produces a prometastatic landscape during postpartum mammary gland involution

scientific article

Emergence of constitutively active estrogen receptor-α mutations in pretreated advanced estrogen receptor-positive breast cancer

scientific article published on 07 January 2014

Emerging biomarkers for cancer immunotherapy in melanoma.

scientific article published on 13 September 2017

Enabling a genetically informed approach to cancer medicine: a retrospective evaluation of the impact of comprehensive tumor profiling using a targeted next-generation sequencing panel

scientific article

Endosomolytic polymersomes increase the activity of cyclic dinucleotide STING agonists to enhance cancer immunotherapy

scientific article published on 21 January 2019

ErbB3 downregulation enhances luminal breast tumor response to antiestrogens

scientific article published on 03 September 2013

ErbB3 drives mammary epithelial survival and differentiation during pregnancy and lactation

scientific article published on 8 September 2017

Extended adjuvant therapy with neratinib plus fulvestrant blocks ER/HER2 crosstalk and maintains complete responses of ER+/HER2+ breast cancers: Implications to the ExteNET trial

article

Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis

article

Fulminant Myocarditis with Combination Immune Checkpoint Blockade

scientific article

Gene expression patterns that predict sensitivity to epidermal growth factor receptor tyrosine kinase inhibitors in lung cancer cell lines and human lung tumors

scientific article published on 10 November 2006

Genomic profiling of ER+ breast cancers after short-term estrogen suppression reveals alterations associated with endocrine resistance.

scientific article published on August 2017

If we build it they will come: targeting the immune response to breast cancer

scientific article published on 29 October 2019

In silico evaluation of DNA Damage Inducible Transcript 4 gene (DDIT4) as prognostic biomarker in several malignancies.

scientific article published on 8 May 2017

Intratumoral delivery of Paclitaxel in solid tumor from biodegradable hyaluronan nanoparticle formulations

scientific article published on 21 April 2009

Key Survival Factor, Mcl-1, Correlates with Sensitivity to Combined Bcl-2/Bcl-xL Blockade.

scientific article

Kinome-wide functional screen identifies role of PLK1 in hormone-independent, ER-positive breast cancer.

scientific article

Lactate Dehydrogenase B: A Metabolic Marker of Response to Neoadjuvant Chemotherapy in Breast Cancer ⬇️

scientific article published on May 22, 2013

MEK and EGFR inhibition demonstrate synergistic activity in EGFR-dependent NSCLC.

scientific article published on 15 March 2009

MUC1 is a downstream target of STAT3 and regulates lung cancer cell survival and invasion

scientific article

Maybe we don't know JAK?

scientific article published on 31 May 2016

Melanoma response to anti-PD-L1 immunotherapy requires JAK1 signaling, but not JAK2.

scientific article

Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

scientific article

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

scientific article published on 24 May 2019

Molecular signatures of lung cancer: defining new diagnostic and therapeutic paradigms

scientific article published in February 2012

Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

scientific article published on 01 November 2021

Multimodal Multiplexed Immunoimaging with Nanostars to Detect Multiple Immunomarkers and Monitor Response to Immunotherapies

scientific article published on 02 January 2020

Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies

scientific article published on 12 August 2013

Neurologic toxicity associated with immune checkpoint inhibitors: a pharmacovigilance study

article

Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling

scientific article

Ovarian carcinoma as a surrogate tumor for lung adenocarcinomas in evaluating the chemo-stability of a gene expression signature

scientific article

PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer

scientific article published on 23 September 2019

PIK3CA mutations in Peruvian patients with HER2-amplified and triple negative non-metastatic breast cancers.

scientific article published on 29 October 2014

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors

scientific article

Phase II study of ruxolitinib, a selective JAK1/2 inhibitor, in patients with metastatic triple-negative breast cancer.

scientific article

Phosphatidylinositol 3-Kinase and Antiestrogen Resistance in Breast Cancer ⬇️

scientific article published on October 17, 2011

Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma

scientific article published on 01 March 2020

Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance

scientific article published on July 2012

Quantitative Spatial Profiling of PD-1/PD-L1 Interaction and HLA-DR/IDO-1 Predicts Improved Outcomes of Anti-PD-1 Therapies in Metastatic Melanoma

scientific article published on 18 July 2018

Quantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma

scientific article

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

scientific article published on 29 October 2015

Severe Epididymo-Orchitis and Encephalitis Complicating Anti-PD-1 Therapy

scientific article published on 01 April 2019

Stand up to cancer phase Ib study of pan-phosphoinositide-3-kinase inhibitor buparlisib with letrozole in estrogen receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer

scientific article published on 24 March 2014

TGF-β inhibition enhances chemotherapy action against triple-negative breast cancer ⬇️

scientific article published on February 8, 2013

Targeted Next Generation Sequencing Identifies Markers of Response to PD-1 Blockade

scientific article published on 26 September 2016

Targeting MYCN-expressing triple-negative breast cancer with BET and MEK inhibitors

scientific article published on 01 March 2020

The genomic map of breast cancer: which roads lead to better targeted therapies?

scientific article published on January 2013

The path to a better biomarker: Application of a risk management framework for the implementation of PD-L1 and TILs as immuno-oncology biomarkers in breast cancer clinical trials and daily practice

scientific article published on 04 March 2020

The receptor tyrosine kinase ErbB3 maintains the balance between luminal and basal breast epithelium

scientific article published on 16 December 2011

Therapeutic potential of DNA methyltransferase inhibitors with immune checkpoint inhibitor therapy in breast cancer

scientific article published on 07 March 2018

Trastuzumab has preferential activity against breast cancers driven by HER2 homodimers

scientific article published on 15 February 2011

Treatment-induced tumor cell apoptosis and secondary necrosis drive tumor progression in the residual tumor microenvironment through MerTK and IDO-1

scientific article published on 09 November 2018

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

scientific article

Triple-negative breast cancers with amplification of JAK2 at the 9p24 locus demonstrate JAK2-specific dependence.

scientific article published on April 2016

Tumor genomic alterations in severe-combined immunodeficiency bare-lymphocyte syndrome genes are associated with high mutational burden and disproportional neo-antigen rates

article

Tumor-specific MHC-II expression drives a unique pattern of resistance to immunotherapy via LAG-3/FCRL6 engagement

Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer

scientific article published on 08 October 2019

WITHDRAWN: Quantitative mass spectrometry analysis of PD-L1 protein expression, N-glycosylation and expression stoichiometry with PD-1 and PD-L2 in human melanoma

retracted scientific article

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