List of works - John Lusingu

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

scientific article

Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age

scientific article

National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010.

scientific article

Severe malaria is associated with parasite binding to endothelial protein C receptor

scientific article

Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes

scientific article

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

scientific article

A progressive declining in the burden of malaria in north-eastern Tanzania

scientific article

Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

scientific article

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria

scientific article

Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania

scientific article published on 4 May 2006

Neonatal mortality risk associated with preterm birth in East Africa, adjusted by weight for gestational age: individual participant level meta-analysis

scientific article

Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets

scientific article

Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania

scientific article

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data

scientific article

Plasmodium falciparum mutant haplotype infection during pregnancy associated with reduced birthweight, Tanzania

scientific article published on January 2013

VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

scientific article

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

scientific article

A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma

scientific article

Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern Tanzania

scientific article

Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene.

scientific article published on April 2009

Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children

scientific article

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

scientific article

Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodes

scientific article published in May 2006

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1.

scientific article

Factors associated with and causes of perinatal mortality in northeastern Tanzania.

scientific article published in September 2012

Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens

scientific article

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

scientific article

Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates

scientific article

Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria

scientific article published on 5 February 2007

Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy

scientific article published on December 2011

Engaging diverse communities participating in clinical trials: case examples from across Africa

scientific article

Malaria and fetal growth alterations in the 3(rd) trimester of pregnancy: a longitudinal ultrasound study

scientific article

Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.

scientific article

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites

scientific article (publication date: 2011)

Development of a fetal weight chart using serial trans-abdominal ultrasound in an East African population: a longitudinal observational study

scientific article

Performance of rapid diagnostic test, blood-film microscopy and PCR for the diagnosis of malaria infection among febrile children from Korogwe District, Tanzania

scientific article published on 26 July 2016

Cytophilic antibodies to Plasmodium falciparum glutamate rich protein are associated with malaria protection in an area of holoendemic transmission

scientific article

Aetiology of acute febrile episodes in children attending Korogwe District Hospital in north-eastern Tanzania

scientific article

Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern Tanzania

scientific article published on 4 February 2008

IgG antibodies to endothelial protein C receptor-binding cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria

scientific article published on 26 May 2015

Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in tanzanian children aged 12-24 months

scientific article published on 17 July 2009

Biomarkers of Plasmodium falciparum infection during pregnancy in women living in northeastern Tanzania.

scientific article

Limited cross-reactivity among domains of the Plasmodium falciparum clone 3D7 erythrocyte membrane protein 1 family

scientific article

Evidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1.

scientific article

Reduced risk of uncomplicated malaria episodes in children with alpha+-thalassemia in northeastern Tanzania

scientific article

Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children

scientific article (publication date: 29 November 2010)

Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia

scientific article

Rapid screening for glucose-6-phosphate dehydrogenase deficiency and haemoglobin polymorphisms in Africa by a simple high-throughput SSOP-ELISA method

scientific article

3D7-Derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensity

scientific article

Spatial variation and socio-economic determinants of Plasmodium falciparum infection in northeastern Tanzania

scientific article

List of works by John Lusingu

A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants

Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age

National and regional estimates of term and preterm babies born small for gestational age in 138 low-income and middle-income countries in 2010.

Severe malaria is associated with parasite binding to endothelial protein C receptor

Plasmodium falciparum associated with severe childhood malaria preferentially expresses PfEMP1 encoded by group A var genes

Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in children

A progressive declining in the burden of malaria in north-eastern Tanzania

Immunogenicity of the RTS,S/AS01 malaria vaccine and implications for duration of vaccine efficacy: secondary analysis of data from a phase 3 randomised controlled trial

Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malaria

Occurrence of the Southeast Asian/South American SVMNT haplotype of the chloroquine-resistance transporter gene in Plasmodium falciparum in Tanzania

Neonatal mortality risk associated with preterm birth in East Africa, adjusted by weight for gestational age: individual participant level meta-analysis

Estimates of burden and consequences of infants born small for gestational age in low and middle income countries with INTERGROWTH-21st standard: analysis of CHERG datasets

