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List of works by Egil Lien

(De-) Oiling Inflammasomes ⬇️

scientific article published on June 27, 2013

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif ⬇️

scientific article published on November 10, 2003

A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling.

scientific article

Absence of the inflammasome adaptor ASC reduces hypoxia-induced pulmonary hypertension in mice

scientific article published on 12 June 2015

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

scientific article

Cell Distributions and Functions of Toll-like Receptor 4 Studied by Fluorescent Gene Constructs ⬇️

scientific article published on January 1, 2003

Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36.

scientific article

Contribution of TLR4 and MyD88 for adjuvant monophosphoryl lipid A (MPLA) activity in a DNA prime-protein boost HIV-1 vaccine

scientific article published on 18 July 2014

D27-pLpxL, an avirulent strain of Yersinia pestis, primes T cells that protect against pneumonic plague

scientific article published on 20 July 2009

Defects in early cell recruitment contribute to the increased susceptibility to respiratory Klebsiella pneumoniae infection in diabetic mice.

scientific article

Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3).

scientific article

Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article published in Nature

Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis

scientific article published on 16 April 2007

Gasdermins and their role in immunity and inflammation

scientific article published on 23 September 2019

Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling

scientific article published on September 2002

Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection

scientific article

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

scientific article

Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication

scientific article published on 18 June 2004

Inflammasomes and host defenses against bacterial infections ⬇️

scientific article published on January 11, 2013

Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome

scientific article

Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4.

scientific article published in February 2002

Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers

scientific article published on 27 June 2002

Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88.

scientific article published on 9 June 2004

Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction

scientific article (publication date: 6 December 2002)

MD-2 expression is not required for cell surface targeting of Toll-like receptor 4 (TLR4).

scientific article published on 31 August 2006

MD-2-mediated ionic interactions between lipid A and TLR4 are essential for receptor activation

scientific article

Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission.

scientific article published on October 2015

Manipulation of Interleukin-1β and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence

scientific article published on 16 February 2016

Manipulation of interleukin-1β and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence.

scientific article published on July 2016

Multiple roles of caspase-8 in cell death, inflammation, and innate immunity

scientific article published on 12 June 2020

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

scientific article (publication date: 29 April 2010)

Palmitate promotes inflammatory responses and cellular senescence in cardiac fibroblasts.

scientific article published on 11 November 2016

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death

scientific article published in Science

Phagocytosis and intracellular killing of MD-2 opsonized gram-negative bacteria depend on TLR4 signaling

scientific article published on 18 January 2008

RNA and β-hemolysin of group B Streptococcus induce interleukin-1β (IL-1β) by activating NLRP3 inflammasomes in mouse macrophages.

scientific article

Recruitment and endo-lysosomal activation of TLR9 in dendritic cells infected with Trypanosoma cruzi.

scientific article

Reduced MyD88 dependency of ISCOMATRIX™ adjuvant in a DNA prime-protein boost HIV vaccine

scientific article published on 10 February 2014

Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever

scientific article published on 16 December 2008

Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of toll-like receptor 4-mediated signaling

scientific article published on March 2002

Role of p38 and early growth response factor 1 in the macrophage response to group B streptococcus

scientific article published on 30 March 2009

Serum cytokine profiles associated with specific adjuvants used in a DNA prime-protein boost vaccination strategy

scientific article

Soluble toll-like receptor 2 in HIV infection: association with disease progression

scientific article published on 01 December 2004

TLR4 is a negative regulator in noninfectious lung inflammation.

scientific article published on 31 March 2010

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

scientific article published on 11 January 2004

TLR9-signaling pathways are involved in Kilham rat virus-induced autoimmune diabetes in the biobreeding diabetes-resistant rat

scientific journal article

The LPS receptor generates inflammatory signals from the cell surface

scientific article published on January 2003

The NLRP12 inflammasome recognizes Yersinia pestis

scientific article published on July 2012

The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia–reperfusion injury ⬇️

scientific article published on April 10, 2013

The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes

scientific article

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

scientific article

The role of Toll-like receptor pathways in the mechanism of type 1 diabetes

scientific article published on February 2009

Toll-like receptor 2 deficiency results in impaired antibody responses and septic shock during Borrelia hermsii infection

scientific article

Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling

scientific article

Toll-like receptors

scientific article (publication date: 2002)

Toll-like receptors and their function in innate and adaptive immunity

scientific article

UNC93B1 mediates host resistance to infection with Toxoplasma gondii

scientific article

Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

scientific article published on 17 September 2006

Yersinia pestis evades TLR4-dependent induction of IL-12(p40)2 by dendritic cells and subsequent cell migration ⬇️

scientific article published on October 2008

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