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List of works by Petros C Karakousis

A tuberculosis ontology for host systems biology

scientific article published in September 2015

Accelerated detection of Mycobacterium tuberculosis genes essential for bacterial survival in guinea pigs, compared with mice

scientific article published on 23 April 2007

Adjunctive Host-Directed Therapy With Statins Improves Tuberculosis-Related Outcomes in Mice

scientific article published on 01 March 2020

Albumin fusion with granulocyte-macrophage colony-stimulating factor acts as an immunotherapy against chronic tuberculosis

scientific article published on 07 May 2020

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D.

scientific article

Altered expression of isoniazid-regulated genes in drug-treated dormant Mycobacterium tuberculosis

scientific article published on 21 December 2007

Antibiotic Treatment Shapes the Antigenic Environment During Chronic TB Infection, Offering Novel Targets for Therapeutic Vaccination

scientific article published on 28 April 2020

Application of (1)h NMR spectroscopy-based metabolomics to sera of tuberculosis patients

scientific article published on 10 September 2013

Association between oral fluoroquinolones and retinal detachment

scientific article published in December 2012

Biphasic kill curve of isoniazid reveals the presence of drug-tolerant, not drug-resistant, Mycobacterium tuberculosis in the guinea pig.

scientific article

Can the duration of tuberculosis treatment be shortened with higher dosages of rifampicin?

scientific article

Characterization of a novel heat shock protein (Hsp22.5) involved in the pathogenesis of Mycobacterium tuberculosis

scientific article

Characterization of a novel necrotic granuloma model of latent tuberculosis infection and reactivation in mice

scientific article

Chronic Q fever in the United States

scientific article

Comparison of the 'Denver regimen' against acute tuberculosis in the mouse and guinea pig.

scientific article

Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection.

scientific article

Deficiency of the novel exopolyphosphatase Rv1026/PPX2 leads to metabolic downshift and altered cell wall permeability in Mycobacterium tuberculosis

scientific article published on 17 March 2015

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

scientific article

Differential expression of miRNAs and their relation to active tuberculosis

scientific article published on 6 March 2015

Differential regulation of the two-component regulatory system senX3-regX3 in Mycobacterium tuberculosis.

scientific article published on 10 April 2014

Dormancy phenotype displayed by extracellular Mycobacterium tuberculosis within artificial granulomas in mice

scientific article

Dose-dependent activity of pyrazinamide in animal models of intracellular and extracellular tuberculosis infections.

scientific article

Dose-ranging comparison of rifampin and rifapentine in two pathologically distinct murine models of tuberculosis

scientific article

Early innate immunity determines outcome of Mycobacterium tuberculosis pulmonary infection in rabbits

scientific article published on 19 August 2013

Effectiveness of tuberculosis chemotherapy correlates with resistance to Mycobacterium tuberculosis infection in animal models ⬇️

scientific article published on May 20, 2011

Empirical Antifungal Therapy in Critically Ill Patients With Sepsis: Another Case of Less Is More in the ICU

scientific article published on 01 October 2016

Erratum for Dutta et al., "Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice".

scientific article published on 25 January 2018

Exosomes Isolated from Mycobacteria-Infected Mice or Cultured Macrophages Can Recruit and Activate Immune Cells In Vitro and In Vivo ⬇️

scientific article published on June 20, 2012

Experimental ocular tuberculosis in guinea pigs

scientific article

Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis

scientific article published on 18 November 2020

First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America

scientific article published on 20 July 2016

From the Infectious Diseases Society of America (IDSA) meeting - important new findings in HIV treatment and pathogenesis, 2003

article

Future target-based drug discovery for tuberculosis?

scientific article published on December 2014

Gene Enrichment Analysis Reveals Major Regulators of Mycobacterium tuberculosis Gene Expression in Two Models of Antibiotic Tolerance.

scientific article published on 4 April 2018

Genetic Determinants of Intrinsic Antibiotic Tolerance in Mycobacterium avium

scientific article published on 15 September 2021

Genome analysis of Mycobacterium avium subspecies hominissuis strain 109

scientific article published on 04 December 2018

Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives

scientific article published on May 2015

Identification of a Transcription Factor That Regulates Host Cell Exit and Virulence of Mycobacterium tuberculosis

scientific article

Identifying the essential genes of Mycobacterium avium subsp. hominissuis with Tn-Seq using a rank-based filter procedure

scientific article published on 23 January 2020

In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D.

