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List of works by Agapios Sachinidis

"Watching the Detectives" report of the general assembly of the EU project DETECTIVE Brussels, 24-25 November 2015.

scientific article published on 29 April 2016

A Cre-based double fluorescence indicator system for monitoring cell fusion events and selection of fused cells.

scientific article published on February 2010

A chemical genetics approach for specific differentiation of stem cells to somatic cells: a new promising therapeutical approach

scientific article published on January 2008

A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system

scientific article published on 2 September 2014

A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity

scientific article

A novel component of the ubiquitin pathway, ubiquitin carboxyl extension protein 1 is overexpressed in prostate cancer.

scientific article published in February 2005

A temporal window of vulnerability for development of atrial fibrillation with advancing heart failure

article

A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors

scientific article

All-trans retinoic acid and basic fibroblast growth factor synergistically direct pluripotent human embryonic stem cells to extraembryonic lineages ⬇️

scientific article published on December 9, 2012

An optimized embryonic stem cell model for consistent gene expression and developmental studies. A fundamental study

article

Are Catechins Natural Tyrosine Kinase Inhibitors?

scientific article published on 01 September 2002

Ascorbic Acid-Induced Cardiac Differentiation of Murine Pluripotent Stem Cells: Transcriptional Profiling and Effect of a Small Molecule Synergist of Wnt/β-Catenin Signaling Pathway.

scientific article published on 22 May 2015

Cardiac specific differentiation of mouse embryonic stem cells

scientific article

Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts

scientific article published on 09 March 2019

Cardiotoxicity and Heart Failure: Lessons from Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Anticancer Drugs

scientific article published on 17 April 2020

Cardiovascular genomics: a current overview of in vivo and in vitro studies

scientific article published on January 2006

Cav3.2 T-Type Calcium Channels Are Physiologically Mandatory for the Auditory System

scientific article published on 25 April 2019

Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells

scientific article published on 3 February 2018

Chemically induced cardiomyogenesis of mouse embryonic stem cells

scientific article published in January 2010

Chemoprotective mechanism of the natural compounds, epigallocatechin-3-O-gallate, quercetin and curcumin against cancer and cardiovascular diseases

scientific article published on January 2009

Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.

scientific article published on 30 December 2016

Correction: Nemade, H.; et al. Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells. Cells 2020, 9, 554

scientific article published on 24 September 2020

Corrigendum to "Gene networks and transcription factor motifs defining the differentiation of human stem cells into hepatocyte-like cells" [J Hepatol 2015;63:934-942].

scientific article published on 2 December 2015

Corrigendum: Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca(2+) release channel.

scientific article

Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications

scientific article published on 30 April 2019

Current status of human pluripotent stem cell based in vitro toxicity tests.

scientific article published on January 2013

Cyclooxygenases Inhibitors Efficiently Induce Cardiomyogenesis in Human Pluripotent Stem Cells

scientific article published on 27 February 2020

Data Acquisition and Analysis In Brainstem Evoked Response Audiometry In Mice

scientific article published on 10 May 2019

Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives

scientific article published on 27 October 2017

Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells.

scientific article published on 21 January 2014

Destabilization of AT 1 Receptor mRNA by Calreticulin ⬇️

scientific article published on January 11, 2002

Development of a Neural Teratogenicity Test Based on Human Embryonic Stem Cells: Response to Retinoic Acid Exposure ⬇️

scientific article published on September 20, 2011

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances

scientific article published on 11 November 2019

Development of a pluripotent stem cell derived neuronal model to identify chemically induced pathway perturbations in relation to neurotoxicity: effects of CREB pathway inhibition

scientific article published on 19 August 2014

Dietary small molecules and large-scale gene expression studies: an experimental approach for understanding their beneficial effects on the development of malignant and non-malignant proliferative diseases

scientific article published on January 2006

Distinct transcriptomic changes in E14.5 mouse skeletal muscle lacking RYR1 or Cav1.1 converge at E18.5.

scientific article published on 15 March 2018

Does the coronary risk factor low density lipoprotein alter growth and signaling in vascular smooth muscle cells?