Malaria morbidity and immunity among residents of villages with different Plasmodium falciparum transmission intensity in North-Eastern Tanzania

Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data

Plasmodium falciparum mutant haplotype infection during pregnancy associated with reduced birthweight, Tanzania

VAR2CSA expression on the surface of placenta-derived Plasmodium falciparum-infected erythrocytes

Plasmodium falciparum var genes expressed in children with severe malaria encode CIDRα1 domains

A semi-automated multiplex high-throughput assay for measuring IgG antibodies against Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) domains in small volumes of plasma

Accuracy of malaria rapid diagnostic tests in community studies and their impact on treatment of malaria in an area with declining malaria burden in north-eastern Tanzania

Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene.

Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children

High efficacy of anti DBL4ɛ-VAR2CSA antibodies in inhibition of CSA-binding Plasmodium falciparum-infected erythrocytes from pregnant women

Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodes

The Severity of Plasmodium falciparum Infection Is Associated with Transcript Levels of var Genes Encoding Endothelial Protein C Receptor-Binding P. falciparum Erythrocyte Membrane Protein 1.

Factors associated with and causes of perinatal mortality in northeastern Tanzania.

Geographical and temporal conservation of antibody recognition of Plasmodium falciparum variant surface antigens

A combined analysis of immunogenicity, antibody kinetics and vaccine efficacy from phase 2 trials of the RTS,S malaria vaccine

Multiple var2csa-type PfEMP1 genes located at different chromosomal loci occur in many Plasmodium falciparum isolates

Immunoglobulin G antibody reactivity to a group A Plasmodium falciparum erythrocyte membrane protein 1 and protection from P. falciparum malaria

Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and after introduction of artemisinin-based combination therapy

Engaging diverse communities participating in clinical trials: case examples from across Africa

Malaria and fetal growth alterations in the 3(rd) trimester of pregnancy: a longitudinal ultrasound study

Plasmodium falciparum expressing domain cassette 5 type PfEMP1 (DC5-PfEMP1) bind PECAM1.

Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites

Development of a fetal weight chart using serial trans-abdominal ultrasound in an East African population: a longitudinal observational study

Performance of rapid diagnostic test, blood-film microscopy and PCR for the diagnosis of malaria infection among febrile children from Korogwe District, Tanzania

Cytophilic antibodies to Plasmodium falciparum glutamate rich protein are associated with malaria protection in an area of holoendemic transmission

Aetiology of acute febrile episodes in children attending Korogwe District Hospital in north-eastern Tanzania

Differences in human antibody reactivity to Plasmodium falciparum variant surface antigens are dependent on age and malaria transmission intensity in northeastern Tanzania

IgG antibodies to endothelial protein C receptor-binding cysteine-rich interdomain region domains of Plasmodium falciparum erythrocyte membrane protein 1 are acquired early in life in individuals exposed to malaria

Satisfactory safety and immunogenicity of MSP3 malaria vaccine candidate in tanzanian children aged 12-24 months

Biomarkers of Plasmodium falciparum infection during pregnancy in women living in northeastern Tanzania.

Limited cross-reactivity among domains of the Plasmodium falciparum clone 3D7 erythrocyte membrane protein 1 family

Evidence for in vitro and in vivo expression of the conserved VAR3 (type 3) plasmodium falciparum erythrocyte membrane protein 1.

Reduced risk of uncomplicated malaria episodes in children with alpha+-thalassemia in northeastern Tanzania

Safety of the malaria vaccine candidate, RTS,S/AS01E in 5 to 17 month old Kenyan and Tanzanian Children

Independent origin of plasmodium falciparum antifolate super-resistance, Uganda, Tanzania, and Ethiopia

Rapid screening for glucose-6-phosphate dehydrogenase deficiency and haemoglobin polymorphisms in Africa by a simple high-throughput SSOP-ELISA method

3D7-Derived Plasmodium falciparum erythrocyte membrane protein 1 is a frequent target of naturally acquired antibodies recognizing protein domains in a particular pattern independent of malaria transmission intensity

Spatial variation and socio-economic determinants of Plasmodium falciparum infection in northeastern Tanzania