scientific article published on 27 March 2017

Inhibiting the stringent response blocks entry into quiescence and reduces persistence

scientific article published on 20 March 2019

Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children

scientific article published on 11 November 2020

Interferon-γ Release Assays in the Diagnosis of Tuberculous Uveitis

scientific article published on 01 October 2008

Intranasal Immunization with DnaK Protein Induces Protective Mucosal Immunity against Tuberculosis in CD4-Depleted Mice

scientific article published on 8 February 2018

Intraocular tuberculosis

scientific article published on August 2010

Latent tuberculosis infection: myths, models, and molecular mechanisms

scientific article

Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study

scientific article published on 2 July 2015

Local ischemia and increased expression of vascular endothelial growth factor following ocular dissemination of Mycobacterium tuberculosis

scientific article

Mechanisms of Antibiotic Tolerance in Mycobacterium avium Complex: Lessons From Related Mycobacteria

scientific article published on 30 September 2020

Metabolomics specificity of tuberculosis plasma revealed by (1)H NMR spectroscopy

scientific article published on 14 February 2015

Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice

scientific article published on 30 May 2017

Metformin Use Reverses the Increased Mortality Associated With Diabetes Mellitus During Tuberculosis Treatment

scientific article published in January 2018

Metronidazole lacks activity against Mycobacterium tuberculosis in an in vivo hypoxic granuloma model of latency

scientific article published on July 2008

Molecular immunologic correlates of spontaneous latency in a rabbit model of pulmonary tuberculosis

scientific article published on 28 February 2013

Multidrug-Resistant Tuberculosis in Panama Is Driven by Clonal Expansion of a Multidrug-Resistant Mycobacterium tuberculosis Strain Related to the KZN Extensively Drug-Resistant M. tuberculosis Strain from South Africa ⬇️

scientific article published on July 24, 2013

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen

scientific article published on 24 December 2015

Mycobacterium avium complex immune reconstitution inflammatory syndrome: long term outcomes

scientific article

Mycobacterium avium complex in patients with HIV infection in the era of highly active antiretroviral therapy

scientific article published in September 2004

Mycobacterium tuberculosis SigF regulates genes encoding cell wall-associated proteins and directly regulates the transcriptional regulatory gene phoY1.

scientific article published on 23 March 2007

Mycobacterium tuberculosis cell envelope lipids and the host immune response

scientific article published on February 2004

Mycobacterium tuberculosis complex enhances susceptibility of CD4 T cells to HIV through a TLR2-mediated pathway

scientific article (publication date: 2012)

Mycobacterium tuberculosis infection drives mitochondria-biased dysregulation of host tRNA-derived fragments

scientific article published on 22 September 2020

New patentable use of an old neuroleptic compound thioridazine to combat tuberculosis: a gene regulation perspective

scientific article published on May 2011

PA-824 is as effective as isoniazid against latent tuberculosis infection in C3HeB/FeJ mice

scientific article

Paraplegia caused by invasive spinal aspergillosis

scientific article published on 01 January 2007

Phosphate depletion: a novel trigger for Mycobacterium tuberculosis persistence

scientific journal article

Pleuropulmonary Kaposi Sarcoma in the Setting of Immune Reactivation

scientific article published on 30 May 2016

Postoperative Pneumococcal Cellulitis in Systemic Lupus Erythematosus ⬇️

scientific article published on January 1, 2003

Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen

scientific article published on 03 June 2013

Preliminary pharmacokinetic study of repeated doses of rifampin and rifapentine in guinea pigs

scientific article published on 7 January 2013

Reduced emergence of isoniazid resistance with concurrent use of thioridazine against acute murine tuberculosis.

scientific article

Remembering the Host in Tuberculosis Drug Development

scientific article published on 01 April 2019

Replication of Mycobacterium tuberculosis in retinal pigment epithelium

scientific article published on June 2014

Reply to Hu et al

scientific article published on 20 December 2019

Reply to “Contradictory Results with High-Dosage Rifamycin in Mice and Humans” ⬇️

scientific article published on February 1, 2013

Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigs

scientific article

Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models.