scientific article

Effect of chemopreventive agents on differentiation of mouse embryonic stem cells ⬇️

scientific article published on January 1, 2012

Effects of cryopreservation on the transcriptome of human embryonic stem cells after thawing and culturing

scientific article published in September 2011

Electrophysiological characteristics of embryonic stem cell-derived cardiomyocytes are cell line-dependent

scientific article

Embryonic stem cells for basic research and potential clinical applications in cardiology

scientific article

Embryonic stem cells produce neurotrophins in response to cerebral tissue extract: Cell line-dependent differences

scientific article

Embryonic stem cells: a promising tool for cell replacement therapy.

scientific article

Entrapment of embryonic stem cells-derived cardiomyocytes in macroporous biodegradable microspheres: preparation and characterization

scientific article

Epigallocatechin-3-O-gallate inhibits the angiotensin II-induced adhesion molecule expression in human umbilical vein endothelial cell via inhibition of MAPK pathways

scientific article published in January 2007

Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome

scientific article published on 20 June 2012

Evaluation of developmental toxicants and signaling pathways in a functional test based on the migration of human neural crest cells

scientific article

Evidence for self-maintaining pluripotent murine stem cells in embryoid bodies

scientific article published in February 2014

Exogenous WNT5A and WNT11 proteins rescue CITED2 dysfunction in mouse embryonic stem cells and zebrafish morphants

scientific article published on 05 August 2019

Extensive transcriptional regulation of chromatin modifiers during human neurodevelopment

scientific article

Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay

scientific article published on 25 March 2016

First steps towards the successful surface-based cultivation of human embryonic stem cells in hanging drop systems.

scientific article published on August 2012

Formation of caspase-3 complexes and fragmentation of caspase-12 during anisomycin-induced apoptosis in AKR-2B cells without aggregation of Apaf-1.

scientific article published in October 2002

From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects.

scientific article

Functional and phenotypic differences of pure populations of stem cell-derived astrocytes and neuronal precursor cells

scientific article published on 22 December 2015

Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 22 September 2017

Functional characterization and gene expression profiling of α-smooth muscle actin expressing cardiomyocytes derived from murine induced pluripotent stem cells.

scientific article published in March 2012

Functional characterization and transcriptome analysis of embryonic stem cell-derived contractile smooth muscle cells.

scientific article

Functional implications of Cav 2.3 R-type voltage-gated calcium channels in the murine auditory system - novel vistas from brainstem-evoked response audiometry

scientific article published on 11 October 2019

GSK-3β inhibition protects the rat heart from the lipopolysaccharide-induced inflammation injury via suppressing FOXO3A activity

scientific article published on 10 September 2019

Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca2.3 R-type voltage-gated calcium channel

Gender specific click and tone burst evoked ABR datasets from mice lacking the Ca3.2 T-type voltage-gated calcium channel

scientific article published on 20 March 2019

Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells

scientific article

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

scientific article published on 23 June 2016

Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

scientific article published on 25 May 2015

Gene profiling of embryonic skeletal muscle lacking type I ryanodine receptor Ca(2+) release channel

scientific article published on February 2016

Generation and characterization of cardiomyocytes under serum-free conditions

scientific article published in January 2006

Generation of Cardiomyocytes in Pipe-Based Microbioreactor Under Segmented Flow

scientific article published on 9 May 2016

Generation of a double-fluorescent double-selectable Cre/loxP indicator vector for monitoring of intracellular recombination events.

scientific article published in January 2008

Generation of cardiomyocytes from embryonic stem cells experimental studies

scientific article published on November 2002

Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations

scientific article published on 25 September 2019

Global transcriptome analysis of murine embryonic stem cell-derived cardiomyocytes

scientific article

Global transcriptomic analysis of murine embryonic stem cell-derived brachyury(+) (T) cells

scientific article published on 24 February 2010

Highlight report: Cardiotoxicity screening

scientific article

Human ES cell derived cardiomyocytes for cell replacement therapy: a current update.

scientific article published on August 2008

Human Embryonic and Induced Pluripotent Stem Cell Based Toxicity Testing Models: Future Applications in New Drug Discovery

scientific article published on 27 June 2016

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation

scientific article

Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach

scientific article

Human endothelial cells selectively express large amounts of pancreatic-type ribonuclease (RNase 1).

scientific article published on January 2002

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response

scientific article published on August 2014

Human skin-derived stem cells as a novel cell source for in vitro hepatotoxicity screening of pharmaceuticals

scientific article published on 21 September 2013

IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis

scientific article published on 04 September 2019

Identification of Thalidomide-Specific Transcriptomics and Proteomics Signatures during Differentiation of Human Embryonic Stem Cells ⬇️

scientific article published on August 28, 2012

Identification of differentially expressed genes involved in the formation of multicellular tumor spheroids by HT-29 colon carcinoma cells

scientific article

Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment

scientific article published on 4 November 2015

Identification of plateled-derived growth factor-BB as cardiogenesis-inducing factor in mouse embryonic stem cells under serum-free conditions

scientific article published in January 2003

Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors.

scientific article published on 24 October 2014

Identification of small signalling molecules promoting cardiac-specific differentiation of mouse embryonic stem cells

scientific article published in January 2006

Identification of specific pluripotent stem cell death--inducing small molecules by chemical screening.

scientific article

Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration.

scientific article

Impairment of human neural crest cell migration by prolonged exposure to interferon-beta.

scientific article

Inflammation-associated suppression of metabolic gene networks in acute and chronic liver disease

scientific article published on 09 January 2020

Inhibition of the Low Density Lipoprotein-Induced Vascular Smooth Muscle Cell Growth by PPARgamma Ligands.

scientific article

Inhibition of the PDGF beta-receptor tyrosine phosphorylation and its downstream intracellular signal transduction pathway in rat and human vascular smooth muscle cells by different catechins

scientific article published on 23 April 2002

Inhibition of the vascular-endothelial growth factor-induced intracellular signaling and mitogenesis of human endothelial cells by epigallocatechin-3 gallate

scientific article

Inhibitory effect of epigallocatechin 3-O-gallate on vascular smooth muscle cell hypertrophy induced by angiotensin II.

scientific article published in February 2004

Isolation and functional characterization of alpha-smooth muscle actin expressing cardiomyocytes from embryonic stem cells.

scientific article

Klf4 and Klf5 differentially inhibit mesoderm and endoderm differentiation in embryonic stem cells

scientific article published on 28 April 2014

Laminin promotes differentiation of rat embryonic stem cells into cardiomyocytes by activating the integrin/FAK/PI3K p85 pathway

scientific article published on 25 March 2019

Lineage-specific regulation of epigenetic modifier genes in human liver and brain

scientific article

Live-Cell Imaging of the Contractile Velocity and Transient Intracellular Ca<sup>2+</sup> Fluctuations in Human Stem Cell-Derived Cardiomyocytes

scientific article published on 09 April 2022

Local delivery of green tea catechins inhibits neointimal formation in the rat carotid artery injury model

scientific article published in September 2004

Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart

scientific article published on 18 March 2019

Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr).

scientific article

Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis

scientific article published on 20 November 2003

Mesoderm-derived stem cells: the link between the transcriptome and their differentiation potential.

scientific article

Metabolite signatures of doxorubicin induced toxicity in human induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 18 April 2017

MicroRNAs as early toxicity signatures of doxorubicin in human-induced pluripotent stem cell-derived cardiomyocytes

scientific article published on 3 February 2016

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

scientific article

Modulation of Differentiation Processes in Murine Embryonic Stem Cells Exposed to Parabolic Flight-Induced Acute Hypergravity and Microgravity

scientific article published on 9 April 2018

Neuronal-specific deficiency of the splicing factor Tra2b causes apoptosis in neurogenic areas of the developing mouse brain

scientific article

Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures

article

Optimization of the culturing conditions of human umbilical cord blood-derived endothelial colony-forming cells under xeno-free conditions applying a transcriptomic approach

scientific article published on 20 May 2010

Parabolic, Flight-Induced, Acute Hypergravity and Microgravity Effects on the Beating Rate of Human Cardiomyocytes

scientific article published on 14 April 2019

Parallel Genome-wide Profiling of Coding and Non-coding RNAs to Identify Novel Regulatory Elements in Embryonic and Maturated Heart.