scientific article published on 22 December 2008

Roles of SigB and SigF in the Mycobacterium tuberculosis sigma factor network

scientific journal article

Rv1894c Is a Novel Hypoxia-Induced Nitronate Monooxygenase Required for Mycobacterium tuberculosis Virulence ⬇️

scientific article published on February 13, 2013

Simvastatin increases the in vivo activity of the first-line tuberculosis regimen

scientific article

Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop

scientific article published on 01 January 2020

Stability and Viability of SARS-CoV-2

scientific article published on 13 April 2020

Statin adjunctive therapy shortens the duration of TB treatment in mice.

scientific article published on 21 February 2016

Sterilizing activity of thioridazine in combination with the first-line regimen against acute murine tuberculosis

scientific article

Strain-dependent CNS dissemination in guinea pigs after Mycobacterium tuberculosis aerosol challenge ⬇️

scientific article published on 09 August 2011

Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo.

scientific article published on 15 August 2016

Systems biology-based identification of Mycobacterium tuberculosis persistence genes in mouse lungs

scientific article

TLR2-Modulating Lipoproteins of the Mycobacterium tuberculosis Complex Enhance the HIV Infectivity of CD4+ T Cells

scientific article published on 25 January 2016

The Global Health Security Index is not predictive of coronavirus pandemic responses among Organization for Economic Cooperation and Development countries

scientific article published on 07 October 2020

The Impact of Hypertension and Use of Calcium Channel Blockers on Tuberculosis Treatment Outcomes

scientific article published on 24 September 2020

The Polyphosphate Kinase Gene ppk2 Is Required for Mycobacterium tuberculosis Inorganic Polyphosphate Regulation and Virulence ⬇️

scientific article published on May 21, 2013

The Stringent Response Is Required for Full Virulence of Mycobacterium tuberculosis in Guinea Pigs ⬇️

scientific article published on November 1, 2010

The anti-tubercular activity of simvastatin is mediated by cholesterol-driven autophagy via the AMPK-mTORC1-TFEB axis

scientific article published on 26 August 2020

The impact of mouse passaging of Mycobacterium tuberculosis strains prior to virulence testing in the mouse and guinea pig aerosol models

scientific article

The potent bactericidal activity of streptomycin in the guinea pig model of tuberculosis ceases due to the presence of persisters ⬇️

scientific article published on August 6, 2010

The role of conjunctival biopsy in the diagnosis of Wegener's granulomatosis: a case report

scientific article published on 01 April 2002

The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence

scientific article published in 2011

Thioridazine for treatment of tuberculosis: promises and pitfalls

scientific article published on 19 September 2014

Thioridazine lacks bactericidal activity in an animal model of extracellular tuberculosis.

scientific article published on 5 March 2013

Timing of Antiretroviral Therapy for HIV in the Setting of TB Treatment ⬇️

scientific article published on December 27, 2010

Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis

scientific article published on 30 November 2018

Treatment with an immature dendritic cell-targeting vaccine supplemented with IFN-α and an inhibitor of DNA methylation markedly enhances survival in a murine melanoma model

scientific article published on 24 January 2020

Tuberculosis chemotherapy : present situation, possible solutions, and progress towards a TB-free world

scientific article published on 01 July 2012

Tuberculosis-associated haemophagocytic syndrome.

scientific article published on July 2006

U.S. medical resident familiarity with national tuberculosis guidelines

scientific article published on 2 August 2007

Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1,10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Selectivity, and Lower Toxicity in Comparison to Their Copper(II) Analogs

scientific article published on 02 July 2018

Upregulation of the phthiocerol dimycocerosate biosynthetic pathway by rifampin-resistant, rpoB mutant Mycobacterium tuberculosis

scientific article

Use of multiplex allele-specific polymerase chain reaction (MAS-PCR) to detect multidrug-resistant tuberculosis in Panama

scientific article

Vaccination with Recombinant Mycobacterium tuberculosis PknD Attenuates Bacterial Dissemination to the Brain in Guinea Pigs ⬇️

scientific article published on June 11, 2013

senX3-independent contribution of regX3 to Mycobacterium tuberculosis virulence

scientific article

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