scientific article

Persistence of Epigenomic Effects After Recovery From Repeated Treatment With Two Nephrocarcinogens

scientific article published on 03 December 2018

Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes

scientific journal article

Possible non-classic intracellular and molecular mechanisms of LDL cholesterol action contributing to the development and progression of atherosclerosis

scientific article published on 01 October 2004

Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations

scientific article published on 27 June 2019

Proliferation and cilia dynamics in neural stem cells prospectively isolated from the SEZ.

scientific article published on 22 January 2014

Radiation Response of Murine Embryonic Stem Cells

scientific article published on 09 July 2020

Regulation of intrinsic prion protein by growth factors and TNF-alpha: the role of intracellular reactive oxygen species

scientific article published in September 2003

Regulation of liver metabolism by the endosomal GTPase Rab5.

scientific article published on 30 April 2015

Regulation of mitogen-activated protein kinase cascades by low density lipoprotein and lysophosphatidic acid

scientific article published in January 2004

Road Map for Development of Stem Cell-Based Alternative Test Methods

scientific article published on 23 May 2019

STRIP2 Is Indispensable for the Onset of Embryonic Stem Cell Differentiation

scientific article published on 14 April 2017

Signaling molecules, transcription growth factors and other regulators revealed from in-vivo and in-vitro models for the regulation of cardiac development

scientific article published on 27 January 2015

Simulated Microgravity Modulates Differentiation Processes of Embryonic Stem Cells

scientific article published on 4 April 2016

Somitovasculin, a novel endothelial-specific transcript involved in the vasculature development.

scientific article published on 18 June 2009

Specific Gene Signatures and Pathways in Mesodermal Cells and Their Derivatives Derived from Embryonic Stem Cells ⬇️

scientific article published on March 1, 2012

Stem Cell Transcriptome Responses and Corresponding Biomarkers That Indicate the Transition from Adaptive Responses to Cytotoxicity.

scientific article published on 21 December 2016

Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants

scientific article published on March 2016

Stem cells and differentiation--a synoptic review of patents granted since 2009.

scientific article

Stromal cell-derived factor 1alpha (SDF-1alpha) induces gene-expression of early growth response-1 (Egr-1) and VEGF in human arterial endothelial cells and enhances VEGF induced cell proliferation

scientific article published in April 2003

Test systems of developmental toxicity: state-of-the art and future perspectives.

scientific article published in December 2013

The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis

scientific article published on 24 January 2002

The FunGenES consortium: functional genomics in engineered embryonic stem cells

scientific article published on January 2006

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation

scientific article

The Potential Application of Biomaterials in Cardiac Stem Cell Therapy.

scientific article published on January 2016

The use of suppression subtractive hybridization for the study of SDF-1α induced gene-expression in human endothelial cells ⬇️

scientific article published on October 1, 2003

Three LIF-dependent signatures and gene clusters with atypical expression profiles, identified by transcriptome studies in mouse ES cells and early derivatives

scientific article

Toxicogenomics directory of chemically exposed human hepatocytes

scientific article

Toxicogenomics directory of rat hepatotoxicants in vivo and in cultivated hepatocytes

scientific article published on 03 December 2018

Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.

scientific article published on 20 October 2015

Transcriptional changes associated with advancing stages of heart failure underlie atrial and ventricular arrhythmogenesis

scientific article

Transcriptional profiling of CD31(+) cells isolated from murine embryonic stem cells

scientific article published on 15 January 2008

Transcriptional responses to epigallocatechin-3 gallate in HT 29 colon carcinoma spheroids

scientific article

Transcriptomic and phenotypic analysis of murine embryonic stem cell derived BMP2+ lineage cells: an insight into mesodermal patterning

scientific article

Transcriptomics of Hepatocytes Treated with Toxicants for Investigating Molecular Mechanisms Underlying Hepatotoxicity

scientific article published in January 2015

Trapping of growth factors by catechins: a possible therapeutical target for prevention of proliferative diseases

scientific article

Unique metabolic features of stem cells, cardiomyocytes, and their progenitors.

scientific article published on April 2014

yylncT Defines a Class of Divergently Transcribed lncRNAs and Safeguards the T-mediated Mesodermal Commitment of Human PSCs

scientific article published on 13 December 2018

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